SZRD1

Summary

SZRD1 (SUZ RNA binding domain containing 1, HGNC:30232) is a protein-coding gene on chromosome 1p36.13, encoding SUZ RNA-binding domain-containing (Q7Z422).

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 5 total
• MANE Select transcript: NM_001114600

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30232
Approved symbol	SZRD1
Name	SUZ RNA binding domain containing 1
Location	1p36.13
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp566C0424
Ensembl gene	ENSG00000055070
Ensembl biotype	protein_coding
OMIM	620682
Entrez	26099

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 9 protein_coding, 5 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000401088, ENST00000401089, ENST00000471507, ENST00000472351, ENST00000472461, ENST00000475078, ENST00000475554, ENST00000476423, ENST00000486763, ENST00000492354, ENST00000864756, ENST00000913786, ENST00000941312, ENST00000941313, ENST00000941314

RefSeq mRNA: 2 — MANE Select: NM_001114600 NM_001114600, NM_001271869

CCDS: CCDS44065, CCDS60000

Canonical transcript exons

ENST00000401088 — 4 exons

Exon	Start	End
ENSE00001857006	16367242	16367308
ENSE00001932014	16395038	16398145
ENSE00003549917	16391375	16391424
ENSE00003674078	16393228	16393482

Expression profiles

Bgee: expression breadth ubiquitous, 286 present calls, max score 97.13.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 60.2676 / max 642.6341, expressed in 1825 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
964	60.0439	1825
201378	0.1202	34
201379	0.1035	24

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of stomach	UBERON:0001199	97.13	gold quality
stromal cell of endometrium	CL:0002255	96.39	gold quality
thoracic aorta	UBERON:0001515	95.95	gold quality
ascending aorta	UBERON:0001496	95.91	gold quality
monocyte	CL:0000576	95.90	gold quality
leukocyte	CL:0000738	95.88	gold quality
mononuclear cell	CL:0000842	95.88	gold quality
aorta	UBERON:0000947	95.85	gold quality
popliteal artery	UBERON:0002250	95.83	gold quality
tibial artery	UBERON:0007610	95.83	gold quality
islet of Langerhans	UBERON:0000006	95.72	gold quality
right coronary artery	UBERON:0001625	95.69	gold quality
gastrocnemius	UBERON:0001388	95.60	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.51	gold quality
descending thoracic aorta	UBERON:0002345	95.45	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	95.42	gold quality
smooth muscle tissue	UBERON:0001135	95.39	gold quality
granulocyte	CL:0000094	95.34	gold quality
muscle of leg	UBERON:0001383	95.34	gold quality
lower esophagus	UBERON:0013473	95.26	gold quality
lower esophagus muscularis layer	UBERON:0035833	95.26	gold quality
left uterine tube	UBERON:0001303	95.03	gold quality
left coronary artery	UBERON:0001626	94.87	gold quality
body of uterus	UBERON:0009853	94.83	gold quality
coronary artery	UBERON:0001621	94.78	gold quality
gall bladder	UBERON:0002110	94.76	gold quality
esophagus	UBERON:0001043	94.64	gold quality
apex of heart	UBERON:0002098	94.63	gold quality
left adrenal gland	UBERON:0001234	94.43	gold quality
left adrenal gland cortex	UBERON:0035825	94.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.77

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

256 targeting SZRD1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-92A-3P	99.98	75.21	1960

Literature-anchored findings (GeneRIF, showing 2)

• Long non-coding RNA LINC00346 regulates proliferation and apoptosis by targeting miR-128-3p/SZRD1 axis in glioma. (PMID:33015801)
• Hsa_circ_0008344 Promotes Glioma Tumor Progression and Angiogenesis Presumably by Regulating miR-638/SZRD1 Pathway. (PMID:35394558)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	szrd1	ENSDARG00000056338
mus_musculus	Szrd1	ENSMUSG00000040842
rattus_norvegicus	Szrd1	ENSRNOG00000009183

Protein

Protein identifiers

SUZ RNA-binding domain-containing — Q7Z422 (reviewed: Q7Z422)

Alternative names: Putative MAPK-activating protein PM18/PM20/PM22

All UniProt accessions (2): Q7Z422, F8WDF4

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the SZRD1 family.

Isoforms (5)

UniProt ID	Names	Canonical?
Q7Z422-1	1	yes
Q7Z422-2	2
Q7Z422-3	3
Q7Z422-4	4
Q7Z422-5	5

RefSeq proteins (2): NP_001108072, NP_001258798 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR024642	SUZ-C	Domain
IPR024771	SUZ	Domain
IPR039228	SZRD1	Family

Pfam: PF12752, PF12901

UniProt features (17 total): modified residue 6, splice variant 4, compositionally biased region 3, domain 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z422-F1	68.04	0.07

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 51, 105, 107, 1, 37, 39

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 181 (showing top): BROWNE_HCMV_INFECTION_30MIN_DN, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, MAZ_Q6, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, YY1_Q6, AMIT_EGF_RESPONSE_480_MCF10A, OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP, DOANE_RESPONSE_TO_ANDROGEN_DN, KMCATNNWGGA_UNKNOWN, MODULE_480, AAAGGGA_MIR204_MIR211, LIAO_METASTASIS, CCCNNNNNNAAGWT_UNKNOWN, AACTTT_UNKNOWN, VETTER_TARGETS_OF_PRKCA_AND_ETS1_UP

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1

Protein interactions and networks

STRING

1725 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SZRD1	TMEM174	Q8WUU8	541
SZRD1	SRP14	P37108	532
SZRD1	SRP9	P49458	531
SZRD1	NSA2	O95478	490
SZRD1	TM9SF1	O15321	434
SZRD1	AFF4	Q9UHB7	431
SZRD1	PIGG	Q5H8A4	413
SZRD1	MCFD2	Q8NI22	413
SZRD1	THAP3	Q8WTV1	370
SZRD1	TMEM117	Q9H0C3	336
SZRD1	OSBPL8	Q9BZF1	333
SZRD1	ZSCAN12	O43309	322
SZRD1	DEFB108B	Q8NET1	321
SZRD1	ZC3H10	Q96K80	314
SZRD1	NDUFB7	P17568	313
SZRD1	TRDMT1	O14717	313

IntAct

9 interactions, top by confidence:

A	B	Type	Score
SZRD1	UPF1	psi-mi:“MI:0915”(physical association)	0.560
TOM1L2	NDUFA6	psi-mi:“MI:0914”(association)	0.530
SZRD1	CCAR1	psi-mi:“MI:0915”(physical association)	0.400
STRAP	GEMIN2	psi-mi:“MI:0914”(association)	0.350
SZRD1	WDR46	psi-mi:“MI:0914”(association)	0.350
	SZRD1	psi-mi:“MI:0915”(physical association)	0.000
bglB	SZRD1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (25): SZRD1 (Affinity Capture-RNA), SZRD1 (Affinity Capture-RNA), SZRD1 (Affinity Capture-RNA), SZRD1 (Affinity Capture-MS), SZRD1 (Affinity Capture-MS), SZRD1 (Affinity Capture-MS), SZRD1 (Affinity Capture-RNA), SZRD1 (Two-hybrid), CCAR1 (Proximity Label-MS), SZRD1 (Proximity Label-MS), SZRD1 (Affinity Capture-RNA), SZRD1 (Affinity Capture-MS), SZRD1 (Affinity Capture-MS), UPF1 (Affinity Capture-MS), SZRD1 (Affinity Capture-MS)

ESM2 similar proteins: A4IFK9, A4IGK3, A6H6W9, A9YWH3, O54941, O70166, O93388, P13668, P16949, P21818, P31395, P54227, P55821, P63042, P63043, Q2KI04, Q32KT0, Q32M00, Q3SZ60, Q3T0C7, Q4R4N5, Q4R712, Q5BJU6, Q5R4C5, Q5R8C6, Q5RBB8, Q5RE12, Q5SQY2, Q5XIA2, Q5ZK25, Q642H2, Q6AYJ2, Q6DUB7, Q6I9Y2, Q6NXN1, Q6PH81, Q7TMY4, Q7Z422, Q8BR65, Q8CJ19

Diamond homologs: Q2KI04, Q504E7, Q5RE12, Q5XIA2, Q5ZK25, Q6GR00, Q6NXN1, Q6P320, Q7Z422

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

5 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

701 predictions. Top by Δscore:

Variant	Effect	Δscore
1:16367304:GCGGG:G	donor_gain	1.0000
1:16393478:GACAG:G	donor_gain	1.0000
1:16393479:ACAG:A	donor_gain	1.0000
1:16393479:ACAGG:A	donor_loss	1.0000
1:16393480:CAGG:C	donor_loss	1.0000
1:16393481:AG:A	donor_gain	1.0000
1:16393482:GG:G	donor_gain	1.0000
1:16393482:GGTG:G	donor_loss	1.0000
1:16393483:G:GA	donor_loss	1.0000
1:16393483:G:GG	donor_gain	1.0000
1:16393484:T:A	donor_loss	1.0000
1:16367306:GGG:G	donor_gain	0.9900
1:16367307:GG:G	donor_gain	0.9900
1:16367307:GGG:G	donor_gain	0.9900
1:16367308:GG:G	donor_gain	0.9900
1:16369269:T:TA	acceptor_gain	0.9900
1:16369342:A:AG	acceptor_gain	0.9900
1:16369342:AAT:A	acceptor_gain	0.9900
1:16372698:GAT:G	donor_gain	0.9900
1:16393226:A:AG	acceptor_gain	0.9900
1:16393227:G:GA	acceptor_gain	0.9900
1:16393227:GCA:G	acceptor_gain	0.9900
1:16393480:CAG:C	donor_gain	0.9900
1:16395034:TCA:T	acceptor_loss	0.9900
1:16395035:CA:C	acceptor_loss	0.9900
1:16395036:A:AC	acceptor_loss	0.9900
1:16395036:A:AG	acceptor_gain	0.9900
1:16395037:G:GT	acceptor_gain	0.9900
1:16395037:GGCCA:G	acceptor_gain	0.9900
1:16367307:GGGTA:G	donor_loss	0.9800

AlphaMissense

1002 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:16367285:T:A	W10R	1.000
1:16367285:T:C	W10R	1.000
1:16367286:G:C	W10S	1.000
1:16367287:G:C	W10C	1.000
1:16367287:G:T	W10C	1.000
1:16393311:T:A	I62N	1.000
1:16393311:T:C	I62T	1.000
1:16393311:T:G	I62S	1.000
1:16393314:T:C	L63P	1.000
1:16393320:G:C	R65T	1.000
1:16393320:G:T	R65M	1.000
1:16393321:G:C	R65S	1.000
1:16393321:G:T	R65S	1.000
1:16393403:G:C	A93P	1.000
1:16393409:T:C	Y95H	1.000
1:16393410:A:C	Y95S	1.000
1:16393410:A:G	Y95C	1.000
1:16393412:G:C	A96P	1.000
1:16393418:G:C	A98P	1.000
1:16393419:C:A	A98D	1.000
1:16393422:G:C	R99P	1.000
1:16393428:G:C	R101P	1.000
1:16393431:T:A	I102N	1.000
1:16393431:T:C	I102T	1.000
1:16393431:T:G	I102S	1.000
1:16367294:G:C	A13P	0.999
1:16391391:T:C	L23S	0.999
1:16393305:T:C	I60T	0.999
1:16393305:T:G	I60S	0.999
1:16393314:T:A	L63H	0.999

dbSNP variants (sampled 300 via entrez): RS1000070632 (1:16386290 C>CT), RS1000098392 (1:16375118 C>T), RS1000144057 (1:16374938 C>T), RS1000157345 (1:16371051 C>A,G), RS1000298752 (1:16380701 C>G,T), RS1000393853 (1:16369282 G>T), RS1000490783 (1:16368543 G>T), RS1000505924 (1:16386945 C>T), RS1000637382 (1:16393843 G>GA), RS1001008743 (1:16393359 C>T), RS1001071577 (1:16376339 G>A), RS1001103392 (1:16376375 T>A), RS1001133005 (1:16387980 G>A), RS1001353308 (1:16380846 A>G,T), RS1001353899 (1:16387225 A>G)

Disease associations

OMIM: gene MIM:620682 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST012490_525	Femur bone mineral density x serum urate levels interaction	8.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs6603859	SZRD1		0.00	0

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases methylation, affects cotreatment, increases expression	2
Acetaminophen	increases expression	2
Valproic Acid	affects expression, increases methylation	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
bisphenol F	affects cotreatment, increases expression	1
tamibarotene	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
cylindrospermopsin	increases expression	1
K 7174	decreases expression	1
obeticholic acid	increases expression	1
torcetrapib	increases expression	1
Grape Seed Proanthocyanidins	increases expression, affects cotreatment	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	decreases expression	1
Vorinostat	decreases expression	1
Gemcitabine	decreases expression	1
Benzo(a)pyrene	decreases methylation, increases methylation	1
Caffeine	decreases phosphorylation	1
Catechin	affects cotreatment, increases expression	1
Copper	affects binding, decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Disulfiram	affects binding, decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Mercury	affects expression	1
Phthalic Acids	increases methylation	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.