TAF11L4

Summary

TAF11L4 (TATA-box binding protein associated factor 11 like 4, HGNC:53847) is a protein-coding gene on chromosome 5p15.1, encoding TATA-box-binding protein-associated factor 11-like protein 4 (A0A1W2PPE2).

Predicted to enable protein heterodimerization activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex.

Source: NCBI Gene 391746 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001401697

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53847
Approved symbol	TAF11L4
Name	TATA-box binding protein associated factor 11 like 4
Location	5p15.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000284283
Ensembl biotype	protein_coding
Entrez	391746

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000638408

RefSeq mRNA: 1 — MANE Select: NM_001401697 NM_001401697

CCDS: CCDS93690

Canonical transcript exons

ENST00000638408 — 1 exons

Exon	Start	End
ENSE00003811445	17521801	17522397

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 37.20.

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	37.03	gold quality
monocyte	CL:0000576	36.93	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
leukocyte	CL:0000738	36.09	gold quality
skeletal muscle tissue	UBERON:0001134	35.30	gold quality
muscle tissue	UBERON:0002385	32.47	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
liver	UBERON:0002107	28.56	gold quality
duodenum	UBERON:0002114	28.14	gold quality
superior frontal gyrus	UBERON:0002661	27.66	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.90	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
calcaneal tendon	UBERON:0003701	25.09	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.14	gold quality
gastrocnemius	UBERON:0001388	24.11	gold quality
kidney	UBERON:0002113	23.19	gold quality
endometrium	UBERON:0001295	22.90	gold quality
corpus callosum	UBERON:0002336	22.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.05

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	taf11	ENSDARG00000037855
drosophila_melanogaster	Taf11	FBGN0011291
caenorhabditis_elegans		WBGENE00006393
caenorhabditis_elegans	taf-11.2	WBGENE00006394

Paralogs (14): TAF11 (ENSG00000064995), TAF11L12 (ENSG00000249156), LINC02218 (ENSG00000249662), TAF11L14 (ENSG00000250782), TAF11L11 (ENSG00000283740), TAF11L13 (ENSG00000283776), TAF11L8 (ENSG00000283967), TAF11L9 (ENSG00000283988), TAF11L6 (ENSG00000284042), TAF11L5 (ENSG00000284234), TAF11L10 (ENSG00000284356), TAF11L2 (ENSG00000284373), TAF11L3 (ENSG00000284439), TAF11L7 (ENSG00000284465)

Protein

Protein identifiers

TATA-box-binding protein-associated factor 11-like protein 4 — A0A1W2PPE2 (reviewed: A0A1W2PPE2)

All UniProt accessions (1): A0A1W2PPE2

UniProt curated annotations — full annotation on UniProt →

Tissue specificity. Expressed in fetal brain and testis.

Similarity. Belongs to the TAF11 family.

RefSeq proteins (1): NP_001388626* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006809	TAFII28_dom	Domain
IPR009072	Histone-fold	Homologous_superfamily
IPR045127	TAF11-like	Family

Pfam: PF04719

UniProt features (5 total): compositionally biased region 3, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A1W2PPE2-F1	71.99	0.47

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 20 (showing top): GOBP_DNA_TEMPLATED_TRANSCRIPTION_INITIATION, GOBP_TRANSCRIPTION_INITIATION_AT_RNA_POLYMERASE_II_PROMOTER, GOCC_RNA_POLYMERASE_COMPLEX, GOBP_PROTEIN_DNA_COMPLEX_ORGANIZATION, GOCC_TRANSCRIPTION_FACTOR_TFIID_COMPLEX, GOCC_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS, GOCC_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATOR_COMPLEX, GOCC_TRANSFERASE_COMPLEX, GOCC_TRANSCRIPTION_REGULATOR_COMPLEX, GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY, GOMF_PROTEIN_DIMERIZATION_ACTIVITY, GOBP_RNA_POLYMERASE_II_PREINITIATION_COMPLEX_ASSEMBLY, GOBP_TRANSCRIPTION_PREINITIATION_COMPLEX_ASSEMBLY, GOMF_GENERAL_TRANSCRIPTION_INITIATION_FACTOR_ACTIVITY, GOCC_NUCLEAR_PROTEIN_CONTAINING_COMPLEX

GO Biological Process (2): RNA polymerase II preinitiation complex assembly (GO:0051123), transcription initiation at RNA polymerase II promoter (GO:0006367)

GO Molecular Function (2): protein heterodimerization activity (GO:0046982), RNA polymerase II general transcription initiation factor activity (GO:0016251)

GO Cellular Component (2): transcription factor TFIID complex (GO:0005669), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transcription by RNA polymerase II	2
transcription initiation at RNA polymerase II promoter	1
transcription preinitiation complex assembly	1
DNA-templated transcription initiation	1
protein dimerization activity	1
general transcription initiation factor activity	1
RNA polymerase II, holoenzyme	1
RNA polymerase II transcription regulator complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

210 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TAF11L4	CT47A11	Q5JQC4	654
TAF11L4	TMEM106A	Q96A25	644
TAF11L4	DUX4L2	P0CJ85	228
TAF11L4	C4BPA	P04003	202
TAF11L4	TAF12	Q16514	166
TAF11L4	TAF10	Q12962	166
TAF11L4	TAF13	Q15543	166
TAF11L4	TAF8	Q7Z7C8	166
TAF11L4	TAF2	Q6P1X5	166
TAF11L4	TAF6	P49848	166
TAF11L4	BTAF1	O14981	164
TAF11L4	C4orf33	Q8N1A6	161
TAF11L4	PRDX4	Q13162	161
TAF11L4	TAF3	Q5VWG9	157
TAF11L4	TAF4	O00268	138
TAF11L4	TAF5L	O75529	138

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A097I2B5, A0A097I2D0, A0A1W2PP81, A0A1W2PPE2, A0A1W2PPH5, A0A1W2PR64, A0A1W2PRV1, A6NLC8, O75367, O93327, P02276, P06898, P0DW11, P0DW12, P0DW13, P0DW14, P25469, P35066, P35067, P40284, P40287, P61830, P61831, P61833, P61836, P81196, P81198, P81201, P81202, P93354, Q00715, Q02874, Q06196, Q0U1A0, Q2HU65, Q43213, Q54LP8, Q54WG6, Q6C0C4, Q757N1

Diamond homologs: A0A1W2PP81, A0A1W2PPE2, A0A1W2PPH5, A0A1W2PPL8, A0A1W2PPW3, A0A1W2PQ09, A0A1W2PR64, A0A1W2PRV1, A6NLC8, F4HR03, P0DW11, P0DW12, P0DW13, P0DW14, P49906, Q15544, Q54XM9, Q5RA91, Q5U1X0, Q99JX1, Q9M565, Q9US54, Q04226

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1288 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:17522332:G:C	A178P	0.986
5:17522324:T:C	L175S	0.973
5:17522237:C:A	A146D	0.972
5:17522333:C:A	A178D	0.972
5:17522269:G:C	A157P	0.970
5:17522241:G:C	K147N	0.968
5:17522241:G:T	K147N	0.968
5:17522222:C:A	A141D	0.963
5:17522150:T:C	F117S	0.962
5:17522328:G:C	R176S	0.960
5:17522328:G:T	R176S	0.960
5:17522149:T:C	F117L	0.950
5:17522151:C:A	F117L	0.950
5:17522151:C:G	F117L	0.950
5:17522309:T:A	L170Q	0.949
5:17522249:T:A	V150D	0.946
5:17522331:G:C	E177D	0.946
5:17522331:G:T	E177D	0.946
5:17522339:G:C	R180P	0.946
5:17522321:A:G	H174R	0.945
5:17522227:G:C	A143P	0.939
5:17522236:G:C	A146P	0.935
5:17522150:T:G	F117C	0.933
5:17522319:G:C	K173N	0.933
5:17522319:G:T	K173N	0.933
5:17522392:T:C	F198L	0.928
5:17522394:C:A	F198L	0.928
5:17522394:C:G	F198L	0.928
5:17522239:A:G	K147E	0.926
5:17522327:G:C	R176T	0.926

dbSNP variants (sampled 300 via entrez): RS112803174 (5:17520306 A>G), RS1156279669 (5:17522580 A>C), RS1157317982 (5:17520562 A>G,T), RS1158102016 (5:17521105 G>C), RS1158538556 (5:17521195 T>C,G), RS1160162089 (5:17521091 C>T), RS1160238417 (5:17520128 C>A,T), RS1161223897 (5:17520945 C>T), RS1162188793 (5:17521661 G>A,T), RS1162570293 (5:17519985 A>G), RS1164608271 (5:17522515 G>A), RS1164717094 (5:17520463 C>T), RS1165891088 (5:17520711 C>A,G), RS1166079085 (5:17521584 G>C), RS1166188133 (5:17520342 C>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Gallic Acid	decreases expression	1
Ivermectin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.