TAF11L6

Summary

TAF11L6 (TATA-box binding protein associated factor 11 like 6, HGNC:53849) is a protein-coding gene on chromosome 5p15.1, encoding TATA-box-binding protein-associated factor 11-like protein 6 (P0DW11).

Predicted to enable protein heterodimerization activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex.

Source: NCBI Gene 391747 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001401698

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53849
Approved symbol	TAF11L6
Name	TATA-box binding protein associated factor 11 like 6
Location	5p15.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000284042
Ensembl biotype	protein_coding
Entrez	391747

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000640558

RefSeq mRNA: 1 — MANE Select: NM_001401698 NM_001401698

CCDS: CCDS93692

Canonical transcript exons

ENST00000640558 — 1 exons

Exon	Start	End
ENSE00003802288	17528669	17529265

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 37.46.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	37.46	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.26	gold quality
monocyte	CL:0000576	33.69	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
leukocyte	CL:0000738	33.14	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.78	gold quality
blood	UBERON:0000178	28.90	gold quality
liver	UBERON:0002107	28.36	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.90	gold quality
superior frontal gyrus	UBERON:0002661	26.73	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
frontal cortex	UBERON:0001870	25.04	gold quality
muscle of leg	UBERON:0001383	24.86	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
cortex of kidney	UBERON:0001225	23.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	taf11	ENSDARG00000037855
drosophila_melanogaster	Taf11	FBGN0011291
caenorhabditis_elegans		WBGENE00006393
caenorhabditis_elegans	taf-11.2	WBGENE00006394

Paralogs (14): TAF11 (ENSG00000064995), TAF11L12 (ENSG00000249156), LINC02218 (ENSG00000249662), TAF11L14 (ENSG00000250782), TAF11L11 (ENSG00000283740), TAF11L13 (ENSG00000283776), TAF11L8 (ENSG00000283967), TAF11L9 (ENSG00000283988), TAF11L5 (ENSG00000284234), TAF11L4 (ENSG00000284283), TAF11L10 (ENSG00000284356), TAF11L2 (ENSG00000284373), TAF11L3 (ENSG00000284439), TAF11L7 (ENSG00000284465)

Protein

Protein identifiers

TATA-box-binding protein-associated factor 11-like protein 6 — P0DW11 (reviewed: P0DW11)

All UniProt accessions (1): P0DW11

UniProt curated annotations — full annotation on UniProt →

Tissue specificity. Expressed in fetal brain and testis.

Similarity. Belongs to the TAF11 family.

RefSeq proteins (1): NP_001388627* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006809	TAFII28_dom	Domain
IPR009072	Histone-fold	Homologous_superfamily
IPR045127	TAF11-like	Family

Pfam: PF04719

UniProt features (5 total): compositionally biased region 3, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DW11-F1	72.47	0.46

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 20 (showing top): GOBP_DNA_TEMPLATED_TRANSCRIPTION_INITIATION, GOBP_TRANSCRIPTION_INITIATION_AT_RNA_POLYMERASE_II_PROMOTER, GOCC_RNA_POLYMERASE_COMPLEX, GOBP_PROTEIN_DNA_COMPLEX_ORGANIZATION, GOCC_TRANSCRIPTION_FACTOR_TFIID_COMPLEX, GOCC_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS, GOCC_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATOR_COMPLEX, GOCC_TRANSFERASE_COMPLEX, GOCC_TRANSCRIPTION_REGULATOR_COMPLEX, GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY, GOMF_PROTEIN_DIMERIZATION_ACTIVITY, GOBP_RNA_POLYMERASE_II_PREINITIATION_COMPLEX_ASSEMBLY, GOBP_TRANSCRIPTION_PREINITIATION_COMPLEX_ASSEMBLY, GOMF_GENERAL_TRANSCRIPTION_INITIATION_FACTOR_ACTIVITY, GOCC_NUCLEAR_PROTEIN_CONTAINING_COMPLEX

GO Biological Process (2): RNA polymerase II preinitiation complex assembly (GO:0051123), transcription initiation at RNA polymerase II promoter (GO:0006367)

GO Molecular Function (2): protein heterodimerization activity (GO:0046982), RNA polymerase II general transcription initiation factor activity (GO:0016251)

GO Cellular Component (2): transcription factor TFIID complex (GO:0005669), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transcription by RNA polymerase II	2
transcription initiation at RNA polymerase II promoter	1
transcription preinitiation complex assembly	1
DNA-templated transcription initiation	1
protein dimerization activity	1
general transcription initiation factor activity	1
RNA polymerase II, holoenzyme	1
RNA polymerase II transcription regulator complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A097I2B5, A0A097I2D0, A0A1W2PP81, A0A1W2PPE2, A0A1W2PPH5, A0A1W2PR64, A0A1W2PRV1, A6NLC8, O75367, O93327, P02276, P06898, P0DW11, P0DW12, P0DW13, P0DW14, P25469, P35066, P35067, P40284, P40287, P61830, P61831, P61833, P61836, P81196, P81198, P81201, P81202, P93354, Q00715, Q02874, Q06196, Q0U1A0, Q2HU65, Q43213, Q54LP8, Q54WG6, Q6C0C4, Q757N1

Diamond homologs: A0A1W2PP81, A0A1W2PPE2, A0A1W2PPH5, A0A1W2PPL8, A0A1W2PPW3, A0A1W2PQ09, A0A1W2PR64, A0A1W2PRV1, A6NLC8, F4HR03, P0DW11, P0DW12, P0DW13, P0DW14, P49906, Q15544, Q54XM9, Q5RA91, Q5U1X0, Q99JX1, Q9M565, Q9US54, Q04226

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1013455847 (5:17527238 T>A,G), RS1045844885 (5:17529453 T>G), RS111505476 (5:17527140 T>C), RS111593106 (5:17527977 G>A), RS111849960 (5:17527131 T>A,C,G), RS112269486 (5:17527126 G>A,T), RS113048781 (5:17528872 A>G), RS113474209 (5:17527732 T>C), RS1157419160 (5:17528184 A>G), RS1157807277 (5:17527276 C>G,T), RS1159285192 (5:17528098 G>A), RS1160522471 (5:17527232 A>ATC), RS1161389367 (5:17529743 A>G,T), RS1162423538 (5:17526913 G>A), RS1162901573 (5:17529591 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.