TAF5L

Summary

TAF5L (TATA-box binding protein associated factor 5 like, HGNC:17304) is a protein-coding gene on chromosome 1q42.13, encoding TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (O75529). Functions as a component of the PCAF complex. It is a selective cancer dependency (DepMap: 27.0% of cell lines).

The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Source: NCBI Gene 27097 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 81 total
• Cancer dependency (DepMap): dependent in 27.0% of screened cell lines
• MANE Select transcript: NM_014409

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17304
Approved symbol	TAF5L
Name	TATA-box binding protein associated factor 5 like
Location	1q42.13
Locus type	gene with protein product
Status	Approved
Aliases	PAF65B
Ensembl gene	ENSG00000135801
Ensembl biotype	protein_coding
Entrez	27097

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 4 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000258281, ENST00000366674, ENST00000366675, ENST00000477957, ENST00000912671

RefSeq mRNA: 2 — MANE Select: NM_014409 NM_001025247, NM_014409

CCDS: CCDS1581, CCDS31051

Canonical transcript exons

ENST00000258281 — 5 exons

Exon	Start	End
ENSE00000921356	229602195	229602919
ENSE00003487022	229610106	229610210
ENSE00003584340	229614341	229614485
ENSE00003978331	229625885	229626122
ENSE00003978332	229593134	229595094

Expression profiles

Bgee: expression breadth ubiquitous, 244 present calls, max score 89.66.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.8637 / max 77.9198, expressed in 1787 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
17924	9.4592	1787
17923	0.4046	175

Top tissues by expression

279 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	89.66	gold quality
popliteal artery	UBERON:0002250	88.69	gold quality
tibial artery	UBERON:0007610	88.67	gold quality
secondary oocyte	CL:0000655	88.44	gold quality
aorta	UBERON:0000947	88.04	gold quality
right coronary artery	UBERON:0001625	87.89	gold quality
thoracic aorta	UBERON:0001515	87.40	gold quality
ascending aorta	UBERON:0001496	87.28	gold quality
descending thoracic aorta	UBERON:0002345	87.20	gold quality
monocyte	CL:0000576	86.55	gold quality
gastrocnemius	UBERON:0001388	86.46	gold quality
left coronary artery	UBERON:0001626	86.45	gold quality
mononuclear cell	CL:0000842	86.42	gold quality
leukocyte	CL:0000738	86.30	gold quality
oocyte	CL:0000023	85.67	gold quality
muscle of leg	UBERON:0001383	85.65	gold quality
coronary artery	UBERON:0001621	85.61	gold quality
lower esophagus muscularis layer	UBERON:0035833	84.59	gold quality
lower esophagus	UBERON:0013473	84.57	gold quality
rectum	UBERON:0001052	84.41	gold quality
mucosa of stomach	UBERON:0001199	84.35	gold quality
granulocyte	CL:0000094	84.14	gold quality
gall bladder	UBERON:0002110	84.14	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	83.80	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.77	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.74	gold quality
cortical plate	UBERON:0005343	83.72	gold quality
left uterine tube	UBERON:0001303	83.50	gold quality
muscle layer of sigmoid colon	UBERON:0035805	83.42	gold quality
ganglionic eminence	UBERON:0004023	83.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.01

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F1

miRNA regulators (miRDB)

59 targeting TAF5L, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-345-3P	99.89	70.23	1421
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-1825	99.72	68.11	1089
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-4255	99.72	67.70	1541
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-670-5P	99.67	69.94	1565
HSA-MIR-1260A	99.61	66.67	1098
HSA-MIR-1260B	99.61	66.67	1098
HSA-MIR-510-3P	99.54	70.06	2965
HSA-MIR-6853-3P	99.36	70.79	1558
HSA-MIR-185-5P	99.35	68.60	2497
HSA-MIR-4644	99.35	69.12	2514
HSA-MIR-6731-5P	99.28	67.42	2375
HSA-MIR-8085	99.28	67.56	2362
HSA-MIR-4721	99.26	66.05	818
HSA-MIR-3978	99.24	68.39	2201
HSA-MIR-4727-5P	99.23	67.55	1154
HSA-MIR-449B-3P	99.20	67.24	1047
HSA-MIR-1286	99.09	66.23	1046

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 27.0% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 5)

• p300 can acetylate DNA-bound Myc:Max complexes and that acetylated Myc:Max heterodimers efficiently interact with Miz-1 (PMID:16126174)
• The TAF5L gene on chromosome 1q42 is associated tie type 1 diabetes in Russian patients. (PMID:16206511)
• p300 or PCAF maintains myoblast viability as effectively as added growth factors through mechanisms requiring the acetyltransferase activity of PCAF but not of p300. (PMID:16672693)
• PCAF is a histone acetyltransferase which regulates gene transcription. PCAF interacts physically and functionally with PTEN. PTEN acetylation by PCAF block the ability of PTEN to downregulate PI3-K signalling and to induce G1 cell cycle arrest. (PMID:16829519)
• latent cytoplasmic coactivator TORC2 mediates target gene activation in response to cAMP signaling by associating with CBP/p300 and increasing its recruitment to a subset of CREB target genes (PMID:17476304)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	taf5l	ENSDARG00000025808
mus_musculus	Taf5l	ENSMUSG00000038697
rattus_norvegicus	Taf5l1	ENSRNOG00000018027
rattus_norvegicus		ENSRNOG00000068380
drosophila_melanogaster	wda	FBGN0039067

Paralogs (1): TAF5 (ENSG00000148835)

Protein

Protein identifiers

TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L — O75529 (reviewed: O75529)

Alternative names: PCAF-associated factor 65 beta

All UniProt accessions (2): O75529, Q5TDI7

UniProt curated annotations — full annotation on UniProt →

Function. Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state.

Subunit / interactions. The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.

Subcellular location. Nucleus.

Miscellaneous. May be due to an intron retention.

Similarity. Belongs to the WD repeat TAF5 family.

Isoforms (2)

UniProt ID	Names	Canonical?
O75529-1	1	yes
O75529-2	2

RefSeq proteins (2): NP_001020418, NP_055224* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR007582	TFIID_NTD2	Domain
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR020472	WD40_PAC1	Repeat
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR037264	TFIID_NTD2_sf	Homologous_superfamily

Pfam: PF00400, PF04494

UniProt features (59 total): strand 31, helix 11, repeat 6, turn 6, splice variant 2, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
9RDK	ELECTRON MICROSCOPY	2.41
7KTR	ELECTRON MICROSCOPY	2.93
8H7G	ELECTRON MICROSCOPY	3.7
7KTS	ELECTRON MICROSCOPY	19.09

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75529-F1	76.54	0.27

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-3214847	HATs acetylate histones
R-HSA-3247509	Chromatin modifying enzymes
R-HSA-4839726	Chromatin organization

MSigDB gene sets: 198 (showing top): RRAGTTGT_UNKNOWN, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, GOBP_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE, HNF3ALPHA_Q6, NAGY_STAGA_COMPONENTS_HUMAN, MORF_MSH3, TGCACTT_MIR519C_MIR519B_MIR519A, MORF_BRCA1, MORF_ATRX, GOBP_REGULATION_OF_DNA_REPAIR, SRF_Q5_01, PUJANA_CHEK2_PCC_NETWORK, BROWNE_HCMV_INFECTION_24HR_UP, GOBP_REGULATION_OF_RESPONSE_TO_STRESS, GOBP_RNA_SPLICING

GO Biological Process (7): regulation of DNA repair (GO:0006282), regulation of DNA-templated transcription (GO:0006355), regulation of transcription by RNA polymerase II (GO:0006357), transcription by RNA polymerase II (GO:0006366), regulation of RNA splicing (GO:0043484), positive regulation of DNA-templated transcription (GO:0045893), regulation of somatic stem cell population maintenance (GO:1904672)

GO Molecular Function (2): transcription coactivator activity (GO:0003713), protein binding (GO:0005515)

GO Cellular Component (5): SAGA complex (GO:0000124), nucleus (GO:0005634), nuclear speck (GO:0016607), transcription factor TFTC complex (GO:0033276), cytoplasmic ribonucleoprotein granule (GO:0036464)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Chromatin modifying enzymes	1
Chromatin organization	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	3
regulation of gene expression	2
regulation of DNA-templated transcription	2
SAGA-type complex	2
DNA repair	1
regulation of DNA metabolic process	1
regulation of cellular response to stress	1
regulation of RNA biosynthetic process	1
transcription by RNA polymerase II	1
RNA splicing	1
regulation of primary metabolic process	1
positive regulation of RNA biosynthetic process	1
somatic stem cell population maintenance	1
regulation of stem cell population maintenance	1
transcription coregulator activity	1
positive regulation of DNA-templated transcription	1
binding	1
DUBm complex	1
peptidase complex	1
intracellular membrane-bounded organelle	1
nuclear ribonucleoprotein granule	1
RNA polymerase II, holoenzyme	1
RNA polymerase II transcription regulator complex	1
cytoplasm	1
ribonucleoprotein granule	1

Protein interactions and networks

STRING

2807 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TAF5L	TAF6L	Q9Y6J9	958
TAF5L	TAF10	Q12962	875
TAF5L	KAT2B	Q92831	841
TAF5L	TAF9B	Q9HBM6	829
TAF5L	TAF12	Q16514	816
TAF5L	TRRAP	Q9Y4A5	812
TAF5L	TAF9	Q16594	795
TAF5L	TAF6	P49848	794
TAF5L	TADA3	O75528	792
TAF5L	SGF29	Q96ES7	762
TAF5L	SUPT7L	O94864	757
TAF5L	SUPT20H	Q8NEM7	739
TAF5L	SUPT3H	O75486	737
TAF5L	KAT2A	Q92830	733
TAF5L	TAF2	Q6P1X5	718

IntAct

103 interactions, top by confidence:

A	B	Type	Score
SGF29	NDC80	psi-mi:“MI:0914”(association)	0.840
TAF12	TAF4	psi-mi:“MI:0914”(association)	0.760
TRRAP	ATXN7	psi-mi:“MI:0914”(association)	0.740
TADA3	TADA2A	psi-mi:“MI:0914”(association)	0.740
KAT2B	TADA2A	psi-mi:“MI:0914”(association)	0.640
TADA1	TAF5L	psi-mi:“MI:0914”(association)	0.640
ATXN7L3	USP27X	psi-mi:“MI:0914”(association)	0.640
MPPED1	TXNDC9	psi-mi:“MI:0914”(association)	0.640
TADA1	TADA3	psi-mi:“MI:0914”(association)	0.640
TAF5L	TUBB8	psi-mi:“MI:0915”(physical association)	0.620
FOXR2	NME2P1	psi-mi:“MI:0914”(association)	0.530
SUPT20H	ATXN7	psi-mi:“MI:0914”(association)	0.530
TAF6L	SUPT3H	psi-mi:“MI:0914”(association)	0.530
TADA2B	SUPT3H	psi-mi:“MI:0914”(association)	0.530
CREB3	MYO9A	psi-mi:“MI:0914”(association)	0.530
SGF29	MATN2	psi-mi:“MI:0914”(association)	0.530
SUPT20H	TAF5L	psi-mi:“MI:0914”(association)	0.530
TAF5L	FOXO3	psi-mi:“MI:0915”(physical association)	0.500
FOXO3	TAF5L	psi-mi:“MI:0914”(association)	0.500
Kat2a	TAF5L	psi-mi:“MI:0915”(physical association)	0.400
CEBPE	TAF5L	psi-mi:“MI:0915”(physical association)	0.370
ANXA7	TAF5L	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (181): TAF5L (Reconstituted Complex), TAF5L (Protein-peptide), TAF5L (Affinity Capture-MS), TAF5L (Affinity Capture-MS), TAF5L (Affinity Capture-MS), TAF5L (Affinity Capture-MS), TUBB8 (Affinity Capture-MS), TADA2B (Affinity Capture-MS), TAF9B (Affinity Capture-MS), SUPT3H (Affinity Capture-MS), TAF5L (Affinity Capture-MS), TAF5L (Affinity Capture-MS), TAF5L (Affinity Capture-MS), TAF5L (Affinity Capture-Western), TAF5L (Affinity Capture-MS)

ESM2 similar proteins: A2RRU3, A7MB12, A8XSW2, A8XYW9, G5ECZ4, G5EFW7, O13282, O14053, O43071, O75529, O94365, P25635, P38328, P40968, P42000, P49846, P87177, P91341, Q04199, Q04305, Q05946, Q05BV3, Q12220, Q15269, Q20059, Q3MKM6, Q5F3D7, Q5REE0, Q5RFQ3, Q5XGE2, Q6ED65, Q7ZW33, Q7ZXZ2, Q8BHB4, Q8BQM8, Q8BU03, Q8C7V3, Q8SQS4, Q8TED0, Q8VYZ5

Diamond homologs: O75529, Q7T2F6, Q91WQ5, A1CUD6, A1DP19, A2QP30, A4R3M4, B0XM00, B6GZD3, B6HP56, B6QC06, B6QC56, B8M0Q1, B8N9H4, C0S902, C1GB49, C4JPW9, C5PFX0, D5GBI7, O13282, P32479, P38129, Q00664, Q0CQ54, Q0D0X6, Q0U1B1, Q2GT28, Q2UBU2, Q2UGU1, Q4WLM7, Q4WTC4, Q5BDU4, Q6BYU4, Q6CXX3, Q6FVD3, Q74ZN0, Q7RY30, Q9C1X1, Q9C270, Q9FLX9

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
TAF5L	“form complex”	“SAGA complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 112 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of WDR5-containing histone-modifying complexes	5	19.5×	4e-04
HATs acetylate histones	15	17.5×	2e-12
Chromatin organization	13	15.6×	4e-10
Chromatin modifying enzymes	13	13.8×	1e-09
Deubiquitination	7	12.8×	1e-04
Epigenetic regulation by WDR5-containing histone modifying complexes	5	11.3×	6e-03
Ub-specific processing proteases	9	7.0×	4e-04

GO biological processes:

GO term	Partners	Fold	FDR
regulation of DNA repair	18	48.8×	2e-23
regulation of RNA splicing	18	38.6×	1e-21
regulation of cell division	5	37.5×	3e-05
regulation of embryonic development	5	16.2×	1e-03
RNA polymerase II preinitiation complex assembly	5	13.3×	3e-03
chromatin remodeling	9	6.4×	1e-03
transcription by RNA polymerase II	9	6.2×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

81 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	69
Likely benign	3
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1015 predictions. Top by Δscore:

Variant	Effect	Δscore
1:229595102:CAG:C	acceptor_gain	1.0000
1:229595103:A:T	acceptor_gain	1.0000
1:229595104:G:C	acceptor_gain	1.0000
1:229595104:G:GC	acceptor_gain	1.0000
1:229595109:G:C	acceptor_gain	1.0000
1:229595109:G:GC	acceptor_gain	1.0000
1:229595114:G:C	acceptor_gain	1.0000
1:229595114:G:GC	acceptor_gain	1.0000
1:229597294:T:TA	donor_gain	1.0000
1:229602196:T:TA	donor_gain	1.0000
1:229602920:C:CC	acceptor_gain	1.0000
1:229610100:ACTT:A	donor_loss	1.0000
1:229610101:CTT:C	donor_loss	1.0000
1:229610102:TTAC:T	donor_loss	1.0000
1:229610103:TA:T	donor_loss	1.0000
1:229610104:A:AC	donor_gain	1.0000
1:229610104:AC:A	donor_gain	1.0000
1:229610105:C:CA	donor_gain	1.0000
1:229610105:C:G	donor_loss	1.0000
1:229610105:CC:C	donor_gain	1.0000
1:229610105:CCA:C	donor_gain	1.0000
1:229610105:CCAG:C	donor_gain	1.0000
1:229610105:CCAGT:C	donor_gain	1.0000
1:229610206:TTGCA:T	acceptor_gain	1.0000
1:229610207:TGCA:T	acceptor_gain	1.0000
1:229610208:GCA:G	acceptor_gain	1.0000
1:229610209:CA:C	acceptor_gain	1.0000
1:229610209:CAC:C	acceptor_gain	1.0000
1:229610211:C:CC	acceptor_gain	1.0000
1:229595090:TCATC:T	acceptor_gain	0.9900

AlphaMissense

3879 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:229594458:A:G	W537R	0.999
1:229594458:A:T	W537R	0.999
1:229594584:A:G	W495R	0.999
1:229594584:A:T	W495R	0.999
1:229594718:A:T	V450D	0.999
1:229594742:G:T	A442D	0.999
1:229594864:G:C	S401R	0.999
1:229594864:G:T	S401R	0.999
1:229594866:T:G	S401R	0.999
1:229594490:G:T	A526D	0.998
1:229594582:C:A	W495C	0.998
1:229594582:C:G	W495C	0.998
1:229594710:A:G	W453R	0.998
1:229594710:A:T	W453R	0.998
1:229594728:C:G	D447H	0.998
1:229594456:C:A	W537C	0.997
1:229594456:C:G	W537C	0.997
1:229594487:G:T	S527Y	0.997
1:229594583:C:G	W495S	0.997
1:229594613:G:T	S485Y	0.997
1:229594715:C:G	R451P	0.997
1:229594727:T:A	D447V	0.997
1:229594736:C:T	G444D	0.997
1:229594739:G:T	T443K	0.997
1:229594463:C:G	R535P	0.996
1:229594487:G:A	S527F	0.996
1:229594488:A:G	S527P	0.996
1:229594613:G:A	S485F	0.996
1:229594614:A:G	S485P	0.996
1:229594712:A:G	L452P	0.996

dbSNP variants (sampled 300 via entrez): RS1000024481 (1:229620845 T>A,C), RS1000166517 (1:229603452 G>C,T), RS1000313113 (1:229615319 C>T), RS1000349076 (1:229620635 T>C), RS1000455566 (1:229609147 C>T), RS1000542859 (1:229621185 A>G), RS1000547496 (1:229608041 G>T), RS1000651653 (1:229616654 T>G), RS1000663504 (1:229608289 G>A), RS1000833222 (1:229595540 C>T), RS1000898431 (1:229616374 AT>A,ATT), RS1000917534 (1:229597828 T>C), RS1001231963 (1:229610596 C>A), RS1001292504 (1:229601959 T>C), RS1001319924 (1:229614027 GTTAA>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST001980_3	Circulating myeloperoxidase levels (plasma)	1.000000e-06
GCST90002403_67	Red blood cell count	2.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005243	myeloperoxidase measurement
EFO:0004305	erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Cadmium Chloride	decreases expression	2
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
titanium dioxide	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	decreases expression	1
butyraldehyde	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
Grape Seed Proanthocyanidins	decreases expression, affects cotreatment	1
dorsomorphin	decreases expression, affects cotreatment	1
Irinotecan	affects cotreatment, decreases expression	1
Amiodarone	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Catechin	affects cotreatment, decreases expression	1
Demecolcine	decreases expression	1
Doxorubicin	decreases expression	1
Estradiol	increases expression, increases reaction	1
Ethyl Methanesulfonate	decreases expression	1
Fluorouracil	affects cotreatment, decreases expression	1
Formaldehyde	decreases expression	1
Ketoconazole	affects expression	1
Methyl Methanesulfonate	decreases expression	1
Nickel	increases expression	1
Quercetin	increases expression	1
Selenium	decreases expression	1
Silicon Dioxide	increases expression	1
Dihydrotestosterone	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Triiodothyronine	increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TR49	HAP1 TAF5L (-) 1	Cancer cell line	Male
CVCL_TR50	HAP1 TAF5L (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.