TARID

Summary

TARID (TCF21 antisense RNA inducing promoter demethylation, HGNC:50506) is a long non-coding RNA gene on chromosome 6q23.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50506
Approved symbol	TARID
Name	TCF21 antisense RNA inducing promoter demethylation
Location	6q23.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227954
Ensembl biotype	lncRNA
OMIM	616058
Entrez	100507308
RNAcentral	URS0000759C5B — lncRNA, 3002 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 67 — 67 lncRNA

ENST00000419627, ENST00000451017, ENST00000606292, ENST00000606544, ENST00000607033, ENST00000607573, ENST00000607641, ENST00000626104, ENST00000630119, ENST00000630728, ENST00000631362, ENST00000666537, ENST00000795401, ENST00000795402, ENST00000795403, ENST00000795404, ENST00000795405, ENST00000795406, ENST00000795407, ENST00000795408, ENST00000795409, ENST00000795410, ENST00000795411, ENST00000795412, ENST00000795413, ENST00000795414, ENST00000795415, ENST00000795416, ENST00000795417, ENST00000795418, ENST00000795419, ENST00000795420, ENST00000795421, ENST00000795422, ENST00000795423, ENST00000795424, ENST00000795425, ENST00000795426, ENST00000795427, ENST00000795428, ENST00000795429, ENST00000795430, ENST00000795431, ENST00000795432, ENST00000795433, ENST00000795434, ENST00000795435, ENST00000795436, ENST00000795437, ENST00000795438, ENST00000795439, ENST00000795440, ENST00000795441, ENST00000795442, ENST00000795443, ENST00000795444, ENST00000795445, ENST00000795446, ENST00000795447, ENST00000795448, ENST00000795449, ENST00000795450, ENST00000795451, ENST00000795452, ENST00000795453, ENST00000795454, ENST00000795455

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419627 — 6 exons

Exon	Start	End
ENSE00001592846	133845877	133845951
ENSE00001688805	133760185	133760260
ENSE00001805991	133768831	133768923
ENSE00003695097	133568190	133568248
ENSE00004180132	133888604	133889050
ENSE00004180156	133538104	133538192

Expression profiles

Bgee: expression breadth ubiquitous, 123 present calls, max score 82.91.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1901 / max 100.4634, expressed in 48 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
75635	0.1587	44
75636	0.0315	7

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	82.91	gold quality
left ovary	UBERON:0002119	81.46	gold quality
ovary	UBERON:0000992	81.07	gold quality
right lung	UBERON:0002167	80.12	gold quality
right ovary	UBERON:0002118	79.89	gold quality
spleen	UBERON:0002106	78.14	gold quality
placenta	UBERON:0001987	77.18	gold quality
ectocervix	UBERON:0012249	76.27	gold quality
bone marrow cell	CL:0002092	76.02	silver quality
metanephros cortex	UBERON:0010533	76.01	gold quality
lung	UBERON:0002048	75.32	gold quality
adenohypophysis	UBERON:0002196	74.38	gold quality
upper lobe of left lung	UBERON:0008952	74.18	gold quality
kidney	UBERON:0002113	73.57	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.52	gold quality
colonic epithelium	UBERON:0000397	73.22	gold quality
mucosa of transverse colon	UBERON:0004991	72.99	gold quality
adult mammalian kidney	UBERON:0000082	72.76	gold quality
cortex of kidney	UBERON:0001225	72.58	gold quality
pituitary gland	UBERON:0000007	72.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.22	gold quality
lower esophagus	UBERON:0013473	72.18	gold quality
right coronary artery	UBERON:0001625	70.84	gold quality
uterine cervix	UBERON:0000002	70.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.20	gold quality
skeletal muscle tissue	UBERON:0001134	70.13	gold quality
muscle tissue	UBERON:0002385	69.72	gold quality
prostate gland	UBERON:0002367	69.63	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.41	gold quality
putamen	UBERON:0001874	69.00	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	2755.97
E-CURD-119	yes	32.27
E-ANND-3	yes	7.72

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Results show that an antisense lncRNA, termed TARID (for TCF21 antisense RNA inducing demethylation), activates TCF21 expression by inducing promoter demethylation. TARID interacts with both the TCF21 promoter and GADD45A. (PMID:25087872)
• LncRNA TARID induces cell proliferation through cell cycle pathway associated with coronary artery disease. (PMID:35304681)
• The long noncoding RNA TARID regulates the CXCL3/ERK/MAPK pathway in trophoblasts and is associated with preeclampsia. (PMID:36401313)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.