TAS2R2

Summary

TAS2R2 (taste 2 receptor member 2 (gene/pseudogene), HGNC:20615) is a processed pseudogene on chromosome 7p21.3. Bitter taste receptor that detects natural and synthetic bitter compounds.

Enables bitter taste receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of bitter taste. Located in plasma membrane.

Source: NCBI Gene 338396 — RefSeq curated summary.

At a glance

• Gene type: non-coding (processed_pseudogene) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20615
Approved symbol	TAS2R2
Name	taste 2 receptor member 2 (gene/pseudogene)
Location	7p21.3
Locus type	gene with protein product
Status	Approved
Aliases	T2R02, T2R2
Ensembl gene	ENSG00000203523
Ensembl biotype	processed_pseudogene
Entrez	338396

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 processed_pseudogene

ENST00000421146

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421146 — 1 exons

Exon	Start	End
ENSE00001622505	12491095	12492004

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 89.35.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.35	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.78	gold quality
metanephros cortex	UBERON:0010533	49.64	gold quality
testis	UBERON:0000473	43.89	gold quality
kidney	UBERON:0002113	43.82	gold quality
left testis	UBERON:0004533	43.29	gold quality
adult mammalian kidney	UBERON:0000082	43.16	gold quality
placenta	UBERON:0001987	42.64	gold quality
right testis	UBERON:0004534	41.15	gold quality
cortex of kidney	UBERON:0001225	40.55	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
mucosa of transverse colon	UBERON:0004991	37.09	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
mucosa of stomach	UBERON:0001199	34.73	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
endometrium	UBERON:0001295	33.19	silver quality
bone marrow	UBERON:0002371	33.04	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.33	gold quality
duodenum	UBERON:0002114	28.14	gold quality
calcaneal tendon	UBERON:0003701	28.11	gold quality
right coronary artery	UBERON:0001625	28.08	gold quality
monocyte	CL:0000576	27.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.