TAS2R30

Summary

TAS2R30 (taste 2 receptor member 30, HGNC:19112) is a protein-coding gene on chromosome 12p13.2, encoding Taste receptor type 2 member 30 (P59541). Receptor that may play a role in the perception of bitterness and is gustducin-linked.

Enables bitter taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste. Predicted to be located in plasma membrane. Predicted to be active in membrane.

Source: NCBI Gene 259293 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 2 total
• Druggable target: yes — 1 molecules with ChEMBL bioactivity
• MANE Select transcript: NM_001097643

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19112
Approved symbol	TAS2R30
Name	taste 2 receptor member 30
Location	12p13.2
Locus type	gene with protein product
Status	Approved
Aliases	T2R30
Ensembl gene	ENSG00000256188
Ensembl biotype	protein_coding
OMIM	613963
Entrez	259293

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000539585

RefSeq mRNA: 1 — MANE Select: NM_001097643 NM_001097643

CCDS: CCDS53750

Canonical transcript exons

ENST00000539585 — 1 exons

Exon	Start	End
ENSE00001750591	11132958	11134644

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 79.40.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	79.40	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.87	gold quality
adrenal tissue	UBERON:0018303	77.46	gold quality
calcaneal tendon	UBERON:0003701	76.89	gold quality
bone marrow cell	CL:0002092	74.06	silver quality
sural nerve	UBERON:0015488	71.71	gold quality
colonic epithelium	UBERON:0000397	69.64	gold quality
tonsil	UBERON:0002372	66.17	gold quality
bone marrow	UBERON:0002371	61.89	silver quality
hindlimb stylopod muscle	UBERON:0004252	56.24	gold quality
skeletal muscle tissue	UBERON:0001134	55.72	gold quality
ventricular zone	UBERON:0003053	54.19	gold quality
endometrium	UBERON:0001295	53.12	gold quality
muscle tissue	UBERON:0002385	52.07	gold quality
monocyte	CL:0000576	51.88	gold quality
urinary bladder	UBERON:0001255	51.24	gold quality
stromal cell of endometrium	CL:0002255	50.48	silver quality
leukocyte	CL:0000738	50.42	gold quality
ovary	UBERON:0000992	50.15	gold quality
left ovary	UBERON:0002119	49.10	gold quality
liver	UBERON:0002107	48.89	gold quality
ganglionic eminence	UBERON:0004023	48.51	silver quality
uterine cervix	UBERON:0000002	48.29	gold quality
kidney	UBERON:0002113	47.84	gold quality
right ovary	UBERON:0002118	47.63	gold quality
lung	UBERON:0002048	47.44	gold quality
cerebellar cortex	UBERON:0002129	47.34	silver quality
cerebellum	UBERON:0002037	47.17	silver quality
superior frontal gyrus	UBERON:0002661	47.10	silver quality
cerebellar hemisphere	UBERON:0002245	47.06	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.05

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tas2r136	ENSMUSG00000053217
mus_musculus	Tas2r120	ENSMUSG00000059382
rattus_norvegicus	Tas2r120	ENSRNOG00000021445
rattus_norvegicus	Tas2r136	ENSRNOG00000029561

Paralogs (23): TAS2R8 (ENSG00000121314), TAS2R10 (ENSG00000121318), TAS2R7 (ENSG00000121377), TAS2R9 (ENSG00000121381), TAS2R3 (ENSG00000127362), TAS2R4 (ENSG00000127364), TAS2R5 (ENSG00000127366), TAS2R16 (ENSG00000128519), TAS2R1 (ENSG00000169777), TAS2R60 (ENSG00000185899), TAS2R42 (ENSG00000186136), TAS2R19 (ENSG00000212124), TAS2R50 (ENSG00000212126), TAS2R14 (ENSG00000212127), TAS2R13 (ENSG00000212128), TAS2R41 (ENSG00000221855), TAS2R40 (ENSG00000221937), TAS2R46 (ENSG00000226761), TAS2R39 (ENSG00000236398), TAS2R43 (ENSG00000255374), TAS2R20 (ENSG00000255837), TAS2R31 (ENSG00000256436), TAS2R38 (ENSG00000257138)

Protein

Protein identifiers

Taste receptor type 2 member 30 — P59541 (reviewed: P59541)

Alternative names: Taste receptor type 2 member 47

All UniProt accessions (1): P59541

UniProt curated annotations — full annotation on UniProt →

Function. Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Subcellular location. Membrane.

Tissue specificity. Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Miscellaneous. Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Similarity. Belongs to the G-protein coupled receptor T2R family.

RefSeq proteins (1): NP_001091112* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007960	TAS2R	Family

Pfam: PF05296

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P59541-F1	85.23	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 161, 176

Function

Pathways and Gene Ontology

Reactome pathways

9 pathways

ID	Pathway
R-HSA-418594	G alpha (i) signalling events
R-HSA-420499	Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-9717207	Sensory perception of sweet, bitter, and umami (glutamate) taste
R-HSA-162582	Signal Transduction
R-HSA-372790	Signaling by GPCR
R-HSA-388396	GPCR downstream signalling
R-HSA-500792	GPCR ligand binding
R-HSA-9709957	Sensory Perception
R-HSA-9717189	Sensory perception of taste

MSigDB gene sets: 25 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE, GOBP_SENSORY_PERCEPTION_OF_TASTE, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_BITTER_TASTE_RECEPTOR_ACTIVITY, GOMF_TASTE_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GOBP_SENSORY_PERCEPTION_OF_BITTER_TASTE, ZIM3_TARGET_GENES, DESCARTES_MAIN_FETAL_PDE1C_ACSM3_POSITIVE_CELLS, OSMAN_BLOOD_CHAD63_KH_AGE_18_50YO_HIGH_DOSE_SUBJECTS_24HR_DN

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of taste (GO:0050909)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), bitter taste receptor activity (GO:0033038)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Signaling by GPCR	2
GPCR downstream signalling	1
GPCR ligand binding	1
Sensory perception of taste	1
Signal Transduction	1
Sensory Perception	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
detection of chemical stimulus involved in sensory perception of taste	1
sensory perception of bitter taste	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of bitter taste	1
taste receptor activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

214 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TAS2R30	TAS1R2	Q8TE23	447
TAS2R30	GNAT3	A8MTJ3	446
TAS2R30	TAS1R3	Q7RTX0	430
TAS2R30	ZNF701	Q9NV72	404
TAS2R30	TRPM5	Q9NZQ8	400
TAS2R30	PLCB2	Q00722	397
TAS2R30	CYB561D1	Q8N8Q1	348
TAS2R30	OR8U1	Q8NH10	327
TAS2R30	HRCT1	Q6UXD1	324
TAS2R30	DNHD1	Q96M86	305
TAS2R30	TOP6BL	Q8N6T0	300
TAS2R30	KIAA0040	Q15053	298
TAS2R30	TAS1R1	Q7RTX1	290
TAS2R30	TAS2R4	Q9NYW5	281
TAS2R30	BCAS4	Q8TDM0	278

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: P0DSN6, P0DTE0, P59537, P59538, P59539, P59540, P59541, P59542, P59543, P59544, Q5Y4Y8, Q5Y4Y9, Q5Y4Z5, Q5Y4Z8, Q5Y500, Q645T2, Q645T3, Q645T4, Q645T6, Q645V2, Q645V3, Q645V4, Q645V6, Q645V7, Q645Z2, Q645Z6, Q645Z7, Q645Z9, Q646A0, Q646A1, Q646B4, Q646B9, Q646C0, Q646C1, Q646C2, Q646C3, Q646E0, Q646E1, Q646E2, Q646E3

Diamond homologs: P0DSN6, P0DTE0, P59528, P59530, P59537, P59538, P59539, P59540, P59541, P59542, P59543, P59544, Q5Y4Y8, Q5Y4Y9, Q5Y4Z5, Q5Y4Z8, Q5Y500, Q645T0, Q645T2, Q645T3, Q645T4, Q645T6, Q645T7, Q645U8, Q645V1, Q645V2, Q645V3, Q645V4, Q645V6, Q645V7, Q645V8, Q645V9, Q645Z2, Q645Z5, Q645Z6, Q645Z7, Q645Z9, Q646A0, Q646A1, Q646A2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	2
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

180 predictions. Top by Δscore:

Variant	Effect	Δscore
12:11133637:C:CT	acceptor_gain	0.8700
12:11133634:T:TC	acceptor_gain	0.8600
12:11133639:C:CT	acceptor_gain	0.8600
12:11133267:C:CT	donor_gain	0.8500
12:11133634:T:C	acceptor_gain	0.8100
12:11133640:A:T	acceptor_gain	0.8000
12:11133807:C:CT	acceptor_gain	0.7700
12:11134590:T:TA	donor_gain	0.7700
12:11133650:T:TC	acceptor_gain	0.7300
12:11133268:C:CT	donor_gain	0.7200
12:11133655:A:T	acceptor_gain	0.6900
12:11133630:A:C	acceptor_gain	0.6400
12:11133825:C:CT	acceptor_gain	0.6400
12:11133265:CA:C	donor_gain	0.6200
12:11133883:A:C	acceptor_gain	0.6200
12:11134591:C:A	donor_gain	0.6100
12:11133658:A:T	acceptor_gain	0.6000
12:11133826:A:T	acceptor_gain	0.6000
12:11133646:C:CT	acceptor_gain	0.5800
12:11133657:C:CT	acceptor_gain	0.5700
12:11133799:A:C	acceptor_gain	0.5700
12:11134541:TGAA:T	donor_gain	0.5700
12:11133809:C:CT	acceptor_gain	0.5600
12:11133810:A:T	acceptor_gain	0.5100
12:11134608:T:A	donor_gain	0.5100
12:11133630:A:AC	acceptor_gain	0.5000
12:11133266:AC:A	donor_gain	0.4800
12:11133798:CA:C	acceptor_gain	0.4700
12:11133879:CTTTA:C	acceptor_gain	0.4700
12:11133880:TTTAT:T	acceptor_gain	0.4700

AlphaMissense

2104 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:11133891:A:C	F118L	0.867
12:11133891:A:T	F118L	0.867
12:11133893:A:G	F118L	0.867
12:11133543:A:C	F234L	0.838
12:11133543:A:T	F234L	0.838
12:11133545:A:G	F234L	0.838
12:11133960:G:C	S95R	0.828
12:11133960:G:T	S95R	0.828
12:11133962:T:G	S95R	0.828
12:11134167:G:C	F26L	0.827
12:11134167:G:T	F26L	0.827
12:11134169:A:G	F26L	0.827
12:11133906:G:C	F113L	0.820
12:11133906:G:T	F113L	0.820
12:11133908:A:G	F113L	0.820
12:11133942:G:C	S101R	0.812
12:11133942:G:T	S101R	0.812
12:11133944:T:G	S101R	0.812
12:11133936:G:C	S103R	0.806
12:11133936:G:T	S103R	0.806
12:11133938:T:G	S103R	0.806
12:11134067:A:G	W60R	0.757
12:11134067:A:T	W60R	0.757
12:11133435:G:C	S270R	0.755
12:11133435:G:T	S270R	0.755
12:11133437:T:G	S270R	0.755
12:11134194:A:C	F17L	0.752
12:11134194:A:T	F17L	0.752
12:11134196:A:G	F17L	0.752
12:11133930:A:C	F105L	0.731

dbSNP variants (sampled 300 via entrez): RS1001020686 (12:11135645 C>T), RS1001066686 (12:11136120 T>C), RS1002078715 (12:11134563 T>C), RS1005023446 (12:11133627 G>C), RS1007616130 (12:11135015 C>T), RS1008156114 (12:11132995 A>G), RS1008268950 (12:11132655 G>A,C), RS1011780027 (12:11133016 AT>A), RS1012075587 (12:11133284 G>T), RS1012408626 (12:11136475 C>A,T), RS1012902574 (12:11135627 G>A), RS1013410099 (12:11134853 T>C), RS1013513178 (12:11134611 T>C), RS1015896328 (12:11134621 T>C,G), RS1017615402 (12:11135023 C>T)

Disease associations

OMIM: gene MIM:613963 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523254 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 40,234 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

Molecule	Name	Phase	Patents
CHEMBL434	ISOPROTERENOL	4	40,234

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Taste 2 receptors

Most potent curated ligand interactions (3 total), top 3:

Ligand	Action	Affinity	Parameter
denatonium	Agonist	6.57	pEC50
absinthin	Agonist	6.4	pEC50
amarogentin	Agonist	6.39	pEC50

ChEMBL bioactivities

1 potent at pChembl≥5 of 1 total, top 1 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
8.31	EC50	4.9	nM	ISOPROTERENOL

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
2-methyl-4-isothiazolin-3-one	decreases expression	1
pentanal	decreases expression	1
Sunitinib	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	increases abundance, increases expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1
Cadmium Chloride	increases abundance, increases expression	1

ChEMBL screening assays

7 unique, capped per target: 7 functional

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4346432	Functional	Antagonist activity at recombinant human TAS2R30 transiently expressed in HEK293T co-expressing Galpha16gust44 assessed as inhibition of denatonium-induced intracellular calcium level by measuring remaining activity at 25 uM by fluo-4AM dye	Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.