TAS2R5

Summary

TAS2R5 (taste 2 receptor member 5, HGNC:14912) is a protein-coding gene on chromosome 7q34, encoding Taste receptor type 2 member 5 (Q9NYW4). Receptor that may play a role in the perception of bitterness and is gustducin-linked.

This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception.

Source: NCBI Gene 54429 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 46 total
• GTEx eGene: eQTL in 32 tissues, sQTL in 0 (q < 0.05)
• ChEMBL bioactivity: 1 clinical-phase molecule tested; no curated mechanism-of-action drug
• Constraint (gnomAD): pLI 0.00 (LoF-tolerant), LOEUF 1.12 (unconstrained)
• MANE Select transcript: NM_018980

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14912
Approved symbol	TAS2R5
Name	taste 2 receptor member 5
Location	7q34
Locus type	gene with protein product
Status	Approved
Aliases	T2R5
Ensembl gene	ENSG00000127366
Ensembl biotype	protein_coding
OMIM	605062
Entrez	54429

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

MANE Select: ENST00000247883

ENST00000247883

RefSeq mRNA: 1 — MANE Select: NM_018980 NM_018980

CCDS: CCDS5869

Canonical transcript exons

ENST00000247883 — 1 exons

Exon	Start	End
ENSE00000872187	141790217	141791367

Expression profiles

Bgee: expression breadth ubiquitous, 156 present calls, max score 90.43.

Highest expression (Bgee): male germ line stem cell (sensu Vertebrata) in testis, uterine tube, ovary, hemisphere of cerebellum, cerebellar hemisphere.

Genetic regulation across tissues (GTEx eQTL / sQTL)

TAS2R5 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 32 tissues and its splicing (sQTL) in 0 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

showing 20 of 32 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Thyroid	eqtl	3.4e-25	-0.34	7:141737464:G:C
Skin Not Sun Exposed Suprapubic	eqtl	5.1e-24	-0.33	7:141747018:C:T
Cells EBV-transformed lymphocytes	eqtl	3.4e-22	-0.50	7:141775254:T:C
Esophagus Mucosa	eqtl	2.8e-21	-0.39	7:141743011:C:T
Skin Sun Exposed Lower leg	eqtl	1.5e-17	-0.29	7:141768038:A:G
Cells Cultured fibroblasts	eqtl	5.3e-13	-0.19	7:141765563:T:C
Brain Cerebellum	eqtl	1.5e-12	-0.47	7:141769762:A:AAAAT
Stomach	eqtl	2.3e-12	-0.32	7:141737464:G:C
Colon Transverse	eqtl	2.8e-12	-0.32	7:141765563:T:C
Esophagus Muscularis	eqtl	7.1e-12	-0.27	7:141768038:A:G
Testis	eqtl	7.4e-11	-0.26	7:141765563:T:C
Pituitary	eqtl	5.3e-10	-0.35	7:141778774:G:C
Esophagus Gastroesophageal Junction	eqtl	1.7e-09	-0.28	7:141742413:G:A
Adipose Visceral Omentum	eqtl	3.5e-09	+0.19	7:141903540:AG:A
Spleen	eqtl	7.8e-09	-0.36	7:141747018:C:T
Whole Blood	eqtl	9.5e-09	-0.27	7:141751282:AGTGCTGT:A
Muscle Skeletal	eqtl	1.7e-08	-0.23	7:141747751:G:C
Lung	eqtl	5.5e-08	-0.21	7:141742852:A:G
Colon Sigmoid	eqtl	6.3e-08	-0.27	7:141778774:G:C
Pancreas	eqtl	1.5e-07	-0.37	7:141778774:G:C

Top tissues by expression

showing 100 of 245 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.43	gold quality
right uterine tube	UBERON:0001302	75.60	gold quality
left ovary	UBERON:0002119	72.31	gold quality
right ovary	UBERON:0002118	71.99	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.24	gold quality
cerebellar hemisphere	UBERON:0002245	70.54	gold quality
cerebellar cortex	UBERON:0002129	70.44	gold quality
endocervix	UBERON:0000458	69.62	gold quality
ectocervix	UBERON:0012249	69.39	gold quality
body of uterus	UBERON:0009853	69.29	gold quality
tibial nerve	UBERON:0001323	69.20	gold quality
cerebellum	UBERON:0002037	68.93	gold quality
skin of abdomen	UBERON:0001416	68.81	gold quality
mucosa of stomach	UBERON:0001199	68.26	gold quality
skin of leg	UBERON:0001511	68.07	gold quality
stromal cell of endometrium	CL:0002255	67.98	gold quality
uterine cervix	UBERON:0000002	66.59	gold quality
left uterine tube	UBERON:0001303	66.39	gold quality
ovary	UBERON:0000992	66.35	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	65.31	gold quality
right coronary artery	UBERON:0001625	65.19	gold quality
zone of skin	UBERON:0000014	65.11	gold quality
pituitary gland	UBERON:0000007	65.08	gold quality
minor salivary gland	UBERON:0001830	65.08	gold quality
body of pancreas	UBERON:0001150	65.02	gold quality
adenohypophysis	UBERON:0002196	64.82	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.77	gold quality
myocardium	UBERON:0002349	64.44	gold quality
vagina	UBERON:0000996	64.32	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.26	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.22	gold quality
left lobe of thyroid gland	UBERON:0001120	63.69	gold quality
metanephros cortex	UBERON:0010533	63.36	gold quality
transverse colon	UBERON:0001157	63.34	gold quality
esophagus mucosa	UBERON:0002469	63.31	gold quality
right lobe of thyroid gland	UBERON:0001119	63.30	gold quality
lower esophagus	UBERON:0013473	63.29	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.29	gold quality
peritoneum	UBERON:0002358	63.15	gold quality
omental fat pad	UBERON:0010414	63.15	gold quality
upper lobe of left lung	UBERON:0008952	63.14	gold quality
thyroid gland	UBERON:0002046	63.00	gold quality
esophagus	UBERON:0001043	62.95	gold quality
popliteal artery	UBERON:0002250	62.85	gold quality
spleen	UBERON:0002106	62.83	gold quality
tibial artery	UBERON:0007610	62.82	gold quality
left coronary artery	UBERON:0001626	62.77	gold quality
apex of heart	UBERON:0002098	62.77	gold quality
gastrocnemius	UBERON:0001388	62.59	gold quality
body of stomach	UBERON:0001161	62.56	gold quality
aorta	UBERON:0000947	62.47	gold quality
ascending aorta	UBERON:0001496	62.31	gold quality
thoracic aorta	UBERON:0001515	62.26	gold quality
muscle of leg	UBERON:0001383	62.21	gold quality
descending thoracic aorta	UBERON:0002345	62.20	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.19	gold quality
adipose tissue of abdominal region	UBERON:0007808	61.92	gold quality
mouth mucosa	UBERON:0003729	61.87	gold quality
coronary artery	UBERON:0001621	61.74	gold quality
small intestine	UBERON:0002108	61.45	gold quality
upper lobe of lung	UBERON:0008948	61.38	gold quality
right atrium auricular region	UBERON:0006631	61.15	gold quality
lower esophagus mucosa	UBERON:0035834	61.13	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.07	gold quality
saliva-secreting gland	UBERON:0001044	60.88	gold quality
cardiac atrium	UBERON:0002081	60.62	gold quality
female reproductive system	UBERON:0000474	60.44	gold quality
granulocyte	CL:0000094	60.43	gold quality
right lung	UBERON:0002167	60.40	gold quality
spinal cord	UBERON:0002240	60.19	gold quality
right frontal lobe	UBERON:0002810	60.06	gold quality
colon	UBERON:0001155	59.94	gold quality
intestine	UBERON:0000160	59.88	gold quality
stomach	UBERON:0000945	59.84	gold quality
uterus	UBERON:0000995	59.80	gold quality
tendon of biceps brachii	UBERON:0008188	59.65	gold quality
myometrium	UBERON:0001296	59.53	gold quality
pancreas	UBERON:0001264	59.52	gold quality
large intestine	UBERON:0000059	59.30	gold quality
tendon	UBERON:0000043	59.23	gold quality
vermiform appendix	UBERON:0001154	59.20	gold quality
calcaneal tendon	UBERON:0003701	59.18	gold quality
right adrenal gland	UBERON:0001233	59.02	gold quality
cortex of kidney	UBERON:0001225	58.71	gold quality
fundus of stomach	UBERON:0001160	58.66	gold quality
Brodmann (1909) area 9	UBERON:0013540	58.56	gold quality
left adrenal gland	UBERON:0001234	58.40	gold quality
nucleus accumbens	UBERON:0001882	58.36	gold quality
right adrenal gland cortex	UBERON:0035827	58.35	gold quality
heart	UBERON:0000948	58.31	gold quality
prostate gland	UBERON:0002367	58.25	gold quality
anatomical system	UBERON:0000467	58.09	gold quality
heart left ventricle	UBERON:0002084	58.08	gold quality
left adrenal gland cortex	UBERON:0035825	58.08	gold quality
right lobe of liver	UBERON:0001114	58.03	gold quality
multicellular organism	UBERON:0000468	57.72	gold quality
material anatomical entity	UBERON:0000465	57.70	gold quality
cardiac ventricle	UBERON:0002082	57.48	gold quality
adrenal gland	UBERON:0002369	57.29	gold quality
ventricular zone	UBERON:0003053	57.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.61

HPA expression

RNA tissue specificity: Low tissue specificity

showing 60 of 61 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM
Cerebellum	tissue	8.2
Hypothalamus	tissue	6.6
Midbrain	tissue	6.5
Cerebral cortex	tissue	6.2
Basal ganglia	tissue	6.2
Nucleus accumbens	tissue	6.2
Medulla oblongata	tissue	5.9
Pons	tissue	5.8
Thalamus	tissue	5.6
Spinal cord	tissue	5.3
Hippocampal formation	tissue	5.3
Amygdala	tissue	5.2
Putamen	tissue	4.9
Postcentral gyrus	tissue	4.8
Occipital cortex	tissue	4.8
Hippocampus	tissue	4.5
Locus coeruleus	tissue	4.4
Substantia nigra	tissue	4.2
Skin 1	tissue	4.0
Retrosplenial cortex	tissue	4.0
Choroid plexus	tissue	3.4
Epididymis	tissue	2.6
Pituitary gland	tissue	2.5
Vagina	tissue	2.3
Breast	tissue	1.5
Retina	tissue	1.5
Skeletal muscle	tissue	1.3
Endometrium 1	tissue	1.3
Fallopian tube	tissue	1.1
Ovary	tissue	1.0
Spleen	tissue	0.9
Cervix	tissue	0.7
Thymus	tissue	0.7
Appendix	tissue	0.7
Lymph node	tissue	0.6
Testis	tissue	0.6
Rectum	tissue	0.6
Pancreas	tissue	0.6
Small intestine	tissue	0.6
Tonsil	tissue	0.6
Seminal vesicle	tissue	0.5
Salivary gland	tissue	0.5
Smooth muscle	tissue	0.5
Placenta	tissue	0.5
Lung	tissue	0.5
Prostate	tissue	0.5
Adrenal gland	tissue	0.5
Colon	tissue	0.4
Thyroid gland	tissue	0.4
Gallbladder	tissue	0.4
Kidney	tissue	0.4
Duodenum	tissue	0.4
Stomach 1	tissue	0.3
Adipose tissue	tissue	0.3
Esophagus	tissue	0.3
Parathyroid gland	tissue	0.3
Urinary bladder	tissue	0.3
Tongue	tissue	0.3
Heart muscle	tissue	0.2
Liver	tissue	0.2

Brain sub-regions (HPA Brain Atlas): detected in 185; highest nTPM — Vermis (8.2), Cerebellar cortex (7.3), Flocculonodular lobe (7.0), Parieto-temporal junction (white matter) (7.0), White matter (7.0).

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

Targeting TAS2R5 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific).

7 miRNAs:

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-4660	97.79	67.44	1328
HSA-MIR-4287	97.55	67.24	1247
HSA-MIR-4685-3P	97.55	67.35	1255
HSA-MIR-7106-3P	97.33	65.33	644
HSA-MIR-3976	96.67	67.79	1187

Functional genomics

gnomAD constraint: pLI 3.22e-05, LOEUF 1.12, missense Z 0.657 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000247883 — one region, missense o/e 0.96.

Literature-anchored findings (GeneRIF, showing 1)

• Polymorphism of TAS2R3, TAS2R5, TAS2R19, and TAS2R50 genes and bitter food intake frequency inelderly woman. (PMID:32227702)

Cross-species orthologs

0 orthologs

Paralogs (23): TAS2R8 (ENSG00000121314), TAS2R10 (ENSG00000121318), TAS2R7 (ENSG00000121377), TAS2R9 (ENSG00000121381), TAS2R3 (ENSG00000127362), TAS2R4 (ENSG00000127364), TAS2R16 (ENSG00000128519), TAS2R1 (ENSG00000169777), TAS2R60 (ENSG00000185899), TAS2R42 (ENSG00000186136), TAS2R19 (ENSG00000212124), TAS2R50 (ENSG00000212126), TAS2R14 (ENSG00000212127), TAS2R13 (ENSG00000212128), TAS2R41 (ENSG00000221855), TAS2R40 (ENSG00000221937), TAS2R46 (ENSG00000226761), TAS2R39 (ENSG00000236398), TAS2R43 (ENSG00000255374), TAS2R20 (ENSG00000255837), TAS2R30 (ENSG00000256188), TAS2R31 (ENSG00000256436), TAS2R38 (ENSG00000257138)

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Pan troglodytes	Q646A4	99.7%	Diamond
Pan paniscus	Q646D5	99.7%	Diamond
Gorilla gorilla gorilla	Q645Z1	98.0%	Diamond
Pongo pygmaeus	Q645U0	95.7%	Diamond
Papio hamadryas	Q646E6	94.0%	Diamond
Rattus norvegicus	Q4VHE7	87.6%	Diamond
Mus musculus	Q7TQB9	83.3%	Diamond
Gallus gallus	Q2AB83	39.9%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
TAS2R3	protein-coding	50831
TAS2R4	protein-coding	50832
SSBP1	protein-coding	6742

Protein

Protein identifiers

Taste receptor type 2 member 5 — Q9NYW4 (reviewed: Q9NYW4)

All UniProt accessions (2): A4D1U0, Q9NYW4

UniProt curated annotations — full annotation on UniProt →

Function. Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Subcellular location. Membrane.

Tissue specificity. Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Miscellaneous. Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

Similarity. Belongs to the G protein-coupled receptor T2R family.

RefSeq proteins (1): NP_061853* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007960	TAS2R	Family

Pfam: PF05296

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 6, chain 1, glycosylation site 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NYW4-F1	79.93	0.22

Human Protein Atlas

Protein class: G-protein coupled receptors, GPCRs excl olfactory receptors, Family T2R receptors (taste receptor GPCRs), Predicted membrane proteins, GPCRHMM predicted membrane proteins

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): nucleoli; nucleoplasm; cytoplasmic bodies

Antibody reliability (HPA): IF approved

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1)

Type	Positions
N-linked (glcnac…) asparagine	155

Function

Pathways and Gene Ontology

Reactome pathways

2 curated (TAS) of 9; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

9 pathways:

ID	Pathway	Evidence
R-HSA-420499	Class C/3 (Metabotropic glutamate/pheromone receptors)	curated
R-HSA-418594	G alpha (i) signalling events	curated
R-HSA-388396	GPCR downstream signalling	—
R-HSA-500792	GPCR ligand binding	—
R-HSA-9709957	Sensory Perception	—
R-HSA-9717207	Sensory perception of sweet, bitter, and umami (glutamate) taste	electronic
R-HSA-9717189	Sensory perception of taste	—
R-HSA-162582	Signal Transduction	—
R-HSA-372790	Signaling by GPCR	—

MSigDB gene sets: 36 (showing top): GOBP_BEHAVIOR, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE, GOBP_SENSORY_PERCEPTION_OF_TASTE, GOBP_CHEMOSENSORY_BEHAVIOR, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_BITTER_TASTE_RECEPTOR_ACTIVITY, GOMF_TASTE_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GOBP_SENSORY_PERCEPTION_OF_BITTER_TASTE, MIR651_3P

GO Biological Process (5): detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580), chemosensory behavior (GO:0007635), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of taste (GO:0050909)

GO Molecular Function (4): G protein-coupled receptor activity (GO:0004930), taste receptor activity (GO:0008527), bitter taste receptor activity (GO:0033038), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

6 top-level categories:

Category	Pathways
Signaling by GPCR	2
GPCR downstream signalling	1
GPCR ligand binding	1
Sensory perception of taste	1
Signal Transduction	1
Sensory Perception	1

GO top-level categories

20 GO namespaces:

Category	Terms
detection of chemical stimulus involved in sensory perception of taste	2
transmembrane signaling receptor activity	2
sensory perception of bitter taste	1
behavior	1
response to chemical	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of bitter taste	1
taste receptor activity	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Experimentally-supported GO annotations

GO terms backed by direct experimental evidence (ECO experimental codes) — 2 of 11 annotations. The rest are phylogenetic / computational / electronic (IEA).

2 experimentally-supported GO terms:

GO term	NS	Evidence
detection of chemical stimulus involved in sensory perception of bitter taste	BP	direct assay
bitter taste receptor activity	MF	direct assay

Protein interactions and networks

STRING

showing 15 of 300 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TAS2R5	GNAT3	A8MTJ3	856
TAS2R5	TAS1R2	Q8TE23	593
TAS2R5	TAS1R3	Q7RTX0	592
TAS2R5	OR52L1	Q8NGH7	569
TAS2R5	OR2J3	O76001	555
TAS2R5	TAS1R1	Q7RTX1	498
TAS2R5	OR4F4	Q96R69	494
TAS2R5	OR11H1	Q8NG94	491
TAS2R5	OR1E1	P30953	468
TAS2R5	OR2T33	Q8NG76	466
TAS2R5	OR2T1	O43869	441
TAS2R5	PLCB2	Q00722	441
TAS2R5	OR2L13	Q8N349	441
TAS2R5	OR10G8	Q8NGN5	441
TAS2R5	TRPM5	Q9NZQ8	437

IntAct

Human interaction partners of TAS2R5 in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

6 partners by confidence:

Partner	Interaction type	MIscore	Records
CCL4	physical association	0.560	3
RTP2	physical association	0.560	3
SFT2D2	physical association	0.560	3
SLC30A2	physical association	0.560	3
TMEM187	physical association	0.560	3
VAMP5	physical association	0.560	3

BioGRID (7 interactions; top human partners by supporting records): CCL4 (Two-hybrid), KRAS (Synthetic Lethality), RTP2 (Two-hybrid), SFT2D2 (Two-hybrid), SLC30A2 (Two-hybrid), TMEM187 (Two-hybrid), VAMP5 (Two-hybrid)

Disease & clinical

Genetic variants

Variant evidence for TAS2R5: 46 ClinVar records (0 pathogenic / likely pathogenic); 2 GWAS associations.

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	43
Likely benign	3
Benign	0

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 10 predictions of 180):

Position(s)	Effect	Δscore	Sites
7:141791365	acceptor_gain	0.6600
7:141790992	donor_gain	0.6500
7:141790960	acceptor_gain	0.6300
7:141790734	donor_gain	0.6100
7:141790953	acceptor_gain	0.6100
7:141791183	acceptor_gain	0.6000
7:141790925	acceptor_gain	0.5800
7:141791176	acceptor_gain	0.5700
7:141790888	donor_gain	0.5300
7:141791062	donor_gain	0.5200

AlphaMissense

359 missense substitutions predicted likely pathogenic (of 1,945 scored), across 139 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
D65	8	0.703	0.783
F227	7	0.770	0.946
F184	7	0.762	0.913
M261	6	0.745	0.826
H268	6	0.737	0.818
P265	6	0.717	0.839
K119	5	0.777	0.912
N24	5	0.745	0.897
C104	5	0.708	0.838
F69	5	0.700	0.748
P180	5	0.686	0.854
S92	4	0.907	0.968
S89	4	0.888	0.953
S100	4	0.856	0.945
F17	4	0.845	0.928
F102	4	0.808	0.880
F56	4	0.804	0.826
W85	4	0.795	0.797
F95	4	0.794	0.861
W94	4	0.782	0.934

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

1 prognostic cancer types:

Cancer	Prognostic	p-value
Rectum Adenocarcinoma (validation)	favorable	0.000762

Disease associations

OMIM: gene MIM:605062 | disease phenotypes:

GWAS associations

2 associations:

Study	Trait	p-value
GCST001961_8	Anorexia nervosa	2e-7
GCST003815_22	Late-onset Alzheimer’s disease	7e-6

EFO canonical traits (from GWAS)

1 canonical traits:

EFO ID	Trait name
EFO:1001870	late-onset Alzheimers disease

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523473 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

Phase ≥1, by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 40,435 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

1 molecules by phase:

Molecule	Name	Phase	Patents
CHEMBL434	ISOPROTERENOL	4	40,435

PharmGKB: 1 entry (CPIC guideline: no)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Taste 2 receptors

Most potent curated ligand interactions (2 total), top 2:

Ligand	Action	Affinity	Parameter
epigallocatechin-3-gallate	Agonist	4.91	pEC50
Procyanidin C2	Agonist	4.45	pEC50

ChEMBL bioactivities

1 potent at pChembl≥5 of 1 total, top 1 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
8.31	EC50	4.9	nM	ISOPROTERENOL

CTD chemical–gene interactions

10 total (human), top 10 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
propionaldehyde	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases expression	1
Benzo(a)pyrene	increases expression	1
Hydralazine	affects cotreatment, increases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	affects cotreatment, increases expression	1
Asbestos, Crocidolite	affects expression	1

ChEMBL screening assays

8 unique, capped per target: 8 functional

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4346425	Functional	Antagonist activity at recombinant human TAS2R5 transiently expressed in HEK293T co-expressing Galpha16gust44 assessed as inhibition of picoline-induced intracellular calcium level by measuring remaining activity at 25 uM by fluo-4AM dye ba	Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists. — *J Med Chem*

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.

Predicted chemistry — Sugi Predict

The predicted patent-compound landscape for TAS2R5 across ~30M SureChEMBL compounds — explore on Sugi Predict.