TAS2R7

Summary

TAS2R7 (taste 2 receptor member 7, HGNC:14913) is a protein-coding gene on chromosome 12p13.2, encoding Taste receptor type 2 member 7 (Q9NYW3). Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.

Source: NCBI Gene 50837 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 56 total
• Druggable target: yes — 1 molecules with ChEMBL bioactivity
• MANE Select transcript: NM_023919

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14913
Approved symbol	TAS2R7
Name	taste 2 receptor member 7
Location	12p13.2
Locus type	gene with protein product
Status	Approved
Aliases	T2R7, TRB4
Ensembl gene	ENSG00000121377
Ensembl biotype	protein_coding
OMIM	604793
Entrez	50837

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000240687

RefSeq mRNA: 1 — MANE Select: NM_023919 NM_023919

CCDS: CCDS8631

Canonical transcript exons

ENST00000240687 — 1 exons

Exon	Start	End
ENSE00000821984	10801532	10802627

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 37.20.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
granulocyte	CL:0000094	37.17	gold quality
calcaneal tendon	UBERON:0003701	37.13	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	35.08	gold quality
muscle tissue	UBERON:0002385	32.31	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
adrenal tissue	UBERON:0018303	31.33	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
right uterine tube	UBERON:0001302	30.67	gold quality
prefrontal cortex	UBERON:0000451	29.98	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
leukocyte	CL:0000738	28.79	silver quality
liver	UBERON:0002107	28.55	gold quality
monocyte	CL:0000576	28.28	silver quality
duodenum	UBERON:0002114	28.14	gold quality
primary visual cortex	UBERON:0002436	27.74	gold quality
superior frontal gyrus	UBERON:0002661	27.68	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.95	gold quality
urinary bladder	UBERON:0001255	26.84	gold quality
frontal cortex	UBERON:0001870	26.50	gold quality
blood	UBERON:0000178	26.44	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Similar to majority of the Class A GPCRs, extracellular loop 2 in T2R7 plays a significant role in agonist binding and activation. (PMID:29355483)
• TAS2R7 is a receptor for bitter tasting salts. (PMID:30928101)
• The TAS2R7 may act as a metal cation receptor mediating bitterness of divalent and trivalent salts. (PMID:31066447)
• Effect of Bitter Compounds on the Expression of Bitter Taste Receptor T2R7 Downstream Signaling Effectors in cT2R7/pDisplay-Galpha16/gust44/pcDNA3.1 (+) Cells. (PMID:31781630)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tas2r130	ENSMUSG00000054497
rattus_norvegicus	Tas2r130	ENSRNOG00000005645

Paralogs (23): TAS2R8 (ENSG00000121314), TAS2R10 (ENSG00000121318), TAS2R9 (ENSG00000121381), TAS2R3 (ENSG00000127362), TAS2R4 (ENSG00000127364), TAS2R5 (ENSG00000127366), TAS2R16 (ENSG00000128519), TAS2R1 (ENSG00000169777), TAS2R60 (ENSG00000185899), TAS2R42 (ENSG00000186136), TAS2R19 (ENSG00000212124), TAS2R50 (ENSG00000212126), TAS2R14 (ENSG00000212127), TAS2R13 (ENSG00000212128), TAS2R41 (ENSG00000221855), TAS2R40 (ENSG00000221937), TAS2R46 (ENSG00000226761), TAS2R39 (ENSG00000236398), TAS2R43 (ENSG00000255374), TAS2R20 (ENSG00000255837), TAS2R30 (ENSG00000256188), TAS2R31 (ENSG00000256436), TAS2R38 (ENSG00000257138)

Protein

Protein identifiers

Taste receptor type 2 member 7 — Q9NYW3 (reviewed: Q9NYW3)

Alternative names: Taste receptor family B member 4

All UniProt accessions (1): Q9NYW3

UniProt curated annotations — full annotation on UniProt →

Function. Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Subcellular location. Membrane.

Tissue specificity. Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.

Miscellaneous. Several bitter taste receptors are expressed in a single taste receptor cell.

Similarity. Belongs to the G-protein coupled receptor T2R family.

RefSeq proteins (1): NP_076408* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007960	TAS2R	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF05296

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, glycosylation site 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NYW3-F1	84.81	0.47

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 167, 175

Function

Pathways and Gene Ontology

Reactome pathways

9 pathways

ID	Pathway
R-HSA-418594	G alpha (i) signalling events
R-HSA-420499	Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-9717207	Sensory perception of sweet, bitter, and umami (glutamate) taste
R-HSA-162582	Signal Transduction
R-HSA-372790	Signaling by GPCR
R-HSA-388396	GPCR downstream signalling
R-HSA-500792	GPCR ligand binding
R-HSA-9709957	Sensory Perception
R-HSA-9717189	Sensory perception of taste

MSigDB gene sets: 35 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE, GOBP_SENSORY_PERCEPTION_OF_TASTE, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, PIT1_Q6, YATGNWAAT_OCT_C, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_BITTER_TASTE_RECEPTOR_ACTIVITY, GOMF_TASTE_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GOBP_SENSORY_PERCEPTION_OF_BITTER_TASTE, S8_01

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of taste (GO:0050909)

GO Molecular Function (4): G protein-coupled receptor activity (GO:0004930), taste receptor activity (GO:0008527), bitter taste receptor activity (GO:0033038), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Signaling by GPCR	2
GPCR downstream signalling	1
GPCR ligand binding	1
Sensory perception of taste	1
Signal Transduction	1
Sensory Perception	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
detection of chemical stimulus involved in sensory perception of taste	2
transmembrane signaling receptor activity	2
sensory perception of bitter taste	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of bitter taste	1
taste receptor activity	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

312 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TAS2R7	GNAT3	A8MTJ3	880
TAS2R7	PLCB2	Q00722	613
TAS2R7	TAS1R3	Q7RTX0	533
TAS2R7	TAS1R2	Q8TE23	509
TAS2R7	TAS1R1	Q7RTX1	476
TAS2R7	OR13C8	Q8NGS7	398
TAS2R7	PKD1L3	Q7Z443	395
TAS2R7	PKD2L1	Q9P0L9	318
TAS2R7	TRPM5	Q9NZQ8	309
TAS2R7	GPR42	O15529	279
TAS2R7	UNC50	Q53HI1	275
TAS2R7	GNA15	P30679	272
TAS2R7	DZIP1L	Q8IYY4	271
TAS2R7	SCNN1D	P51172	268
TAS2R7	CCK	P06307	261

IntAct

4 interactions, top by confidence:

A	B	Type	Score
TAS2R7	ATP2B4	psi-mi:“MI:0914”(association)	0.500
TAS2R7	ATP2B4	psi-mi:“MI:0915”(physical association)	0.500
TAS2R7	PRKCA	psi-mi:“MI:0914”(association)	0.350

BioGRID (38): ATP2B4 (Affinity Capture-MS), ATP2B2 (Affinity Capture-MS), INTS12 (Affinity Capture-MS), TLDC1 (Affinity Capture-MS), CD2AP (Affinity Capture-MS), PRKCA (Affinity Capture-MS), GNA13 (Affinity Capture-MS), GNAQ (Affinity Capture-MS), MVB12A (Affinity Capture-MS), BIRC2 (Affinity Capture-MS), EPHA2 (Affinity Capture-MS), MICAL1 (Affinity Capture-MS), CCNYL1 (Affinity Capture-MS), MVB12A (Affinity Capture-MS), MICAL1 (Affinity Capture-MS)

ESM2 similar proteins: P59530, Q645T0, Q645T7, Q645T9, Q645U2, Q645U8, Q645V0, Q645V1, Q645V8, Q645V9, Q645Y5, Q645Z4, Q645Z5, Q646A2, Q646A7, Q646B5, Q646B6, Q646C4, Q646C6, Q646D2, Q646D6, Q646D8, Q646D9, Q646E8, Q646F6, Q646F7, Q646G3, Q646G5, Q67ER8, Q67ES1, Q67ES6, Q67ET3, Q67ET5, Q7M707, Q7M711, Q7M713, Q7M720, Q7M721, Q7M725, Q9JKA3

Diamond homologs: P0DSN6, P0DTE0, P59528, P59530, P59537, P59538, P59539, P59540, P59541, P59542, P59543, P59544, Q5Y4Y8, Q5Y4Y9, Q5Y4Z5, Q5Y4Z8, Q5Y500, Q645T0, Q645T2, Q645T3, Q645T4, Q645T6, Q645T7, Q645U8, Q645V1, Q645V2, Q645V3, Q645V4, Q645V6, Q645V7, Q645V8, Q645V9, Q645Z2, Q645Z5, Q645Z6, Q645Z7, Q645Z9, Q646A0, Q646A1, Q646A2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	4
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

405 predictions. Top by Δscore:

Variant	Effect	Δscore
12:10801945:C:CT	acceptor_gain	0.8300
12:10801945:C:T	acceptor_gain	0.8100
12:10801959:C:CT	acceptor_gain	0.7000
12:10801948:A:T	acceptor_gain	0.6700
12:10801960:A:T	acceptor_gain	0.6600
12:10802051:CT:C	donor_gain	0.6500
12:10802078:T:TA	donor_gain	0.6300
12:10802053:CTGCA:C	donor_gain	0.6200
12:10801938:A:C	acceptor_gain	0.6100
12:10801943:TCC:T	acceptor_gain	0.6100
12:10801947:C:CT	acceptor_gain	0.6100
12:10802209:C:CT	acceptor_gain	0.6100
12:10801976:T:TC	acceptor_gain	0.6000
12:10802240:T:C	donor_gain	0.5400
12:10802021:A:C	donor_gain	0.5300
12:10801975:A:C	acceptor_gain	0.5200
12:10801984:A:T	donor_gain	0.5200
12:10802047:T:C	donor_gain	0.5200
12:10802061:C:CA	donor_gain	0.5200
12:10801879:A:AC	donor_gain	0.5000
12:10801880:C:CC	donor_gain	0.5000
12:10802210:A:T	acceptor_gain	0.4800
12:10802386:A:AC	donor_gain	0.4700
12:10801756:GACT:G	donor_loss	0.4600
12:10801757:ACT:A	donor_loss	0.4600
12:10801758:CT:C	donor_loss	0.4600
12:10801759:TCA:T	donor_loss	0.4600
12:10801760:CA:C	donor_loss	0.4600
12:10801762:C:A	donor_loss	0.4600
12:10802587:A:AC	donor_gain	0.4600

AlphaMissense

2097 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:10802283:A:C	S96R	0.979
12:10802283:A:T	S96R	0.979
12:10802285:T:G	S96R	0.979
12:10802259:G:C	S104R	0.957
12:10802259:G:T	S104R	0.957
12:10802261:T:G	S104R	0.957
12:10801851:G:C	F240L	0.953
12:10801851:G:T	F240L	0.953
12:10801853:A:G	F240L	0.953
12:10802136:G:C	S145R	0.952
12:10802136:G:T	S145R	0.952
12:10802138:T:G	S145R	0.952
12:10802292:A:C	N93K	0.951
12:10802292:A:T	N93K	0.951
12:10802406:T:A	R55S	0.951
12:10802406:T:G	R55S	0.951
12:10802499:A:C	N24K	0.944
12:10802499:A:T	N24K	0.944
12:10802513:C:G	G20R	0.944
12:10802513:C:T	G20R	0.944
12:10801731:A:C	S280R	0.939
12:10801731:A:T	S280R	0.939
12:10801733:T:G	S280R	0.939
12:10801696:A:G	L292S	0.933
12:10802421:A:C	S50R	0.932
12:10802421:A:T	S50R	0.932
12:10802423:T:G	S50R	0.932
12:10802241:C:A	K110N	0.931
12:10802241:C:G	K110N	0.931
12:10801714:A:T	I286K	0.924

dbSNP variants (sampled 300 via entrez): RS1000608562 (12:10804373 C>T), RS1000749813 (12:10804551 T>A,C,G), RS1002018752 (12:10803303 G>A,T), RS1002686667 (12:10803008 T>C), RS1003078486 (12:10804019 G>C), RS1003109648 (12:10803653 T>A,C), RS1005515835 (12:10802720 C>T), RS1005868935 (12:10804067 C>T), RS1006200192 (12:10803610 T>C), RS1006517260 (12:10801337 A>G), RS1009372134 (12:10802729 C>T), RS1009404490 (12:10802953 A>G), RS1010379390 (12:10804145 G>A), RS1010412217 (12:10804337 G>C), RS1013533885 (12:10803422 A>C)

Disease associations

OMIM: gene MIM:604793 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523472 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 40,234 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

Molecule	Name	Phase	Patents
CHEMBL434	ISOPROTERENOL	4	40,234

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Taste 2 receptors

Most potent curated ligand interactions (3 total), top 3:

Ligand	Action	Affinity	Parameter
grandinin	Agonist	5.61	pEC50
malvidin-3-glucoside	Agonist	4.9	pEC50
cromoglicic acid	Agonist	2.35	pEC50

ChEMBL bioactivities

1 potent at pChembl≥5 of 1 total, top 1 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
8.31	EC50	4.9	nM	ISOPROTERENOL

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation	1
Asbestos, Crocidolite	affects expression	1

ChEMBL screening assays

27 unique, capped per target: 27 functional

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4346426	Functional	Antagonist activity at recombinant human TAS2R7 transiently expressed in HEK293T co-expressing Galpha16gust44 assessed as inhibition of chloroquine-induced intracellular calcium level by measuring remaining activity at 25 uM by fluo-4AM dye	Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.