TAX1BP1

Summary

TAX1BP1 (Tax1 binding protein 1, HGNC:11575) is a protein-coding gene on chromosome 7p15.2, encoding Tax1-binding protein 1 (Q86VP1). Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation.

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 8887 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 118 total
• MANE Select transcript: NM_006024

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11575
Approved symbol	TAX1BP1
Name	Tax1 binding protein 1
Location	7p15.2
Locus type	gene with protein product
Status	Approved
Aliases	TXBP151, CALCOCO3
Ensembl gene	ENSG00000106052
Ensembl biotype	protein_coding
OMIM	605326
Entrez	8887

Gene structure

Transcript identifiers

Ensembl transcripts: 48 — 44 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000265393, ENST00000396319, ENST00000409980, ENST00000416801, ENST00000418691, ENST00000422800, ENST00000433216, ENST00000457186, ENST00000460059, ENST00000488564, ENST00000490455, ENST00000494033, ENST00000543117, ENST00000871702, ENST00000871703, ENST00000871704, ENST00000871705, ENST00000871706, ENST00000871707, ENST00000871708, ENST00000871709, ENST00000871710, ENST00000871711, ENST00000871712, ENST00000871713, ENST00000871714, ENST00000871715, ENST00000871716, ENST00000871717, ENST00000916538, ENST00000916539, ENST00000916540, ENST00000916541, ENST00000916542, ENST00000945737, ENST00000945738, ENST00000945739, ENST00000945740, ENST00000945741, ENST00000945742, ENST00000945743, ENST00000945744, ENST00000945745, ENST00000945746, ENST00000945747, ENST00000945748, ENST00000945749, ENST00000945750

RefSeq mRNA: 6 — MANE Select: NM_006024 NM_001079864, NM_001206901, NM_001206902, NM_001362794, NM_001362795, NM_006024

CCDS: CCDS43561, CCDS5415, CCDS56471

Canonical transcript exons

ENST00000396319 — 17 exons

Exon	Start	End
ENSE00000674591	27765834	27766021
ENSE00001211691	27816349	27816520
ENSE00001821209	27740162	27740269
ENSE00001937095	27828628	27829767
ENSE00003465471	27827738	27827820
ENSE00003470986	27793066	27793212
ENSE00003485482	27816890	27817038
ENSE00003511962	27769676	27769834
ENSE00003532002	27758031	27758133
ENSE00003535259	27792006	27792230
ENSE00003553608	27794323	27794446
ENSE00003559350	27796116	27796219
ENSE00003579484	27799965	27800090
ENSE00003593880	27787418	27787603
ENSE00003679784	27785399	27785489
ENSE00003684717	27785163	27785311
ENSE00003692003	27748518	27748686

Expression profiles

Bgee: expression breadth ubiquitous, 301 present calls, max score 99.75.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 62.1144 / max 2569.2970, expressed in 1817 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
77826	60.2837	1817
77827	0.9992	536
77833	0.8315	320

Top tissues by expression

301 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	99.75	gold quality
oocyte	CL:0000023	99.74	gold quality
bronchial epithelial cell	CL:0002328	99.43	gold quality
pigmented layer of retina	UBERON:0001782	99.22	gold quality
epithelium of bronchus	UBERON:0002031	99.22	gold quality
retina	UBERON:0000966	99.19	gold quality
bronchus	UBERON:0002185	99.14	gold quality
amniotic fluid	UBERON:0000173	98.82	gold quality
epithelium of nasopharynx	UBERON:0001951	98.70	gold quality
oral cavity	UBERON:0000167	98.69	gold quality
nasopharynx	UBERON:0001728	98.68	gold quality
choroid plexus epithelium	UBERON:0003911	98.64	gold quality
mucosa of paranasal sinus	UBERON:0005030	98.62	gold quality
nasal cavity epithelium	UBERON:0005384	98.53	gold quality
heart right ventricle	UBERON:0002080	98.46	gold quality
tongue squamous epithelium	UBERON:0006919	98.43	gold quality
calcaneal tendon	UBERON:0003701	98.40	gold quality
caput epididymis	UBERON:0004358	98.40	gold quality
cervix squamous epithelium	UBERON:0006922	98.38	gold quality
adrenal tissue	UBERON:0018303	98.31	gold quality
middle temporal gyrus	UBERON:0002771	98.29	gold quality
corpus epididymis	UBERON:0004359	98.23	gold quality
right adrenal gland	UBERON:0001233	98.22	gold quality
postcentral gyrus	UBERON:0002581	98.21	gold quality
esophagus squamous epithelium	UBERON:0006920	98.19	gold quality
right adrenal gland cortex	UBERON:0035827	98.19	gold quality
nasal cavity mucosa	UBERON:0001826	98.18	gold quality
eye	UBERON:0000970	98.08	gold quality
type B pancreatic cell	CL:0000169	98.05	gold quality
renal medulla	UBERON:0000362	98.05	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-6701	yes	37.33
E-MTAB-7316	yes	36.54
E-MTAB-6379	no	5440.62
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

56 targeting TAX1BP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-4495	99.82	72.08	3080
HSA-MIR-4639-5P	99.81	67.37	1028
HSA-MIR-556-3P	99.74	68.75	1203
HSA-MIR-148A-3P	99.74	73.77	1700
HSA-MIR-148B-3P	99.74	73.75	1700
HSA-MIR-152-3P	99.74	73.75	1703
HSA-MIR-10393-3P	99.72	66.56	961
HSA-MIR-6801-5P	99.72	66.50	981
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-4756-3P	99.62	66.30	1319
HSA-MIR-6758-3P	99.57	67.55	1078
HSA-MIR-543	99.52	69.03	2595
HSA-MIR-7159-3P	99.51	70.17	1920
HSA-MIR-5584-5P	99.49	68.22	2814
HSA-MIR-1324	99.46	66.57	1302

Literature-anchored findings (GeneRIF, showing 20)

• myosin VI-T6BP interactions may link membrane trafficking pathways with cell adhesion and cytokine-dependent cell signalling. (PMID:17635994)
• results demonstrate TBK1-IKKi to be novel substrates for A20 and further identify a novel mechanism whereby A20 and TAX1BP1 restrict antiviral signaling by disrupting a TRAF3-TBK1-IKKi signaling complex (PMID:20304918)
• There is evidence of the association between the TAX1BP1 polymorphism and oral cavity cancer but there are no differences in the distribution of the polymorphism among patients with head and neck cancer and individuals without history of neoplasm. (PMID:20549079)
• In a link with T cell leukemia virus-1-associated myelopathy/tropical spastic paraparesis, an alphabeta T cell receptor recognizes a self peptide from neuronal protein HuD in context of histocompatibility antigen HLA-A2. (PMID:21282516)
• ABIN1 requires its ubiquitin binding domain and cooperates with TAX1BP1 and A20 to restrict antiviral signaling. (PMID:21885437)
• Allele frequencies of three Alu insertions that are located in MEF2C (two of them) and TAX1BP1 genes significantly differ between cohorts of healthy donors and ALL(acute lymphoblastic leukemia) patients. (PMID:22997707)
• Autophagy of Tax1bp1/Ndp52 promotes non-canonical NF-kappaB signalling. (PMID:23209807)
• RNF11 functions together with TAX1BP1 to restrict antiviral signaling and IFN-beta production. (PMID:23308279)
• A protein construct corresponding to the SKICH domain plus the linker region was expressed, purified and crystallized for TAX1BP1. (PMID:24817723)
• The induction of antibodies to an AQP4 epitope in mice immunized with the TAX1BP1-derived peptide suggests that a latent HTLV-1 infection could lead to TAX1BP1 antigen presentation and the production of anti-AQP4 antibodies in human neuromyelitis optica. (PMID:26287441)
• we demonstrate that myosin VI and TAX1BP1 are recruited to ubiquitylated Salmonella and play a key role in xenophagy (PMID:26451915)
• Results show that TAX1BP1 translocates to mitochondria in response to RNA virus infection and inducibly interacts with the MAVS adaptor protein and indicate that TAX1BP1 functions as an adaptor molecule for Itch to target MAVS during RNA virus infection and thus restrict virus-induced apoptosis. (PMID:27736772)
• TAX1BP1 downregulation by EBV-miR-BART15-3p enhances chemosensitivity of gastric cancer cells to 5-fluorouracil. (PMID:27757686)
• evaluated the currently known TBK1-mediated phosphorylation sites in the SKICH domains of NDP52 and TAX1BP1 on the basis of their interactions with NAP1 (PMID:30459273)
• Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. (PMID:33207181)
• Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages. (PMID:34225486)
• FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates. (PMID:34226595)
• Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation. (PMID:34471133)
• TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1. (PMID:36898370)
• Decreased TAX1BP1 participates in systemic lupus erythematosus by regulating monocyte/macrophage function. (PMID:37465957)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	tax1bp1b	ENSDARG00000056856
danio_rerio	tax1bp1a	ENSDARG00000098288
mus_musculus	Tax1bp1	ENSMUSG00000004535
rattus_norvegicus	Tax1bp1	ENSRNOG00000008393

Paralogs (2): CALCOCO1 (ENSG00000012822), CALCOCO2 (ENSG00000136436)

Protein

Protein identifiers

Tax1-binding protein 1 — Q86VP1 (reviewed: Q86VP1)

Alternative names: TRAF6-binding protein

All UniProt accessions (7): Q86VP1, B8ZZD4, C9J7J4, C9JBZ7, F8WBU9, H7C3L5, V9GZ06

UniProt curated annotations — full annotation on UniProt →

Function. Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation. Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates. Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate ‘Lys63’-linked polyubiquitination of TBK1 and thereby IFN-beta production. Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways. Inhibits virus-induced apoptosis by inducing the ‘Lys-48’-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS-mediated apoptosis signaling. As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis. Upon NBR1 recruitment to the SQSTM1-ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation. Mediates the autophagic degradation of other substrates including TICAM1.

Subunit / interactions. Homooligomer. Interacts with TNFAIP3. Interacts with STARD13. Interacts with MYO6. Interacts with TOM1; the interaction is indirect and is mediated by MYO6, which acts as a bridge between TOM1 and TAX1BP1. Interacts with MAVS; this interaction induces MAVS polyubiquitination. Interacts with TNIP1. Interacts with TRAF6; this interaction mediates deubiquitination of TRAF6 and inhibition of NF-kappa-B activation. Interacts with RIPK1; this interaction negatively regulates RIPK1 ubiquitination. Interacts with NBR1. Interacts with TBK1. Interacts with RB1CC1. Interacts with SQSTM1. Interacts with AZI2. Interacts with TICAM1 and TRIM32; these interactions target TICAM1 to TAX1BP1-mediated selective autophagic degradation. (Microbial infection) Interacts with the HTLV-1 protein Tax. (Microbial infection) Interacts with Respiratory syncytial virus protein N; this interaction may promote viral growth by inhibiting the innate immune response. (Microbial infection) Interacts with Lassa virus protein Z. (Microbial infection) Interacts with Mopeia virus protein Z.

Subcellular location. Cytoplasm. Mitochondrion. Preautophagosomal structure. Cytoplasmic vesicle. Autophagosome.

Tissue specificity. Expressed in all tissues tested.

Post-translational modifications. Phosphorylated in the C-terminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.

Domain organisation. The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.

Isoforms (4)

UniProt ID	Names	Canonical?
Q86VP1-1	1	yes
Q86VP1-2	2, TXBP151-L
Q86VP1-3	3, TXBP151-S
Q86VP1-4	4

RefSeq proteins (6): NP_001073333, NP_001193830, NP_001193831, NP_001349723, NP_001349724, NP_006015* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012852	CALCOCO1-like	Domain
IPR041611	SKICH	Domain
IPR041641	CALCOCO1/2_Zn_UBZ1	Domain
IPR051002	UBA_autophagy_assoc_protein	Family

Pfam: PF07888, PF17751, PF18112

UniProt features (58 total): strand 12, binding site 8, mutagenesis site 8, modified residue 6, helix 5, region of interest 4, splice variant 3, sequence variant 3, zinc finger region 2, sequence conflict 2, turn 2, chain 1, coiled-coil region 1, compositionally biased region 1

Structure

Experimental structures (PDB)

10 structures.

PDB	Method	Resolution (Å)
5YT6	X-RAY DIFFRACTION	1.5
8W6A	X-RAY DIFFRACTION	1.53
4NLH	X-RAY DIFFRACTION	1.9
4Z4M	X-RAY DIFFRACTION	2.15
5Z7G	X-RAY DIFFRACTION	2.3
8W6B	X-RAY DIFFRACTION	2.39
4BMJ	X-RAY DIFFRACTION	2.75
4Z4K	X-RAY DIFFRACTION	2.8
2M7Q	SOLUTION NMR
5AAS	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86VP1-F1	76.79	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (8): 733; 749; 753; 757; 760; 776; 780; 730

Post-translational modifications (6): 124, 138, 225, 593, 609, 666

Mutagenesis-validated functional residues (8):

Position	Phenotype
114	complete loss of tbk1 and rb1cc1 binding.
143	complete loss of map1lc3b binding.
771	normal affinity for ubiquitin.
774	reduced affinity for ubiquitin.
775	normal affinity for ubiquitin.
777	reduced affinity for ubiquitin.
778	reduced affinity for ubiquitin.
781	reduced affinity for ubiquitin.

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-5357905	Regulation of TNFR1 signaling
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling
R-HSA-162582	Signal Transduction
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-73887	Death Receptor Signaling
R-HSA-75893	TNF signaling

MSigDB gene sets: 282 (showing top): REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA, FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP, REACTOME_INNATE_IMMUNE_SYSTEM, GOBP_RESPONSE_TO_PEPTIDE, GOBP_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION, GOBP_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY, HSIAO_HOUSEKEEPING_GENES, GOBP_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY, ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, MORF_TERF1, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS, GOBP_REGULATION_OF_IMMUNE_RESPONSE, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, MILI_PSEUDOPODIA_HAPTOTAXIS_UP

GO Biological Process (14): autophagy (GO:0006914), apoptotic process (GO:0006915), negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804), negative regulation of toll-like receptor 4 signaling pathway (GO:0034144), negative regulation of cytoplasmic pattern recognition receptor signaling pathway (GO:0039532), negative regulation of apoptotic process (GO:0043066), negative regulation of canonical NF-kappaB signal transduction (GO:0043124), innate immune response (GO:0045087), protein localization to phagocytic vesicle (GO:1905161), negative regulation of interleukin-1-mediated signaling pathway (GO:2000660), immune system process (GO:0002376), cytoplasmic pattern recognition receptor signaling pathway (GO:0002753), toll-like receptor 4 signaling pathway (GO:0034142), protein K48-linked ubiquitination (GO:0070936)

GO Molecular Function (6): zinc ion binding (GO:0008270), kinase binding (GO:0019900), protein-macromolecule adaptor activity (GO:0030674), signaling adaptor activity (GO:0035591), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (7): phagophore assembly site (GO:0000407), cytoplasm (GO:0005737), mitochondrion (GO:0005739), autophagosome (GO:0005776), cytosol (GO:0005829), cytoplasmic vesicle (GO:0031410), extracellular exosome (GO:0070062)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
TNF signaling	1
DDX58/IFIH1-mediated induction of interferon-alpha/beta	1
Immune System	1
Innate Immune System	1
Signal Transduction	1
Death Receptor Signaling	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	4
cellular anatomical structure	3
negative regulation of cytokine-mediated signaling pathway	2
negative regulation of immune system process	2
negative regulation of intracellular signal transduction	2
catabolic process	1
transmembrane transport	1
process utilizing autophagic mechanism	1
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
regulation of tumor necrosis factor-mediated signaling pathway	1
tumor necrosis factor-mediated signaling pathway	1
negative regulation of signal transduction	1
toll-like receptor 4 signaling pathway	1
regulation of toll-like receptor 4 signaling pathway	1
cytoplasmic pattern recognition receptor signaling pathway	1
regulation of cytoplasmic pattern recognition receptor signaling pathway	1
apoptotic process	1
regulation of apoptotic process	1
negative regulation of programmed cell death	1
canonical NF-kappaB signal transduction	1
regulation of canonical NF-kappaB signal transduction	1
immune response	1
defense response to symbiont	1
protein localization to organelle	1
interleukin-1-mediated signaling pathway	1
regulation of interleukin-1-mediated signaling pathway	1
biological_process	1
positive regulation of cytokine production	1
pattern recognition receptor signaling pathway	1
intracellular receptor signaling pathway	1
cell surface toll-like receptor signaling pathway	1
protein polyubiquitination	1
transition metal ion binding	1
enzyme binding	1
protein binding	1
molecular adaptor activity	1
protein-macromolecule adaptor activity	1
binding	1

Protein interactions and networks

STRING

2212 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TAX1BP1	RNF11	Q9Y3C5	994
TAX1BP1	CNTN2	P78432	988
TAX1BP1	UBE2N	P61088	980
TAX1BP1	TRAF6	Q9Y4K3	952
TAX1BP1	OPTN	Q96CV9	942
TAX1BP1	ITCH	Q96J02	909
TAX1BP1	A0A087WY85	A0A087WY85	907
TAX1BP1	SQSTM1	Q13501	895
TAX1BP1	GABARAP	O95166	850
TAX1BP1	NBR1	Q14596	824
TAX1BP1	TNFAIP3	P21580	810
TAX1BP1	CD300C	Q08708	802
TAX1BP1	GABARAPL2	P60520	765
TAX1BP1	F5GZY7	F5GZY7	763
TAX1BP1	BIRC2	Q13490	734

IntAct

376 interactions, top by confidence:

A	B	Type	Score
TAX1BP1	COG7	psi-mi:“MI:0915”(physical association)	0.850
COG7	TAX1BP1	psi-mi:“MI:0915”(physical association)	0.850
TNFAIP3	TAX1BP1	psi-mi:“MI:0915”(physical association)	0.810
TAX1BP1	TNIP1	psi-mi:“MI:0915”(physical association)	0.780
TAX1BP1	TNIP3	psi-mi:“MI:0915”(physical association)	0.780
TNIP1	TAX1BP1	psi-mi:“MI:0915”(physical association)	0.780
TNIP3	TAX1BP1	psi-mi:“MI:0915”(physical association)	0.780
TAX1BP1	LGALS8	psi-mi:“MI:0915”(physical association)	0.740
LGALS8	TAX1BP1	psi-mi:“MI:0915”(physical association)	0.740
TAX1BP1	DSTN	psi-mi:“MI:0915”(physical association)	0.720
DAZAP2	TAX1BP1	psi-mi:“MI:0915”(physical association)	0.720
TSG101	TAX1BP1	psi-mi:“MI:0915”(physical association)	0.720
TAX1BP1	RAD18	psi-mi:“MI:0915”(physical association)	0.720
TAX1BP1	NMRK1	psi-mi:“MI:0915”(physical association)	0.720
TAX1BP1	MRPL11	psi-mi:“MI:0915”(physical association)	0.720
DSTN	TAX1BP1	psi-mi:“MI:0915”(physical association)	0.720

BioGRID (501): TAX1BP1 (Two-hybrid), TAX1BP1 (Two-hybrid), TAX1BP1 (Two-hybrid), TAX1BP1 (Two-hybrid), TAX1BP1 (Two-hybrid), TAX1BP1 (Two-hybrid), FAM189A2 (Two-hybrid), DAZAP2 (Two-hybrid), TNIP1 (Two-hybrid), DSTN (Two-hybrid), EMILIN1 (Two-hybrid), RAB18 (Two-hybrid), FAM168A (Two-hybrid), CXXC1 (Two-hybrid), NMRK1 (Two-hybrid)

ESM2 similar proteins: A0PJP4, O18737, O75665, P0C219, P12757, P35689, P97817, Q01850, Q13137, Q14596, Q14BN4, Q17QT2, Q28623, Q2KJE0, Q3B7M3, Q3SYW5, Q3UKC1, Q3URD3, Q3ZBK7, Q4KLN4, Q4KLY0, Q4KMA0, Q4R3X1, Q4R914, Q53GS7, Q5R431, Q5R4U3, Q5R7H1, Q5RAS2, Q5RD40, Q5ZJA3, Q66HA4, Q6DH86, Q6IMY1, Q6NRH3, Q6P132, Q6P3P1, Q6ZUS6, Q76CY8, Q7TPQ3

Diamond homologs: A2A6M5, A2BGD5, O18737, Q13137, Q1LWB0, Q2KJ21, Q2KJE0, Q3UKC1, Q4R914, Q5R4U3, Q5R7H1, Q5RD60, Q66HA4, Q66HR5, Q6DD09, Q6DF48, Q6P132, Q6P3P1, Q86VP1, Q8CGU1, Q9DEX1, Q9P1Z2

SIGNOR signaling

5 interactions.

A	Effect	B	Mechanism
TAX1BP1	“up-regulates activity”	TNFAIP3	binding
CHUK	“up-regulates activity”	TAX1BP1	phosphorylation
TNIP1	“up-regulates activity”	TAX1BP1	relocalization
TAX1BP1	“down-regulates activity”	TRAF3	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 70 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
TNFR1-induced NF-kappa-B signaling pathway	6	50.4×	3e-07
Ovarian tumor domain proteases	7	48.7×	3e-08
Negative regulators of DDX58/IFIH1 signaling	5	40.8×	7e-06
NOD1/2 Signaling Pathway	5	39.6×	7e-06
Regulation of TP53 Degradation	5	36.6×	8e-06
Regulation of TNFR1 signaling	6	33.6×	3e-06
Ub-specific processing proteases	6	8.0×	4e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

118 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	95
Likely benign	2
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

3348 predictions. Top by Δscore:

Variant	Effect	Δscore
7:27740254:G:GT	donor_gain	1.0000
7:27740267:TGGG:T	donor_loss	1.0000
7:27740268:GG:G	donor_gain	1.0000
7:27740269:GG:G	donor_gain	1.0000
7:27740269:GGT:G	donor_loss	1.0000
7:27740270:G:GG	donor_gain	1.0000
7:27740270:GTA:G	donor_loss	1.0000
7:27740271:T:A	donor_loss	1.0000
7:27748513:TTCA:T	acceptor_loss	1.0000
7:27748514:TCA:T	acceptor_loss	1.0000
7:27748516:A:AG	acceptor_gain	1.0000
7:27748517:G:GA	acceptor_gain	1.0000
7:27748517:GA:G	acceptor_gain	1.0000
7:27748517:GATTC:G	acceptor_gain	1.0000
7:27748683:CAAG:C	donor_loss	1.0000
7:27748684:AAG:A	donor_loss	1.0000
7:27748687:G:GC	donor_loss	1.0000
7:27748688:T:A	donor_loss	1.0000
7:27758020:T:G	acceptor_gain	1.0000
7:27758025:CTTTA:C	acceptor_loss	1.0000
7:27758026:TTTAG:T	acceptor_loss	1.0000
7:27758028:TAGGT:T	acceptor_loss	1.0000
7:27758029:A:AG	acceptor_gain	1.0000
7:27758029:AG:A	acceptor_gain	1.0000
7:27758029:AGGTT:A	acceptor_gain	1.0000
7:27758030:G:A	acceptor_loss	1.0000
7:27758030:G:GA	acceptor_gain	1.0000
7:27758030:GG:G	acceptor_gain	1.0000
7:27758030:GGT:G	acceptor_gain	1.0000
7:27758030:GGTT:G	acceptor_gain	1.0000

AlphaMissense

5288 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:27748574:T:A	V17D	1.000
7:27748579:T:C	F19L	1.000
7:27748580:T:C	F19S	1.000
7:27748581:T:A	F19L	1.000
7:27748581:T:G	F19L	1.000
7:27748669:T:A	W49R	1.000
7:27748669:T:C	W49R	1.000
7:27748671:G:C	W49C	1.000
7:27748671:G:T	W49C	1.000
7:27748673:T:A	V50D	1.000
7:27748675:G:C	G51R	1.000
7:27748676:G:A	G51D	1.000
7:27748679:T:A	I52K	1.000
7:27748681:T:C	F53L	1.000
7:27748683:C:A	F53L	1.000
7:27748683:C:G	F53L	1.000
7:27758035:G:A	G56E	1.000
7:27758037:T:A	W57R	1.000
7:27758037:T:C	W57R	1.000
7:27758064:T:C	F66L	1.000
7:27758065:T:C	F66S	1.000
7:27758066:T:A	F66L	1.000
7:27758066:T:G	F66L	1.000
7:27758070:T:A	W68R	1.000
7:27758070:T:C	W68R	1.000
7:27765863:T:C	F99L	1.000
7:27765865:T:A	F99L	1.000
7:27765865:T:G	F99L	1.000
7:27765866:T:G	Y100D	1.000
7:27765873:T:C	F102S	1.000

dbSNP variants (sampled 300 via entrez): RS1000018181 (7:27792367 A>G), RS1000026536 (7:27750056 G>T), RS1000079904 (7:27741222 C>A), RS1000082591 (7:27770355 G>A), RS1000096251 (7:27747873 T>G), RS1000209182 (7:27777317 T>A), RS1000299035 (7:27755870 A>G), RS1000363739 (7:27750994 C>A,G), RS1000381247 (7:27821907 T>C), RS1000478459 (7:27750720 T>C), RS1000556355 (7:27768551 C>A), RS1000588897 (7:27814829 A>G,T), RS1000602288 (7:27817549 A>G), RS1000604743 (7:27773893 A>G), RS1000617285 (7:27775442 C>A,T)

Disease associations

OMIM: gene MIM:605326 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST002563_10	Hypospadias	8.000000e-12
GCST004860_36	Alcoholic chronic pancreatitis	9.000000e-06
GCST006409_4	Allergic rhinitis	3.000000e-14
GCST007324_87	Adventurousness	4.000000e-09
GCST007995_52	Asthma (childhood onset)	2.000000e-09
GCST009391_404	Metabolite levels	9.000000e-06
GCST009798_87	Asthma	9.000000e-13

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0008579	risk-taking behaviour
EFO:0010386	phosphatidylcholine 38:4 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, decreases methylation, affects expression	2
sodium arsenite	increases abundance, increases expression	2
Tobacco Smoke Pollution	increases expression	2
Cyclosporine	increases expression	2
Cadmium Chloride	increases abundance, increases expression	2
Particulate Matter	decreases expression, increases abundance, affects expression, increases reaction	2
FR900359	affects phosphorylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
cobaltous chloride	increases expression	1
1-nitropyrene	increases expression	1
di-n-butylphosphoric acid	affects expression	1
4-phenylbutyric acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
chloropicrin	increases expression	1
corosolic acid	increases expression	1
K 7174	increases expression	1
oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	affects expression, increases reaction	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
NSC 689534	affects binding, increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	increases abundance, increases expression	1
Vehicle Emissions	affects expression, increases reaction	1
Benzo(a)pyrene	increases methylation	1
Cadmium	increases abundance, increases expression	1
Copper	affects binding, increases expression	1

Cellosaurus cell lines

10 cell lines: 9 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3J2	Abcam HEK293T TAX1BP1 KO	Transformed cell line	Female
CVCL_C2VN	HeLa S3 penta KO	Cancer cell line	Female
CVCL_C2VP	HeLa S3 penta KO-ATG13 KO	Cancer cell line	Female
CVCL_C2VQ	HeLa S3 penta KO-ATG14 KO	Cancer cell line	Female
CVCL_C2VR	HeLa S3 penta KO-TBK1 KO	Cancer cell line	Female
CVCL_C2VS	HeLa S3 penta KO-ULK1/ULK2 DKO	Cancer cell line	Female
CVCL_C2VT	HeLa S3 penta KO-TBK1/ULK1/ULK2 TKO	Cancer cell line	Female
CVCL_C8QB	HeLa S3 penta KO-AZI2/TBKBP1 DKO clone 20	Cancer cell line	Female
CVCL_C9DW	HeLa S3 penta KO-ULK1/ULK2 DKO-AZI2/TBKBP1 DKO	Cancer cell line	Female
CVCL_D2Q1	HeLa S3 penta KO-AZI2/TBKBP1 DKO clone 26	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.