TBC1D10B

Summary

TBC1D10B (TBC1 domain family member 10B, HGNC:24510) is a protein-coding gene on chromosome 16p11.2, encoding TBC1 domain family member 10B (Q4KMP7). Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35.

Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]).

Source: NCBI Gene 26000 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 56 total
• MANE Select transcript: NM_015527

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24510
Approved symbol	TBC1D10B
Name	TBC1 domain family member 10B
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Aliases	DKFZP434P1750, Rab27A-GAPbeta, FLJ13130, EPI64B
Ensembl gene	ENSG00000169221
Ensembl biotype	protein_coding
OMIM	613620
Entrez	26000

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 6 protein_coding, 5 retained_intron

ENST00000409939, ENST00000464644, ENST00000475650, ENST00000475872, ENST00000478158, ENST00000490703, ENST00000566671, ENST00000936813, ENST00000936814, ENST00000955945, ENST00000955946

RefSeq mRNA: 1 — MANE Select: NM_015527 NM_015527

CCDS: CCDS10676

Canonical transcript exons

ENST00000409939 — 9 exons

Exon	Start	End
ENSE00001139893	30365495	30365594
ENSE00001958615	30369228	30370494
ENSE00003533965	30359538	30359603
ENSE00003547418	30365105	30365212
ENSE00003587908	30359172	30359361
ENSE00003590953	30364900	30365006
ENSE00003629676	30359727	30359841
ENSE00003657394	30357102	30358573
ENSE00003682454	30358663	30358817

Expression profiles

Bgee: expression breadth ubiquitous, 264 present calls, max score 93.52.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.0333 / max 356.9954, expressed in 1797 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
157040	14.0333	1797

Top tissues by expression

283 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	93.52	gold quality
right testis	UBERON:0004534	93.30	gold quality
mucosa of transverse colon	UBERON:0004991	92.72	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	92.66	gold quality
granulocyte	CL:0000094	91.84	gold quality
apex of heart	UBERON:0002098	91.72	gold quality
right hemisphere of cerebellum	UBERON:0014890	91.68	gold quality
cerebellar hemisphere	UBERON:0002245	91.63	gold quality
cerebellar cortex	UBERON:0002129	91.59	gold quality
spinal cord	UBERON:0002240	91.55	gold quality
right frontal lobe	UBERON:0002810	91.33	gold quality
sperm	CL:0000019	90.97	gold quality
prefrontal cortex	UBERON:0000451	90.91	gold quality
male germ cell	CL:0000015	90.81	gold quality
cingulate cortex	UBERON:0003027	90.79	gold quality
anterior cingulate cortex	UBERON:0009835	90.79	gold quality
gastrocnemius	UBERON:0001388	90.73	gold quality
testis	UBERON:0000473	90.58	gold quality
right adrenal gland cortex	UBERON:0035827	90.48	gold quality
hindlimb stylopod muscle	UBERON:0004252	90.47	gold quality
lower esophagus mucosa	UBERON:0035834	90.43	gold quality
ileal mucosa	UBERON:0000331	90.36	gold quality
cerebellum	UBERON:0002037	90.35	gold quality
stromal cell of endometrium	CL:0002255	90.17	gold quality
sural nerve	UBERON:0015488	90.11	gold quality
ganglionic eminence	UBERON:0004023	90.03	gold quality
right adrenal gland	UBERON:0001233	89.97	gold quality
muscle of leg	UBERON:0001383	89.90	gold quality
Brodmann (1909) area 9	UBERON:0013540	89.90	gold quality
amygdala	UBERON:0001876	89.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

63 targeting TBC1D10B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-23B-5P	99.98	66.07	587
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-23A-5P	99.94	65.39	468
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-3065-3P	99.87	70.25	1407
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-4495	99.82	72.08	3080
HSA-MIR-4524A-3P	99.72	66.85	2406
HSA-MIR-1825	99.72	68.11	1089
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-4472	99.56	66.08	1478
HSA-MIR-4761-5P	99.51	66.69	804
HSA-MIR-657	99.48	66.02	848
HSA-MIR-330-3P	99.41	69.95	2521
HSA-MIR-1912-3P	99.32	67.40	936
HSA-MIR-7515	99.31	68.22	1795
HSA-MIR-504-3P	99.30	67.18	1745
HSA-MIR-4651	99.06	67.57	2002
HSA-MIR-1295B-5P	99.03	67.50	810
HSA-MIR-670-3P	99.03	68.88	2404

Literature-anchored findings (GeneRIF, showing 5)

• Data suggest that EPI64A and B, which are ubiquitously expressed members of the EPI64 subfamily, inactivate Ras and certain Rabs at the periphery of cells. (PMID:23248241)
• Regulation of VEGFR2 trafficking and signaling by Rab GTPase-activating proteins. (PMID:31527750)
• STAT4-mediated down-regulation of miR-3619-5p facilitates stomach adenocarcinoma by modulating TBC1D10B. (PMID:32397798)
• The RabGAPs EPI64A and EPI64B regulate the apical structure of epithelial cells (dagger). (PMID:34757852)
• TBC1D10B promotes tumor progression in colon cancer via PAK4-mediated promotion of the PI3K/AKT/mTOR pathway. (PMID:38824479)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tbc1d10b	ENSDARG00000078604
mus_musculus	Tbc1d10b	ENSMUSG00000042492
rattus_norvegicus	Tbc1d10b	ENSRNOG00000017349

Paralogs (45): RABGAP1 (ENSG00000011454), TBC1D22A (ENSG00000054611), TBC1D22B (ENSG00000065491), TBC1D1 (ENSG00000065882), EVI5 (ENSG00000067208), TBC1D25 (ENSG00000068354), TBC1D2 (ENSG00000095383), TBC1D10A (ENSG00000099992), SGSM3 (ENSG00000100359), TBC1D17 (ENSG00000104946), TBC1D13 (ENSG00000107021), TBC1D12 (ENSG00000108239), TBC1D9 (ENSG00000109436), TBC1D30 (ENSG00000111490), TBC1D15 (ENSG00000121749), TBC1D5 (ENSG00000131374), TBC1D14 (ENSG00000132405), TBC1D8B (ENSG00000133138), TBC1D4 (ENSG00000136111), GRTP1 (ENSG00000139835), SGSM2 (ENSG00000141258), EVI5L (ENSG00000142459), TBCK (ENSG00000145348), USP6NL (ENSG00000148429), RABGAP1L (ENSG00000152061), SGSM1 (ENSG00000167037), TBC1D21 (ENSG00000167139), TBC1D2B (ENSG00000167202), TBC1D16 (ENSG00000167291), TBC1D10C (ENSG00000175463), TBC1D28 (ENSG00000189375), TBC1D9B (ENSG00000197226), TBC1D8 (ENSG00000204634), TBC1D26 (ENSG00000214946), TBC1D3G (ENSG00000260287), TBC1D3K (ENSG00000273513), TBC1D3H (ENSG00000274226), TBC1D3D (ENSG00000274419), TBC1D3L (ENSG00000274512), TBC1D3 (ENSG00000274611)

Protein

Protein identifiers

TBC1 domain family member 10B — Q4KMP7 (reviewed: Q4KMP7)

Alternative names: Rab27A-GAP-beta

All UniProt accessions (2): Q4KMP7, H3BSE1

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A.

Subcellular location. Cytoplasm. Cell membrane.

Isoforms (2)

UniProt ID	Names	Canonical?
Q4KMP7-1	1	yes
Q4KMP7-2	2

RefSeq proteins (1): NP_056342* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000195	Rab-GAP-TBC_dom	Domain
IPR035969	Rab-GAP_TBC_sf	Homologous_superfamily
IPR050302	Rab_GAP_TBC_domain	Family

Pfam: PF00566

UniProt features (33 total): compositionally biased region 11, modified residue 8, sequence conflict 5, region of interest 4, chain 1, domain 1, splice variant 1, mutagenesis site 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q4KMP7-F1	69.94	0.45

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (8): 22, 141, 152, 186, 658, 661, 678, 687

Mutagenesis-validated functional residues (1):

Position	Phenotype
409	loss of gap activity. unable to exclude rab3a from the dense-core vesicles, when tested in a pheochromocytoma cell line.

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-8854214	TBC/RABGAPs
R-HSA-199991	Membrane Trafficking
R-HSA-5653656	Vesicle-mediated transport
R-HSA-9007101	Rab regulation of trafficking

MSigDB gene sets: 154 (showing top): GCM_MAP4K4, GCM_GSPT1, GOBP_REGULATION_OF_GTPASE_ACTIVITY, RACCACAR_AML_Q6, GOBP_VESICLE_MEDIATED_TRANSPORT, AP2_Q3, REACTOME_MEMBRANE_TRAFFICKING, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GCGCTTT_MIR518B_MIR518C_MIR518D, CEBPB_01, CATRRAGC_UNKNOWN, GOBP_REGULATION_OF_HYDROLASE_ACTIVITY, GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, TGCTGAY_UNKNOWN, GOBP_CILIUM_ORGANIZATION

GO Biological Process (2): retrograde transport, endosome to Golgi (GO:0042147), regulation of GTPase activity (GO:0043087)

GO Molecular Function (2): GTPase activator activity (GO:0005096), protein binding (GO:0005515)

GO Cellular Component (4): cytosol (GO:0005829), plasma membrane (GO:0005886), cytoplasm (GO:0005737), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Rab regulation of trafficking	1
Vesicle-mediated transport	1
Membrane Trafficking	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
GTPase activity	2
intercellular transport	1
endosomal transport	1
cytosolic transport	1
regulation of hydrolase activity	1
enzyme activator activity	1
GTPase regulator activity	1
binding	1
cytoplasm	1
membrane	1
cell periphery	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

998 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TBC1D10B	RAB35	Q15286	877
TBC1D10B	RAB27A	P51159	851
TBC1D10B	RAB22A	Q9UL26	823
TBC1D10B	CDC16	Q13042	774
TBC1D10B	RAB6A	P20340	667
TBC1D10B	RAB2A	P08886	666
TBC1D10B	ARF6	P26438	664
TBC1D10B	EIF3K	Q9UBQ5	644
TBC1D10B	RAB3A	P20336	643
TBC1D10B	TBC1D22B	Q9NU19	607
TBC1D10B	TBC1D13	Q9NVG8	584
TBC1D10B	NRDE2	Q9H7Z3	571
TBC1D10B	TBC1D19	Q8N5T2	517
TBC1D10B	TMUB2	Q71RG4	511
TBC1D10B	TBC1D21	Q8IYX1	508

IntAct

45 interactions, top by confidence:

A	B	Type	Score
RIOK1	PRMT5	psi-mi:“MI:0914”(association)	0.710
TBC1D10B	CCDC70	psi-mi:“MI:0915”(physical association)	0.560
ZYX	TBC1D10B	psi-mi:“MI:0914”(association)	0.530
GALNS	CLGN	psi-mi:“MI:0914”(association)	0.530
Tipin	NEMF	psi-mi:“MI:0914”(association)	0.350
Kif20b	SHTN1	psi-mi:“MI:0914”(association)	0.350
SYNCRIP	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
ORF73	ECI2	psi-mi:“MI:0914”(association)	0.350
RYBP	PIPSL	psi-mi:“MI:0914”(association)	0.350
	HLA-C	psi-mi:“MI:0914”(association)	0.350
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
EAF1	C1orf226	psi-mi:“MI:0914”(association)	0.350
KCMF1	CIT	psi-mi:“MI:0914”(association)	0.350
RNPS1	WWP2	psi-mi:“MI:0914”(association)	0.350
RPS19	ZNF316	psi-mi:“MI:0914”(association)	0.350
RRP7A	MAGEB2	psi-mi:“MI:0914”(association)	0.350
UTP4	POLR3A	psi-mi:“MI:0914”(association)	0.350
ZCCHC10	ARHGAP10	psi-mi:“MI:0914”(association)	0.350
ZNF692	U2SURP	psi-mi:“MI:0914”(association)	0.350
CDH1	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
CTDSPL	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
EPHA7	PIK3R2	psi-mi:“MI:2364”(proximity)	0.270
EPHB2	ARHGAP32	psi-mi:“MI:2364”(proximity)	0.270
FGFR1	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270
NTRK1	C1orf226	psi-mi:“MI:2364”(proximity)	0.270
NTRK3	C1orf226	psi-mi:“MI:2364”(proximity)	0.270
ROR2	SH3PXD2B	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (120): TBC1D10B (Affinity Capture-MS), TBC1D10B (Affinity Capture-MS), TBC1D10B (Affinity Capture-MS), TBC1D10B (Affinity Capture-MS), TBC1D10B (Affinity Capture-MS), TBC1D10B (Affinity Capture-MS), TBC1D10B (Proximity Label-MS), TBC1D10B (Proximity Label-MS), TBC1D10B (Affinity Capture-MS), TBC1D10B (Affinity Capture-MS), TBC1D10B (Affinity Capture-MS), TBC1D10B (Affinity Capture-MS), TBC1D10B (Proximity Label-MS), TBC1D10B (Affinity Capture-MS), TBC1D10B (Affinity Capture-MS)

ESM2 similar proteins: A1L1I3, A5PKW4, O08919, O70405, O75385, O75420, O75553, P16554, P42128, P49757, P53814, P85037, P97318, P98081, Q04637, Q2LC84, Q3UCQ1, Q4KMP7, Q5DTT2, Q5I1X5, Q5RBR0, Q5VZ18, Q69ZH9, Q69ZI1, Q7TN02, Q7Z6J0, Q80VC9, Q80XI3, Q80Z38, Q86V15, Q8BGT6, Q8BHL3, Q8BSD5, Q8C120, Q8CI12, Q8IY33, Q8K4J6, Q8N3F8, Q8TEH3, Q8TEJ3

Diamond homologs: A0A087WVF3, A0A087WXS9, A0A087X179, A0A087X1G2, A2AWA9, A3KGB4, A6H6A9, A6NDS4, A6NER0, A6QP29, B0R0W9, B7ZAP0, B9A6J9, H2KZZ6, O60343, O60447, O95759, O97790, P0C7X1, P35125, P58802, P97366, Q0IIM8, Q10496, Q12317, Q12344, Q28CB1, Q3UYK3, Q4KMP7, Q5R372, Q5RAN1, Q5RCW6, Q5SVR0, Q5TC63, Q5ZJ17, Q60949, Q66K14, Q6DHY5, Q6IPX1, Q6ZT07

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 64 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SARS-CoV-1-host interactions	6	22.4×	4e-05
SARS-CoV-1 Infection	6	18.2×	1e-04
Apoptosis	5	17.9×	6e-04
Programmed Cell Death	5	15.6×	9e-04
mRNA Splicing	6	14.0×	3e-04
SARS-CoV-2-host interactions	5	12.7×	1e-03
Metabolism of RNA	12	10.6×	3e-07
Processing of Capped Intron-Containing Pre-mRNA	6	10.5×	9e-04

GO biological processes:

GO term	Partners	Fold	FDR
ribosomal small subunit biogenesis	5	20.3×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	52
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1432 predictions. Top by Δscore:

Variant	Effect	Δscore
16:30358569:GTCAC:G	acceptor_gain	1.0000
16:30358570:TCAC:T	acceptor_gain	1.0000
16:30358571:CAC:C	acceptor_gain	1.0000
16:30358571:CACC:C	acceptor_gain	1.0000
16:30358572:AC:A	acceptor_gain	1.0000
16:30358573:CC:C	acceptor_gain	1.0000
16:30358574:C:CC	acceptor_gain	1.0000
16:30358575:T:C	acceptor_loss	1.0000
16:30358577:C:CT	acceptor_gain	1.0000
16:30358659:CTACC:C	donor_loss	1.0000
16:30358660:TACCT:T	donor_loss	1.0000
16:30358662:C:A	donor_loss	1.0000
16:30358682:T:TA	donor_gain	1.0000
16:30358813:AACGC:A	acceptor_gain	1.0000
16:30358814:ACGC:A	acceptor_gain	1.0000
16:30358815:CGC:C	acceptor_gain	1.0000
16:30358815:CGCC:C	acceptor_gain	1.0000
16:30358816:GC:G	acceptor_gain	1.0000
16:30358817:CC:C	acceptor_gain	1.0000
16:30358818:C:CC	acceptor_gain	1.0000
16:30358818:CT:C	acceptor_loss	1.0000
16:30358821:C:CT	acceptor_gain	1.0000
16:30358822:A:T	acceptor_gain	1.0000
16:30358826:G:C	acceptor_gain	1.0000
16:30358826:G:GC	acceptor_gain	1.0000
16:30359722:CTGA:C	donor_loss	1.0000
16:30359723:TGACC:T	donor_loss	1.0000
16:30359726:C:A	donor_loss	1.0000
16:30359726:CCT:C	donor_gain	1.0000
16:30359728:T:TA	donor_gain	1.0000

AlphaMissense

5087 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:30358712:A:G	L583P	1.000
16:30359172:C:G	G548R	1.000
16:30359189:T:A	D542V	1.000
16:30359189:T:G	D542A	1.000
16:30359190:C:A	D542Y	1.000
16:30359190:C:G	D542H	1.000
16:30359193:A:G	W541R	1.000
16:30359193:A:T	W541R	1.000
16:30359214:A:G	W534R	1.000
16:30359214:A:T	W534R	1.000
16:30359219:A:G	L532P	1.000
16:30359236:G:C	C526W	1.000
16:30359237:C:T	C526Y	1.000
16:30359238:A:G	C526R	1.000
16:30359245:C:A	W523C	1.000
16:30359245:C:G	W523C	1.000
16:30359247:A:G	W523R	1.000
16:30359247:A:T	W523R	1.000
16:30359288:A:G	L509P	1.000
16:30359321:A:G	L498P	1.000
16:30359343:C:A	G491W	1.000
16:30359343:C:G	G491R	1.000
16:30359343:C:T	G491R	1.000
16:30359345:T:A	D490V	1.000
16:30359348:A:G	L489P	1.000
16:30359354:A:T	I487N	1.000
16:30359539:A:G	L484P	1.000
16:30359563:A:G	L476P	1.000
16:30359587:A:G	L468P	1.000
16:30359595:A:C	F465L	1.000

dbSNP variants (sampled 300 via entrez): RS1000062567 (16:30364676 C>T), RS1000240179 (16:30370832 TAA>T), RS1000653113 (16:30369674 C>A,G), RS1000808286 (16:30362849 C>T), RS1000947587 (16:30366666 G>T), RS1001062444 (16:30366374 A>G), RS1001274748 (16:30372325 G>A), RS1001310302 (16:30371885 C>T), RS1001619879 (16:30370491 T>A,C), RS1001773677 (16:30369942 G>C,T), RS1001890416 (16:30356707 C>A,G), RS1002090171 (16:30357050 C>T), RS1002187004 (16:30367053 G>A,C), RS1002382708 (16:30363234 T>C), RS1002410126 (16:30360068 C>G)

Disease associations

OMIM: gene MIM:613620 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010703_269	Brain morphology (MOSTest)	4.000000e-13
GCST010796_3833	Electrocardiogram morphology (amplitude at temporal datapoints)	9.000000e-09
GCST010796_3834	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-08

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement
EFO:0004327	electrocardiography

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression, decreases expression	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
beta-lapachone	decreases expression	1
perfluorooctanoic acid	decreases expression	1
coumarin	affects phosphorylation	1
nutlin 3	affects cotreatment, increases secretion	1
ICG 001	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Sunitinib	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Aspirin	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Caffeine	affects phosphorylation	1
Dactinomycin	increases secretion, affects cotreatment	1
Diazinon	increases methylation	1
Doxorubicin	decreases expression	1
Ivermectin	decreases expression	1
Ozone	affects expression, increases abundance	1
Quercetin	increases phosphorylation	1
Smoke	decreases expression	1
Sulindac	increases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	affects expression	1
Tretinoin	increases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.