TBC1D10C

Summary

TBC1D10C (TBC1 domain family member 10C, HGNC:24702) is a protein-coding gene on chromosome 11q13.2, encoding Carabin (Q8IV04). Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity.

The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for calcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by calcium and calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 374403 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 87 total
• MANE Select transcript: NM_001369496

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24702
Approved symbol	TBC1D10C
Name	TBC1 domain family member 10C
Location	11q13.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ00332, Carabin, EPI64C
Ensembl gene	ENSG00000175463
Ensembl biotype	protein_coding
OMIM	610831
Entrez	374403

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 15 protein_coding, 5 retained_intron, 1 nonsense_mediated_decay

ENST00000312390, ENST00000524662, ENST00000526387, ENST00000526474, ENST00000529132, ENST00000529635, ENST00000530967, ENST00000533745, ENST00000542590, ENST00000868931, ENST00000868932, ENST00000868933, ENST00000868934, ENST00000868935, ENST00000868936, ENST00000946007, ENST00000946008, ENST00000946009, ENST00000946010, ENST00000946011, ENST00000946012

RefSeq mRNA: 8 — MANE Select: NM_001369496 NM_001256508, NM_001369492, NM_001369494, NM_001369495, NM_001369496, NM_001369497, NM_001369498, NM_198517

CCDS: CCDS58150, CCDS8162

Canonical transcript exons

ENST00000542590 — 9 exons

Exon	Start	End
ENSE00002154148	67404083	67404354
ENSE00002227202	67409407	67410089
ENSE00003461941	67405399	67405506
ENSE00003500550	67405903	67406017
ENSE00003557963	67406627	67406692
ENSE00003570585	67405595	67405701
ENSE00003596500	67405085	67405184
ENSE00003642558	67408979	67409133
ENSE00003693919	67406827	67407016

Expression profiles

Bgee: expression breadth ubiquitous, 175 present calls, max score 99.24.

FANTOM5 (CAGE): breadth broad, TPM avg 4.2513 / max 159.2340, expressed in 325 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
115449	2.6904	255
115448	0.7466	185
115452	0.3457	83
115453	0.2004	90
115450	0.1490	74
115451	0.1192	66

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	99.24	gold quality
blood	UBERON:0000178	96.71	gold quality
spleen	UBERON:0002106	95.98	gold quality
lymph node	UBERON:0000029	95.54	gold quality
bone marrow cell	CL:0002092	94.77	gold quality
vermiform appendix	UBERON:0001154	94.19	gold quality
thymus	UBERON:0002370	92.73	gold quality
leukocyte	CL:0000738	91.98	gold quality
monocyte	CL:0000576	91.49	gold quality
bone marrow	UBERON:0002371	90.35	gold quality
caecum	UBERON:0001153	87.75	gold quality
small intestine Peyer’s patch	UBERON:0003454	86.48	gold quality
tonsil	UBERON:0002372	85.31	gold quality
small intestine	UBERON:0002108	83.92	gold quality
mucosa of transverse colon	UBERON:0004991	82.74	gold quality
right lobe of thyroid gland	UBERON:0001119	82.62	gold quality
upper lobe of left lung	UBERON:0008952	81.80	gold quality
left lobe of thyroid gland	UBERON:0001120	81.73	gold quality
right lung	UBERON:0002167	81.33	gold quality
thyroid gland	UBERON:0002046	81.10	gold quality
upper lobe of lung	UBERON:0008948	80.81	gold quality
colonic epithelium	UBERON:0000397	80.61	gold quality
gall bladder	UBERON:0002110	80.44	gold quality
trabecular bone tissue	UBERON:0002483	79.54	gold quality
epithelium of nasopharynx	UBERON:0001951	78.80	gold quality
right uterine tube	UBERON:0001302	77.44	gold quality
lung	UBERON:0002048	75.98	gold quality
body of stomach	UBERON:0001161	75.43	gold quality
superficial temporal artery	UBERON:0001614	75.13	silver quality
duodenum	UBERON:0002114	75.01	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-MTAB-6701	yes	32.50
E-MTAB-10287	yes	30.65
E-MTAB-8410	yes	13.84
E-ANND-3	yes	8.88
E-CURD-120	no	7.43

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

14 targeting TBC1D10C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-5580-5P	99.38	66.96	1139
HSA-MIR-4758-3P	99.12	63.96	869
HSA-MIR-4699-5P	98.99	67.50	1210
HSA-MIR-4742-5P	98.89	68.41	1542
HSA-MIR-5006-5P	98.79	66.92	1246
HSA-MIR-26B-3P	98.71	67.49	1102
HSA-MIR-615-5P	98.10	63.76	591
HSA-MIR-637	97.91	64.05	1517
HSA-MIR-1271-3P	97.56	64.85	865
HSA-MIR-550A-3-5P	97.56	65.35	823
HSA-MIR-550A-5P	97.56	65.35	823
HSA-MIR-4286	97.20	64.37	1587
HSA-MIR-5588-3P	94.96	65.59	500

Literature-anchored findings (GeneRIF, showing 5)

• Carabin inhibits calcineurin and Ras and was identified by a yeast-two-hybrid screen with calcineurin (PMID:17230191)
• Carabin is a negative feedback inhibitor of the calcineurin signalling pathway that also mediates crosstalk between calcineurin and Ras (PMID:17230191)
• Carabin as a new negative regulator of B-cell function, whose deficiency in B cells speeds up early B-cell responses (PMID:23109291)
• identify prolyl 4-hydroxylase 2 (P4HA2) as a specific proline hydroxylase of Carabin. Carabin hydroxylation leads to its proteasomal degradation, thereby activating the Ras/extracellular signal-regulated kinase pathway and increasing B-cell lymphoma proliferation. (PMID:29437589)
• Weighted Gene Coexpression Network Analysis Identifies TBC1D10C as a New Prognostic Biomarker for Breast Cancer. (PMID:35425695)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tbc1d10c	ENSDARG00000037408
mus_musculus	Tbc1d10c	ENSMUSG00000040247
rattus_norvegicus	Tbc1d10c	ENSRNOG00000021510

Paralogs (45): RABGAP1 (ENSG00000011454), TBC1D22A (ENSG00000054611), TBC1D22B (ENSG00000065491), TBC1D1 (ENSG00000065882), EVI5 (ENSG00000067208), TBC1D25 (ENSG00000068354), TBC1D2 (ENSG00000095383), TBC1D10A (ENSG00000099992), SGSM3 (ENSG00000100359), TBC1D17 (ENSG00000104946), TBC1D13 (ENSG00000107021), TBC1D12 (ENSG00000108239), TBC1D9 (ENSG00000109436), TBC1D30 (ENSG00000111490), TBC1D15 (ENSG00000121749), TBC1D5 (ENSG00000131374), TBC1D14 (ENSG00000132405), TBC1D8B (ENSG00000133138), TBC1D4 (ENSG00000136111), GRTP1 (ENSG00000139835), SGSM2 (ENSG00000141258), EVI5L (ENSG00000142459), TBCK (ENSG00000145348), USP6NL (ENSG00000148429), RABGAP1L (ENSG00000152061), SGSM1 (ENSG00000167037), TBC1D21 (ENSG00000167139), TBC1D2B (ENSG00000167202), TBC1D16 (ENSG00000167291), TBC1D10B (ENSG00000169221), TBC1D28 (ENSG00000189375), TBC1D9B (ENSG00000197226), TBC1D8 (ENSG00000204634), TBC1D26 (ENSG00000214946), TBC1D3G (ENSG00000260287), TBC1D3K (ENSG00000273513), TBC1D3H (ENSG00000274226), TBC1D3D (ENSG00000274419), TBC1D3L (ENSG00000274512), TBC1D3 (ENSG00000274611)

Protein

Protein identifiers

Carabin — Q8IV04 (reviewed: Q8IV04)

Alternative names: TBC1 domain family member 10C

All UniProt accessions (2): E9PSB7, Q8IV04

UniProt curated annotations — full annotation on UniProt →

Function. Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.

Subunit / interactions. Interacts with both calcineurin and HRAS.

Tissue specificity. Most abundant in spleen and peripheral blood leukocytes.

Domain organisation. The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab’s ‘switch 2’ glutamine and insert in Rab’s active site.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8IV04-1	1	yes
Q8IV04-2	2

RefSeq proteins (8): NP_001243437, NP_001356421, NP_001356423, NP_001356424, NP_001356425, NP_001356426, NP_001356427, NP_940919 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000195	Rab-GAP-TBC_dom	Domain
IPR035969	Rab-GAP_TBC_sf	Homologous_superfamily
IPR050302	Rab_GAP_TBC_domain	Family

Pfam: PF00566

UniProt features (13 total): region of interest 3, compositionally biased region 3, splice variant 2, site 2, chain 1, domain 1, mutagenesis site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IV04-F1	82.08	0.69

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (2): 137 (arginine finger); 178 (glutamine finger)

Mutagenesis-validated functional residues (1):

Position	Phenotype
141	loss of gap activity.

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-6798695	Neutrophil degranulation
R-HSA-8854214	TBC/RABGAPs
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System
R-HSA-199991	Membrane Trafficking
R-HSA-5653656	Vesicle-mediated transport
R-HSA-9007101	Rab regulation of trafficking

MSigDB gene sets: 169 (showing top): GOBP_REGULATION_OF_CELL_ACTIVATION, GOBP_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE, REACTOME_INNATE_IMMUNE_SYSTEM, ZHAN_MULTIPLE_MYELOMA_PR_DN, GOBP_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING, GOBP_B_CELL_ACTIVATION, GOCC_SECRETORY_GRANULE, GOBP_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION, GOBP_VESICLE_MEDIATED_TRANSPORT, REACTOME_MEMBRANE_TRAFFICKING, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, chr11q13, GOBP_NEGATIVE_REGULATION_OF_MAPK_CASCADE, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS

GO Biological Process (7): calcineurin-NFAT signaling cascade (GO:0033173), B cell activation (GO:0042113), retrograde transport, endosome to Golgi (GO:0042147), negative regulation of B cell activation (GO:0050869), ERK1 and ERK2 cascade (GO:0070371), negative regulation of ERK1 and ERK2 cascade (GO:0070373), negative regulation of calcineurin-NFAT signaling cascade (GO:0070885)

GO Molecular Function (2): GTPase activator activity (GO:0005096), protein binding (GO:0005515)

GO Cellular Component (5): cytosol (GO:0005829), plasma membrane (GO:0005886), membrane (GO:0016020), filopodium membrane (GO:0031527), ficolin-1-rich granule membrane (GO:0101003)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Innate Immune System	1
Rab regulation of trafficking	1
Immune System	1
Vesicle-mediated transport	1
Membrane Trafficking	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
calcineurin-mediated signaling	1
lymphocyte activation	1
intercellular transport	1
endosomal transport	1
cytosolic transport	1
B cell activation	1
regulation of B cell activation	1
negative regulation of lymphocyte activation	1
MAPK cascade	1
negative regulation of MAPK cascade	1
ERK1 and ERK2 cascade	1
regulation of ERK1 and ERK2 cascade	1
calcineurin-NFAT signaling cascade	1
regulation of calcineurin-NFAT signaling cascade	1
negative regulation of calcineurin-mediated signaling	1
GTPase activity	1
enzyme activator activity	1
GTPase regulator activity	1
binding	1
cytoplasm	1
membrane	1
cell periphery	1
filopodium	1
cell projection membrane	1
secretory granule membrane	1
tertiary granule	1
ficolin-1-rich granule	1

Protein interactions and networks

STRING

940 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TBC1D10C	RASA1	P20936	667
TBC1D10C	TBC1D13	Q9NVG8	618
TBC1D10C	RAB35	Q15286	609
TBC1D10C	TBC1D22B	Q9NU19	593
TBC1D10C	TBC1D19	Q8N5T2	592
TBC1D10C	TBC1D21	Q8IYX1	589
TBC1D10C	TBC1D20	Q96BZ9	539
TBC1D10C	TBC1D5	Q92609	527
TBC1D10C	TBC1D22A	Q8WUA7	482
TBC1D10C	TBC1D7	Q9P0N9	474
TBC1D10C	TBC1D15	Q8TC07	440
TBC1D10C	TBC1D16	Q8TBP0	427
TBC1D10C	TBC1D17	Q9HA65	426
TBC1D10C	IL2	P01585	424
TBC1D10C	ACAP1	Q15027	415

IntAct

25 interactions, top by confidence:

A	B	Type	Score
TBC1D10C	HOXA1	psi-mi:“MI:0915”(physical association)	0.720
KLHL12	TBC1D10C	psi-mi:“MI:0915”(physical association)	0.720
HOXA1	TBC1D10C	psi-mi:“MI:0915”(physical association)	0.720
TBC1D10C	KLHL12	psi-mi:“MI:0915”(physical association)	0.720
TBC1D10C	KRTAP5-9	psi-mi:“MI:0915”(physical association)	0.560
NOTCH2NLA	TBC1D10C	psi-mi:“MI:0915”(physical association)	0.560
	TBC1D10C	psi-mi:“MI:0915”(physical association)	0.560
KRTAP5-9	TBC1D10C	psi-mi:“MI:0915”(physical association)	0.560
TBC1D10C	NOTCH2NLA	psi-mi:“MI:0915”(physical association)	0.560
SHANK1	TBC1D10C	psi-mi:“MI:0407”(direct interaction)	0.440
METTL3	TUBAL3	psi-mi:“MI:0914”(association)	0.350
CHD8	IGLV4-60	psi-mi:“MI:0914”(association)	0.350
TBC1D10C	KLHL12	psi-mi:“MI:0915”(physical association)	0.000
TBC1D10C	HOXA1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (16): TBC1D10C (Two-hybrid), TBC1D10C (Two-hybrid), TBC1D10C (Two-hybrid), TBC1D10C (Two-hybrid), NOTCH2NL (Two-hybrid), TBC1D10C (Affinity Capture-MS), TBC1D10C (Two-hybrid), TBC1D10C (Two-hybrid), TBC1D10C (Affinity Capture-MS), TBC1D10C (Affinity Capture-RNA), TBC1D10C (Affinity Capture-MS), TBC1D10C (Affinity Capture-MS), TBC1D10C (Affinity Capture-MS), TBC1D10C (Affinity Capture-MS), TBC1D10C (Reconstituted Complex)

ESM2 similar proteins: A6H8I2, A6QP29, B1AVH7, B2DD29, B5DFA1, D2H0G5, O14976, O43147, O60343, O95398, P58802, P98171, Q08493, Q2KI13, Q3U1Y4, Q4KMP7, Q5DU57, Q5RJI5, Q5SVR0, Q60949, Q66K14, Q69Z98, Q6P6R7, Q6TLK4, Q7T2D0, Q7TSI1, Q80U12, Q86TI0, Q86VW2, Q8BHL3, Q8BYJ6, Q8C9V1, Q8IV04, Q8IWQ3, Q8K337, Q8TC07, Q8TDC3, Q8TDY4, Q8VCC8, Q8VCZ6

Diamond homologs: A0A087WVF3, A0A087WXS9, A0A087X179, A0A087X1G2, A2AWA9, A3KGB4, A6H6A9, A6NDS4, A6NER0, A6QP29, B0R0W9, B7ZAP0, B9A6J9, H2KZZ6, O60343, O60447, O95759, O97790, P0C7X1, P35125, P58802, P97366, Q0IIM8, Q10496, Q12317, Q12344, Q28CB1, Q3UYK3, Q4KMP7, Q5R372, Q5RAN1, Q5RCW6, Q5SVR0, Q5TC63, Q5ZJ17, Q60949, Q66K14, Q6DHY5, Q6IPX1, Q6ZT07

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

87 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	70
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2637 predictions. Top by Δscore:

Variant	Effect	Δscore
11:67398643:GAT:G	acceptor_gain	1.0000
11:67398646:C:CC	acceptor_gain	1.0000
11:67398646:CTA:C	acceptor_loss	1.0000
11:67398717:CTCA:C	donor_loss	1.0000
11:67398718:TCA:T	donor_loss	1.0000
11:67398719:CACCT:C	donor_loss	1.0000
11:67398720:A:AC	donor_gain	1.0000
11:67398720:ACCTG:A	donor_loss	1.0000
11:67398721:C:CC	donor_gain	1.0000
11:67398721:C:CT	donor_loss	1.0000
11:67398721:CCT:C	donor_gain	1.0000
11:67398852:ACCAC:A	acceptor_gain	1.0000
11:67398853:CCAC:C	acceptor_gain	1.0000
11:67398853:CCACC:C	acceptor_gain	1.0000
11:67398854:C:CT	acceptor_gain	1.0000
11:67398854:CAC:C	acceptor_gain	1.0000
11:67398855:AC:A	acceptor_gain	1.0000
11:67398856:CC:C	acceptor_gain	1.0000
11:67398857:C:CC	acceptor_gain	1.0000
11:67398857:C:T	acceptor_gain	1.0000
11:67398862:C:CT	acceptor_gain	1.0000
11:67398937:CACC:C	donor_loss	1.0000
11:67398938:ACC:A	donor_loss	1.0000
11:67399159:CAGGC:C	acceptor_gain	1.0000
11:67399160:AGGC:A	acceptor_gain	1.0000
11:67399161:GGC:G	acceptor_gain	1.0000
11:67399164:C:CC	acceptor_gain	1.0000
11:67399164:CTG:C	acceptor_loss	1.0000
11:67399173:C:CT	acceptor_gain	1.0000
11:67399555:CCTCA:C	donor_loss	1.0000

AlphaMissense

2817 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:67405450:T:A	W102R	0.999
11:67405450:T:C	W102R	0.999
11:67405452:G:C	W102C	0.999
11:67405452:G:T	W102C	0.999
11:67405679:T:C	F149L	0.999
11:67405681:T:A	F149L	0.999
11:67405681:T:G	F149L	0.999
11:67404326:T:C	F42L	0.998
11:67404327:T:C	F42S	0.998
11:67404328:C:A	F42L	0.998
11:67404328:C:G	F42L	0.998
11:67405131:T:A	W67R	0.998
11:67405131:T:C	W67R	0.998
11:67405133:G:C	W67C	0.998
11:67405133:G:T	W67C	0.998
11:67405680:T:C	F149S	0.998
11:67405680:T:G	F149C	0.998
11:67406998:G:C	D274H	0.998
11:67405638:T:A	I135N	0.997
11:67405647:A:C	D138A	0.997
11:67405661:T:C	F143L	0.997
11:67405662:T:C	F143S	0.997
11:67405663:C:A	F143L	0.997
11:67405663:C:G	F143L	0.997
11:67405679:T:A	F149I	0.997
11:67405989:C:A	A185D	0.997
11:67406633:T:C	F197L	0.997
11:67406635:C:A	F197L	0.997
11:67406635:C:G	F197L	0.997
11:67406995:T:A	W273R	0.997

dbSNP variants (sampled 300 via entrez): RS1000494452 (11:67405426 C>G), RS1000661218 (11:67410532 C>T), RS1000966734 (11:67407765 C>T), RS1001102815 (11:67407496 G>A,C), RS1001692033 (11:67403596 G>A,C), RS1001955345 (11:67405769 TAGCCC>T), RS1001984746 (11:67402021 G>T), RS1002136281 (11:67408147 G>C), RS1002247918 (11:67402240 C>G), RS1002455779 (11:67410088 G>A), RS1002565261 (11:67408710 C>T), RS1002614623 (11:67408442 A>C), RS1002962900 (11:67404913 T>A,C), RS1003113814 (11:67404560 G>A), RS1003704599 (11:67403352 A>T)

Disease associations

OMIM: gene MIM:610831 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST007293_14	Body fat distribution (arm fat ratio)	9.000000e-08
GCST007294_129	Body fat distribution (trunk fat ratio)	8.000000e-28
GCST007294_95	Body fat distribution (trunk fat ratio)	1.000000e-35
GCST007295_43	Body fat distribution (leg fat ratio)	1.000000e-25
GCST007295_76	Body fat distribution (leg fat ratio)	1.000000e-21

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004341	body fat distribution

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
GSK-J4	decreases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
perfluorooctanoic acid	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression, affects response to substance, increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
perfluoro-n-nonanoic acid	decreases expression	1
perfluorohexanesulfonic acid	decreases expression	1
(+)-JQ1 compound	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Benzo(a)pyrene	increases expression	1
Lipopolysaccharides	decreases expression, affects response to substance, increases expression, affects cotreatment	1
Nickel	increases expression	1
Ozone	affects expression, increases abundance	1
Tretinoin	increases expression	1
Aflatoxin B1	increases expression	1
Antirheumatic Agents	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.