TBC1D14

Summary

TBC1D14 (TBC1 domain family member 14, HGNC:29246) is a protein-coding gene on chromosome 4p16.1, encoding TBC1 domain family member 14 (Q9P2M4). Plays a role in the regulation of starvation-induced autophagosome formation.

Enables protein kinase binding activity. Involved in negative regulation of autophagy; recycling endosome to Golgi transport; and regulation of autophagosome assembly. Located in several cellular components, including Golgi apparatus; autophagosome; and recycling endosome.

Source: NCBI Gene 57533 — RefSeq curated summary.

At a glance

• GWAS associations: 19
• Clinical variants (ClinVar): 116 total
• MANE Select transcript: NM_020773

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29246
Approved symbol	TBC1D14
Name	TBC1 domain family member 14
Location	4p16.1
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1322
Ensembl gene	ENSG00000132405
Ensembl biotype	protein_coding
OMIM	614855
Entrez	57533

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 21 protein_coding, 1 retained_intron

ENST00000409757, ENST00000410031, ENST00000427736, ENST00000439515, ENST00000444368, ENST00000446947, ENST00000448507, ENST00000451522, ENST00000467966, ENST00000854331, ENST00000854332, ENST00000854333, ENST00000854334, ENST00000854335, ENST00000854336, ENST00000913760, ENST00000953322, ENST00000953323, ENST00000953324, ENST00000953325, ENST00000953326, ENST00000953327

RefSeq mRNA: 5 — MANE Select: NM_020773 NM_001113361, NM_001113363, NM_001286805, NM_001330638, NM_020773

CCDS: CCDS3394, CCDS47006, CCDS75104, CCDS82909

Canonical transcript exons

ENST00000409757 — 14 exons

Exon	Start	End
ENSE00001080285	7006632	7006726
ENSE00001080288	7014448	7014557
ENSE00001080289	7004844	7004924
ENSE00001080292	7010653	7010781
ENSE00001080293	7025004	7025262
ENSE00001588330	7030327	7033114
ENSE00001595890	6994184	6994302
ENSE00001628243	7001145	7001251
ENSE00001672694	7009877	7009948
ENSE00001676050	6967304	6967424
ENSE00001884352	6909826	6909951
ENSE00002242087	6923373	6924111
ENSE00003466183	6996325	6996407
ENSE00003511987	6999085	6999202

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 98.98.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 33.7946 / max 619.1498, expressed in 1818 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
46808	21.2045	1645
46820	6.1335	1647
46807	4.6417	1717
46821	1.4482	911
46819	0.1457	60
46806	0.0809	30
46818	0.0601	27
46805	0.0487	15
46817	0.0314	13

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	98.98	gold quality
kidney epithelium	UBERON:0004819	98.27	gold quality
cortical plate	UBERON:0005343	98.08	gold quality
upper arm skin	UBERON:0004263	98.05	gold quality
oocyte	CL:0000023	98.00	gold quality
cardiac muscle of right atrium	UBERON:0003379	97.43	gold quality
tibialis anterior	UBERON:0001385	96.52	gold quality
left ventricle myocardium	UBERON:0006566	96.42	gold quality
ileal mucosa	UBERON:0000331	96.27	gold quality
adrenal tissue	UBERON:0018303	95.51	gold quality
ganglionic eminence	UBERON:0004023	95.46	gold quality
sural nerve	UBERON:0015488	95.15	gold quality
deltoid	UBERON:0001476	94.26	gold quality
renal medulla	UBERON:0000362	94.20	gold quality
body of stomach	UBERON:0001161	94.15	gold quality
adult mammalian kidney	UBERON:0000082	93.98	gold quality
cardia of stomach	UBERON:0001162	93.79	gold quality
right adrenal gland cortex	UBERON:0035827	93.45	gold quality
adrenal cortex	UBERON:0001235	93.36	gold quality
left adrenal gland cortex	UBERON:0035825	93.34	gold quality
stomach	UBERON:0000945	93.33	gold quality
left adrenal gland	UBERON:0001234	93.33	gold quality
amygdala	UBERON:0001876	93.33	gold quality
right adrenal gland	UBERON:0001233	93.31	gold quality
ventricular zone	UBERON:0003053	93.18	gold quality
nucleus accumbens	UBERON:0001882	93.13	gold quality
calcaneal tendon	UBERON:0003701	93.13	gold quality
adrenal gland	UBERON:0002369	93.08	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.06	gold quality
blood	UBERON:0000178	93.03	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	41.27
E-ANND-3	yes	6.58

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CTCF, NR1I2

miRNA regulators (miRDB)

62 targeting TBC1D14, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-4713-3P	100.00	65.92	505
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-589-3P	99.91	69.62	2088
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-4679	99.76	69.19	1229
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-875-3P	99.63	69.47	2548
HSA-MIR-4499	99.62	67.29	1470
HSA-MIR-802	99.61	67.70	1254

Literature-anchored findings (GeneRIF, showing 3)

• crystal structures of the first two mammalian TBCs, human TBC1 family members 22A (TBC1D22A) and 14 (TBC1D14) (PMID:18186464)
• TBC1D14 binds activated Rab11 but is not a GAP for Rab11, and loss of Rab11 prevents TBC1D14-induced tubulation of recycling endosomes. (PMID:22613832)
• TRAPPC8 modulates autophagy and secretory trafficking and is required for TBC1D14 to bind TRAPPIII. (PMID:26711178)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tbc1d14	ENSDARG00000003520
mus_musculus	Tbc1d14	ENSMUSG00000029192
rattus_norvegicus	Tbc1d14	ENSRNOG00000006400

Paralogs (45): RABGAP1 (ENSG00000011454), TBC1D22A (ENSG00000054611), TBC1D22B (ENSG00000065491), TBC1D1 (ENSG00000065882), EVI5 (ENSG00000067208), TBC1D25 (ENSG00000068354), TBC1D2 (ENSG00000095383), TBC1D10A (ENSG00000099992), SGSM3 (ENSG00000100359), TBC1D17 (ENSG00000104946), TBC1D13 (ENSG00000107021), TBC1D12 (ENSG00000108239), TBC1D9 (ENSG00000109436), TBC1D30 (ENSG00000111490), TBC1D15 (ENSG00000121749), TBC1D5 (ENSG00000131374), TBC1D8B (ENSG00000133138), TBC1D4 (ENSG00000136111), GRTP1 (ENSG00000139835), SGSM2 (ENSG00000141258), EVI5L (ENSG00000142459), TBCK (ENSG00000145348), USP6NL (ENSG00000148429), RABGAP1L (ENSG00000152061), SGSM1 (ENSG00000167037), TBC1D21 (ENSG00000167139), TBC1D2B (ENSG00000167202), TBC1D16 (ENSG00000167291), TBC1D10B (ENSG00000169221), TBC1D10C (ENSG00000175463), TBC1D28 (ENSG00000189375), TBC1D9B (ENSG00000197226), TBC1D8 (ENSG00000204634), TBC1D26 (ENSG00000214946), TBC1D3G (ENSG00000260287), TBC1D3K (ENSG00000273513), TBC1D3H (ENSG00000274226), TBC1D3D (ENSG00000274419), TBC1D3L (ENSG00000274512), TBC1D3 (ENSG00000274611)

Protein

Protein identifiers

TBC1 domain family member 14 — Q9P2M4 (reviewed: Q9P2M4)

All UniProt accessions (6): Q9P2M4, B9A071, C9J541, C9JP26, F5GXK4, H7BZD7

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy.

Subunit / interactions. Interacts with ULK1. May interact with RAB11A and RAB11B, but does not exhibit any GTPase-activating activity toward these proteins. Interacts with TRAPPC8.

Subcellular location. Golgi apparatus. cis-Golgi network. trans-Golgi network.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9P2M4-1	1	yes
Q9P2M4-2	2

RefSeq proteins (5): NP_001106832, NP_001106834, NP_001273734, NP_001317567, NP_065824* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000195	Rab-GAP-TBC_dom	Domain
IPR035969	Rab-GAP_TBC_sf	Homologous_superfamily
IPR050302	Rab_GAP_TBC_domain	Family

Pfam: PF00566

UniProt features (37 total): helix 21, sequence variant 2, mutagenesis site 2, region of interest 2, turn 2, modified residue 2, splice variant 2, chain 1, domain 1, strand 1, compositionally biased region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2QQ8	X-RAY DIFFRACTION	2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9P2M4-F1	66.40	0.43

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 91, 295

Mutagenesis-validated functional residues (2):

Position	Phenotype
472	loss of inhibition of autophagosome formation; when associated with a-508.
508	loss of inhibition of autophagosome formation; when associated with a-472.

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-8854214	TBC/RABGAPs
R-HSA-199991	Membrane Trafficking
R-HSA-5653656	Vesicle-mediated transport
R-HSA-9007101	Rab regulation of trafficking

MSigDB gene sets: 227 (showing top): GOBP_REGULATION_OF_AUTOPHAGY, GOBP_VACUOLE_ORGANIZATION, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_REGULATION_OF_VACUOLE_ORGANIZATION, REACTOME_MEMBRANE_TRAFFICKING, MODULE_308, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, YY1_Q6, GOBP_MACROAUTOPHAGY, GOBP_NEGATIVE_REGULATION_OF_AUTOPHAGY, GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, GOBP_REGULATION_OF_CATABOLIC_PROCESS, YY1_02, GOBP_CILIUM_ORGANIZATION

GO Biological Process (5): autophagy (GO:0006914), negative regulation of autophagy (GO:0010507), recycling endosome to Golgi transport (GO:0071955), regulation of autophagosome assembly (GO:2000785), vesicle-mediated transport (GO:0016192)

GO Molecular Function (4): GTPase activator activity (GO:0005096), protein kinase binding (GO:0019901), protein binding (GO:0005515), enzyme binding (GO:0019899)

GO Cellular Component (7): nucleoplasm (GO:0005654), autophagosome (GO:0005776), Golgi apparatus (GO:0005794), cytosol (GO:0005829), recycling endosome (GO:0055037), vacuole (GO:0005773), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Rab regulation of trafficking	1
Vesicle-mediated transport	1
Membrane Trafficking	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	4
cellular anatomical structure	2
intracellular membrane-bounded organelle	2
catabolic process	1
transmembrane transport	1
process utilizing autophagic mechanism	1
autophagy	1
negative regulation of catabolic process	1
regulation of autophagy	1
retrograde transport, endosome to Golgi	1
Golgi vesicle transport	1
autophagosome assembly	1
regulation of vacuole organization	1
regulation of organelle assembly	1
transport	1
cellular process	1
GTPase activity	1
enzyme activator activity	1
GTPase regulator activity	1
kinase binding	1
binding	1
protein binding	1
nuclear lumen	1
vacuole	1
endomembrane system	1
endosome	1
intracellular vesicle	1

Protein interactions and networks

STRING

762 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TBC1D14	RAB11A	P24410	816
TBC1D14	TRAPPC8	Q9Y2L5	754
TBC1D14	CDC16	Q13042	640
TBC1D14	TBC1D17	Q9HA65	599
TBC1D14	TBC1D5	Q92609	594
TBC1D14	TBC1D19	Q8N5T2	591
TBC1D14	TBC1D23	Q9NUY8	540
TBC1D14	TBC1D15	Q8TC07	540
TBC1D14	RAB33B	Q9H082	532
TBC1D14	SNX18	Q96RF0	527
TBC1D14	TBC1D20	Q96BZ9	509
TBC1D14	TBC1D13	Q9NVG8	506
TBC1D14	TBC1D21	Q8IYX1	494
TBC1D14	RAB1A	P11476	472
TBC1D14	TBC1D7	Q9P0N9	446

IntAct

32 interactions, top by confidence:

A	B	Type	Score
TBC1D14	NXF1	psi-mi:“MI:0915”(physical association)	0.560
TBC1D14	ULK1	psi-mi:“MI:0915”(physical association)	0.540
ULK1	TBC1D14	psi-mi:“MI:0403”(colocalization)	0.540
ULK1	TBC1D14	psi-mi:“MI:0915”(physical association)	0.540
TGM4	DDHD2	psi-mi:“MI:0914”(association)	0.530
RAB11B	TBC1D14	psi-mi:“MI:0915”(physical association)	0.510
TBC1D14	EEF1G	psi-mi:“MI:0915”(physical association)	0.400
TBC1D14	SPARC	psi-mi:“MI:0915”(physical association)	0.400
TBC1D14	MMGT1	psi-mi:“MI:0915”(physical association)	0.400
TBC1D14	OCIAD2	psi-mi:“MI:0915”(physical association)	0.400
TBC1D14	RAB11FIP3	psi-mi:“MI:0915”(physical association)	0.400
TBC1D14	UBE3A	psi-mi:“MI:0915”(physical association)	0.370
TBC1D14	RAB11A	psi-mi:“MI:0915”(physical association)	0.370
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
TBC1D14		psi-mi:“MI:0914”(association)	0.350
TBC1D14	TRAPPC13	psi-mi:“MI:0914”(association)	0.350
GAB2	TRAPPC13	psi-mi:“MI:0914”(association)	0.350
ZNF418	ZNF195	psi-mi:“MI:0914”(association)	0.350
AGGF1	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270
BUD13	RPSA2	psi-mi:“MI:2364”(proximity)	0.270
CPSF6	CNOT1	psi-mi:“MI:2364”(proximity)	0.270
DGCR8	VWA8	psi-mi:“MI:2364”(proximity)	0.270
U2AF2	NACA	psi-mi:“MI:2364”(proximity)	0.270
TBC1D14	ATG13	psi-mi:“MI:0403”(colocalization)	0.270
TBC1D14	TFRC	psi-mi:“MI:0403”(colocalization)	0.270
TBC1D14	NXF1	psi-mi:“MI:0915”(physical association)	0.000
NXF1	TBC1D14	psi-mi:“MI:0915”(physical association)	0.000
TBC1D14		psi-mi:“MI:0915”(physical association)	0.000

BioGRID (58): TBC1D14 (Affinity Capture-MS), TBC1D14 (Affinity Capture-MS), TBC1D14 (Affinity Capture-MS), TBC1D14 (Affinity Capture-MS), TBC1D14 (Affinity Capture-MS), TBC1D14 (Affinity Capture-MS), TRAPPC11 (Affinity Capture-MS), TRAPPC12 (Affinity Capture-MS), TRAPPC13 (Affinity Capture-MS), ADRBK1 (Affinity Capture-MS), TRAPPC8 (Affinity Capture-MS), TRAPPC4 (Affinity Capture-MS), TRAPPC3 (Affinity Capture-MS), TRAPPC6B (Affinity Capture-MS), SELENBP1 (Affinity Capture-MS)

ESM2 similar proteins: A1YFY6, A2T6X9, A6H7I8, B2RUJ5, F1M5F3, F1N2W9, O35430, O35431, O95487, O95628, O95644, P0C6S7, P14316, P17863, P22681, P22682, P23798, P23906, P35227, P81133, P98084, Q02410, Q0IHY4, Q13469, Q14190, Q14432, Q1L994, Q3UR85, Q52L14, Q5CD77, Q5RD33, Q60591, Q61045, Q61079, Q66JB6, Q69ZT9, Q6NRE7, Q6QB00, Q8BIZ1, Q8BT14

Diamond homologs: A6H7I8, M0R7T9, O60347, O96904, Q0IHY4, Q10496, Q5CD77, Q6A039, Q86UD7, Q8CGA2, Q96CN4, Q9P2M4, A2AWA9, Q5RAN1, Q755I4, Q9Y3P9, Q9Y7J5, Q5R372, Q5RCW6, A0A087WVF3, A0A087WXS9, A0A087X179, A0A087X1G2, A3KGB4, A6H6A9, A6NDS4, A6NER0, A6QP29, B9A6J9, D2H0G5, H2KZZ6, O60343, O95759, O97790, P0C7X1, P35125, P53258, P58802, Q0IIM8, Q28CB1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

116 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	88
Likely benign	4
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

3989 predictions. Top by Δscore:

Variant	Effect	Δscore
4:6923371:A:AG	acceptor_gain	1.0000
4:6923371:A:G	acceptor_loss	1.0000
4:6923372:G:GT	acceptor_gain	1.0000
4:6923372:GT:G	acceptor_gain	1.0000
4:6923372:GTT:G	acceptor_gain	1.0000
4:6923372:GTTT:G	acceptor_gain	1.0000
4:6923372:GTTTC:G	acceptor_gain	1.0000
4:6924057:C:G	donor_gain	1.0000
4:6924066:G:GT	donor_gain	1.0000
4:6924066:G:T	donor_gain	1.0000
4:6994298:CCAGC:C	donor_gain	1.0000
4:6994300:AGCGT:A	donor_loss	1.0000
4:6994301:GC:G	donor_gain	1.0000
4:6994301:GCGTG:G	donor_loss	1.0000
4:6994302:CG:C	donor_loss	1.0000
4:6994303:G:GG	donor_gain	1.0000
4:6994303:GTG:G	donor_loss	1.0000
4:6994304:T:G	donor_loss	1.0000
4:6994342:GAAA:G	donor_gain	1.0000
4:6996318:T:TA	acceptor_gain	1.0000
4:6996323:A:G	acceptor_gain	1.0000
4:7006723:GCAA:G	donor_gain	1.0000
4:7006727:G:GG	donor_gain	1.0000
4:7010777:GCCTT:G	donor_gain	1.0000
4:7010782:G:GG	donor_gain	1.0000
4:7014443:CCTA:C	acceptor_loss	1.0000
4:7014444:CTAG:C	acceptor_loss	1.0000
4:7014445:TA:T	acceptor_loss	1.0000
4:7014446:A:AG	acceptor_gain	1.0000
4:7014447:G:GG	acceptor_gain	1.0000

AlphaMissense

4586 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:6994281:T:A	L314H	1.000
4:6994281:T:C	L314P	1.000
4:6994284:T:C	I315T	1.000
4:6999168:T:A	W377R	1.000
4:6999168:T:C	W377R	1.000
4:7001201:G:C	R407T	1.000
4:7001201:G:T	R407I	1.000
4:7001210:T:A	V410D	1.000
4:7001212:T:A	W411R	1.000
4:7001212:T:C	W411R	1.000
4:7006686:A:T	D469V	1.000
4:7006718:T:C	F480L	1.000
4:7006719:T:C	F480S	1.000
4:7006719:T:G	F480C	1.000
4:7006720:C:A	F480L	1.000
4:7006720:C:G	F480L	1.000
4:7009899:T:G	L490W	1.000
4:7009919:T:G	Y497D	1.000
4:7009931:C:G	R501G	1.000
4:7009932:G:C	R501P	1.000
4:7009944:G:A	G505D	1.000
4:7009946:T:C	Y506H	1.000
4:7010659:G:C	G509R	1.000
4:7010678:C:A	A515E	1.000
4:7010732:T:C	L533P	1.000
4:7025056:T:A	W604R	1.000
4:7025056:T:C	W604R	1.000
4:7025059:G:C	D605H	1.000
4:6994284:T:A	I315N	0.999
4:6994284:T:G	I315S	0.999

dbSNP variants (sampled 300 via entrez): RS10000433 (4:6959074 G>A), RS1000069459 (4:6924946 A>C,T), RS1000069927 (4:6996528 C>A,T), RS1000072627 (4:7011998 A>G), RS1000100382 (4:6939185 T>C), RS1000105846 (4:6975173 C>G,T), RS1000119360 (4:7030239 T>A), RS1000152184 (4:6949043 G>A,T), RS1000152404 (4:7026950 C>T), RS1000174849 (4:7001926 G>A), RS1000178447 (4:6915613 A>T), RS1000180316 (4:7026410 T>G), RS10002398 (4:6998694 A>C,G), RS1000241761 (4:7012174 C>G,T), RS1000283329 (4:6982678 A>G)

Disease associations

OMIM: gene MIM:614855 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

19 associations (top):

Study	Trait	p-value
GCST004599_87	Mean platelet volume	1.000000e-12
GCST004608_84	Granulocyte percentage of myeloid white cells	9.000000e-12
GCST004609_121	Monocyte percentage of white cells	8.000000e-18
GCST004625_79	Monocyte count	1.000000e-19
GCST012462_3	Asthma and eczema	6.000000e-06
GCST90002381_202	Eosinophil count	9.000000e-10
GCST90002389_37	Lymphocyte percentage of white cells	4.000000e-19
GCST90002393_217	Monocyte count	8.000000e-11
GCST90002394_270	Monocyte percentage of white cells	1.000000e-09
GCST90002394_271	Monocyte percentage of white cells	6.000000e-12
GCST90002395_565	Mean platelet volume	2.000000e-27
GCST90002395_566	Mean platelet volume	2.000000e-18
GCST90002397_1	Mean spheric corpuscular volume	6.000000e-09
GCST90002398_443	Neutrophil count	1.000000e-19
GCST90002398_444	Neutrophil count	1.000000e-11
GCST90002399_413	Neutrophil percentage of white cells	9.000000e-13
GCST90002407_423	White blood cell count	7.000000e-16
GCST90002407_424	White blood cell count	3.000000e-10
GCST90020028_1959	Hip circumference adjusted for BMI	4.000000e-08

EFO canonical traits (8, from GWAS)

EFO ID	Trait name
EFO:0007997	granulocyte percentage of myeloid white cells
EFO:0007989	monocyte percentage of leukocytes
EFO:0005091	monocyte count
EFO:0004842	eosinophil count
EFO:0007993	lymphocyte percentage of leukocytes
EFO:0004833	neutrophil count
EFO:0007990	neutrophil percentage of leukocytes
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression	3
bisphenol A	affects cotreatment, decreases methylation, increases expression	2
sodium arsenite	increases abundance, increases expression, decreases expression, affects cotreatment	2
Air Pollutants	affects cotreatment, decreases expression, increases abundance, increases oxidation, affects expression	2
Arsenic	increases expression, affects methylation, affects cotreatment, increases abundance	2
Estradiol	affects cotreatment, increases expression	2
Ozone	affects cotreatment, decreases expression, increases oxidation, increases abundance, affects expression	2
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
alpha-pinene	affects cotreatment, decreases expression, increases oxidation, increases abundance	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
methacrylaldehyde	affects cotreatment, decreases expression, increases oxidation, increases abundance	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
Fulvestrant	decreases methylation, affects cotreatment	1
Norethindrone Acetate	affects cotreatment, increases expression	1
Acrolein	increases abundance, affects cotreatment, decreases expression, increases oxidation	1
Cisplatin	affects cotreatment, increases expression	1
Diazinon	increases methylation	1
Manganese	affects cotreatment, increases abundance, increases expression	1
Methapyrilene	increases methylation	1
Phthalic Acids	decreases methylation	1
Thiram	decreases expression	1
Tretinoin	decreases expression	1
Valproic Acid	decreases methylation	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.