TBC1D22A

Summary

TBC1D22A (TBC1 domain family member 22A, HGNC:1309) is a protein-coding gene on chromosome 22q13.31, encoding TBC1 domain family member 22A (Q8WUA7). May act as a GTPase-activating protein for Rab family protein(s).

Enables 14-3-3 protein binding activity and protein homodimerization activity. Predicted to be active in Golgi apparatus.

Source: NCBI Gene 25771 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 95 total
• MANE Select transcript: NM_014346

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1309
Approved symbol	TBC1D22A
Name	TBC1 domain family member 22A
Location	22q13.31
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000054611
Ensembl biotype	protein_coding
OMIM	616879
Entrez	25771

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 13 protein_coding, 3 nonsense_mediated_decay, 3 protein_coding_CDS_not_defined

ENST00000337137, ENST00000355704, ENST00000380995, ENST00000394449, ENST00000406733, ENST00000407381, ENST00000441162, ENST00000441936, ENST00000472791, ENST00000486163, ENST00000496139, ENST00000859789, ENST00000859790, ENST00000859791, ENST00000859792, ENST00000859793, ENST00000859794, ENST00000918112, ENST00000954015

RefSeq mRNA: 5 — MANE Select: NM_014346 NM_001284303, NM_001284304, NM_001284305, NM_001410803, NM_014346

CCDS: CCDS14078, CCDS63511, CCDS63512, CCDS74877, CCDS93180

Canonical transcript exons

ENST00000337137 — 13 exons

Exon	Start	End
ENSE00001145586	46878653	46878723
ENSE00001145595	46797444	46797620
ENSE00001916547	46762650	46762848
ENSE00001936582	47173498	47175693
ENSE00003472449	46894784	46894846
ENSE00003480642	47111508	47111603
ENSE00003505512	46997634	46997709
ENSE00003538733	46792520	46792576
ENSE00003560068	46793501	46793841
ENSE00003581676	46891266	46891394
ENSE00003586677	46912074	46912188
ENSE00003616709	46974290	46974399
ENSE00003628731	47037071	47037198

Expression profiles

Bgee: expression breadth ubiquitous, 276 present calls, max score 96.66.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 33.1142 / max 308.3397, expressed in 1822 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
192835	30.5622	1820
192836	0.7802	489
192837	0.6783	243
192839	0.5159	249
192840	0.4397	229
209514	0.1377	32

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	96.66	gold quality
cervix squamous epithelium	UBERON:0006922	92.44	gold quality
amniotic fluid	UBERON:0000173	92.07	gold quality
epithelium of nasopharynx	UBERON:0001951	90.88	gold quality
gingival epithelium	UBERON:0001949	90.73	gold quality
granulocyte	CL:0000094	90.70	gold quality
palpebral conjunctiva	UBERON:0001812	90.33	gold quality
ileal mucosa	UBERON:0000331	90.21	gold quality
squamous epithelium	UBERON:0006914	90.01	gold quality
blood	UBERON:0000178	89.87	gold quality
monocyte	CL:0000576	89.80	gold quality
leukocyte	CL:0000738	89.71	gold quality
mononuclear cell	CL:0000842	89.66	gold quality
colonic epithelium	UBERON:0000397	89.04	gold quality
tongue squamous epithelium	UBERON:0006919	89.03	gold quality
esophagus squamous epithelium	UBERON:0006920	88.93	gold quality
epithelium of esophagus	UBERON:0001976	88.69	gold quality
sural nerve	UBERON:0015488	88.53	gold quality
gingiva	UBERON:0001828	88.26	gold quality
endothelial cell	CL:0000115	88.21	gold quality
mucosa of transverse colon	UBERON:0004991	87.67	gold quality
tonsil	UBERON:0002372	87.25	gold quality
germinal epithelium of ovary	UBERON:0001304	87.22	gold quality
tibialis anterior	UBERON:0001385	87.08	gold quality
esophagus mucosa	UBERON:0002469	86.80	gold quality
lower esophagus mucosa	UBERON:0035834	86.68	gold quality
gastrocnemius	UBERON:0001388	86.67	gold quality
hair follicle	UBERON:0002073	86.61	silver quality
spleen	UBERON:0002106	86.46	gold quality
skin of leg	UBERON:0001511	86.36	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	29.82
E-HCAD-25	yes	14.54
E-CURD-119	yes	6.49
E-ANND-3	no	0.00

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
ACBD3	Unknown

miRNA regulators (miRDB)

56 targeting TBC1D22A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-3680-3P	99.75	72.51	3095
HSA-MIR-3618	99.69	68.57	1012
HSA-MIR-1290	99.59	69.90	2079
HSA-MIR-2113	99.58	71.22	1521
HSA-MIR-4437	99.52	65.29	1266
HSA-MIR-4761-5P	99.51	66.69	804
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-1324	99.46	66.57	1302
HSA-MIR-4318	99.38	66.94	1505
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-4685-5P	99.25	65.99	1563
HSA-MIR-6837-5P	99.25	65.47	1632
HSA-MIR-499A-3P	99.18	69.20	1392
HSA-MIR-499B-3P	99.18	69.27	1391
HSA-MIR-6809-5P	99.13	68.45	1223

Literature-anchored findings (GeneRIF, showing 3)

• crystal structures of the first two mammalian TBCs, human TBC1 family members 22A (TBC1D22A) and 14 (TBC1D14) (PMID:18186464)
• genetic association studies in population in Han Chinese: Data suggest that SNPs in TBC1D22A (rs7755450 and rs11758293) are associated with body mass index in obese females; other SNPs in TBC1D22A are associated with body mass index in obese males. (PMID:23526746)
• Using affinity purification-mass spectrometry, we identified the putative Rab33 GTPase-activating proteins TBC1D22A and TBC1D22B as ACBD3-interacting factors. (PMID:23572552)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tbc1d22a	ENSDARG00000045510
mus_musculus	Tbc1d22a	ENSMUSG00000051864
rattus_norvegicus	Tbc1d22a	ENSRNOG00000017057

Paralogs (45): RABGAP1 (ENSG00000011454), TBC1D22B (ENSG00000065491), TBC1D1 (ENSG00000065882), EVI5 (ENSG00000067208), TBC1D25 (ENSG00000068354), TBC1D2 (ENSG00000095383), TBC1D10A (ENSG00000099992), SGSM3 (ENSG00000100359), TBC1D17 (ENSG00000104946), TBC1D13 (ENSG00000107021), TBC1D12 (ENSG00000108239), TBC1D9 (ENSG00000109436), TBC1D30 (ENSG00000111490), TBC1D15 (ENSG00000121749), TBC1D5 (ENSG00000131374), TBC1D14 (ENSG00000132405), TBC1D8B (ENSG00000133138), TBC1D4 (ENSG00000136111), GRTP1 (ENSG00000139835), SGSM2 (ENSG00000141258), EVI5L (ENSG00000142459), TBCK (ENSG00000145348), USP6NL (ENSG00000148429), RABGAP1L (ENSG00000152061), SGSM1 (ENSG00000167037), TBC1D21 (ENSG00000167139), TBC1D2B (ENSG00000167202), TBC1D16 (ENSG00000167291), TBC1D10B (ENSG00000169221), TBC1D10C (ENSG00000175463), TBC1D28 (ENSG00000189375), TBC1D9B (ENSG00000197226), TBC1D8 (ENSG00000204634), TBC1D26 (ENSG00000214946), TBC1D3G (ENSG00000260287), TBC1D3K (ENSG00000273513), TBC1D3H (ENSG00000274226), TBC1D3D (ENSG00000274419), TBC1D3L (ENSG00000274512), TBC1D3 (ENSG00000274611)

Protein

Protein identifiers

TBC1 domain family member 22A — Q8WUA7 (reviewed: Q8WUA7)

All UniProt accessions (5): A0A0A0MRY0, B0QYI1, Q8WUA7, F8WBF7, F8WDP1

UniProt curated annotations — full annotation on UniProt →

Function. May act as a GTPase-activating protein for Rab family protein(s).

Subunit / interactions. Homodimer. Interacts with ACBD3 and ARFGEF1. Interacts with YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ.

Isoforms (4)

UniProt ID	Names	Canonical?
Q8WUA7-1	1	yes
Q8WUA7-2	2
Q8WUA7-3	3
Q8WUA7-4	4

RefSeq proteins (5): NP_001271232, NP_001271233, NP_001271234, NP_001397732, NP_055161* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000195	Rab-GAP-TBC_dom	Domain
IPR035969	Rab-GAP_TBC_sf	Homologous_superfamily

Pfam: PF00566

UniProt features (58 total): helix 22, mutagenesis site 15, splice variant 5, modified residue 4, sequence conflict 3, turn 3, compositionally biased region 2, initiator methionine 1, chain 1, domain 1, region of interest 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2QFZ	X-RAY DIFFRACTION	2.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WUA7-F1	77.51	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 2, 132, 145, 167

Mutagenesis-validated functional residues (15):

Position	Phenotype
90–92	no effect on acbd3-binding.
92–93	no effect on interaction with acbd3, nor with 14-3-3 proteins.
93–96	decreased acbd3-binding.
96–97	no effect on acbd3-binding.
99–100	no effect on acbd3-binding.
101–102	drastically decreased acbd3-binding. no effect on binding to 14-3-3 protein.
103–105	no effect on acbd3-binding.
132	no effect on 14-3-3 protein-binding.
149–150	decreased 14-3-3 protein-binding.
165–167	complete loss of 14-3-3 protein-binding.
165	no effect on interaction with acbd3. decreased 14-3-3 protein-binding.
165	complete loss of 14-3-3 protein-binding.
167	complete loss of 14-3-3 protein-binding.
320	decreased 14-3-3 protein-binding.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 182 (showing top): RRAGTTGT_UNKNOWN, MORF_FLT1, PAX4_01, MORF_MSH3, LFA1_Q6, MORF_BRCA1, MORF_ATRX, TGACCTY_ERR1_Q2, MORF_ESR1, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, RICKMAN_METASTASIS_DN, GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, GOBP_CILIUM_ORGANIZATION, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, GOBP_ORGANELLE_ASSEMBLY

GO Biological Process (0):

GO Molecular Function (4): GTPase activator activity (GO:0005096), protein homodimerization activity (GO:0042803), 14-3-3 protein binding (GO:0071889), protein binding (GO:0005515)

GO Cellular Component (1): Golgi apparatus (GO:0005794)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
GTPase activity	1
enzyme activator activity	1
GTPase regulator activity	1
identical protein binding	1
protein dimerization activity	1
protein binding	1
binding	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1633 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TBC1D22A	GRTP1	Q5TC63	588
TBC1D22A	TBC1D20	Q96BZ9	586
TBC1D22A	TRABD	Q9H4I3	549
TBC1D22A	TBC1D21	Q8IYX1	542
TBC1D22A	TBC1D8B	Q0IIM8	539
TBC1D22A	TBC1D19	Q8N5T2	522
TBC1D22A	MON2	Q7Z3U7	503
TBC1D22A	RBM12B	Q8IXT5	491
TBC1D22A	MOSPD3	O75425	485
TBC1D22A	TBC1D10C	Q8IV04	482
TBC1D22A	TBC1D8	O95759	464
TBC1D22A	SLC38A10	Q9HBR0	461
TBC1D22A	TBC1D9B	Q66K14	457
TBC1D22A	PI4KB	P78405	454
TBC1D22A	ZNF516	Q92618	449

IntAct

31 interactions, top by confidence:

A	B	Type	Score
ACBD3	TBC1D22A	psi-mi:“MI:0915”(physical association)	0.720
TBC1D22A	ACBD3	psi-mi:“MI:0915”(physical association)	0.720
YWHAB	BLTP3B	psi-mi:“MI:0914”(association)	0.610
ACBD3	PI4KB	psi-mi:“MI:0914”(association)	0.570
TBC1D22B	A2ML1	psi-mi:“MI:0914”(association)	0.530
DNAJB8	DNAJB6	psi-mi:“MI:0914”(association)	0.530
TBC1D22A		psi-mi:“MI:0914”(association)	0.460
TBC1D22A	STT3B	psi-mi:“MI:0915”(physical association)	0.400
CERK	WDR46	psi-mi:“MI:0914”(association)	0.350
ACBD3	PIP4P1	psi-mi:“MI:0914”(association)	0.350
ACBD3	BCKDHB	psi-mi:“MI:0914”(association)	0.350
TBC1D22A	VPS26A	psi-mi:“MI:0914”(association)	0.350
TBC1D22A		psi-mi:“MI:0914”(association)	0.350
TACSTD2	RIMOC1	psi-mi:“MI:0914”(association)	0.350
TBC1D22A	ACSL4	psi-mi:“MI:0914”(association)	0.350
TBC1D22A	CTSV	psi-mi:“MI:0914”(association)	0.350
AURKB	VWA8	psi-mi:“MI:0914”(association)	0.350
CD33	SPAG9	psi-mi:“MI:0914”(association)	0.350
CLEC4C	ENTPD6	psi-mi:“MI:0914”(association)	0.350
CREB3L2	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
EPHA1	ENC1	psi-mi:“MI:0914”(association)	0.350
RIC3	QSOX1	psi-mi:“MI:0914”(association)	0.350
SCN2B	RIMOC1	psi-mi:“MI:0914”(association)	0.350
TGOLN2	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270
TBC1D22A		psi-mi:“MI:0915”(physical association)	0.000

BioGRID (69): HSPA1L (Affinity Capture-MS), ACBD3 (Affinity Capture-MS), FDXR (Affinity Capture-MS), ACSL4 (Affinity Capture-MS), FLYWCH2 (Affinity Capture-MS), BIRC6 (Affinity Capture-MS), ARFGEF1 (Affinity Capture-MS), QSOX2 (Affinity Capture-MS), MICU1 (Affinity Capture-MS), KIRREL (Affinity Capture-MS), MICU2 (Affinity Capture-MS), DNAJB4 (Affinity Capture-MS), SUPT6H (Affinity Capture-MS), EFNB3 (Affinity Capture-MS), EPHA4 (Affinity Capture-MS)

ESM2 similar proteins: A0FI79, A1A4I4, A1A5B6, A4D2P6, A6H7I8, F1LXF1, O60346, P11274, P53349, P59672, P70268, Q0QWG9, Q13905, Q3MII6, Q3U0J8, Q504T8, Q50H33, Q5EBH1, Q62865, Q63433, Q69ZT9, Q6NS60, Q6PAJ1, Q6WVG3, Q6ZWB6, Q7Z5H3, Q8BL80, Q8BUP8, Q8BYH7, Q8C190, Q8CGA2, Q8CHE4, Q8N2R8, Q8R554, Q8TE49, Q8TF61, Q8WUA7, Q92625, Q95KI1, Q96CX2

Diamond homologs: O59737, Q08484, Q8R5A6, Q8WUA7, Q95KI1, Q95LL3, Q9NU19, Q54VM3, Q8R3D1, Q9NVG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

95 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	71
Likely benign	6
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

7544 predictions. Top by Δscore:

Variant	Effect	Δscore
22:46792577:G:GG	donor_gain	1.0000
22:46793499:A:AG	acceptor_gain	1.0000
22:46793499:AGTTT:A	acceptor_gain	1.0000
22:46793500:G:GT	acceptor_gain	1.0000
22:46793500:GT:G	acceptor_gain	1.0000
22:46793500:GTT:G	acceptor_gain	1.0000
22:46793500:GTTT:G	acceptor_gain	1.0000
22:46793500:GTTTG:G	acceptor_gain	1.0000
22:46793839:CAGG:C	donor_loss	1.0000
22:46793840:AGGT:A	donor_loss	1.0000
22:46793841:GGTA:G	donor_loss	1.0000
22:46793842:G:GC	donor_loss	1.0000
22:46793843:T:A	donor_loss	1.0000
22:46797618:TTGGT:T	donor_loss	1.0000
22:46797621:G:GC	donor_loss	1.0000
22:46797621:G:GG	donor_gain	1.0000
22:46797622:T:A	donor_loss	1.0000
22:46878651:A:AG	acceptor_gain	1.0000
22:46878652:G:GG	acceptor_gain	1.0000
22:46878724:G:GG	donor_gain	1.0000
22:46891392:CAG:C	donor_loss	1.0000
22:46891395:GTG:G	donor_loss	1.0000
22:46912072:A:AG	acceptor_gain	1.0000
22:46912072:AG:A	acceptor_loss	1.0000
22:46912073:G:GA	acceptor_gain	1.0000
22:46912073:GA:G	acceptor_gain	1.0000
22:46912073:GAT:G	acceptor_gain	1.0000
22:46912073:GATT:G	acceptor_gain	1.0000
22:46912185:ATAGG:A	donor_loss	1.0000
22:46912187:AGGT:A	donor_loss	1.0000

AlphaMissense

3437 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:46912134:G:C	G321R	1.000
22:47037124:T:C	F419L	1.000
22:47037126:C:A	F419L	1.000
22:47037126:C:G	F419L	1.000
22:47037130:T:A	W421R	1.000
22:47037130:T:C	W421R	1.000
22:47037152:G:T	R428M	1.000
22:46878709:T:A	W232R	0.999
22:46878709:T:C	W232R	0.999
22:46891326:T:G	Y257D	0.999
22:46894795:C:A	D283E	0.999
22:46894795:C:G	D283E	0.999
22:46912101:G:C	A310P	0.999
22:46912108:G:C	R312P	0.999
22:46912110:C:G	H313D	0.999
22:46912125:T:C	Y318H	0.999
22:46912129:T:A	V319D	0.999
22:46912133:G:C	Q320H	0.999
22:46912133:G:T	Q320H	0.999
22:46912134:G:T	G321C	0.999
22:46912142:T:A	N323K	0.999
22:46912142:T:G	N323K	0.999
22:47037118:T:C	F417L	0.999
22:47037120:T:A	F417L	0.999
22:47037120:T:G	F417L	0.999
22:47037125:T:C	F419S	0.999
22:47037125:T:G	F419C	0.999
22:47037138:C:A	N423K	0.999
22:47037138:C:G	N423K	0.999
22:47037141:C:A	N424K	0.999

dbSNP variants (sampled 300 via entrez): RS1000000544 (22:47163450 C>T), RS1000003756 (22:47041266 C>G,T), RS1000009391 (22:47157717 G>GCACA), RS1000030084 (22:46838524 A>G,T), RS1000033260 (22:47041405 T>A), RS1000041121 (22:47098556 T>A), RS1000048133 (22:46867960 A>G), RS1000048546 (22:46971635 G>C,T), RS1000050421 (22:46985512 T>C), RS1000051865 (22:46944396 C>T), RS1000055459 (22:47110736 G>A), RS1000055636 (22:46843487 G>A,C), RS1000073319 (22:46797557 G>A), RS1000078023 (22:46761527 G>T), RS1000081674 (22:47149945 G>A)

Disease associations

OMIM: gene MIM:616879 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST000785_25	Longevity	1.000000e-06
GCST001585_4	Breast size	7.000000e-06
GCST003478_4	Hair greying	5.000000e-06
GCST004351_28	Bone ultrasound measurement (broadband ultrasound attenuation)	2.000000e-07
GCST009086_4	Pneumococcal meningitis	6.000000e-07
GCST009391_1684	Metabolite levels	4.000000e-06
GCST90093325_20	Language functional connectivity	3.000000e-12

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004514	bone quantitative ultrasound measurement
EFO:0010343	cholesteryl ester 18:0 measurement
EFO:0007797	language measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression	7
Aflatoxin B1	decreases expression, decreases methylation, increases methylation, affects expression	4
bisphenol A	decreases expression, decreases methylation, affects cotreatment, increases methylation	2
aristolochic acid I	decreases expression	1
FR900359	decreases phosphorylation	1
triphenyl phosphate	affects expression	1
sodium arsenite	decreases expression	1
zinc chromate	increases abundance, decreases expression	1
benzo(e)pyrene	affects methylation	1
aflatoxin B2	affects methylation	1
coumarin	decreases phosphorylation	1
1-hydroxypyrene	affects cotreatment, decreases methylation	1
chromium hexavalent ion	decreases expression, increases abundance	1
pentabromodiphenyl ether	increases expression	1
CGP 52608	affects binding, increases reaction	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Acetaminophen	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Arsenic	affects methylation	1
Caffeine	decreases phosphorylation	1
Carcinogens	decreases expression	1
Cisplatin	decreases expression	1
Doxorubicin	affects expression	1
Formaldehyde	decreases expression	1
Ivermectin	decreases expression	1
Methapyrilene	affects methylation	1
Mutagens	decreases expression	1
Ozone	increases abundance, affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.