TBC1D25

Summary

TBC1D25 (TBC1 domain family member 25, HGNC:8092) is a protein-coding gene on chromosome Xp11.23, encoding TBC1 domain family member 25 (Q3MII6). Acts as a GTPase-activating protein specific for RAB33B.

This gene encodes a protein with a TBC domain and functions as a Rab GTPase activating protein. The encoded protein is involved in the fusion of autophagosomes with endosomes and lysosomes. This gene was previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase.

Source: NCBI Gene 4943 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 95 total — 1 likely-pathogenic
• Phenotypes (HPO): 1
• MANE Select transcript: NM_002536

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8092
Approved symbol	TBC1D25
Name	TBC1 domain family member 25
Location	Xp11.23
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000068354
Ensembl biotype	protein_coding
OMIM	311240
Entrez	4943

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 8 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000376771, ENST00000418627, ENST00000476141, ENST00000481090, ENST00000494495, ENST00000858094, ENST00000858095, ENST00000858096, ENST00000858097, ENST00000941579, ENST00000941580

RefSeq mRNA: 5 — MANE Select: NM_002536 NM_001348262, NM_001348263, NM_001348264, NM_001348265, NM_002536

CCDS: CCDS35242

Canonical transcript exons

ENST00000376771 — 6 exons

Exon	Start	End
ENSE00001471631	48559614	48562609
ENSE00001817600	48539714	48539920
ENSE00003509057	48544869	48545023
ENSE00003559308	48559158	48559346
ENSE00003609249	48558897	48559024
ENSE00003711017	48541333	48541442

Expression profiles

Bgee: expression breadth ubiquitous, 188 present calls, max score 88.89.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.5594 / max 64.1693, expressed in 1778 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
196257	8.5594	1778

Top tissues by expression

234 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ileal mucosa	UBERON:0000331	88.89	gold quality
tibialis anterior	UBERON:0001385	87.44	silver quality
granulocyte	CL:0000094	86.02	gold quality
epithelial cell of pancreas	CL:0000083	85.96	gold quality
upper arm skin	UBERON:0004263	85.25	gold quality
vena cava	UBERON:0004087	84.98	silver quality
nasal cavity epithelium	UBERON:0005384	84.61	gold quality
kidney epithelium	UBERON:0004819	84.54	gold quality
endothelial cell	CL:0000115	84.46	gold quality
blood	UBERON:0000178	84.35	gold quality
apex of heart	UBERON:0002098	83.83	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.62	gold quality
cortical plate	UBERON:0005343	83.59	gold quality
pancreatic ductal cell	CL:0002079	83.49	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.45	gold quality
cerebellar cortex	UBERON:0002129	83.37	gold quality
cerebellar hemisphere	UBERON:0002245	83.31	gold quality
prefrontal cortex	UBERON:0000451	83.06	gold quality
heart left ventricle	UBERON:0002084	83.06	gold quality
cerebellum	UBERON:0002037	82.97	gold quality
gastrocnemius	UBERON:0001388	82.93	gold quality
cardiac ventricle	UBERON:0002082	82.91	gold quality
deltoid	UBERON:0001476	82.48	silver quality
muscle of leg	UBERON:0001383	82.42	gold quality
popliteal artery	UBERON:0002250	82.28	gold quality
cerebellar vermis	UBERON:0004720	82.27	gold quality
tibial artery	UBERON:0007610	82.27	gold quality
right atrium auricular region	UBERON:0006631	82.25	gold quality
cardiac atrium	UBERON:0002081	82.14	gold quality
mucosa of stomach	UBERON:0001199	82.12	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-100618	yes	158.00
E-ANND-3	yes	2.87

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

64 targeting TBC1D25, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-4697-3P	99.89	67.09	1123
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-548AG	99.77	69.25	1492
HSA-MIR-548AI	99.69	69.24	1494
HSA-MIR-548BA	99.69	69.14	1514
HSA-MIR-570-5P	99.69	69.24	1494
HSA-MIR-4470	99.66	69.35	1767
HSA-MIR-6887-3P	99.66	67.83	1778
HSA-MIR-10393-5P	99.65	68.01	1368
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-888-3P	99.53	69.77	1057
HSA-MIR-1207-5P	99.49	69.11	2983
HSA-MIR-128-1-5P	99.33	60.46	332
HSA-MIR-128-2-5P	99.33	60.83	311
HSA-MIR-6808-5P	99.31	66.23	2150

Literature-anchored findings (GeneRIF, showing 4)

• Our study showed that adenovirus-mediated antisense ODC and expression inhibits tumor cell growth through blocking the polyamine synthesis pathway. (PMID:17558447)
• Studies indicate that each of the 4 genes was associated with at least one main outcome: anxiety (SAT1, SMS), mood disorders (SAT1, SMOX), and suicide attempts (SAT1, OATL1). (PMID:21152090)
• Rab33b, OATL1 and Myo6 have roles in nanoparticle trafficking in HeLa cells (PMID:27374232)
• RabGAP TBC1D25 is involved in human osteoclast activity. (PMID:33353759)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	tbc1d25	ENSDARG00000075333
mus_musculus	Tbc1d25	ENSMUSG00000039201
rattus_norvegicus	Tbc1d25	ENSRNOG00000005303
drosophila_melanogaster	CG8155	FBGN0034009

Paralogs (45): RABGAP1 (ENSG00000011454), TBC1D22A (ENSG00000054611), TBC1D22B (ENSG00000065491), TBC1D1 (ENSG00000065882), EVI5 (ENSG00000067208), TBC1D2 (ENSG00000095383), TBC1D10A (ENSG00000099992), SGSM3 (ENSG00000100359), TBC1D17 (ENSG00000104946), TBC1D13 (ENSG00000107021), TBC1D12 (ENSG00000108239), TBC1D9 (ENSG00000109436), TBC1D30 (ENSG00000111490), TBC1D15 (ENSG00000121749), TBC1D5 (ENSG00000131374), TBC1D14 (ENSG00000132405), TBC1D8B (ENSG00000133138), TBC1D4 (ENSG00000136111), GRTP1 (ENSG00000139835), SGSM2 (ENSG00000141258), EVI5L (ENSG00000142459), TBCK (ENSG00000145348), USP6NL (ENSG00000148429), RABGAP1L (ENSG00000152061), SGSM1 (ENSG00000167037), TBC1D21 (ENSG00000167139), TBC1D2B (ENSG00000167202), TBC1D16 (ENSG00000167291), TBC1D10B (ENSG00000169221), TBC1D10C (ENSG00000175463), TBC1D28 (ENSG00000189375), TBC1D9B (ENSG00000197226), TBC1D8 (ENSG00000204634), TBC1D26 (ENSG00000214946), TBC1D3G (ENSG00000260287), TBC1D3K (ENSG00000273513), TBC1D3H (ENSG00000274226), TBC1D3D (ENSG00000274419), TBC1D3L (ENSG00000274512), TBC1D3 (ENSG00000274611)

Protein

Protein identifiers

TBC1 domain family member 25 — Q3MII6 (reviewed: Q3MII6)

All UniProt accessions (3): Q3MII6, B4DF03, C9JMI8

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.

Subunit / interactions. Interacts (via N-terminus) with MAP1LC3B, GABARAP and GABARAPL2.

Subcellular location. Cytoplasm. Cytoplasmic vesicle. Autophagosome.

Isoforms (2)

UniProt ID	Names	Canonical?
Q3MII6-1	1	yes
Q3MII6-2	2

RefSeq proteins (5): NP_001335191, NP_001335192, NP_001335193, NP_001335194, NP_002527* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000195	Rab-GAP-TBC_dom	Domain
IPR035969	Rab-GAP_TBC_sf	Homologous_superfamily

Pfam: PF00566

UniProt features (15 total): modified residue 3, splice variant 2, mutagenesis site 2, region of interest 2, compositionally biased region 2, chain 1, domain 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q3MII6-F1	71.10	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 140, 160, 506

Mutagenesis-validated functional residues (2):

Position	Phenotype
134–135	severely affects interaction with gabarap. does not localize at autophagosomes.
136	abolishes interaction with gabarap. does not localize at autophagosomes.

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-8854214	TBC/RABGAPs
R-HSA-199991	Membrane Trafficking
R-HSA-5653656	Vesicle-mediated transport
R-HSA-9007101	Rab regulation of trafficking

MSigDB gene sets: 85 (showing top): GOBP_REGULATION_OF_AUTOPHAGY, REACTOME_MEMBRANE_TRAFFICKING, GOBP_MACROAUTOPHAGY, WANG_LMO4_TARGETS_DN, GOBP_REGULATION_OF_CATABOLIC_PROCESS, ATCATGA_MIR433, CAAGGAT_MIR362, GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_DISASSEMBLY, GOCC_AUTOPHAGOSOME, GOMF_ENZYME_ACTIVATOR_ACTIVITY, GOMF_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY, CTGTTAC_MIR194, GOMF_ENZYME_REGULATOR_ACTIVITY, CACTGCC_MIR34A_MIR34C_MIR449, chrXp11

GO Biological Process (2): autophagy (GO:0006914), regulation of autophagosome maturation (GO:1901096)

GO Molecular Function (4): GTPase activator activity (GO:0005096), protein binding (GO:0005515), transaminase activity (GO:0008483), transferase activity (GO:0016740)

GO Cellular Component (3): autophagosome (GO:0005776), cytoplasmic vesicle (GO:0031410), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Rab regulation of trafficking	1
Vesicle-mediated transport	1
Membrane Trafficking	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
catabolic process	1
transmembrane transport	1
process utilizing autophagic mechanism	1
regulation of macroautophagy	1
regulation of organelle organization	1
regulation of protein-containing complex disassembly	1
autophagosome maturation	1
GTPase activity	1
enzyme activator activity	1
GTPase regulator activity	1
binding	1
transferase activity, transferring nitrogenous groups	1
catalytic activity	1
vacuole	1
cytoplasm	1
intracellular vesicle	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

992 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TBC1D25	GABARAPL2	P60520	897
TBC1D25	F5GZY7	F5GZY7	882
TBC1D25	USP6	P35125	812
TBC1D25	CDC16	Q13042	810
TBC1D25	TFE3	P19532	803
TBC1D25	RAB33B	Q9H082	770
TBC1D25	ELK1	P19419	761
TBC1D25	OAT	P04181	735
TBC1D25	ASPSCR1	Q9BZE9	697
TBC1D25	KCNH3	Q9ULD8	684
TBC1D25	PRCC	Q92733	669
TBC1D25	RBMY1D	P0C7P1	652
TBC1D25	TBC1D5	Q92609	650
TBC1D25	RBM3	P98179	645
TBC1D25	TIMP1	P01033	635

IntAct

77 interactions, top by confidence:

A	B	Type	Score
GABARAPL2	TBC1D25	psi-mi:“MI:0915”(physical association)	0.740
TBC1D25	GABARAPL1	psi-mi:“MI:0915”(physical association)	0.740
GYPA	TCAF2	psi-mi:“MI:0914”(association)	0.640
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
ATF4	TBC1D25	psi-mi:“MI:0915”(physical association)	0.590
TBC1D25	TRIML2	psi-mi:“MI:0915”(physical association)	0.560
TBC1D25	LGALS14	psi-mi:“MI:0915”(physical association)	0.560
TBC1D25	MAP1LC3C	psi-mi:“MI:0915”(physical association)	0.560
TBC1D25	RUSC1	psi-mi:“MI:0915”(physical association)	0.560
TBC1D25	KCNIP1	psi-mi:“MI:0915”(physical association)	0.560
RAB2A	TBC1D25	psi-mi:“MI:0915”(physical association)	0.560
TBC1D25	LARP1B	psi-mi:“MI:0915”(physical association)	0.560
TBC1D25	FAM9B	psi-mi:“MI:0915”(physical association)	0.560
TBC1D25	LMNTD2	psi-mi:“MI:0915”(physical association)	0.560
TBC1D25	GABARAP	psi-mi:“MI:0914”(association)	0.530
YWHAB	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
TBC1D25	SMC3	psi-mi:“MI:0915”(physical association)	0.400
HMGB2	TBC1D25	psi-mi:“MI:0915”(physical association)	0.370
PCCA	TBC1D25	psi-mi:“MI:0914”(association)	0.350
CREB3L2	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
TBC1D25	DCLK1	psi-mi:“MI:0915”(physical association)	0.000
TBC1D25	SIPA1L1	psi-mi:“MI:0915”(physical association)	0.000
TBC1D25	GIGYF1	psi-mi:“MI:0915”(physical association)	0.000
TBC1D25	AFDN	psi-mi:“MI:0915”(physical association)	0.000
EIF4E2	TBC1D25	psi-mi:“MI:0915”(physical association)	0.000
SRGAP2	TBC1D25	psi-mi:“MI:0915”(physical association)	0.000
CDC25B	TBC1D25	psi-mi:“MI:0915”(physical association)	0.000
CDK16	TBC1D25	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (76): TBC1D25 (Reconstituted Complex), TBC1D25 (Reconstituted Complex), TBC1D25 (Affinity Capture-MS), GABARAPL1 (Affinity Capture-MS), GABARAP (Affinity Capture-MS), GABARAPL2 (Affinity Capture-MS), OMA1 (Affinity Capture-MS), TBC1D25 (Affinity Capture-MS), FAM110A (Affinity Capture-MS), TBC1D25 (Affinity Capture-MS), TBC1D25 (Affinity Capture-MS), TBC1D25 (Affinity Capture-MS), FAM110B (Affinity Capture-MS), TBC1D25 (Affinity Capture-MS), TBC1D25 (Affinity Capture-MS)

ESM2 similar proteins: A0A8I3NFE2, A0FI79, A1A5B6, A4D2P6, D7PF45, F1LXF1, O15357, O60346, O75808, P11274, P49796, P52734, P53349, P59672, P70268, P78524, P98174, Q0QWG9, Q13233, Q13905, Q16825, Q3MII6, Q50H33, Q5RDA9, Q62925, Q63433, Q6NS60, Q6P549, Q6PDJ6, Q6WVG3, Q7Z5H3, Q8BL80, Q8BUP8, Q8N2R8, Q8TF61, Q8VHK2, Q8WXD9, Q924W7, Q92625, Q96CX2

Diamond homologs: A1A5B6, O43147, P09379, P48365, Q2NKQ1, Q3MII6, Q6FWI1, Q80U12, Q8BPQ7, Q8BYH7, Q8TBP0, Q8TC07, Q94BY9, Q9CXF4, Q9HA65, Q9UUH7, I2HAA0, Q09830, Q6BU76, Q28CB1, Q8R3D1, Q9NVG8, P48566, Q12344, O95759, O97790, Q5ZJ17, Q60949, Q86TI0, Q8BYJ6, Q9D9D3, Q9Z1A9

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
GABARAP	up-regulates	TBC1D25	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

95 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	46
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
816940	NM_002536.4(TBC1D25):c.4609C>T	Likely pathogenic

SpliceAI

963 predictions. Top by Δscore:

Variant	Effect	Δscore
X:48541439:GTGG:G	donor_gain	1.0000
X:48545024:G:GG	donor_gain	1.0000
X:48559156:AGGT:A	acceptor_gain	1.0000
X:48559156:AGGTG:A	acceptor_gain	1.0000
X:48559157:GGT:G	acceptor_gain	1.0000
X:48559157:GGTG:G	acceptor_gain	1.0000
X:48559157:GGTGG:G	acceptor_gain	1.0000
X:48559342:GAAAG:G	donor_gain	1.0000
X:48559345:AG:A	donor_gain	1.0000
X:48559346:GG:G	donor_gain	1.0000
X:48559346:GGT:G	donor_loss	1.0000
X:48559347:G:GA	donor_loss	1.0000
X:48559347:G:GG	donor_gain	1.0000
X:48559607:T:TA	acceptor_gain	1.0000
X:48559608:G:A	acceptor_gain	1.0000
X:48559609:GGCA:G	acceptor_loss	1.0000
X:48559610:GCA:G	acceptor_loss	1.0000
X:48559612:A:AG	acceptor_gain	1.0000
X:48559612:AG:A	acceptor_gain	1.0000
X:48559612:AGGT:A	acceptor_gain	1.0000
X:48559612:AGGTG:A	acceptor_gain	1.0000
X:48559613:G:A	acceptor_loss	1.0000
X:48559613:G:GT	acceptor_gain	1.0000
X:48559613:GG:G	acceptor_gain	1.0000
X:48559613:GGT:G	acceptor_gain	1.0000
X:48559613:GGTG:G	acceptor_gain	1.0000
X:48559613:GGTGG:G	acceptor_gain	1.0000
X:48541332:GAAAT:G	acceptor_gain	0.9900
X:48541441:GG:G	donor_gain	0.9900
X:48541442:GG:G	donor_gain	0.9900

AlphaMissense

4441 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:48541370:T:C	F54S	1.000
X:48558914:T:A	W136R	1.000
X:48558914:T:C	W136R	1.000
X:48559620:T:A	W238R	1.000
X:48559620:T:C	W238R	1.000
X:48559771:T:A	V288D	1.000
X:48559779:G:C	D291H	1.000
X:48559780:A:C	D291A	1.000
X:48559780:A:G	D291G	1.000
X:48559780:A:T	D291V	1.000
X:48559781:T:A	D291E	1.000
X:48559781:T:G	D291E	1.000
X:48559905:G:C	G333R	1.000
X:48559911:A:C	S335R	1.000
X:48559913:T:A	S335R	1.000
X:48559913:T:G	S335R	1.000
X:48559915:A:G	D336G	1.000
X:48560092:T:C	L395P	1.000
X:48560126:T:G	C406W	1.000
X:48560133:T:A	W409R	1.000
X:48560133:T:C	W409R	1.000
X:48560199:T:A	W431R	1.000
X:48560199:T:C	W431R	1.000
X:48539910:T:A	V38D	0.999
X:48541369:T:C	F54L	0.999
X:48541370:T:G	F54C	0.999
X:48541371:T:A	F54L	0.999
X:48541371:T:G	F54L	0.999
X:48541373:C:A	A55D	0.999
X:48541376:T:A	V56E	0.999

dbSNP variants (sampled 300 via entrez): RS1000001287 (X:48541796 G>A), RS1000143427 (X:48562407 A>G), RS1000433336 (X:48561917 G>A), RS1000483857 (X:48553955 C>T), RS1000597228 (X:48543833 G>A), RS1001112677 (X:48544393 C>T), RS1001597535 (X:48546370 G>A), RS1001719064 (X:48546546 C>G,T), RS1001932783 (X:48556553 G>C), RS1002602212 (X:48548769 A>G), RS1002627996 (X:48539630 C>T), RS1002708510 (X:48549344 C>T), RS1002774423 (X:48538955 C>G,T), RS1003222126 (X:48541663 C>A), RS1003495778 (X:48558473 G>C)

Disease associations

OMIM: gene MIM:311240 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): oligospermia (MONDO:0001913)

Orphanet (0):

HPO phenotypes

1 total (1 of 1 shown, HPO-id order):

HPO	Term
HP:0000798	Oligozoospermia

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D009845	Oligospermia	C12.100.500.430.508; C12.100.750.700.508; C12.200.294.430.508

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

16 total (human), top 16 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases abundance, increases expression	2
Benzo(a)pyrene	affects methylation, increases methylation	2
FR900359	decreases phosphorylation	1
triphenyl phosphate	affects expression	1
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	increases expression	1
pinosylvin	increases expression	1
CGP 52608	affects binding, increases reaction	1
acyline	decreases expression	1
abrine	increases expression	1
Arsenic	increases abundance, increases expression	1
Doxorubicin	decreases expression	1
Methotrexate	decreases expression	1
Progesterone	increases expression	1
Smoke	decreases expression	1
Urethane	increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	increases expression	1

Clinical trials (associated diseases)

26 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT02307994	PHASE4	UNKNOWN	Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH
NCT05320536	PHASE4	UNKNOWN	A Clinical Study of Gulingji Capsule in the Treatment of Idiopathic Oligospermia, Asthenia, and Teratozoospermia
NCT06260007	PHASE4	RECRUITING	Efficacy and Safety Study of Products Based on Tribulus Terrestris, L. in Men With Oligospermia
NCT00440180	PHASE3	TERMINATED	Aromatase Inhibitors in the Treatment of Male Infertility
NCT01409837	PHASE2	COMPLETED	The Effect and Safety of Lisinopril in Non-hypertensive Men With Infertility From Low Sperm Count
NCT02234206	PHASE2	COMPLETED	A Clinical Trial to Study the Safety and Efficacy of Chandrakanthi Choornam in Patients With Low Sperm Count
NCT07481370	PHASE2	ENROLLING_BY_INVITATION	Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm
NCT05158114	PHASE1	WITHDRAWN	Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Testicular Injury and Oligospermia
NCT02063256	PHASE2/PHASE3	UNKNOWN	7 NUTS Study. Diet Modification and Male Fertility.
NCT06869863	PHASE1/PHASE2	RECRUITING	Study of Tolerability, Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Medicinal Product MediReg®
NCT00479960	EARLY_PHASE1	UNKNOWN	A Preliminary Study on Effect of Omega-3 on Human Sperm
NCT06342856	EARLY_PHASE1	UNKNOWN	Evaluation of Treatment With Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile Men With Idiopathic Oligoasthenoteratospermia
NCT00548977	Not specified	COMPLETED	Genetic Studies Spermatogenic Failure
NCT01239186	Not specified	COMPLETED	Identification and Characterization of the Methylation Abnormalities on Whole Genome Among Infertile Men
NCT01509482	Not specified	COMPLETED	Insulin Resistance in Idiopathic Oligospermia and Azoospermia
NCT01520584	Not specified	UNKNOWN	Supplement Intake in Infertile Men;the Effect on Sperm Parameters,Fertilization Rate and Embryo Quality
NCT01828710	Not specified	COMPLETED	Myo-inositol on Human Semen Parameters
NCT01856361	Not specified	TERMINATED	Ramipril for the Treatment of Oligospermia
NCT02155179	Not specified	COMPLETED	Sperm Pathology Samples and Morphokinetics
NCT03898752	Not specified	COMPLETED	Is Oxidative Stress in Semen Reduced by Lifestyle Intervention
NCT04349345	Not specified	COMPLETED	Seminal Fluid’s Changes Over 20 Years
NCT04795440	Not specified	COMPLETED	Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF
NCT05506722	Not specified	UNKNOWN	Using of Testes Shocker in Improving the Spermatogenesis and Sperms Activity
NCT05842239	Not specified	RECRUITING	Hyperbaric Oxygen Therapy for Men Suffering From Infertility Due to Oligospermia.
NCT06202469	Not specified	COMPLETED	Creatine and Ubiquinol for Sperm Quality
NCT07357701	Not specified	RECRUITING	Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)