TBL3

Summary

TBL3 (transducin beta like 3, HGNC:11587) is a protein-coding gene on chromosome 16p13.3, encoding Transducin beta-like protein 3 (Q12788). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. It is a common-essential gene (DepMap: required in 97.8% of cancer cell lines).

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet.

Source: NCBI Gene 10607 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 233 total — 1 pathogenic
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 97.8% of screened cell lines (common-essential)
• MANE Select transcript: NM_006453

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11587
Approved symbol	TBL3
Name	transducin beta like 3
Location	16p13.3
Locus type	gene with protein product
Status	Approved
Aliases	SAZD, UTP13
Ensembl gene	ENSG00000183751
Ensembl biotype	protein_coding
OMIM	605915
Entrez	10607

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 11 protein_coding, 4 retained_intron, 1 nonsense_mediated_decay

ENST00000332704, ENST00000561907, ENST00000564171, ENST00000567615, ENST00000568546, ENST00000569628, ENST00000569792, ENST00000861852, ENST00000861853, ENST00000939202, ENST00000939203, ENST00000939204, ENST00000939205, ENST00000960652, ENST00000960653, ENST00000960654

RefSeq mRNA: 1 — MANE Select: NM_006453 NM_006453

CCDS: CCDS10453

Canonical transcript exons

ENST00000568546 — 22 exons

Exon	Start	End
ENSE00001409862	1974197	1974292
ENSE00001413730	1972053	1972205
ENSE00001416451	1974056	1974107
ENSE00002606279	1978552	1982929
ENSE00003467568	1975808	1975949
ENSE00003500273	1977356	1977426
ENSE00003514088	1977514	1977670
ENSE00003523346	1975345	1975438
ENSE00003538180	1975529	1975710
ENSE00003539608	1977054	1977284
ENSE00003570053	1976211	1976314
ENSE00003576766	1976814	1976961
ENSE00003591757	1977958	1978061
ENSE00003596870	1975187	1975262
ENSE00003600841	1978313	1978471
ENSE00003602268	1978149	1978220
ENSE00003627325	1974928	1975098
ENSE00003637684	1976056	1976114
ENSE00003661279	1974538	1974679
ENSE00003664126	1974763	1974847
ENSE00003680343	1977742	1977800
ENSE00003694145	1974376	1974423

Expression profiles

Bgee: expression breadth ubiquitous, 247 present calls, max score 94.10.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.7314 / max 284.4786, expressed in 1804 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
152148	26.7314	1804

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	94.10	gold quality
left testis	UBERON:0004533	93.73	gold quality
lower esophagus mucosa	UBERON:0035834	93.34	gold quality
gastrocnemius	UBERON:0001388	92.46	gold quality
apex of heart	UBERON:0002098	92.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	92.13	gold quality
skin of leg	UBERON:0001511	91.98	gold quality
muscle of leg	UBERON:0001383	91.24	gold quality
skin of abdomen	UBERON:0001416	91.24	gold quality
testis	UBERON:0000473	91.12	gold quality
ectocervix	UBERON:0012249	90.57	gold quality
mucosa of transverse colon	UBERON:0004991	90.33	gold quality
esophagus mucosa	UBERON:0002469	90.30	gold quality
right lobe of thyroid gland	UBERON:0001119	89.59	gold quality
body of stomach	UBERON:0001161	89.53	gold quality
adenohypophysis	UBERON:0002196	89.50	gold quality
body of uterus	UBERON:0009853	89.49	gold quality
right ovary	UBERON:0002118	89.39	gold quality
esophagus	UBERON:0001043	89.37	gold quality
left uterine tube	UBERON:0001303	89.35	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	89.23	gold quality
granulocyte	CL:0000094	89.07	gold quality
lower esophagus	UBERON:0013473	89.03	gold quality
lower esophagus muscularis layer	UBERON:0035833	89.02	gold quality
body of pancreas	UBERON:0001150	88.99	gold quality
minor salivary gland	UBERON:0001830	88.97	gold quality
right lobe of liver	UBERON:0001114	88.96	gold quality
zone of skin	UBERON:0000014	88.92	gold quality
left lobe of thyroid gland	UBERON:0001120	88.81	gold quality
left coronary artery	UBERON:0001626	88.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 97.8% of screened cell lines, common-essential.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tbl3	ENSDARG00000052344
mus_musculus	Tbl3	ENSMUSG00000040688
rattus_norvegicus	Tbl3	ENSRNOG00000013429
drosophila_melanogaster	CG1671	FBGN0033454
caenorhabditis_elegans		WBGENE00013143

Paralogs (1): GNB1L (ENSG00000185838)

Protein

Protein identifiers

Transducin beta-like protein 3 — Q12788 (reviewed: Q12788)

Alternative names: WD repeat-containing protein SAZD

All UniProt accessions (3): Q12788, H3BN88, J3KNP2

UniProt curated annotations — full annotation on UniProt →

Function. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Subunit / interactions. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.

Subcellular location. Nucleus. Nucleolus.

RefSeq proteins (1): NP_006444* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR011044	Quino_amine_DH_bsu	Homologous_superfamily
IPR013934	Utp13_C	Domain
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR020472	WD40_PAC1	Repeat
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily

Pfam: PF00400, PF08625

UniProt features (25 total): repeat 13, sequence conflict 4, sequence variant 3, modified residue 2, initiator methionine 1, chain 1, cross-link 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
7MQA	ELECTRON MICROSCOPY	2.7
7MQ8	ELECTRON MICROSCOPY	3.6
7MQ9	ELECTRON MICROSCOPY	3.87

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q12788-F1	84.48	0.32

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 2, 257, 407

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-6790901	rRNA modification in the nucleus and cytosol
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72312	rRNA processing
R-HSA-8868773	rRNA processing in the nucleus and cytosol
R-HSA-8953854	Metabolism of RNA

MSigDB gene sets: 151 (showing top): GOBP_RIBOSOME_BIOGENESIS, GOBP_MATURATION_OF_SSU_RRNA, STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN, SHIPP_DLBCL_CURED_VS_FATAL_DN, MODULE_70, SCHUHMACHER_MYC_TARGETS_UP, AMIT_EGF_RESPONSE_120_HELA, GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS, GOBP_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA, MODULE_48, MODULE_95, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, BERENJENO_TRANSFORMED_BY_RHOA_UP, REACTOME_METABOLISM_OF_RNA, GOCC_90S_PRERIBOSOME

GO Biological Process (4): endonucleolytic cleavage to generate mature 5’-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000472), endonucleolytic cleavage in 5’-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000480), ribosomal small subunit biogenesis (GO:0042274), rRNA processing (GO:0006364)

GO Molecular Function (3): RNA binding (GO:0003723), U3 snoRNA binding (GO:0034511), protein binding (GO:0005515)

GO Cellular Component (5): nucleoplasm (GO:0005654), nucleolus (GO:0005730), 90S preribosome (GO:0030686), small-subunit processome (GO:0032040), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
rRNA processing in the nucleus and cytosol	2
Metabolism of RNA	1
rRNA processing	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2
endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2
ribosome biogenesis	2
nuclear lumen	2
preribosome	2
t-UTP complex	2
rRNA 5’-end processing	1
ribonucleoprotein complex biogenesis	1
RNA processing	1
rRNA metabolic process	1
nucleic acid binding	1
snoRNA binding	1
binding	1
cellular anatomical structure	1
intracellular membraneless organelle	1
nucleolus	1
nuclear protein-containing complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

2553 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TBL3	UTP18	Q9Y5J1	986
TBL3	UTP6	Q9NYH9	981
TBL3	PWP2	Q15269	949
TBL3	WDR36	Q8NI36	934
TBL3	WDR3	Q9UNX4	815
TBL3	NOP58	Q9Y2X3	748
TBL3	HEATR1	Q9H583	732
TBL3	PWP1	Q13610	720
TBL3	WDR43	Q15061	715
TBL3	CUL4B	Q13620	708
TBL3	NOP14	P78316	698
TBL3	NOP56	O00567	694
TBL3	NOL6	Q9H6R4	677
TBL3	UTP14A	Q9BVJ6	668
TBL3	DDB1	Q16531	664

IntAct

120 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
APPBP2	TBL3	psi-mi:“MI:0915”(physical association)	0.670
TBL3	APPBP2	psi-mi:“MI:0915”(physical association)	0.670
NCBP2	KPNA3	psi-mi:“MI:0914”(association)	0.640
C1D	ZFC3H1	psi-mi:“MI:0914”(association)	0.640
NOP53	RRP8	psi-mi:“MI:0914”(association)	0.640
RPS14	CCZ1B	psi-mi:“MI:0914”(association)	0.640
PWP2	FBL	psi-mi:“MI:0914”(association)	0.610
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
HSD3B2	NARS1	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
RBM4	NVL	psi-mi:“MI:0914”(association)	0.530
RRP8	MAGEB2	psi-mi:“MI:0914”(association)	0.530
EXOSC4	ZFC3H1	psi-mi:“MI:0914”(association)	0.530
MPHOSPH6	ZFC3H1	psi-mi:“MI:0914”(association)	0.530
RPL13	RRP8	psi-mi:“MI:0914”(association)	0.530
FAIM	WDR47	psi-mi:“MI:0914”(association)	0.500
TBL3	NUDC	psi-mi:“MI:0915”(physical association)	0.400
TBL3		psi-mi:“MI:0915”(physical association)	0.370
SFN	TBL3	psi-mi:“MI:0915”(physical association)	0.370
Ruvbl1	AAR2	psi-mi:“MI:0914”(association)	0.350
Srp72		psi-mi:“MI:0914”(association)	0.350
Rrbp1	PIPSL	psi-mi:“MI:0914”(association)	0.350
NOP56	C12orf43	psi-mi:“MI:0914”(association)	0.350
HNRNPU		psi-mi:“MI:0914”(association)	0.350

BioGRID (240): TBL3 (Two-hybrid), TBL3 (Affinity Capture-MS), TBL3 (Affinity Capture-MS), TBL3 (Affinity Capture-MS), TBL3 (Affinity Capture-MS), TBL3 (Affinity Capture-MS), TBL3 (Affinity Capture-MS), TBL3 (Affinity Capture-MS), TBL3 (Affinity Capture-MS), TBL3 (Affinity Capture-MS), TBL3 (Affinity Capture-MS), TBL3 (Two-hybrid), TBL3 (Two-hybrid), TBL3 (Affinity Capture-MS), AATF (Co-fractionation)

ESM2 similar proteins: A4FV98, A5PK51, A6NDG6, E1BE10, O00587, O35595, O95294, P60487, Q12788, Q17QS4, Q1JPJ0, Q2T9S4, Q2TBI8, Q32NY4, Q3T063, Q3ZBF9, Q501J2, Q5E9V4, Q5F4B1, Q5IS64, Q5SUV1, Q5T9C9, Q6AYG0, Q6AYR8, Q6XQN1, Q6XQN6, Q6ZMM2, Q80US4, Q8BNV1, Q8BZG5, Q8CC86, Q8IZ69, Q8N9H8, Q8NE01, Q8R2H9, Q8TCT1, Q8VCA8, Q8VD52, Q969S8, Q96AZ1

Diamond homologs: A1C7E4, A1CBP8, A1DDL6, A1DHW6, A2QCU8, A2R3Z3, A4RJV3, A6ZQL5, A6ZZZ8, A7ETB3, A7THX0, A7TNS8, A8PTE4, A8Q2R5, B0XTS1, B6GZA1, B6Q4Z5, B8M7Q5, B8NGT5, C5FP68, D1ZEB4, D4AM37, D4D8P3, O42937, P0CS44, P0CS45, P25387, P36130, P47025, Q01277, Q0CJD8, Q0CY32, Q0U2T3, Q12788, Q1DIW7, Q2H139, Q2U5Z8, Q2UFN8, Q4P8R5, Q4V837

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
TBL3	“form complex”	“UTP-B complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 145 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Nuclear RNA decay	7	22.7×	5e-06
rRNA modification in the nucleus and cytosol	8	15.8×	6e-06
Major pathway of rRNA processing in the nucleolus and cytosol	19	12.3×	3e-13
Nonsense-Mediated Decay (NMD)	5	12.3×	3e-03
rRNA processing in the nucleus and cytosol	7	11.8×	3e-04
SARS-CoV-1-host interactions	6	11.1×	1e-03
rRNA processing	7	10.8×	3e-04
Influenza Infection	5	9.2×	6e-03

GO biological processes:

GO term	Partners	Fold	FDR
ribosomal small subunit biogenesis	12	21.7×	1e-10
ribosomal large subunit biogenesis	6	21.1×	8e-05
rRNA processing	14	15.7×	1e-10
RNA processing	8	13.9×	3e-05
cytoplasmic translation	7	10.3×	8e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

233 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	183
Likely benign	13
Benign	3

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
2498682	GRCh37/hg19 16p13.3(chr16:811896-2130379)x1	Pathogenic

SpliceAI

3801 predictions. Top by Δscore:

Variant	Effect	Δscore
16:1972204:AAGT:A	donor_loss	1.0000
16:1972205:AGTG:A	donor_loss	1.0000
16:1972206:G:GG	donor_gain	1.0000
16:1974050:TTCCA:T	acceptor_loss	1.0000
16:1974051:TCCA:T	acceptor_loss	1.0000
16:1974052:CCA:C	acceptor_loss	1.0000
16:1974053:CAGC:C	acceptor_loss	1.0000
16:1974054:A:AG	acceptor_gain	1.0000
16:1974054:A:C	acceptor_loss	1.0000
16:1974055:G:A	acceptor_loss	1.0000
16:1974055:G:GT	acceptor_gain	1.0000
16:1974055:GC:G	acceptor_gain	1.0000
16:1974055:GCT:G	acceptor_gain	1.0000
16:1974055:GCTA:G	acceptor_gain	1.0000
16:1974055:GCTAT:G	acceptor_gain	1.0000
16:1974104:ACAG:A	donor_loss	1.0000
16:1974105:CAGGT:C	donor_loss	1.0000
16:1974108:G:T	donor_loss	1.0000
16:1974109:T:G	donor_loss	1.0000
16:1974193:CCA:C	acceptor_loss	1.0000
16:1974194:CA:C	acceptor_loss	1.0000
16:1974195:A:AG	acceptor_gain	1.0000
16:1974195:AGCT:A	acceptor_gain	1.0000
16:1974195:AGCTG:A	acceptor_gain	1.0000
16:1974196:G:GC	acceptor_gain	1.0000
16:1974196:GC:G	acceptor_gain	1.0000
16:1974196:GCT:G	acceptor_gain	1.0000
16:1974196:GCTG:G	acceptor_gain	1.0000
16:1974196:GCTGG:G	acceptor_gain	1.0000
16:1974198:T:A	acceptor_gain	1.0000

AlphaMissense

5213 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:1976103:A:C	S393R	0.999
16:1976105:C:A	S393R	0.999
16:1976105:C:G	S393R	0.999
16:1977097:C:A	A495D	0.997
16:1977105:T:C	S498P	0.997
16:1977255:T:A	W548R	0.997
16:1977255:T:C	W548R	0.997
16:1977539:T:A	W590R	0.997
16:1977539:T:C	W590R	0.997
16:1975097:A:C	S212R	0.996
16:1975187:C:A	S212R	0.996
16:1975187:C:G	S212R	0.996
16:1976842:A:C	S441R	0.996
16:1976844:C:A	S441R	0.996
16:1976844:C:G	S441R	0.996
16:1977121:C:A	A503D	0.996
16:1977198:T:C	F529L	0.996
16:1977199:T:C	F529S	0.996
16:1977200:C:A	F529L	0.996
16:1977200:C:G	F529L	0.996
16:1977223:C:A	A537D	0.995
16:1977100:C:A	T496K	0.994
16:1977103:G:A	G497D	0.994
16:1977111:G:C	D500H	0.994
16:1977186:T:A	W525R	0.994
16:1977186:T:C	W525R	0.994
16:1977665:T:A	W632R	0.994
16:1977665:T:C	W632R	0.994
16:1978339:T:A	W721R	0.994
16:1978339:T:C	W721R	0.994

dbSNP variants (sampled 300 via entrez): RS1000316832 (16:1970698 G>A,C), RS1000429083 (16:1975255 T>C), RS1000521284 (16:1982785 C>T), RS1000621875 (16:1971176 A>G), RS1000667225 (16:1970909 T>G), RS1001300102 (16:1973254 C>A), RS1001437970 (16:1982394 G>A,C), RS1002240340 (16:1978958 C>G,T), RS1002264008 (16:1972336 G>A,C), RS1002507014 (16:1971243 T>C), RS1002509390 (16:1982895 G>A), RS1002701556 (16:1972125 G>A,T), RS1002841948 (16:1979724 T>G), RS1003101357 (16:1972232 G>A,C,T), RS1003527786 (16:1973429 G>A)

Disease associations

OMIM: gene MIM:605915 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067168 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.50	Kd	3142	nM	CHEMBL3752910
5.33	ED50	4700	nM	CHEMBL3752910

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149948: Binding affinity to human TBL3 incubated for 45 mins by Kinobead based pull down assay	kd	3.1416	uM

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	3
bisphenol A	decreases expression, decreases methylation	2
Air Pollutants	affects cotreatment, increases abundance, increases oxidation, affects expression	2
Ozone	affects cotreatment, increases oxidation, increases abundance, affects expression	2
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
alpha-pinene	increases oxidation, increases abundance, affects cotreatment	1
deoxynivalenol	increases expression	1
beta-lapachone	decreases expression	1
cobaltous chloride	decreases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
bisphenol S	affects expression	1
(+)-JQ1 compound	decreases expression	1
Sunitinib	increases expression	1
Acetaminophen	decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Arsenic	affects methylation	1
Cisplatin	decreases expression	1
Clozapine	increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Dimethyl Sulfoxide	increases expression	1
Ethyl Methanesulfonate	decreases expression	1
Formaldehyde	decreases expression	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	decreases expression	1
Ribonucleotides	affects binding	1
Selenium	increases expression	1
Smoke	decreases expression	1
Valproic Acid	increases methylation	1
Cyclosporine	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652990	Binding	Binding affinity to human TBL3 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.