TBX5-AS1

Summary

TBX5-AS1 (TBX5 antisense RNA 1, HGNC:27402) is a long non-coding RNA gene on chromosome 12q24.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27402
Approved symbol	TBX5-AS1
Name	TBX5 antisense RNA 1
Location	12q24.21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000255399
Ensembl biotype	lncRNA
Entrez	255480
RNAcentral	URS000075C09F — lncRNA, 3655 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 30 lncRNA

ENST00000528549, ENST00000531024, ENST00000531202, ENST00000532697, ENST00000655553, ENST00000687334, ENST00000689769, ENST00000836222, ENST00000836223, ENST00000836224, ENST00000836225, ENST00000836226, ENST00000836227, ENST00000836228, ENST00000836229, ENST00000836230, ENST00000836231, ENST00000836232, ENST00000836233, ENST00000836234, ENST00000836235, ENST00000836236, ENST00000836237, ENST00000836238, ENST00000836239, ENST00000836240, ENST00000836241, ENST00000836242, ENST00000836243, ENST00000836244

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000528549 — 3 exons

Exon	Start	End
ENSE00002166996	114408828	114409007
ENSE00003982208	114409466	114412832
ENSE00004255445	114408114	114408285

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 89.56.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4936 / max 66.1860, expressed in 199 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
128213	0.2498	128
128212	0.1448	59
128214	0.0991	61

Top tissues by expression

202 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.56	gold quality
cardiac muscle of right atrium	UBERON:0003379	87.13	silver quality
right atrium auricular region	UBERON:0006631	85.66	gold quality
cardiac atrium	UBERON:0002081	85.38	gold quality
right lung	UBERON:0002167	85.34	gold quality
left ventricle myocardium	UBERON:0006566	85.26	gold quality
lower lobe of lung	UBERON:0008949	81.79	gold quality
sperm	CL:0000019	80.94	gold quality
upper lobe of left lung	UBERON:0008952	80.51	gold quality
upper lobe of lung	UBERON:0008948	80.47	gold quality
myocardium	UBERON:0002349	80.31	silver quality
lung	UBERON:0002048	80.12	gold quality
lower esophagus muscularis layer	UBERON:0035833	78.64	gold quality
lower esophagus	UBERON:0013473	78.56	gold quality
placenta	UBERON:0001987	77.50	gold quality
heart	UBERON:0000948	76.96	gold quality
heart left ventricle	UBERON:0002084	76.93	gold quality
cardiac ventricle	UBERON:0002082	76.62	gold quality
apex of heart	UBERON:0002098	75.23	gold quality
visceral pleura	UBERON:0002401	72.26	gold quality
pancreatic ductal cell	CL:0002079	71.50	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	70.37	gold quality
esophagus	UBERON:0001043	67.91	gold quality
skin of hip	UBERON:0001554	66.52	gold quality
vena cava	UBERON:0004087	66.25	gold quality
tibialis anterior	UBERON:0001385	61.96	silver quality
urethra	UBERON:0000057	61.61	gold quality
mammalian vulva	UBERON:0000997	60.48	silver quality
hindlimb stylopod muscle	UBERON:0004252	59.84	gold quality
urinary bladder	UBERON:0001255	59.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.24

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.