TCEA3
geneOn this page
Also known as TFIIS.H
Summary
TCEA3 (transcription elongation factor A3, HGNC:11615) is a protein-coding gene on chromosome 1p36.12, encoding Transcription elongation factor A protein 3 (O75764). Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
Predicted to enable DNA binding activity; translation elongation factor activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.
Source: NCBI Gene 6920 — RefSeq curated summary.
At a glance
- GWAS associations: 60
- Clinical variants (ClinVar): 75 total
- MANE Select transcript:
NM_003196
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:11615 |
| Approved symbol | TCEA3 |
| Name | transcription elongation factor A3 |
| Location | 1p36.12 |
| Locus type | gene with protein product |
| Status | Approved |
| Aliases | TFIIS.H |
| Ensembl gene | ENSG00000204219 |
| Ensembl biotype | protein_coding |
| OMIM | 604128 |
| Entrez | 6920 |
Gene structure
Transcript identifiers
Ensembl transcripts: 22 — 20 protein_coding, 2 retained_intron
ENST00000374601, ENST00000374602, ENST00000450454, ENST00000461794, ENST00000476978, ENST00000492271, ENST00000898818, ENST00000898819, ENST00000898820, ENST00000898821, ENST00000898822, ENST00000898823, ENST00000898824, ENST00000898825, ENST00000898826, ENST00000941055, ENST00000941056, ENST00000941057, ENST00000941058, ENST00000941059, ENST00000941060, ENST00000941061
RefSeq mRNA: 1 — MANE Select: NM_003196
NM_003196
CCDS: CCDS44086
Canonical transcript exons
ENST00000450454 — 11 exons
| Exon | Start | End |
|---|---|---|
| ENSE00001463958 | 23380909 | 23381474 |
| ENSE00001463967 | 23397792 | 23397955 |
| ENSE00001463973 | 23419077 | 23419139 |
| ENSE00001463974 | 23424565 | 23424748 |
| ENSE00001592094 | 23397545 | 23397601 |
| ENSE00001641729 | 23393879 | 23394033 |
| ENSE00003464044 | 23384346 | 23384417 |
| ENSE00003478049 | 23417249 | 23417390 |
| ENSE00003484973 | 23417904 | 23418009 |
| ENSE00003543012 | 23408664 | 23408726 |
| ENSE00003559521 | 23387273 | 23387419 |
Expression profiles
Bgee: expression breadth ubiquitous, 134 present calls, max score 99.23.
FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.7784 / max 414.4001, expressed in 981 samples.
FANTOM5 promoters (5 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 10972 | 6.7101 | 919 |
| 10973 | 0.8501 | 367 |
| 10970 | 0.1104 | 49 |
| 10971 | 0.1029 | 49 |
| 10974 | 0.0049 | 1 |
Top tissues by expression
134 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| skeletal muscle tissue | UBERON:0001134 | 99.23 | gold quality |
| hindlimb stylopod muscle | UBERON:0004252 | 99.12 | gold quality |
| gastrocnemius | UBERON:0001388 | 98.91 | gold quality |
| muscle of leg | UBERON:0001383 | 98.83 | gold quality |
| body of pancreas | UBERON:0001150 | 98.65 | gold quality |
| mucosa of transverse colon | UBERON:0004991 | 97.41 | gold quality |
| right lobe of liver | UBERON:0001114 | 97.12 | gold quality |
| rectum | UBERON:0001052 | 96.79 | gold quality |
| liver | UBERON:0002107 | 96.78 | gold quality |
| right adrenal gland | UBERON:0001233 | 96.65 | gold quality |
| sural nerve | UBERON:0015488 | 96.65 | gold quality |
| muscle tissue | UBERON:0002385 | 96.58 | gold quality |
| right adrenal gland cortex | UBERON:0035827 | 96.53 | gold quality |
| left adrenal gland cortex | UBERON:0035825 | 96.15 | gold quality |
| left adrenal gland | UBERON:0001234 | 96.06 | gold quality |
| saliva-secreting gland | UBERON:0001044 | 95.72 | gold quality |
| transverse colon | UBERON:0001157 | 95.60 | gold quality |
| right uterine tube | UBERON:0001302 | 95.55 | gold quality |
| adrenal tissue | UBERON:0018303 | 95.55 | gold quality |
| minor salivary gland | UBERON:0001830 | 95.53 | gold quality |
| adrenal gland | UBERON:0002369 | 95.36 | gold quality |
| apex of heart | UBERON:0002098 | 95.05 | gold quality |
| left ovary | UBERON:0002119 | 95.02 | gold quality |
| ovary | UBERON:0000992 | 95.00 | gold quality |
| calcaneal tendon | UBERON:0003701 | 94.98 | gold quality |
| fundus of stomach | UBERON:0001160 | 94.80 | gold quality |
| heart left ventricle | UBERON:0002084 | 94.68 | gold quality |
| body of stomach | UBERON:0001161 | 94.52 | gold quality |
| stomach | UBERON:0000945 | 94.39 | gold quality |
| cortex of kidney | UBERON:0001225 | 94.12 | gold quality |
Single-cell (SCXA)
Detected in 2 experiment(s), a significant marker in 1.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | yes | 22.29 |
| E-GEOD-83139 | no | 2.75 |
Regulation
Is transcription factor: no
miRNA regulators (miRDB)
25 targeting TCEA3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-3925-3P | 100.00 | 69.95 | 1237 |
| HSA-MIR-4775 | 99.98 | 75.00 | 6394 |
| HSA-MIR-515-5P | 99.92 | 69.82 | 2343 |
| HSA-MIR-519E-5P | 99.92 | 69.62 | 2358 |
| HSA-MIR-576-5P | 99.84 | 70.46 | 2582 |
| HSA-MIR-92A-2-5P | 99.75 | 67.01 | 2164 |
| HSA-MIR-17-3P | 99.55 | 66.77 | 1311 |
| HSA-MIR-1324 | 99.46 | 66.57 | 1302 |
| HSA-MIR-330-3P | 99.41 | 69.95 | 2521 |
| HSA-MIR-6731-5P | 99.28 | 67.42 | 2375 |
| HSA-MIR-8085 | 99.28 | 67.56 | 2362 |
| HSA-MIR-4505 | 99.27 | 67.81 | 2678 |
| HSA-MIR-5787 | 99.22 | 67.86 | 2628 |
| HSA-MIR-371A-5P | 99.08 | 66.51 | 1914 |
| HSA-MIR-6871-5P | 98.90 | 66.67 | 671 |
| HSA-MIR-16-1-3P | 98.70 | 69.23 | 1538 |
| HSA-MIR-7155-5P | 98.65 | 66.14 | 1290 |
| HSA-MIR-6881-5P | 98.16 | 67.38 | 665 |
| HSA-MIR-4799-3P | 97.78 | 65.97 | 893 |
| HSA-MIR-4720-5P | 97.46 | 65.67 | 893 |
| HSA-MIR-5588-5P | 97.46 | 65.70 | 913 |
| HSA-MIR-5000-5P | 97.40 | 66.11 | 1055 |
| HSA-MIR-3976 | 96.67 | 67.79 | 1187 |
| HSA-MIR-6742-5P | 96.32 | 64.01 | 869 |
| HSA-MIR-29C-5P | 87.36 | 66.96 | 29 |
Literature-anchored findings (GeneRIF, showing 6)
- Study demonstrates a strong synergy between hPAF1C and elongation factor SII/TFIIS and an underlying mechanism involving direct hPAF1C-SII interactions and cooperative binding to RNA polymerase II. (PMID:20178742)
- Tcea3 binds to TGF-beta I receptor and activates TGF-beta signaling pathway. (PMID:23357533)
- TCEA3 attenuates the proliferation and induces apoptosis of gastric cancer cells (PMID:26498664)
- Findings reveal a novel mechanism by which p53 utilizes TFIIS.h to selectively promote the transcriptional elongation of the bax gene, upsurging cell death in response to severe DNA damage. (PMID:27005522)
- The transcription elongation factor TCEA3 induces apoptosis in rhabdomyosarcoma. (PMID:31988307)
- Oncogenic tRNA-derived fragment tRF-Leu-CAG promotes tumorigenesis of lung cancer via targeting TCEA3 and increasing autophagy. (PMID:39198937)
Cross-species orthologs
3 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| danio_rerio | tcea3 | ENSDARG00000004724 |
| mus_musculus | Tcea3 | ENSMUSG00000001604 |
| rattus_norvegicus | Tcea3 | ENSRNOG00000011794 |
Paralogs (3): TCEA2 (ENSG00000171703), TCEANC (ENSG00000176896), TCEA1 (ENSG00000187735)
Protein
Protein identifiers
Transcription elongation factor A protein 3 — O75764 (reviewed: O75764)
Alternative names: Transcription elongation factor S-II protein 3, Transcription elongation factor TFIIS.h
All UniProt accessions (3): O75764, S4R3M9, S4R419
UniProt curated annotations — full annotation on UniProt →
Function. Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3’-terminus.
Subcellular location. Nucleus.
Similarity. Belongs to the TFS-II family.
Isoforms (2)
| UniProt ID | Names | Canonical? |
|---|---|---|
| O75764-1 | 1 | yes |
| O75764-2 | 2 |
RefSeq proteins (1): NP_003187* (*=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR001222 | Znf_TFIIS | Domain |
| IPR003617 | TFIIS/CRSP70_N_sub | Domain |
| IPR003618 | TFIIS_cen_dom | Domain |
| IPR006289 | TFSII | Family |
| IPR017923 | TFIIS_N | Domain |
| IPR035100 | TF_IIS-typ | Family |
| IPR035441 | TFIIS/LEDGF_dom_sf | Homologous_superfamily |
| IPR036575 | TFIIS_cen_dom_sf | Homologous_superfamily |
Pfam: PF01096, PF07500, PF08711
UniProt features (16 total): binding site 4, compositionally biased region 3, domain 2, modified residue 2, splice variant 2, chain 1, zinc finger region 1, region of interest 1
Structure
Experimental structures (PDB)
0 structures.
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-O75764-F1 | 74.57 | 0.34 |
Functional residue map
Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.
Ligand- & substrate-binding residues (4): 338; 341; 310; 313
Post-translational modifications (2): 115, 140
Function
Pathways and Gene Ontology
Reactome pathways
0 pathways
MSigDB gene sets: 103 (showing top):
BENPORATH_ES_WITH_H3K27ME3, MAZ_Q6, MEF2_02, SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN, GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN, SANSOM_APC_TARGETS_DN, HNF1_01, MEF2_Q6_01, CTAWWWATA_RSRFC4_Q2, WENG_POR_TARGETS_GLOBAL_UP, MEF2_03, MASSARWEH_TAMOXIFEN_RESISTANCE_UP, KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP, NUYTTEN_NIPP1_TARGETS_DN, DODD_NASOPHARYNGEAL_CARCINOMA_DN
GO Biological Process (3): regulation of transcription by RNA polymerase II (GO:0006357), transcription elongation by RNA polymerase II (GO:0006368), DNA-templated transcription (GO:0006351)
GO Molecular Function (5): DNA binding (GO:0003677), zinc ion binding (GO:0008270), nucleic acid binding (GO:0003676), protein binding (GO:0005515), metal ion binding (GO:0046872)
GO Cellular Component (1): nucleus (GO:0005634)
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| transcription by RNA polymerase II | 2 |
| binding | 2 |
| regulation of DNA-templated transcription | 1 |
| DNA-templated transcription elongation | 1 |
| gene expression | 1 |
| RNA biosynthetic process | 1 |
| nucleic acid binding | 1 |
| transition metal ion binding | 1 |
| cation binding | 1 |
| intracellular membrane-bounded organelle | 1 |
Protein interactions and networks
STRING
1680 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| TCEA3 | GTF2B | Q00403 | 894 |
| TCEA3 | SUPT4H1 | P63272 | 872 |
| TCEA3 | SUPT5H | O00267 | 868 |
| TCEA3 | POLR2I | P36954 | 834 |
| TCEA3 | TBP | P20226 | 808 |
| TCEA3 | SUPT6H | Q7KZ85 | 806 |
| TCEA3 | POLR2B | P30876 | 802 |
| TCEA3 | PLAG1 | Q6DJT9 | 763 |
| TCEA3 | POLR1H | Q9P1U0 | 750 |
| TCEA3 | POLI | Q9UNA4 | 729 |
| TCEA3 | POLR3K | Q9Y2Y1 | 719 |
| TCEA3 | POLR2A | P24928 | 717 |
| TCEA3 | LEO1 | Q8WVC0 | 713 |
| TCEA3 | ELOA2 | Q8IYF1 | 706 |
| TCEA3 | ELOA | Q14241 | 694 |
IntAct
8 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| TCEA3 | LEO1 | psi-mi:“MI:0915”(physical association) | 0.560 |
| SAV1 | TCEA3 | psi-mi:“MI:0915”(physical association) | 0.370 |
| RPH3AL | TCEA3 | psi-mi:“MI:0915”(physical association) | 0.370 |
| M | psi-mi:“MI:0914”(association) | 0.350 | |
| TCEA1 | TCEA3 | psi-mi:“MI:0914”(association) | 0.350 |
| LEO1 | TCEA3 | psi-mi:“MI:0915”(physical association) | 0.000 |
BioGRID (12): TCEA3 (Two-hybrid), TCEA3 (Protein-RNA), TCEA3 (Affinity Capture-RNA), TCEA3 (Affinity Capture-MS), USP47 (Affinity Capture-Western), TCEA3 (Affinity Capture-Western), TCEA3 (Affinity Capture-MS), TCEA3 (Affinity Capture-MS), TCEA3 (Cross-Linking-MS (XL-MS)), TCEA3 (Cross-Linking-MS (XL-MS)), TCEA3 (Cross-Linking-MS (XL-MS)), TCEA3 (Two-hybrid)
ESM2 similar proteins: A2VE39, B0UYI1, D2HRF1, O46563, O60308, O75764, P10711, P23193, P23881, P54729, Q0P5J9, Q148K0, Q15560, Q29RL9, Q2KI09, Q4KLL0, Q5R8Y3, Q5R952, Q5R981, Q5U2Z5, Q5XGZ8, Q5XIC7, Q5ZM30, Q63799, Q6GQ76, Q7ZYU8, Q803R5, Q84ZC0, Q8BVE3, Q8BW49, Q8N1G2, Q8R2M0, Q8R3N6, Q8VDS4, Q8VI84, Q8WTT2, Q91Y26, Q95LY5, Q96MN5, Q96P16
Diamond homologs: A6ZZW1, O44498, O75764, P10711, P20232, P23193, P36106, P52652, Q29RL9, Q2KI09, Q4KLL0, Q6FJ00, Q6ZMY3, Q9U263, A5PKE4, B0UYI1, F4J4Y5, P23881, Q148K0, Q5XIC7, Q8R2M0, Q96MN5, Q9FHK9, Q14241, Q63187, Q8CB77, O13896, O27369, O29033, P07273, P36958, P49373, Q04307, Q07271, Q2M2S7, Q56254, Q58548, Q5JF34, Q5UQS8, Q980K2
SIGNOR signaling
0 interactions.
Disease & clinical
Clinical variants and AI predictions
ClinVar
75 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 0 |
| Likely pathogenic | 0 |
| Uncertain significance | 57 |
| Likely benign | 1 |
| Benign | 0 |
Top pathogenic / likely-pathogenic (0)
SpliceAI
2446 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 1:23387267:CCTTA:C | donor_loss | 1.0000 |
| 1:23387268:CTTA:C | donor_loss | 1.0000 |
| 1:23387269:TTAC:T | donor_loss | 1.0000 |
| 1:23387270:TACCT:T | donor_loss | 1.0000 |
| 1:23387271:A:AC | donor_gain | 1.0000 |
| 1:23387271:AC:A | donor_gain | 1.0000 |
| 1:23387271:ACCTG:A | donor_loss | 1.0000 |
| 1:23387272:C:CC | donor_gain | 1.0000 |
| 1:23387272:CC:C | donor_gain | 1.0000 |
| 1:23387272:CCT:C | donor_gain | 1.0000 |
| 1:23387272:CCTG:C | donor_gain | 1.0000 |
| 1:23387272:CCTGG:C | donor_gain | 1.0000 |
| 1:23387416:TTTC:T | acceptor_gain | 1.0000 |
| 1:23397450:T:TA | donor_gain | 1.0000 |
| 1:23397459:T:TA | donor_gain | 1.0000 |
| 1:23417387:GAGT:G | acceptor_gain | 1.0000 |
| 1:23417391:C:CC | acceptor_gain | 1.0000 |
| 1:23417391:C:CG | acceptor_loss | 1.0000 |
| 1:23417392:T:G | acceptor_loss | 1.0000 |
| 1:23418010:C:CC | acceptor_gain | 1.0000 |
| 1:23424559:CCTCA:C | donor_loss | 1.0000 |
| 1:23424560:CTCA:C | donor_loss | 1.0000 |
| 1:23424561:TCAC:T | donor_loss | 1.0000 |
| 1:23424562:CACCG:C | donor_loss | 1.0000 |
| 1:23424563:A:AC | donor_gain | 1.0000 |
| 1:23424563:ACCGT:A | donor_loss | 1.0000 |
| 1:23424564:C:CC | donor_gain | 1.0000 |
| 1:23424573:T:TA | donor_gain | 1.0000 |
| 1:23381475:C:CC | acceptor_gain | 0.9900 |
| 1:23387415:ATTTC:A | acceptor_gain | 0.9900 |
AlphaMissense
2297 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 1:23384349:C:A | W345C | 1.000 |
| 1:23384349:C:G | W345C | 1.000 |
| 1:23384351:A:G | W345R | 1.000 |
| 1:23384351:A:T | W345R | 1.000 |
| 1:23384362:C:G | C341S | 1.000 |
| 1:23384363:A:G | C341R | 1.000 |
| 1:23384363:A:T | C341S | 1.000 |
| 1:23384370:G:C | C338W | 1.000 |
| 1:23384371:C:A | C338F | 1.000 |
| 1:23384371:C:G | C338S | 1.000 |
| 1:23384371:C:T | C338Y | 1.000 |
| 1:23384372:A:G | C338R | 1.000 |
| 1:23384372:A:T | C338S | 1.000 |
| 1:23384377:A:T | V336D | 1.000 |
| 1:23384379:A:C | F335L | 1.000 |
| 1:23384379:A:T | F335L | 1.000 |
| 1:23384381:A:G | F335L | 1.000 |
| 1:23384392:G:T | P331H | 1.000 |
| 1:23384398:T:A | D329V | 1.000 |
| 1:23384399:C:G | D329H | 1.000 |
| 1:23384412:C:A | Q324H | 1.000 |
| 1:23384412:C:G | Q324H | 1.000 |
| 1:23387273:C:A | Q322H | 1.000 |
| 1:23387273:C:G | Q322H | 1.000 |
| 1:23387281:A:C | Y320D | 1.000 |
| 1:23387285:G:C | C318W | 1.000 |
| 1:23387301:C:G | C313S | 1.000 |
| 1:23387302:A:T | C313S | 1.000 |
| 1:23387310:C:G | C310S | 1.000 |
| 1:23387311:A:G | C310R | 1.000 |
dbSNP variants (sampled 300 via entrez): RS1000375672 (1:23403715 G>A), RS1000421758 (1:23391935 A>C), RS1000426431 (1:23407950 T>G), RS1000579563 (1:23403062 C>A), RS1000645599 (1:23422389 G>A), RS1001088626 (1:23389845 G>A), RS1001110197 (1:23397253 A>C), RS1001161798 (1:23415858 A>G), RS1001163610 (1:23413377 C>T), RS1001207 (1:23422655 G>A), RS1001223029 (1:23407002 C>T), RS1001257711 (1:23400470 A>G), RS1001323910 (1:23412956 G>A,T), RS1001375235 (1:23419434 A>T), RS1001479559 (1:23396981 G>A)
Disease associations
OMIM: gene MIM:604128 | disease phenotypes:
GenCC curated gene-disease
Mondo (0):
Orphanet (0):
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
60 associations (top):
| Study | Trait | p-value |
|---|---|---|
| GCST002500_48 | QT interval | 1.000000e-14 |
| GCST005171_56 | QT interval | 2.000000e-07 |
| GCST005985_1 | Creatinine levels | 3.000000e-11 |
| GCST006613_151 | Triglycerides | 2.000000e-11 |
| GCST006614_90 | Total cholesterol levels | 4.000000e-08 |
| GCST007324_80 | Adventurousness | 4.000000e-09 |
| GCST007876_64 | Estimated glomerular filtration rate | 8.000000e-15 |
| GCST010204_159 | Low density lipoprotein cholesterol levels | 4.000000e-09 |
| GCST010241_81 | Apolipoprotein A1 levels | 2.000000e-13 |
| GCST010242_325 | HDL cholesterol levels | 2.000000e-13 |
| GCST010796_2023 | Electrocardiogram morphology (amplitude at temporal datapoints) | 3.000000e-08 |
| GCST010796_2024 | Electrocardiogram morphology (amplitude at temporal datapoints) | 8.000000e-11 |
| GCST010796_2025 | Electrocardiogram morphology (amplitude at temporal datapoints) | 4.000000e-10 |
| GCST010796_2076 | Electrocardiogram morphology (amplitude at temporal datapoints) | 4.000000e-16 |
| GCST010796_2077 | Electrocardiogram morphology (amplitude at temporal datapoints) | 8.000000e-16 |
| GCST010796_2078 | Electrocardiogram morphology (amplitude at temporal datapoints) | 1.000000e-15 |
| GCST010796_2079 | Electrocardiogram morphology (amplitude at temporal datapoints) | 2.000000e-15 |
| GCST010796_2080 | Electrocardiogram morphology (amplitude at temporal datapoints) | 6.000000e-15 |
| GCST010796_2081 | Electrocardiogram morphology (amplitude at temporal datapoints) | 5.000000e-14 |
| GCST010796_2082 | Electrocardiogram morphology (amplitude at temporal datapoints) | 8.000000e-13 |
| GCST010796_2083 | Electrocardiogram morphology (amplitude at temporal datapoints) | 6.000000e-13 |
| GCST010796_2084 | Electrocardiogram morphology (amplitude at temporal datapoints) | 7.000000e-13 |
| GCST010796_2085 | Electrocardiogram morphology (amplitude at temporal datapoints) | 3.000000e-12 |
| GCST010796_2086 | Electrocardiogram morphology (amplitude at temporal datapoints) | 8.000000e-12 |
| GCST010796_2087 | Electrocardiogram morphology (amplitude at temporal datapoints) | 2.000000e-11 |
| GCST010796_2088 | Electrocardiogram morphology (amplitude at temporal datapoints) | 3.000000e-10 |
| GCST010796_2089 | Electrocardiogram morphology (amplitude at temporal datapoints) | 2.000000e-09 |
| GCST010796_2090 | Electrocardiogram morphology (amplitude at temporal datapoints) | 2.000000e-09 |
| GCST010796_2091 | Electrocardiogram morphology (amplitude at temporal datapoints) | 4.000000e-09 |
| GCST010796_2092 | Electrocardiogram morphology (amplitude at temporal datapoints) | 3.000000e-18 |
EFO canonical traits (10, from GWAS)
| EFO ID | Trait name |
|---|---|
| EFO:0004682 | QT interval |
| EFO:0004530 | triglyceride measurement |
| EFO:0004574 | total cholesterol measurement |
| EFO:0008579 | risk-taking behaviour |
| EFO:0004611 | low density lipoprotein cholesterol measurement |
| EFO:0004614 | apolipoprotein A 1 measurement |
| EFO:0004612 | high density lipoprotein cholesterol measurement |
| EFO:0004327 | electrocardiography |
| EFO:0007991 | eosinophil percentage of leukocytes |
| EFO:0007788 | BMI-adjusted waist-hip ratio |
Drugs & pharmacology
Drug and pharmacology data
Is drug target: no
PharmGKB: 1 entry (VIP=true, CPIC=false)
CTD chemical–gene interactions
55 total (human), top 30 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| Estradiol | affects cotreatment, increases expression, decreases expression, affects expression | 4 |
| bisphenol A | affects expression, increases expression | 2 |
| (+)-JQ1 compound | decreases expression | 2 |
| Acetaminophen | decreases expression, increases expression | 2 |
| Arsenic | affects methylation, decreases expression, increases abundance | 2 |
| Benzo(a)pyrene | affects methylation, decreases expression, decreases methylation | 2 |
| Tetrachlorodibenzodioxin | decreases expression | 2 |
| Valproic Acid | increases expression, decreases expression | 2 |
| Cyclosporine | decreases expression | 2 |
| FR900359 | affects phosphorylation | 1 |
| propionaldehyde | increases expression | 1 |
| pirinixic acid | affects binding, decreases expression, increases activity | 1 |
| deoxynivalenol | decreases expression | 1 |
| sodium arsenate | decreases expression, increases abundance | 1 |
| tris(1,3-dichloro-2-propyl)phosphate | decreases expression | 1 |
| perfluorooctanoic acid | decreases expression | 1 |
| nickel sulfate | decreases expression | 1 |
| butylparaben | increases expression | 1 |
| S-(1,2-dichlorovinyl)cysteine | affects cotreatment, decreases expression | 1 |
| perfluorooctane sulfonic acid | decreases expression | 1 |
| perfluoro-n-nonanoic acid | decreases expression | 1 |
| entinostat | increases expression | 1 |
| K 7174 | decreases expression | 1 |
| perfluorohexanesulfonic acid | decreases expression | 1 |
| nutlin 3 | affects cotreatment, increases expression | 1 |
| ICG 001 | increases expression | 1 |
| abrine | increases expression | 1 |
| jinfukang | affects cotreatment, increases expression | 1 |
| NSC 689534 | affects binding, decreases expression | 1 |
| 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid | increases expression | 1 |
Cellosaurus cell lines
3 cell lines: 3 embryonic stem cell
First 10 cell lines (id-ordered, not curated):
| Cellosaurus | Name | Category | Sex |
|---|---|---|---|
| CVCL_A7B0 | SEES3-1V human TCEA3, clone1 | Embryonic stem cell | Male |
| CVCL_A7B1 | SEES3-1V human TCEA3, clone2 | Embryonic stem cell | Male |
| CVCL_A7B2 | SEES3-1V human TCEA3, clone3 | Embryonic stem cell | Male |
Clinical trials (associated diseases)
0 trials via MONDO — disease-level, not drug-specific.
Related Atlas pages
- Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): type 2 diabetes mellitus