TCEAL8

Summary

TCEAL8 (transcription elongation factor A like 8, HGNC:28683) is a protein-coding gene on chromosome Xq22.1, encoding Transcription elongation factor A protein-like 8 (Q8IYN2). May be involved in transcriptional regulation.

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.

Source: NCBI Gene 90843 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 17 total
• MANE Select transcript: NM_153333

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28683
Approved symbol	TCEAL8
Name	transcription elongation factor A like 8
Location	Xq22.1
Locus type	gene with protein product
Status	Approved
Aliases	MGC45400, WEX3
Ensembl gene	ENSG00000180964
Ensembl biotype	protein_coding
OMIM	301157
Entrez	90843

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 protein_coding

ENST00000360000, ENST00000372685, ENST00000451678, ENST00000866567, ENST00000866568, ENST00000866569, ENST00000866570, ENST00000866571, ENST00000918610, ENST00000918611, ENST00000918612, ENST00000918613, ENST00000918614, ENST00000918615, ENST00000918616

RefSeq mRNA: 2 — MANE Select: NM_153333 NM_001006684, NM_153333

CCDS: CCDS14504

Canonical transcript exons

ENST00000372685 — 3 exons

Exon	Start	End
ENSE00001263715	103254605	103254677
ENSE00001419203	103252995	103254017
ENSE00001815787	103255078	103255155

Expression profiles

Bgee: expression breadth ubiquitous, 252 present calls, max score 97.57.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 67.0269 / max 1706.3043, expressed in 1743 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
199981	64.1644	1738
199983	1.7746	970
199982	1.0879	751

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	97.57	gold quality
islet of Langerhans	UBERON:0000006	97.56	gold quality
corpus epididymis	UBERON:0004359	97.40	gold quality
adrenal tissue	UBERON:0018303	97.26	gold quality
smooth muscle tissue	UBERON:0001135	96.86	gold quality
gall bladder	UBERON:0002110	96.60	gold quality
cardiac muscle of right atrium	UBERON:0003379	96.39	gold quality
descending thoracic aorta	UBERON:0002345	96.30	gold quality
caput epididymis	UBERON:0004358	95.96	gold quality
left ventricle myocardium	UBERON:0006566	95.87	gold quality
stromal cell of endometrium	CL:0002255	95.81	gold quality
Brodmann (1909) area 9	UBERON:0013540	95.74	gold quality
thoracic aorta	UBERON:0001515	95.63	gold quality
ascending aorta	UBERON:0001496	95.58	gold quality
adenohypophysis	UBERON:0002196	95.58	gold quality
prefrontal cortex	UBERON:0000451	95.51	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.46	gold quality
ganglionic eminence	UBERON:0004023	95.43	gold quality
rectum	UBERON:0001052	95.38	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	95.33	gold quality
right coronary artery	UBERON:0001625	95.28	gold quality
cauda epididymis	UBERON:0004360	95.24	gold quality
anterior cingulate cortex	UBERON:0009835	95.19	gold quality
aorta	UBERON:0000947	94.97	gold quality
left coronary artery	UBERON:0001626	94.89	gold quality
ventricular zone	UBERON:0003053	94.88	gold quality
right atrium auricular region	UBERON:0006631	94.83	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	94.81	gold quality
right adrenal gland cortex	UBERON:0035827	94.74	gold quality
right adrenal gland	UBERON:0001233	94.73	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-CURD-112	no	2.59
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

85 targeting TCEAL8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489
HSA-MIR-548O-5P	99.94	71.24	3488
HSA-MIR-548W	99.94	71.24	3488
HSA-MIR-548Y	99.94	71.28	3514

Literature-anchored findings (GeneRIF, showing 1)

• Characterizes TCEAL1, another member of the human TCEAL gene family. (PMID:10051408)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tceal8	ENSMUSG00000051579
rattus_norvegicus	Tceal8	ENSRNOG00000028585

Paralogs (8): TCEAL4 (ENSG00000133142), TCEAL1 (ENSG00000172465), TCEAL7 (ENSG00000182916), TCEAL2 (ENSG00000184905), TCEAL9 (ENSG00000185222), TCEAL3 (ENSG00000196507), TCEAL5 (ENSG00000204065), TCEAL6 (ENSG00000204071)

Protein

Protein identifiers

Transcription elongation factor A protein-like 8 — Q8IYN2 (reviewed: Q8IYN2)

Alternative names: Transcription elongation factor S-II protein-like 8

All UniProt accessions (2): Q8IYN2, Q5H9L1

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the TFS-II family. TFA subfamily.

RefSeq proteins (2): NP_001006685, NP_699164* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR021156	TF_A-like/BEX	Family

Pfam: PF04538

UniProt features (5 total): compositionally biased region 2, chain 1, region of interest 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IYN2-F1	66.96	0.16

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 106 (showing top): BENPORATH_ES_WITH_H3K27ME3, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, KOYAMA_SEMA3B_TARGETS_UP, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2, AACTTT_UNKNOWN, PIT1_Q6, GTAAACC_MIR2995P, WANG_SMARCE1_TARGETS_UP, TCANNTGAY_SREBP1_01, MIKKELSEN_ES_ICP_WITH_H3K4ME3, MIKKELSEN_NPC_ICP_WITH_H3K4ME3, THILLAINADESAN_ZNF217_TARGETS_DN, chrXq22, PASINI_SUZ12_TARGETS_DN, RAO_BOUND_BY_SALL4_ISOFORM_B

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

224 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TCEAL8	TCEAL5	Q5H9L2	678
TCEAL8	BEX3	Q00994	530
TCEAL8	TCEAL3	Q969E4	521
TCEAL8	TCEAL2	Q9H3H9	490
TCEAL8	TCEAL4	Q96EI5	464
TCEAL8	BEX2	Q9BXY8	426
TCEAL8	BEX1	Q9HBH7	424
TCEAL8	TCEANC2	Q96MN5	392
TCEAL8	SPMIP5	Q8WW14	371
TCEAL8	TMEM234	Q8WY98	370
TCEAL8	RPP21	Q9H633	349
TCEAL8	TACO1	Q9BSH4	344
TCEAL8	TCEA1	P23193	336
TCEAL8	SUPT5H	O00267	316
TCEAL8	MRPL16	Q9NX20	308

IntAct

42 interactions, top by confidence:

A	B	Type	Score
KRT31	HGS	psi-mi:“MI:0914”(association)	0.780
TCEAL8	CCDC24	psi-mi:“MI:0915”(physical association)	0.560
TCEAL8	COMMD1	psi-mi:“MI:0915”(physical association)	0.560
TCEAL8	CD209	psi-mi:“MI:0915”(physical association)	0.560
GRN	TCEAL8	psi-mi:“MI:0915”(physical association)	0.560
TCEAL8	HSPB1	psi-mi:“MI:0915”(physical association)	0.560
TCEAL8	WFS1	psi-mi:“MI:0915”(physical association)	0.560
TCEAL8	YARS1	psi-mi:“MI:0915”(physical association)	0.560
KIF1B	TCEAL8	psi-mi:“MI:0915”(physical association)	0.560
RNF11	TCEAL8	psi-mi:“MI:0915”(physical association)	0.560
TCEAL8	SPRED1	psi-mi:“MI:0915”(physical association)	0.560
MAGEA4	MAGEB16	psi-mi:“MI:0914”(association)	0.530
MAGEA4	MAGEA8	psi-mi:“MI:0914”(association)	0.530
S100A2	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
S100P	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
MAGEA9	CIBAR1	psi-mi:“MI:0914”(association)	0.350

BioGRID (19): TCEAL8 (Affinity Capture-RNA), TCEAL8 (Two-hybrid), TCEAL8 (Two-hybrid), TCEAL8 (Two-hybrid), TCEAL8 (Affinity Capture-MS), TCEAL8 (Affinity Capture-MS), TCEAL8 (Affinity Capture-MS), TCEAL8 (Affinity Capture-MS), TCEAL8 (Affinity Capture-MS), TCEAL8 (Affinity Capture-MS), TCEAL8 (Affinity Capture-MS), TCEAL8 (Affinity Capture-MS), TCEAL8 (Affinity Capture-MS), TCEAL8 (Proximity Label-MS), TCEAL8 (Affinity Capture-MS)

ESM2 similar proteins: A1L429, A6NDE8, A6NER3, A6NGK3, O41801, O55777, O60829, O75459, O76087, P03204, P04611, P06937, P0CL80, P0CL81, P0CL82, P0DSO3, P0DTW1, P18804, P22421, P86478, P86479, P86480, P86481, P86496, Q13066, Q13069, Q13070, Q2T9P9, Q3KST0, Q4V321, Q4V326, Q5JRK9, Q5JUK9, Q6AY45, Q6I7R5, Q6IPX3, Q6NT46, Q7Z2X7, Q8AIH8, Q8CCT4

Diamond homologs: A1YEW9, A2D4U8, A2D5N1, A2D671, A2T6K9, Q15170, Q2KIJ9, Q3T020, Q5PPP3, Q6I7R5, Q8IYN2, Q921P9, Q9CZY2, Q9DD24, Q9UHQ7, A3KGA4, D3ZT37, Q9BRU2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

17 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	14
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

271 predictions. Top by Δscore:

Variant	Effect	Δscore
X:103255074:TAA:T	donor_loss	0.9900
X:103255075:AACCT:A	donor_loss	0.9900
X:103255076:A:AG	donor_loss	0.9900
X:103254013:TAATC:T	acceptor_gain	0.9800
X:103254018:C:CA	acceptor_loss	0.9800
X:103254018:C:CC	acceptor_gain	0.9800
X:103254019:T:A	acceptor_loss	0.9800
X:103255076:A:AC	donor_gain	0.9800
X:103255077:C:CC	donor_gain	0.9800
X:103254016:TC:T	acceptor_gain	0.9600
X:103254017:CC:C	acceptor_gain	0.9600
X:103254015:ATC:A	acceptor_gain	0.9300
X:103254676:TC:T	acceptor_gain	0.9100
X:103254677:CC:C	acceptor_gain	0.9100
X:103254015:ATCCT:A	acceptor_gain	0.8900
X:103254014:AATC:A	acceptor_gain	0.8800
X:103254676:TCCT:T	acceptor_loss	0.8400
X:103254678:C:A	acceptor_loss	0.8400
X:103254678:C:CC	acceptor_gain	0.8400
X:103254679:TG:T	acceptor_loss	0.8400
X:103254680:G:C	acceptor_loss	0.8400
X:103254685:CAGA:C	acceptor_loss	0.8400
X:103254688:A:C	acceptor_loss	0.8400
X:103254674:TATC:T	acceptor_gain	0.8300
X:103254955:T:TA	donor_gain	0.8300
X:103254600:CTGA:C	donor_loss	0.8000
X:103254601:TGACC:T	donor_loss	0.8000
X:103254602:GA:G	donor_loss	0.8000
X:103254016:TCCT:T	acceptor_gain	0.7900
X:103254597:AAACT:A	donor_loss	0.7900

AlphaMissense

780 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:103253701:T:A	R93S	0.996
X:103253701:T:G	R93S	0.996
X:103253695:C:A	K95N	0.993
X:103253695:C:G	K95N	0.993
X:103253702:C:A	R93I	0.993
X:103253692:A:C	F96L	0.992
X:103253692:A:T	F96L	0.992
X:103253694:A:G	F96L	0.992
X:103253702:C:G	R93T	0.992
X:103253674:C:A	K102N	0.986
X:103253674:C:G	K102N	0.986
X:103253693:A:G	F96S	0.986
X:103253677:C:A	W101C	0.983
X:103253677:C:G	W101C	0.983
X:103253710:T:A	R90S	0.983
X:103253710:T:G	R90S	0.983
X:103253696:T:A	K95M	0.982
X:103253697:T:C	K95E	0.982
X:103253717:T:A	E88V	0.981
X:103253718:C:T	E88K	0.977
X:103253635:A:C	F115L	0.975
X:103253635:A:T	F115L	0.975
X:103253637:A:G	F115L	0.975
X:103253679:A:G	W101R	0.973
X:103253679:A:T	W101R	0.973
X:103253693:A:C	F96C	0.973
X:103253675:T:G	K102T	0.972
X:103253697:T:G	K95Q	0.972
X:103253722:C:A	R86S	0.970
X:103253722:C:G	R86S	0.970

dbSNP variants (sampled 300 via entrez): RS1004376515 (X:103253967 A>C), RS1006805737 (X:103253577 T>A,G), RS1007443776 (X:103254380 C>G), RS1008484324 (X:103256630 TGAGA>T), RS1008944785 (X:103256597 C>A), RS1012544284 (X:103257060 C>T), RS1013047769 (X:103255786 T>G), RS1013796191 (X:103254914 T>C), RS1015022073 (X:103256640 C>A,G), RS1015359020 (X:103254464 G>A), RS1016553581 (X:103255109 C>T), RS1016850245 (X:103255821 A>G), RS1017238250 (X:103256654 A>G), RS1020407154 (X:103254479 C>T), RS1020853345 (X:103253848 C>T)

Disease associations

OMIM: gene MIM:301157 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases methylation, decreases expression, increases expression	3
Acetaminophen	decreases expression	2
Valproic Acid	affects expression, decreases expression	2
bisphenol F	affects cotreatment, increases expression	1
dicrotophos	decreases expression	1
propionaldehyde	increases expression	1
bisphenol A	affects expression	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
butyraldehyde	increases expression	1
manganese chloride	increases abundance, increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
beta-methylcholine	affects expression	1
epigallocatechin gallate	decreases expression, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
K 7174	decreases expression	1
ICG 001	decreases expression	1
abrine	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Air Pollutants	increases abundance, decreases expression	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	affects cotreatment, increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	increases expression	1
Estradiol	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.