TCF25

Summary

TCF25 (TCF25 ribosome quality control complex subunit, HGNC:29181) is a protein-coding gene on chromosome 16q24.3, encoding Ribosome quality control complex subunit TCF25 (Q9BQ70). Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.

TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).

Source: NCBI Gene 22980 — RefSeq curated summary.

At a glance

• GWAS associations: 22
• Clinical variants (ClinVar): 167 total
• MANE Select transcript: NM_014972

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29181
Approved symbol	TCF25
Name	TCF25 ribosome quality control complex subunit
Location	16q24.3
Locus type	gene with protein product
Status	Approved
Aliases	Nulp1, KIAA1049
Ensembl gene	ENSG00000141002
Ensembl biotype	protein_coding
OMIM	612326
Entrez	22980

Gene structure

Transcript identifiers

Ensembl transcripts: 44 — 29 protein_coding, 8 retained_intron, 5 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000263346, ENST00000263347, ENST00000561585, ENST00000561958, ENST00000562184, ENST00000562193, ENST00000562256, ENST00000563032, ENST00000563406, ENST00000563484, ENST00000563636, ENST00000564652, ENST00000564957, ENST00000565196, ENST00000565404, ENST00000565860, ENST00000566158, ENST00000566283, ENST00000566751, ENST00000567171, ENST00000568409, ENST00000568412, ENST00000568870, ENST00000570116, ENST00000614813, ENST00000640279, ENST00000856677, ENST00000856678, ENST00000856679, ENST00000856680, ENST00000856681, ENST00000940255, ENST00000940256, ENST00000940257, ENST00000940258, ENST00000943599, ENST00000943600, ENST00000943601, ENST00000943602, ENST00000943603, ENST00000943604, ENST00000943605, ENST00000943606, ENST00000943607

RefSeq mRNA: 1 — MANE Select: NM_014972 NM_014972

CCDS: CCDS10987

Canonical transcript exons

ENST00000263346 — 18 exons

Exon	Start	End
ENSE00000946038	89904938	89905096
ENSE00001231707	89904118	89904205
ENSE00002624794	89873592	89873859
ENSE00003483785	89895038	89895137
ENSE00003487422	89900635	89900794
ENSE00003496457	89893728	89893858
ENSE00003542327	89911080	89911379
ENSE00003544533	89885848	89885966
ENSE00003569087	89887652	89887717
ENSE00003577855	89883351	89883512
ENSE00003583927	89884582	89884656
ENSE00003621638	89898767	89898872
ENSE00003649619	89910591	89910663
ENSE00003672244	89898557	89898649
ENSE00003679001	89907243	89907322
ENSE00003682078	89906194	89906284
ENSE00003787258	89892193	89892275
ENSE00003787729	89895990	89896083

Expression profiles

Bgee: expression breadth ubiquitous, 302 present calls, max score 99.34.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 125.5268 / max 1427.9818, expressed in 1826 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155658	89.5282	1826
155657	34.9814	1819
155659	0.8373	436
155663	0.0944	27
155661	0.0354	11
155665	0.0223	7
155662	0.0198	5
155664	0.0082	3

Top tissues by expression

303 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.34	gold quality
tendon of biceps brachii	UBERON:0008188	99.32	gold quality
granulocyte	CL:0000094	98.99	gold quality
right lobe of thyroid gland	UBERON:0001119	98.99	gold quality
adenohypophysis	UBERON:0002196	98.98	gold quality
left lobe of thyroid gland	UBERON:0001120	98.92	gold quality
pituitary gland	UBERON:0000007	98.83	gold quality
right uterine tube	UBERON:0001302	98.83	gold quality
mucosa of stomach	UBERON:0001199	98.81	gold quality
right hemisphere of cerebellum	UBERON:0014890	98.74	gold quality
nipple	UBERON:0002030	98.73	gold quality
metanephros cortex	UBERON:0010533	98.73	gold quality
left ovary	UBERON:0002119	98.72	gold quality
endocervix	UBERON:0000458	98.69	gold quality
thyroid gland	UBERON:0002046	98.69	gold quality
right ovary	UBERON:0002118	98.68	gold quality
cerebellar hemisphere	UBERON:0002245	98.66	gold quality
pylorus	UBERON:0001166	98.65	gold quality
cerebellar cortex	UBERON:0002129	98.63	gold quality
left testis	UBERON:0004533	98.62	gold quality
tibial nerve	UBERON:0001323	98.61	gold quality
body of uterus	UBERON:0009853	98.52	gold quality
body of stomach	UBERON:0001161	98.51	gold quality
skin of leg	UBERON:0001511	98.51	gold quality
small intestine Peyer’s patch	UBERON:0003454	98.51	gold quality
stromal cell of endometrium	CL:0002255	98.50	gold quality
right testis	UBERON:0004534	98.49	gold quality
tendon	UBERON:0000043	98.48	gold quality
minor salivary gland	UBERON:0001830	98.48	gold quality
right adrenal gland cortex	UBERON:0035827	98.45	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-137537	yes	986.70
E-MTAB-9467	no	32.17
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

3 targeting TCF25, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-4742-5P	98.89	68.41	1542

Literature-anchored findings (GeneRIF, showing 4)

• hnulp1 may act as a novel transcriptional repressor in serum response factor signaling pathways. (PMID:16574069)
• These results indicate that Nulp1 plays a role in cell death control and may influence tumor growth. (PMID:18068114)
• Hearing ability was strongly associated with DNA methylation levels in the promoter regions of several genes, including TCF25, FGFR1, and POLE. (PMID:25184702)
• NULP1 Alleviates Cardiac Hypertrophy by Suppressing NFAT3 Transcriptional Activity. (PMID:32805187)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tcf25	ENSDARG00000040861
mus_musculus	Tcf25	ENSMUSG00000001472
rattus_norvegicus	Tcf25	ENSRNOG00000017023
drosophila_melanogaster	Nulp1	FBGN0027549
caenorhabditis_elegans	K07A12.1	WBGENE00010620

Protein

Protein identifiers

Ribosome quality control complex subunit TCF25 — Q9BQ70 (reviewed: Q9BQ70)

Alternative names: Nuclear localized protein 1, Transcription factor 25

All UniProt accessions (12): Q9BQ70, H3BMJ8, H3BPU1, H3BQ53, H3BR53, H3BRP4, H3BS87, H3BSP8, H3BSS3, H3BTU3, Q9H384, Q9H7D3

UniProt curated annotations — full annotation on UniProt →

Function. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. In the RQC complex, required to promote formation of ‘Lys-48’-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1. May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4. May play a role in cell death control.

Subunit / interactions. Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase LTN1, TCF25 and NEMF associated with the 60S ribosomal subunit. Interacts (via C-terminus) with NFATC4; the interaction leads to suppresson of NFATC4 transcription factor activity and is reduced following stimulation with angiotensin-2. Interacts with XIAP.

Subcellular location. Nucleus. Cytoplasm. Cytosol.

Tissue specificity. In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart. Repressed in cardiac tissue of patients with heart failure (at protein level). mRNA levels in the heart are unchanged in patients with heart failure.

Similarity. Belongs to the TCF25 family.

RefSeq proteins (1): NP_055787* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006994	TCF25/Rqc1	Family
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily

Pfam: PF04910

UniProt features (5 total): region of interest 2, chain 1, compositionally biased region 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BQ70-F1	72.87	0.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 602

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9954709	Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide

MSigDB gene sets: 164 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_DN, GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_DN, TGCGCANK_UNKNOWN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_1, GOBP_TRANSLATION, NIKOLSKY_BREAST_CANCER_16Q24_AMPLICON, RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4, ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBP_PROTEIN_POLYUBIQUITINATION, GOBP_TRANSLATIONAL_ELONGATION, CUI_TCF21_TARGETS_2_DN

GO Biological Process (2): regulation of protein K48-linked ubiquitination (GO:0061945), rescue of stalled cytosolic ribosome (GO:0072344)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (4): nucleus (GO:0005634), cytosol (GO:0005829), RQC complex (GO:1990112), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Ribosome-associated quality control	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
protein K48-linked ubiquitination	1
regulation of protein polyubiquitination	1
cytoplasmic translational elongation	1
ribosome disassembly	1
binding	1
intracellular membrane-bounded organelle	1
cytoplasm	1
protein-containing complex	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1223 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TCF25	NEMF	O60524	864
TCF25	LTN1	O94822	841
TCF25	ANKZF1	Q9H8Y5	754
TCF25	VCP	P55072	697
TCF25	SRF	P11831	629
TCF25	DEF8	Q6ZN54	577
TCF25	XIAP	P98170	574
TCF25	SPIRE2	Q8WWL2	572
TCF25	UFD1	Q92890	538
TCF25	HBS1L	Q9Y450	526
TCF25	ZNF598	Q86UK7	520
TCF25	NPLOC4	Q8TAT6	516
TCF25	LGALS4	P56470	495
TCF25	ZNF276	Q8N554	475
TCF25	FANCA	O15360	471

IntAct

115 interactions, top by confidence:

A	B	Type	Score
SAT1	TCF25	psi-mi:“MI:0915”(physical association)	0.910
TCF25	SAT1	psi-mi:“MI:0915”(physical association)	0.910
TCF25	GPRASP2	psi-mi:“MI:0915”(physical association)	0.900
GPRASP2	TCF25	psi-mi:“MI:0915”(physical association)	0.900
MLF1	DNAJB6	psi-mi:“MI:0914”(association)	0.750
MAGEA11	TCF25	psi-mi:“MI:0915”(physical association)	0.740
LRRK2	TCF25	psi-mi:“MI:0407”(direct interaction)	0.590
MAGEA11	TCF25	psi-mi:“MI:0915”(physical association)	0.560
KASH5	TCF25	psi-mi:“MI:0915”(physical association)	0.560
TCF25	APPBP2	psi-mi:“MI:0915”(physical association)	0.560
DERL1	TCF25	psi-mi:“MI:0915”(physical association)	0.560
TCF25	KASH5	psi-mi:“MI:0915”(physical association)	0.560
APPBP2	TCF25	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (131): TCF25 (Two-hybrid), TCF25 (Two-hybrid), TCF25 (Two-hybrid), DERL1 (Two-hybrid), GPRASP2 (Two-hybrid), CCDC155 (Two-hybrid), TCF25 (Affinity Capture-MS), TCF25 (Affinity Capture-MS), TCF25 (Affinity Capture-MS), TCF25 (Affinity Capture-MS), TCF25 (Affinity Capture-MS), TCF25 (Two-hybrid), TCF25 (Two-hybrid), SAT1 (Two-hybrid), TCF25 (Affinity Capture-MS)

ESM2 similar proteins: A0A1S4D1D3, A0A1W2PR95, A0A8I6ASZ5, A8WE67, D2K8N5, D3Z8X7, D3ZND0, E1C760, E7EXT2, F6Y9J3, F7AEX0, O08836, O60308, P27641, P54729, P78318, Q0P4W3, Q14CX7, Q15021, Q2QY04, Q2YD98, Q3ZC62, Q4V8E4, Q5EAU9, Q61249, Q68FJ0, Q6NY52, Q6PBQ2, Q6PGY6, Q6QI44, Q7ZXA8, Q80V31, Q86VS3, Q8BWZ3, Q8C6E0, Q8C9J3, Q8IYW2, Q8K2Z4, Q8LDQ4, Q8LNU5

Diamond homologs: A0A8I6ASZ5, Q8R3L2, Q9BQ70

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
TCF25	“form complex”	“RQC complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 95 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	5	57.9×	4e-06
RHO GTPases activate PKNs	5	27.4×	1e-04
SARS-CoV-1-host interactions	5	15.2×	1e-03
Signaling by BRAF and RAF1 fusions	5	14.7×	1e-03
Apoptosis	5	14.5×	1e-03
Translocation of SLC2A4 (GLUT4) to the plasma membrane	5	13.3×	1e-03
Programmed Cell Death	5	12.6×	1e-03
SARS-CoV-1 Infection	5	12.3×	1e-03

GO biological processes:

GO term	Partners	Fold	FDR
cellular response to insulin stimulus	6	12.2×	4e-03
MAPK cascade	6	10.9×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

167 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	122
Likely benign	16
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

4172 predictions. Top by Δscore:

Variant	Effect	Δscore
16:89873823:G:T	donor_gain	1.0000
16:89873856:GCTG:G	donor_gain	1.0000
16:89873858:TGGTG:T	donor_loss	1.0000
16:89873859:GGTGA:G	donor_loss	1.0000
16:89873860:G:GG	donor_gain	1.0000
16:89873860:GT:G	donor_loss	1.0000
16:89883442:G:GT	donor_gain	1.0000
16:89884578:TTAGT:T	acceptor_loss	1.0000
16:89884579:TA:T	acceptor_loss	1.0000
16:89884580:A:AG	acceptor_gain	1.0000
16:89884580:A:C	acceptor_loss	1.0000
16:89884581:G:GG	acceptor_gain	1.0000
16:89884581:GT:G	acceptor_gain	1.0000
16:89884581:GTCT:G	acceptor_gain	1.0000
16:89884581:GTCTC:G	acceptor_gain	1.0000
16:89884657:G:GG	donor_gain	1.0000
16:89884661:G:GG	donor_gain	1.0000
16:89885842:TTTTA:T	acceptor_loss	1.0000
16:89885843:TTTA:T	acceptor_loss	1.0000
16:89885844:TTAGG:T	acceptor_loss	1.0000
16:89885846:A:T	acceptor_loss	1.0000
16:89885847:G:T	acceptor_loss	1.0000
16:89885940:G:GT	donor_gain	1.0000
16:89895988:A:AG	acceptor_gain	1.0000
16:89895989:G:GG	acceptor_gain	1.0000
16:89896084:G:GC	donor_loss	1.0000
16:89896084:G:GG	donor_gain	1.0000
16:89898544:A:AG	acceptor_gain	1.0000
16:89898548:T:TA	acceptor_gain	1.0000
16:89898549:G:A	acceptor_gain	1.0000

AlphaMissense

4439 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:89896083:G:T	R341M	1.000
16:89892254:T:A	W226R	0.999
16:89892254:T:C	W226R	0.999
16:89893817:T:C	F263L	0.999
16:89893818:T:C	F263S	0.999
16:89893819:C:A	F263L	0.999
16:89893819:C:G	F263L	0.999
16:89895075:T:C	L289P	0.999
16:89895078:T:C	L290P	0.999
16:89895084:T:C	L292P	0.999
16:89895995:G:C	A312P	0.999
16:89896081:C:A	N340K	0.999
16:89896081:C:G	N340K	0.999
16:89896083:G:C	R341T	0.999
16:89898640:T:C	L369P	0.999
16:89904996:T:A	W510R	0.999
16:89904996:T:C	W510R	0.999
16:89906234:C:A	R557S	0.999
16:89887675:T:C	L191P	0.998
16:89895071:T:C	S288P	0.998
16:89895132:T:C	L308P	0.998
16:89896059:T:C	L333P	0.998
16:89898557:G:C	R341S	0.998
16:89898557:G:T	R341S	0.998
16:89906235:G:C	R557P	0.998
16:89887657:T:C	L185S	0.997
16:89887686:T:C	F195L	0.997
16:89887688:T:A	F195L	0.997
16:89887688:T:G	F195L	0.997
16:89893737:T:A	M236K	0.997

dbSNP variants (sampled 300 via entrez): RS1000002708 (16:89906280 C>G,T), RS1000041954 (16:89883916 T>C), RS1000059004 (16:89901034 T>C), RS1000073767 (16:89871986 C>G,T), RS1000223486 (16:89888326 G>A), RS1000256623 (16:89911341 C>G,T), RS1000269034 (16:89884108 A>G), RS1000308311 (16:89892591 C>A), RS1000336590 (16:89878709 C>A,G,T), RS1000366104 (16:89876002 A>G,T), RS1000453971 (16:89880031 C>T), RS1000513403 (16:89901199 G>A,C,T), RS1000570100 (16:89897962 G>A,C), RS1000634261 (16:89891550 C>A), RS1000821470 (16:89897026 C>G,T)

Disease associations

OMIM: gene MIM:612326 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

22 associations (top):

Study	Trait	p-value
GCST003996_47	Monobrow	7.000000e-14
GCST004611_213	High light scatter reticulocyte count	4.000000e-13
GCST004612_203	High light scatter reticulocyte percentage of red cells	8.000000e-12
GCST004619_9	Reticulocyte fraction of red cells	1.000000e-14
GCST004622_45	Reticulocyte count	2.000000e-16
GCST005790_41	Rosacea symptom severity	1.000000e-07
GCST006986_17	Red vs. brown/black hair color	5.000000e-25
GCST006986_2	Red vs. brown/black hair color	3.000000e-13
GCST006986_20	Red vs. brown/black hair color	3.000000e-61
GCST006986_23	Red vs. brown/black hair color	1.000000e-13
GCST006986_26	Red vs. brown/black hair color	5.000000e-10
GCST006988_153	Blond vs. brown/black hair color	7.000000e-36
GCST006988_174	Blond vs. brown/black hair color	2.000000e-33
GCST006989_45	Brown vs. black hair color	3.000000e-18
GCST006989_46	Brown vs. black hair color	1.000000e-11
GCST010102_8	White matter integrity (fractional anisotropy)	1.000000e-09
GCST010148_22	Cutaneous squamous cell carcinoma	6.000000e-87
GCST010703_280	Brain morphology (MOSTest)	2.000000e-15
GCST90002385_85	High light scatter reticulocyte count	3.000000e-27
GCST90002386_297	High light scatter reticulocyte percentage of red cells	2.000000e-24
GCST90002405_322	Reticulocyte count	2.000000e-25
GCST90002406_446	Reticulocyte fraction of red cells	2.000000e-25

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0007906	synophrys measurement
EFO:0007986	reticulocyte count
EFO:0009180	rosacea severity measurement
EFO:0003924	hair color
EFO:0004641	white matter integrity
EFO:1001927	cutaneous squamous cell carcinoma
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

54 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, increases expression, affects cotreatment	3
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	3
bisphenol F	increases methylation, decreases expression, affects cotreatment	2
Air Pollutants	increases oxidation, affects expression, affects cotreatment, increases abundance	2
Arsenic	affects cotreatment, decreases expression, increases abundance, increases expression	2
Ozone	increases oxidation, increases abundance, affects expression, affects cotreatment	2
p-Chloromercuribenzoic Acid	affects cotreatment, decreases expression	2
testosterone enanthate	affects expression	1
methylmercuric chloride	decreases expression, increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
geraniol	increases expression	1
beta-lapachone	increases expression	1
manganese chloride	decreases expression, increases abundance, affects cotreatment	1
benzo(e)pyrene	decreases methylation	1
aflatoxin B2	decreases methylation	1
nickel sulfate	increases expression	1
coumarin	decreases phosphorylation	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	increases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	affects cotreatment, decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A7D7	SEES3-1V human TCF25, clone1	Embryonic stem cell	Male
CVCL_A7D8	SEES3-1V human TCF25, clone2	Embryonic stem cell	Male
CVCL_A7D9	SEES3-1V human TCF25, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.