TCF7L1-IT1

Summary

TCF7L1-IT1 (TCF7L1 intronic transcript 1, HGNC:41388) is a long non-coding RNA gene on chromosome 2p11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41388
Approved symbol	TCF7L1-IT1
Name	TCF7L1 intronic transcript 1
Location	2p11.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231134
Ensembl biotype	lncRNA
Entrez	100874334
RNAcentral	URS0000186F20 — lncRNA, 458 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000433581

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433581 — 2 exons

Exon	Start	End
ENSE00001758163	85187186	85187253
ENSE00001786945	85186409	85186798

Expression profiles

Bgee: expression breadth broad, 99 present calls, max score 89.07.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0254 / max 5.3428, expressed in 12 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
21202	0.0254	12

Top tissues by expression

99 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.07	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	72.22	gold quality
colonic epithelium	UBERON:0000397	70.78	silver quality
calcaneal tendon	UBERON:0003701	69.75	gold quality
sural nerve	UBERON:0015488	69.75	gold quality
skeletal muscle tissue	UBERON:0001134	65.62	gold quality
tonsil	UBERON:0002372	62.45	silver quality
kidney	UBERON:0002113	62.08	gold quality
liver	UBERON:0002107	60.82	gold quality
adrenal tissue	UBERON:0018303	58.16	gold quality
stromal cell of endometrium	CL:0002255	57.36	gold quality
muscle of leg	UBERON:0001383	54.00	gold quality
prefrontal cortex	UBERON:0000451	53.96	gold quality
adrenal gland	UBERON:0002369	53.78	gold quality
stomach	UBERON:0000945	52.60	gold quality
right lobe of liver	UBERON:0001114	52.17	gold quality
corpus callosum	UBERON:0002336	52.09	gold quality
blood	UBERON:0000178	51.83	gold quality
gastrocnemius	UBERON:0001388	51.80	gold quality
uterine cervix	UBERON:0000002	51.26	silver quality
right coronary artery	UBERON:0001625	51.11	gold quality
lung	UBERON:0002048	50.61	gold quality
thoracic mammary gland	UBERON:0005200	50.57	gold quality
endometrium	UBERON:0001295	50.46	silver quality
fundus of stomach	UBERON:0001160	50.43	gold quality
urinary bladder	UBERON:0001255	49.98	silver quality
pancreas	UBERON:0001264	49.47	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	49.29	gold quality
heart left ventricle	UBERON:0002084	49.02	gold quality
heart	UBERON:0000948	48.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.98

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.