TCL6

Summary

TCL6 (T cell leukemia/lymphoma 6, HGNC:13463) is a long non-coding RNA gene on chromosome 14q32.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13463
Approved symbol	TCL6
Name	T cell leukemia/lymphoma 6
Location	14q32.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCL6e1, TNG2, TNG1, TCL6148
Ensembl gene	ENSG00000187621
Ensembl biotype	lncRNA
OMIM	604412
Entrez	27004
RNAcentral	URS0000CCE05D — lncRNA, 2388 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 18 lncRNA, 4 retained_intron

ENST00000352367, ENST00000357168, ENST00000459662, ENST00000460130, ENST00000465501, ENST00000467865, ENST00000483087, ENST00000484207, ENST00000486671, ENST00000495696, ENST00000497248, ENST00000555032, ENST00000619182, ENST00000655483, ENST00000661620, ENST00000662225, ENST00000663425, ENST00000702257, ENST00000716989, ENST00000716990, ENST00000716991, ENST00000716992

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000352367 — 6 exons

Exon	Start	End
ENSE00001514015	95679072	95679833
ENSE00003509043	95670442	95670577
ENSE00003585932	95671331	95671487
ENSE00003596011	95663256	95665076
ENSE00003616624	95669551	95669617
ENSE00003680174	95668126	95668580

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 82.79.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4044 / max 78.8019, expressed in 50 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
141298	0.2000	33
141297	0.1094	34
141295	0.0577	21
141299	0.0373	15

Top tissues by expression

268 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.79	gold quality
buccal mucosa cell	CL:0002336	80.13	silver quality
superficial temporal artery	UBERON:0001614	77.55	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.40	gold quality
nephron tubule	UBERON:0001231	77.25	gold quality
lymph node	UBERON:0000029	75.63	gold quality
placenta	UBERON:0001987	75.60	gold quality
adult mammalian kidney	UBERON:0000082	74.80	gold quality
kidney	UBERON:0002113	73.73	gold quality
kidney epithelium	UBERON:0004819	73.51	gold quality
triceps brachii	UBERON:0001509	73.36	gold quality
gluteal muscle	UBERON:0002000	73.28	gold quality
sural nerve	UBERON:0015488	72.61	gold quality
cortex of kidney	UBERON:0001225	72.30	gold quality
renal glomerulus	UBERON:0000074	71.99	gold quality
metanephric glomerulus	UBERON:0004736	71.99	gold quality
type B pancreatic cell	CL:0000169	71.77	gold quality
choroid plexus epithelium	UBERON:0003911	71.17	gold quality
granulocyte	CL:0000094	70.91	gold quality
hindlimb stylopod muscle	UBERON:0004252	70.66	gold quality
bone marrow cell	CL:0002092	70.38	silver quality
tonsil	UBERON:0002372	69.67	gold quality
bone marrow	UBERON:0002371	69.16	gold quality
cartilage tissue	UBERON:0002418	68.49	gold quality
blood	UBERON:0000178	68.28	gold quality
cervix squamous epithelium	UBERON:0006922	67.34	gold quality
gingival epithelium	UBERON:0001949	67.32	gold quality
spleen	UBERON:0002106	67.05	gold quality
orbitofrontal cortex	UBERON:0004167	66.90	gold quality
cerebellar vermis	UBERON:0004720	66.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Results show decreased TCL6 expression in clear cell renal cell carcinoma (ccRCC), associated with poor prognosis and that its overexpression in 786-O and Caki-1 ccRCC cells decreased proliferation and increased apoptosis. (PMID:27494890)
• LncRNA-TCL6 promotes early abortion and inhibits placenta implantation via the EGFR pathway (PMID:30468451)
• Overexpression of lncRNA TCL6 promotes preeclampsia progression by regulating PTEN. (PMID:31173275)
• we have identified TCL6 as a novel lncRNA strongly related to ETV6-RUNX1-positive pediatric B-ALL. We suggest that low TCL6 levels may be associated with poor disease-free survival, even within ETV6-RUNX1-positive B-ALL (PMID:31767830)
• lncRNA TCL6 correlates with immune cell infiltration and indicates worse survival in breast cancer. (PMID:31960363)
• Long noncoding RNA TCL6 binds to miR-106a-5p to regulate hepatocellular carcinoma cells through PI3K/AKT signaling pathway. (PMID:32020591)
• A lncRNA TCL6-miR-155 Interaction Regulates the Src-Akt-EMT Network to Mediate Kidney Cancer Progression and Metastasis. (PMID:33500248)
• Long non-coding RNA TCL6 induced by SCRT1 promotes proliferation and metastasis of non-small cell lung cancer through PDK1/AKT signaling. (PMID:37141697)
• Downregulation of TCL6 protected human trophoblast cells from LPS-induced inflammation and ferroptosis. (PMID:37420113)
• Association between expression levels of p53, miRNA-21, and lncRNA-TCL6 and the risk of preeclampsia in pregnant women. (PMID:37898451)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.