TDRG1

Summary

TDRG1 (testis development related 1, HGNC:43642) is a long non-coding RNA gene on chromosome 6p21.2.

Predicted to be located in cytoplasm.

Source: NCBI Gene 732253 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43642
Approved symbol	TDRG1
Name	testis development related 1
Location	6p21.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC00532, lincRNA-NR_024015
Ensembl gene	ENSG00000204091
Ensembl biotype	lncRNA
OMIM	615676
Entrez	732253
RNAcentral	URS0000E60A6F — lncRNA, 1173 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 39 — 39 lncRNA

ENST00000373170, ENST00000448433, ENST00000448559, ENST00000451810, ENST00000652779, ENST00000653048, ENST00000654292, ENST00000655318, ENST00000660693, ENST00000660989, ENST00000664585, ENST00000665433, ENST00000665631, ENST00000670828, ENST00000671430, ENST00000737788, ENST00000737789, ENST00000737790, ENST00000737791, ENST00000737792, ENST00000737793, ENST00000737794, ENST00000737795, ENST00000737796, ENST00000737797, ENST00000737798, ENST00000737799, ENST00000737800, ENST00000737801, ENST00000737802, ENST00000737803, ENST00000737804, ENST00000737805, ENST00000737806, ENST00000737807, ENST00000737808, ENST00000737809, ENST00000737810, ENST00000737811

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000373170 — 2 exons

Exon	Start	End
ENSE00001459704	40378337	40378897
ENSE00001721899	40379282	40379885

Expression profiles

Bgee: expression breadth ubiquitous, 116 present calls, max score 97.01.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4388 / max 209.7545, expressed in 61 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
67718	0.3835	54
67716	0.0289	4
67717	0.0146	4
67715	0.0117	2

Top tissues by expression

202 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	97.01	gold quality
left testis	UBERON:0004533	96.86	gold quality
testis	UBERON:0000473	94.05	gold quality
adult organism	UBERON:0007023	89.10	gold quality
sperm	CL:0000019	87.31	gold quality
ileal mucosa	UBERON:0000331	86.78	silver quality
left ventricle myocardium	UBERON:0006566	86.78	gold quality
cardiac muscle of right atrium	UBERON:0003379	86.71	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.00	gold quality
epithelial cell of pancreas	CL:0000083	83.25	gold quality
tibialis anterior	UBERON:0001385	79.65	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.45	gold quality
kidney epithelium	UBERON:0004819	77.06	gold quality
upper arm skin	UBERON:0004263	75.13	gold quality
nasal cavity epithelium	UBERON:0005384	75.02	gold quality
pancreatic ductal cell	CL:0002079	74.94	silver quality
mucosa of paranasal sinus	UBERON:0005030	73.66	gold quality
superficial temporal artery	UBERON:0001614	72.94	gold quality
myocardium	UBERON:0002349	72.65	gold quality
epithelium of nasopharynx	UBERON:0001951	72.47	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	72.26	gold quality
palpebral conjunctiva	UBERON:0001812	70.96	gold quality
vena cava	UBERON:0004087	70.19	silver quality
islet of Langerhans	UBERON:0000006	69.74	gold quality
quadriceps femoris	UBERON:0001377	69.45	gold quality
lower esophagus mucosa	UBERON:0035834	68.79	gold quality
cardia of stomach	UBERON:0001162	68.41	silver quality
endothelial cell	CL:0000115	68.19	gold quality
vastus lateralis	UBERON:0001379	68.01	gold quality
deltoid	UBERON:0001476	67.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• The significantly reduced expression of the TDRG1 protein in patients with seminoma or teratoma indicates that TDRG1 may be a candidate cancer suppressor gene. (PMID:21243750)
• TDRG1, a newly identified testis-specific gene, may play important roles in human spermatogenesis. (PMID:22123530)
• A robust association is established between the rs8506G>A polymorphism in the lincRNA-NR_024015 exon and the risk of non-cardia gastric cancer. (PMID:24595048)
• The localization of TDRG1 in human normal spermatozoa implies its potential regulatory role in sperm motility. (PMID:25749352)
• Study demonstrates that lincRNA-NR_024015 is up-regulated in esophageal squamous cell carcinoma (ESCC) tumor, especially in advanced stage. Furthermore, the G to A variant of rs8506 in lincRNA-NR_024015 may disrupt the binding of hsa-miR-526b to the gene, up regulate the expression level of lincRNA-NR_024015, promote cell proliferation, and associated with increased risk of ESCC. (PMID:27583835)
• LncRNA TDRG1 overexpression induced tumor development and RhoC expression. (PMID:28984384)
• lncRNA TDRG1 may promote endometrial carcinoma cell proliferation and invasion by positively targeting VEGF-A and modulating relative genes. (PMID:29920344)
• Testis developmental related gene 1 regulates the chemosensitivity of seminoma TCam-2 cells to cisplatin via autophagy. (PMID:31496041)
• LncRNA TDRG1 functions as an oncogene in cervical cancer through sponging miR-330-5p to modulate ELK1 expression. (PMID:31539116)
• The crucial function of TDRG1-miR-873-5p-HDGF axis in human gastric cancer. (PMID:31726370)
• LncRNA TDRG1 promotes the metastasis of NSCLC cell through regulating miR-873-5p/ZEB1 axis. (PMID:31742752)
• LncRNA TDRG1/miR-214-5p axis affects preeclampsia by modulating trophoblast cells. (PMID:31885100)
• LncRNA TDRG1 promotes the proliferation, migration, and invasion of cervical cancer cells by sponging miR-214-5p to target SOX4. (PMID:32106739)
• Testis developmental related gene 1 (TDRG1) encodes a progressive motility-associated protein in human spermatozoa. (PMID:33279973)
• Long non-coding RNA TDRG1 facilitates cell proliferation, migration and invasion in breast cancer via targeting miR-214-5p/CLIC4 axis. (PMID:33822672)
• Long Noncoding RNAs Testis Development Related Gene 1 Aggravates Transforming Growth Factor-beta1-Induced Fibrogenesis and Inflammatory Response of Cardiac Fibroblasts Via miR-605-3p/Tumor Necrosis Factor Receptor Superfamily-21 Axis. (PMID:34775426)
• The rs8506 TT Genotype in lincRNA-NR_024015 Contributes to the Risk of Sepsis in a Southern Chinese Child Population. (PMID:35910890)
• Long non-coding RNA TDRG1 aggravates lung cancer stemness by binding to Sox2 mRNA. (PMID:36444968)
• Analysis of Correlation Between LncRNA TDRG1 Expression and its Prognosis in Cervical Carcinoma Tissues. (PMID:37318688)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.