TDRKH-AS1

Summary

TDRKH-AS1 (TDRKH antisense RNA 1, HGNC:40578) is a long non-coding RNA gene on chromosome 1q21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40578
Approved symbol	TDRKH-AS1
Name	TDRKH antisense RNA 1
Location	1q21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-98D18.9
Ensembl gene	ENSG00000203288
Ensembl biotype	lncRNA
Entrez	109729141
RNAcentral	URS0000BC4629 — lncRNA, 1099 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000389897, ENST00000533481, ENST00000660232, ENST00000703074, ENST00000729139, ENST00000729140, ENST00000729141, ENST00000729142, ENST00000729143, ENST00000729144

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000389897 — 2 exons

Exon	Start	End
ENSE00001679001	151793815	151794402
ENSE00001728290	151790842	151791245

Expression profiles

Bgee: expression breadth ubiquitous, 165 present calls, max score 88.87.

FANTOM5 (CAGE): breadth broad, TPM avg 2.2447 / max 29.1327, expressed in 756 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
5248	1.2994	520
5249	0.9453	389

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	88.87	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.46	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.69	gold quality
left testis	UBERON:0004533	76.89	gold quality
right testis	UBERON:0004534	76.44	gold quality
cerebellar hemisphere	UBERON:0002245	76.43	gold quality
cerebellar cortex	UBERON:0002129	76.30	gold quality
right hemisphere of cerebellum	UBERON:0014890	76.21	gold quality
testis	UBERON:0000473	74.85	gold quality
cerebellum	UBERON:0002037	74.71	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.88	gold quality
medial globus pallidus	UBERON:0002477	72.80	gold quality
cortical plate	UBERON:0005343	70.85	gold quality
spinal cord	UBERON:0002240	70.13	gold quality
bone marrow cell	CL:0002092	69.33	silver quality
ganglionic eminence	UBERON:0004023	68.63	gold quality
sperm	CL:0000019	68.55	gold quality
ventricular zone	UBERON:0003053	68.47	gold quality
prefrontal cortex	UBERON:0000451	68.37	gold quality
oviduct epithelium	UBERON:0004804	68.03	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.25	gold quality
globus pallidus	UBERON:0001875	67.05	gold quality
calcaneal tendon	UBERON:0003701	67.03	gold quality
muscle of leg	UBERON:0001383	66.83	gold quality
granulocyte	CL:0000094	66.82	gold quality
gastrocnemius	UBERON:0001388	66.73	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	66.42	gold quality
hypothalamus	UBERON:0001898	65.68	gold quality
right frontal lobe	UBERON:0002810	65.51	gold quality
hindlimb stylopod muscle	UBERON:0004252	65.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.04

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA TDRKH-AS1 promotes breast cancer progression via the miR-134-5p/CREB1 axis. (PMID:38008726)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.