TECPR1

Summary

TECPR1 (tectonin beta-propeller repeat containing 1, HGNC:22214) is a protein-coding gene on chromosome 7q21.3, encoding Tectonin beta-propeller repeat-containing protein 1 (Q7Z6L1). Tethering factor involved in autophagy.

This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy

Source: NCBI Gene 25851 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 246 total — 2 likely-pathogenic
• MANE Select transcript: NM_015395

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:22214
Approved symbol	TECPR1
Name	tectonin beta-propeller repeat containing 1
Location	7q21.3
Locus type	gene with protein product
Status	Approved
Aliases	DKFZP434B0335, FLJ23419, FLJ90593, KIAA1358
Ensembl gene	ENSG00000205356
Ensembl biotype	protein_coding
OMIM	614781
Entrez	25851

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 14 protein_coding, 7 retained_intron, 6 protein_coding_CDS_not_defined

ENST00000415086, ENST00000420697, ENST00000423128, ENST00000447648, ENST00000462511, ENST00000463402, ENST00000463648, ENST00000471397, ENST00000472845, ENST00000474915, ENST00000476659, ENST00000479911, ENST00000479975, ENST00000483740, ENST00000485716, ENST00000488667, ENST00000490842, ENST00000871694, ENST00000871695, ENST00000871696, ENST00000871697, ENST00000962624, ENST00000962625, ENST00000962626, ENST00000962627, ENST00000962628, ENST00000962629

RefSeq mRNA: 1 — MANE Select: NM_015395 NM_015395

CCDS: CCDS47648

Canonical transcript exons

ENST00000447648 — 26 exons

Exon	Start	End
ENSE00001482527	98232827	98232972
ENSE00001482530	98233421	98233911
ENSE00001482531	98236776	98236921
ENSE00001482533	98238509	98238610
ENSE00001482537	98243467	98243592
ENSE00001482540	98245922	98246165
ENSE00001482542	98251394	98251548
ENSE00001915572	98252126	98252232
ENSE00001924942	98214624	98217503
ENSE00003472749	98222990	98223170
ENSE00003474478	98230961	98231118
ENSE00003476319	98244571	98244693
ENSE00003491809	98221661	98221753
ENSE00003501734	98225006	98225102
ENSE00003508899	98231804	98231959
ENSE00003510895	98223662	98223718
ENSE00003521800	98240851	98240951
ENSE00003524807	98229039	98229166
ENSE00003533806	98231224	98231373
ENSE00003573450	98217936	98218042
ENSE00003607537	98217692	98217811
ENSE00003609037	98241070	98241244
ENSE00003615524	98228014	98228116
ENSE00003626443	98244885	98245067
ENSE00003628635	98222386	98222521
ENSE00003642236	98224801	98224880

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 99.22.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.2129 / max 77.1087, expressed in 1767 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
85043	8.2129	1767

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	99.22	gold quality
pancreatic ductal cell	CL:0002079	97.84	gold quality
ileal mucosa	UBERON:0000331	96.49	gold quality
endothelial cell	CL:0000115	94.37	gold quality
sural nerve	UBERON:0015488	93.89	gold quality
trachea	UBERON:0003126	93.12	gold quality
granulocyte	CL:0000094	93.07	gold quality
middle temporal gyrus	UBERON:0002771	92.73	gold quality
prefrontal cortex	UBERON:0000451	92.39	gold quality
tibialis anterior	UBERON:0001385	92.24	gold quality
apex of heart	UBERON:0002098	91.32	gold quality
blood	UBERON:0000178	91.31	gold quality
vermiform appendix	UBERON:0001154	91.15	gold quality
cortical plate	UBERON:0005343	91.07	gold quality
Brodmann (1909) area 23	UBERON:0013554	90.65	gold quality
frontal cortex	UBERON:0001870	90.31	gold quality
bone marrow cell	CL:0002092	89.92	gold quality
pituitary gland	UBERON:0000007	89.72	gold quality
cardiac muscle of right atrium	UBERON:0003379	89.47	silver quality
neocortex	UBERON:0001950	89.42	gold quality
nasal cavity epithelium	UBERON:0005384	89.26	silver quality
caecum	UBERON:0001153	89.08	gold quality
entorhinal cortex	UBERON:0002728	88.89	gold quality
superior frontal gyrus	UBERON:0002661	88.79	gold quality
right frontal lobe	UBERON:0002810	88.69	gold quality
ganglionic eminence	UBERON:0004023	88.41	gold quality
parietal lobe	UBERON:0001872	88.28	gold quality
upper arm skin	UBERON:0004263	88.28	silver quality
postcentral gyrus	UBERON:0002581	88.21	gold quality
right hemisphere of cerebellum	UBERON:0014890	88.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	19.03

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

39 targeting TECPR1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-1208	99.70	68.28	1533
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-6715B-5P	99.64	69.63	1420
HSA-MIR-6132	99.60	65.83	1554
HSA-MIR-6836-5P	99.60	65.62	1538
HSA-MIR-4269	99.55	69.89	1373
HSA-MIR-3120-3P	99.54	70.28	2669
HSA-MIR-203A-3P	99.49	70.56	2806
HSA-MIR-766-3P	99.47	65.24	1811
HSA-MIR-365A-3P	99.43	70.02	836
HSA-MIR-365B-3P	99.43	70.02	836
HSA-MIR-4251	99.40	69.19	3363
HSA-MIR-128-1-5P	99.33	60.46	332
HSA-MIR-128-2-5P	99.33	60.83	311
HSA-MIR-3606-5P	99.31	69.67	1168
HSA-MIR-4667-3P	99.26	65.45	1608
HSA-MIR-4685-5P	99.25	65.99	1563
HSA-MIR-6837-5P	99.25	65.47	1632
HSA-MIR-7151-3P	99.04	69.72	2370
HSA-MIR-6761-5P	98.71	68.03	1504
HSA-MIR-374B-3P	98.63	68.24	1360

Literature-anchored findings (GeneRIF, showing 4)

• The concerted interactions among TECPR1, Atg12-Atg5, and PtdIns(3)P provide the fusion specificity between autophagosomes and lysosomes and that the assembly of this complex initiates the autophagosome maturation process. (PMID:22342342)
• TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes. (PMID:32532970)
• TECPR1 Induces Apoptosis in Non-Small Cell Lung Carcinoma via ATG5 Upregulation-Induced Autophagy Promotion. (PMID:36197771)
• TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy. (PMID:37409525)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tecpr1a	ENSDARG00000062515
danio_rerio	tecpr1b	ENSDARG00000074086
mus_musculus	Tecpr1	ENSMUSG00000066621
rattus_norvegicus	Tecpr1	ENSRNOG00000001010
drosophila_melanogaster	Pex23	FBGN0288469

Protein

Protein identifiers

Tectonin beta-propeller repeat-containing protein 1 — Q7Z6L1 (reviewed: Q7Z6L1)

All UniProt accessions (4): C9J2A1, C9JEV4, C9JUV4, Q7Z6L1

UniProt curated annotations — full annotation on UniProt →

Function. Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.

Subunit / interactions. Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex.

Subcellular location. Cytoplasmic vesicle. Autophagosome membrane. Lysosome membrane.

Domain organisation. The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns(3)P). While full-length protein is unable to bind PtdIns(3)P in vitro, it is assumed that the binding to the ATG5-ATG12 conjugate exposes the PH domain, allowing the association with PtdIns(3)P.

Similarity. Belongs to the TECPR1 family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q7Z6L1-1	1	yes
Q7Z6L1-2	2
Q7Z6L1-3	3
Q7Z6L1-4	4

RefSeq proteins (1): NP_056210* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006614	Peroxin/Ferlin	Domain
IPR006624	Beta-propeller_rpt_TECPR	Repeat
IPR010482	TECPR1-like_DysF	Domain
IPR011993	PH-like_dom_sf	Homologous_superfamily
IPR051513	Tectonin_beta-prop	Family

Pfam: PF06398, PF06462, PF19193

UniProt features (38 total): repeat 9, modified residue 7, splice variant 6, sequence conflict 6, region of interest 2, sequence variant 2, chain 1, compositionally biased region 1, helix 1, turn 1, strand 1, domain 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
4TQ1	X-RAY DIFFRACTION	1.8
8P5P	X-RAY DIFFRACTION	1.9

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z6L1-F1	79.53	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (7): 386, 388, 391, 412, 417, 938, 949

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 143 (showing top): GOBP_REGULATION_OF_AUTOPHAGY, GOCC_VACUOLAR_MEMBRANE, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_MACROAUTOPHAGY, GOBP_REGULATION_OF_CATABOLIC_PROCESS, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, HEN1_01, LIAO_METASTASIS, MYOD_Q6, NRF2_Q4, BROWN_MYELOID_CELL_DEVELOPMENT_UP, CUI_TCF21_TARGETS_2_DN, GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_DISASSEMBLY, GOCC_AUTOPHAGOSOME, GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN

GO Biological Process (4): autophagy (GO:0006914), macroautophagy (GO:0016236), autophagosome maturation (GO:0097352), regulation of autophagosome maturation (GO:1901096)

GO Molecular Function (3): phosphatidylinositol-3-phosphate binding (GO:0032266), protein binding (GO:0005515), lipid binding (GO:0008289)

GO Cellular Component (9): autophagosome membrane (GO:0000421), nucleoplasm (GO:0005654), lysosomal membrane (GO:0005765), cytoplasmic vesicle (GO:0031410), protein-containing complex (GO:0032991), cytoplasm (GO:0005737), lysosome (GO:0005764), membrane (GO:0016020), bounding membrane of organelle (GO:0098588)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
binding	2
catabolic process	1
transmembrane transport	1
process utilizing autophagic mechanism	1
autophagosome assembly	1
autophagy	1
macroautophagy	1
protein-containing complex disassembly	1
regulation of macroautophagy	1
regulation of organelle organization	1
regulation of protein-containing complex disassembly	1
autophagosome maturation	1
phosphatidylinositol phosphate binding	1
vacuolar membrane	1
autophagosome	1
nuclear lumen	1
lysosome	1
lytic vacuole membrane	1
cytoplasm	1
intracellular vesicle	1
cellular_component	1
intracellular anatomical structure	1
lytic vacuole	1
organelle membrane	1

Protein interactions and networks

STRING

1677 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TECPR1	ATG5	Q9H1Y0	992
TECPR1	ATG12	O94817	979
TECPR1	WIPI2	Q9Y4P8	977
TECPR1	WIPI1	Q5MNZ9	747
TECPR1	ATG16L1	Q676U5	724
TECPR1	PLEKHM1	Q9Y4G2	681
TECPR1	GABARAPL2	P60520	654
TECPR1	F5GZY7	F5GZY7	646
TECPR1	ATG3	Q9NT62	641
TECPR1	EPG5	Q9HCE0	589
TECPR1	CALCOCO2	Q13137	466
TECPR1	TRAPPC12	Q8WVT3	437
TECPR1	STX17	P56962	434
TECPR1	MAP1LC3C	Q9BXW4	433
TECPR1	ATG14	Q6ZNE5	418

IntAct

30 interactions, top by confidence:

A	B	Type	Score
TECPR1	ATG5	psi-mi:“MI:0915”(physical association)	0.820
ATG5	ATG12	psi-mi:“MI:0914”(association)	0.800
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
ATG3	MAP1LC3B2	psi-mi:“MI:0914”(association)	0.530
ATG3	TECPR1	psi-mi:“MI:0915”(physical association)	0.500
CFTR	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
TECPR1	H1-2	psi-mi:“MI:0915”(physical association)	0.400
TECPR1	PRPF8	psi-mi:“MI:0915”(physical association)	0.400
ATG5	IGKV1-5	psi-mi:“MI:0914”(association)	0.350
FYCO1	SEC24B	psi-mi:“MI:0914”(association)	0.350
TECPR1	PLOD3	psi-mi:“MI:0914”(association)	0.350
ATG12	GABARAP	psi-mi:“MI:0914”(association)	0.350
ATG5	PLOD2	psi-mi:“MI:0914”(association)	0.350
BECN1		psi-mi:“MI:0914”(association)	0.350
ATG12	EMC8	psi-mi:“MI:0914”(association)	0.350
CDH5	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
STXBP1	TECPR1	psi-mi:“MI:0915”(physical association)	0.000
ATG5	TECPR1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (32): TECPR1 (Co-crystal Structure), TECPR1 (Two-hybrid), TECPR1 (Reconstituted Complex), TECPR1 (Two-hybrid), ATG5 (Reconstituted Complex), TECPR1 (Proximity Label-MS), TECPR1 (Proximity Label-MS), TECPR1 (Affinity Capture-RNA), TECPR1 (Affinity Capture-MS), TECPR1 (Affinity Capture-MS), TECPR1 (Affinity Capture-MS), TECPR1 (Protein-peptide), TMEM63B (Cross-Linking-MS (XL-MS)), TECPR1 (Affinity Capture-MS), TECPR1 (Affinity Capture-MS)

ESM2 similar proteins: A1L3L1, A2RT67, A2RUS2, A3KPW7, A4IJ06, A6QNT4, D2HNY3, D3ZV31, E1BGQ2, E1C3P4, F1R7R1, O15040, O75031, P48553, P50747, Q0IHB3, Q2TBA3, Q3TLI0, Q3U0J8, Q3ZBA0, Q3ZBK7, Q496Y0, Q5F3F2, Q5M7Q1, Q5R5Y0, Q5ZJK1, Q66H91, Q69ZK0, Q69ZT1, Q6GR37, Q6NTL4, Q6VNB8, Q7TPQ3, Q7Z6L1, Q80VP0, Q8BKW4, Q8BXK4, Q8HXH0, Q8IWR0, Q8IYL2

Diamond homologs: A9JRJ2, E1BZR9, O94611, Q3ZBA0, Q5R5Y0, Q7Z6L1, Q80VP0, Q9VWB0, O44126, P36573, Q09581, Q9JL15

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 19 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Macroautophagy	5	38.5×	1e-05

GO biological processes:

GO term	Partners	Fold	FDR
autophagosome assembly	6	74.9×	3e-08

Disease & clinical

Clinical variants and AI predictions

ClinVar

246 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	2
Uncertain significance	192
Likely benign	7
Benign	4

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
916572	NM_015395.3(TECPR1):c.2617G>A (p.Asp873Asn)	Likely pathogenic
982232	NM_015395.3(TECPR1):c.2899C>T (p.Arg967Cys)	Likely pathogenic

SpliceAI

4810 predictions. Top by Δscore:

Variant	Effect	Δscore
7:98217920:C:CA	donor_gain	1.0000
7:98222379:CACT:C	donor_loss	1.0000
7:98222380:ACTC:A	donor_loss	1.0000
7:98222381:CT:C	donor_loss	1.0000
7:98222382:TCA:T	donor_loss	1.0000
7:98222383:CAC:C	donor_loss	1.0000
7:98222384:A:AC	donor_gain	1.0000
7:98222384:A:C	donor_loss	1.0000
7:98222385:C:CC	donor_gain	1.0000
7:98222385:CCGG:C	donor_gain	1.0000
7:98222517:GAGCC:G	acceptor_gain	1.0000
7:98222519:GCC:G	acceptor_gain	1.0000
7:98222520:CC:C	acceptor_gain	1.0000
7:98222520:CCC:C	acceptor_gain	1.0000
7:98222521:CC:C	acceptor_gain	1.0000
7:98222522:C:CC	acceptor_gain	1.0000
7:98222522:C:T	acceptor_gain	1.0000
7:98222983:CACT:C	donor_loss	1.0000
7:98222984:ACTC:A	donor_loss	1.0000
7:98222985:CTCA:C	donor_loss	1.0000
7:98222986:TCA:T	donor_loss	1.0000
7:98222987:CACCG:C	donor_loss	1.0000
7:98222988:A:AC	donor_gain	1.0000
7:98222989:C:CC	donor_gain	1.0000
7:98222989:C:CG	donor_loss	1.0000
7:98222989:CCG:C	donor_gain	1.0000
7:98228009:CTTA:C	donor_loss	1.0000
7:98228010:TTAC:T	donor_loss	1.0000
7:98228011:TA:T	donor_loss	1.0000
7:98228013:C:CA	donor_loss	1.0000

AlphaMissense

7619 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:98217989:A:G	W1071R	0.999
7:98217989:A:T	W1071R	0.999
7:98222512:A:G	W980R	0.999
7:98222512:A:T	W980R	0.999
7:98223679:C:A	R910S	0.999
7:98223679:C:G	R910S	0.999
7:98223680:C:G	R910T	0.999
7:98224826:A:G	W889R	0.999
7:98224826:A:T	W889R	0.999
7:98217709:A:G	W1123R	0.998
7:98217709:A:T	W1123R	0.998
7:98217987:C:A	W1071C	0.998
7:98217987:C:G	W1071C	0.998
7:98221745:A:G	W1025R	0.998
7:98221745:A:T	W1025R	0.998
7:98223142:A:G	W926R	0.998
7:98223142:A:T	W926R	0.998
7:98223676:C:A	R911S	0.998
7:98223676:C:G	R911S	0.998
7:98223680:C:A	R910M	0.998
7:98224824:C:A	W889C	0.998
7:98224824:C:G	W889C	0.998
7:98224871:A:G	W874R	0.998
7:98224871:A:T	W874R	0.998
7:98225077:A:G	W847R	0.998
7:98225077:A:T	W847R	0.998
7:98228042:A:G	W829R	0.998
7:98228042:A:T	W829R	0.998
7:98228045:G:T	R828S	0.998
7:98229105:A:G	W782R	0.998

dbSNP variants (sampled 300 via entrez): RS1000104157 (7:98245239 A>C), RS1000189366 (7:98242028 T>C), RS1000191248 (7:98230065 C>G), RS1000272864 (7:98245019 G>A), RS1000360363 (7:98215339 T>G), RS1000431052 (7:98253034 G>C), RS1000583312 (7:98247021 G>A,T), RS1000585491 (7:98219619 C>A,T), RS1000673098 (7:98234384 C>A,T), RS1000759598 (7:98253325 A>G), RS1000794856 (7:98240505 C>T), RS1000822954 (7:98233226 G>A), RS1000879074 (7:98217865 G>A), RS1000884980 (7:98229445 T>C), RS1000931003 (7:98234626 T>A)

Disease associations

OMIM: gene MIM:614781 | disease phenotypes: MIM:189960

GenCC curated gene-disease

Mondo (1): esophageal atresia/tracheoesophageal fistula (MONDO:0008586)

Orphanet (2): Esophageal atresia (Orphanet:1199), Moyamoya angiopathy (Orphanet:477768)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST008971_65	Urate levels	2.000000e-08
GCST008972_40	Urate levels	2.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C531835	Esophageal atresia with or without tracheoesophageal fistula (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
bisphenol A	decreases methylation	1
beta-lapachone	decreases expression	1
sodium arsenite	increases expression	1
aflatoxin B2	decreases methylation	1
sulphoraphene	decreases expression	1
clothianidin	decreases expression	1
abrine	decreases expression	1
Sunitinib	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	decreases expression	1
Doxorubicin	decreases expression	1
Ozone	affects expression, increases abundance	1
Smoke	decreases expression	1
Asbestos, Crocidolite	decreases expression	1
Cadmium Chloride	increases expression	1

Clinical trials (associated diseases)

5 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT03792360	PHASE1	WITHDRAWN	Adipose Derived SVF for Aero-digestive & Enterocutaneous Fistulae
NCT02033772	Not specified	COMPLETED	Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic Surgery
NCT02364843	Not specified	TERMINATED	A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 Months
NCT03455881	Not specified	UNKNOWN	Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients
NCT03730454	Not specified	ACTIVE_NOT_RECRUITING	Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair