TEF

Summary

TEF (TEF transcription factor, PAR bZIP family member, HGNC:11722) is a protein-coding gene on chromosome 22q13.2, encoding Thyrotroph embryonic factor (Q10587). Transcription factor that binds to and transactivates the TSHB promoter.

This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 7008 — RefSeq curated summary.

At a glance

• GWAS associations: 16
• Clinical variants (ClinVar): 21 total
• Transcription factor: yes — 22 downstream targets (CollecTRI)
• MANE Select transcript: NM_003216

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11722
Approved symbol	TEF
Name	TEF transcription factor, PAR bZIP family member
Location	22q13.2
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1655
Ensembl gene	ENSG00000167074
Ensembl biotype	protein_coding
OMIM	188595
Entrez	7008

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000266304, ENST00000406644, ENST00000413942, ENST00000958295

RefSeq mRNA: 2 — MANE Select: NM_003216 NM_001145398, NM_003216

CCDS: CCDS14014, CCDS46716

Canonical transcript exons

ENST00000266304 — 4 exons

Exon	Start	End
ENSE00000655754	41387351	41387668
ENSE00000655762	41394096	41394316
ENSE00001860832	41381942	41382201
ENSE00001939875	41395745	41399326

Expression profiles

Bgee: expression breadth ubiquitous, 269 present calls, max score 95.20.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.6182 / max 218.6348, expressed in 1722 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
192472	11.3004	1716
192470	1.8938	374
192467	0.1853	54
192468	0.0837	45
192469	0.0787	43
192471	0.0763	40

Top tissues by expression

298 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar hemisphere	UBERON:0002245	95.20	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.19	gold quality
cerebellar cortex	UBERON:0002129	95.11	gold quality
right frontal lobe	UBERON:0002810	93.75	gold quality
cerebellum	UBERON:0002037	93.69	gold quality
nucleus accumbens	UBERON:0001882	93.61	gold quality
lateral globus pallidus	UBERON:0002476	92.83	gold quality
parietal lobe	UBERON:0001872	92.78	gold quality
postcentral gyrus	UBERON:0002581	92.60	gold quality
parotid gland	UBERON:0001831	92.56	gold quality
lateral nuclear group of thalamus	UBERON:0002736	92.44	gold quality
caudate nucleus	UBERON:0001873	92.19	gold quality
mucosa of stomach	UBERON:0001199	91.61	gold quality
putamen	UBERON:0001874	91.53	gold quality
prefrontal cortex	UBERON:0000451	91.46	gold quality
superior frontal gyrus	UBERON:0002661	90.94	gold quality
entorhinal cortex	UBERON:0002728	90.78	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	90.50	gold quality
temporal lobe	UBERON:0001871	90.41	gold quality
inferior vagus X ganglion	UBERON:0005363	90.19	gold quality
amygdala	UBERON:0001876	90.17	gold quality
superior vestibular nucleus	UBERON:0007227	90.08	gold quality
pons	UBERON:0000988	89.98	gold quality
cingulate cortex	UBERON:0003027	89.97	gold quality
frontal cortex	UBERON:0001870	89.90	gold quality
telencephalon	UBERON:0001893	89.90	gold quality
frontal lobe	UBERON:0016525	89.87	gold quality
anterior cingulate cortex	UBERON:0009835	89.86	gold quality
ventral tegmental area	UBERON:0002691	89.81	gold quality
Brodmann (1909) area 9	UBERON:0013540	89.77	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.51
E-GEOD-98556	no	75.61
E-MTAB-7249	no	15.62

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

22 targets.

Target	Regulation
ACTA1
ADAM2
ALB	Activation
BCL2
CAD
CD74
CHRNB1
CXCL8
DBP	Unknown
EIF3K
HEXIM1
HSPA4
LMO2	Activation
MYH11
MYH13
MYH6
MYH7
MYLK
NPPB	Unknown
PER2
TNF
TSHB

JASPAR motifs

Motif	Name	Family
MA0843.1	TEF	CEBP-related
MA0843.2	TEF	CEBP-related

JASPAR matrix evidence (PMIDs): PMID:25215497

miRNA regulators (miRDB)

159 targeting TEF, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753

Literature-anchored findings (GeneRIF, showing 10)

• TEF-expressing cells accumulated in G(0)/G(1) phase without undergoing apoptosis. (PMID:15665112)
• evidence of TEF regulation through a miR-125b-mediated pathway (PMID:21347262)
• the TT genotype in Tef rs738499 is associated with sleep disturbances in Parkinson disease. (PMID:22257907)
• The polymorphism of Tef rs738499 is associated with depression symptoms in parkinson disease. (PMID:23138696)
• findings show the polymorphisms of Cry1 rs2287161 and Tef rs738499 are associated to major depressive disorder in the Chinese population (PMID:24581835)
• Resequencing three candidate genes (HOMER1, SLC6A4, and TEF) discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese. (PMID:27964944)
• TEF is downregulated in bladder cancer and correlates with poor patient survival. (PMID:30515906)
• Characterization of rearrangements in pediatric B-lymphoblastic leukemia/lymphoma by mate-pair sequencing (MPseq) identified a novel TCF3/TEF gene fusion. (PMID:31575852)
• Evaluation of ASPM and TEF Gene Expressions as Potential Biomarkers for Bladder Cancer. (PMID:32274607)
• Thyrotroph embryonic factor polymorphism predicts faster progression of Parkinson’s disease in a longitudinal study. (PMID:33834695)

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
danio_rerio	tefa	ENSDARG00000039117
danio_rerio	tefb	ENSDARG00000098103
danio_rerio		ENSDARG00000111269
mus_musculus	Tef	ENSMUSG00000022389
rattus_norvegicus	Tef	ENSRNOG00000019383
drosophila_melanogaster	Pdp1	FBGN0016694
drosophila_melanogaster	CG7786	FBGN0034096
caenorhabditis_elegans		WBGENE00011130
caenorhabditis_elegans		WBGENE00017535

Paralogs (2): DBP (ENSG00000105516), HLF (ENSG00000108924)

Protein

Protein identifiers

Thyrotroph embryonic factor — Q10587 (reviewed: Q10587)

All UniProt accessions (3): B4DIH3, Q10587, H0Y797

UniProt curated annotations — full annotation on UniProt →

Function. Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5’-[TC][AG][AG]TTA[TC][AG]-3'.

Subunit / interactions. Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP.

Subcellular location. Nucleus.

Induction. Accumulates according to a robust circadian rhythm.

Similarity. Belongs to the bZIP family. PAR subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q10587-1	1	yes
Q10587-2	2

RefSeq proteins (2): NP_001138870, NP_003207* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004827	bZIP	Domain
IPR040223	PAR_bZIP	Family
IPR046347	bZIP_sf	Homologous_superfamily

Pfam: PF07716

UniProt features (12 total): region of interest 4, compositionally biased region 2, chain 1, domain 1, sequence conflict 1, helix 1, modified residue 1, splice variant 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
4U5T	X-RAY DIFFRACTION	3.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q10587-F1	74.46	0.42

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 32

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 203 (showing top): TGCGCANK_UNKNOWN, GCANCTGNY_MYOD_Q6, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, AREB6_01, MEF2_02, AAAYRNCTG_UNKNOWN, USF_C, CAGCTG_AP4_Q5, SP1_Q2_01, JOHANSSON_BRAIN_CANCER_EARLY_VS_LATE_DN, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM6, BRN2_01, USF_01, PPAR_DR1_Q2, HIF1_Q3

GO Biological Process (4): regulation of transcription by RNA polymerase II (GO:0006357), positive regulation of transcription by RNA polymerase II (GO:0045944), rhythmic process (GO:0048511), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), double-stranded DNA binding (GO:0003690), DNA-binding transcription factor activity (GO:0003700), protein binding (GO:0005515)

GO Cellular Component (2): chromatin (GO:0000785), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	2
regulation of transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
positive regulation of DNA-templated transcription	1
biological_process	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
DNA binding	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

986 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TEF	PDXK	O00764	832
TEF	TSHB	P01222	752
TEF	BMAL1	O00327	737
TEF	NR1D1	P20393	729
TEF	PER3	P56645	713
TEF	PER2	O15055	712
TEF	CRY1	Q16526	703
TEF	NR1D2	Q14995	688
TEF	CRY2	Q49AN0	662
TEF	NPAS2	Q99743	645
TEF	CLOCK	O15516	625
TEF	CIART	Q8N365	566
TEF	SRPX2	O60687	549
TEF	TLE6	Q9H808	543
TEF	TLE2	Q04725	541

IntAct

42 interactions, top by confidence:

A	B	Type	Score
NFE2L2	TEF	psi-mi:“MI:0915”(physical association)	0.630
MRPL28	TEF	psi-mi:“MI:0915”(physical association)	0.560
TEF	MRPL28	psi-mi:“MI:0915”(physical association)	0.560
TEF	DNM2	psi-mi:“MI:0915”(physical association)	0.560
TEF		psi-mi:“MI:0915”(physical association)	0.400
rpoB	TEF	psi-mi:“MI:0915”(physical association)	0.000
TEF	nusA	psi-mi:“MI:0915”(physical association)	0.000
TEF	manB	psi-mi:“MI:0915”(physical association)	0.000
TEF	bipA	psi-mi:“MI:0915”(physical association)	0.000
TEF		psi-mi:“MI:0915”(physical association)	0.000
TEF	sasP1	psi-mi:“MI:0915”(physical association)	0.000
TEF	rpoB	psi-mi:“MI:0915”(physical association)	0.000
TEF	argS1	psi-mi:“MI:0915”(physical association)	0.000
parE	TEF	psi-mi:“MI:0915”(physical association)	0.000
TEF	nadC	psi-mi:“MI:0915”(physical association)	0.000
flaV	TEF	psi-mi:“MI:0915”(physical association)	0.000
mtfA	TEF	psi-mi:“MI:0915”(physical association)	0.000
ubiG	TEF	psi-mi:“MI:0915”(physical association)	0.000
TEF	glnG	psi-mi:“MI:0915”(physical association)	0.000
	TEF	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (7): MRPL28 (Two-hybrid), TEF (Affinity Capture-RNA), TEF (Two-hybrid), TEF (Affinity Capture-Western), TEF (FRET), TEF (Affinity Capture-MS), TEF (Affinity Capture-MS)

ESM2 similar proteins: A6ZJ71, B8NNN3, G5ECU7, G5EDE9, G5EDW7, G5EFT5, G5EGF4, H2L0N3, O02039, O17862, P22293, P22980, P27610, P30651, P34522, P40650, P41224, P45972, P46582, P48987, P97516, Q09664, Q10587, Q16534, Q18171, Q18221, Q18412, Q18909, Q20435, Q22812, Q23272, Q2UMT9, Q3BJS3, Q60ZS1, Q64709, Q66JF1, Q6CQB7, Q6FJQ9, Q6FU75, Q8BW74

Diamond homologs: A0A5F9ZHS7, O08750, P16443, P41224, P97516, Q08D88, Q10586, Q10587, Q16534, Q16649, Q32PF6, Q5FW38, Q60925, Q64709, Q66J36, Q68EL6, Q6IMZ0, Q8BW74, Q90Z72, Q92172, Q94126, Q9JLC6

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
TEF	unknown	NPPB	“transcriptional regulation”

Disease & clinical

Clinical variants and AI predictions

ClinVar

21 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	18
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

634 predictions. Top by Δscore:

Variant	Effect	Δscore
22:41387583:G:T	donor_gain	1.0000
22:41394091:TTTA:T	acceptor_loss	1.0000
22:41394092:TTAG:T	acceptor_loss	1.0000
22:41394094:A:AG	acceptor_gain	1.0000
22:41394094:A:G	acceptor_loss	1.0000
22:41394095:G:GA	acceptor_gain	1.0000
22:41394095:GA:G	acceptor_gain	1.0000
22:41394095:GAA:G	acceptor_gain	1.0000
22:41394095:GAAT:G	acceptor_gain	1.0000
22:41394095:GAATC:G	acceptor_gain	1.0000
22:41394313:GAAG:G	donor_gain	1.0000
22:41394315:AG:A	donor_loss	1.0000
22:41394316:GGTAA:G	donor_loss	1.0000
22:41394317:GTA:G	donor_loss	1.0000
22:41395740:CACA:C	acceptor_loss	1.0000
22:41395742:CA:C	acceptor_loss	1.0000
22:41395743:A:AC	acceptor_loss	1.0000
22:41395743:A:AG	acceptor_gain	1.0000
22:41395743:AG:A	acceptor_gain	1.0000
22:41395743:AGGAT:A	acceptor_gain	1.0000
22:41395744:G:GG	acceptor_gain	1.0000
22:41395744:GG:G	acceptor_gain	1.0000
22:41395744:GGA:G	acceptor_gain	1.0000
22:41395744:GGAT:G	acceptor_gain	1.0000
22:41395744:GGATG:G	acceptor_gain	1.0000
22:41395901:G:GT	donor_gain	1.0000
22:41387497:GA:G	donor_gain	0.9900
22:41387583:G:GT	donor_gain	0.9900
22:41387664:CACAG:C	donor_loss	0.9900
22:41387665:ACAGG:A	donor_loss	0.9900

AlphaMissense

1968 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:41387440:T:A	W83R	1.000
22:41387440:T:C	W83R	1.000
22:41387442:G:C	W83C	1.000
22:41387442:G:T	W83C	1.000
22:41387495:T:C	L101P	1.000
22:41387503:T:C	F104L	1.000
22:41387504:T:C	F104S	1.000
22:41387504:T:G	F104C	1.000
22:41387505:C:A	F104L	1.000
22:41387505:C:G	F104L	1.000
22:41387507:T:C	L105P	1.000
22:41394221:T:C	F201L	1.000
22:41394222:T:C	F201S	1.000
22:41394222:T:G	F201C	1.000
22:41394223:C:A	F201L	1.000
22:41394223:C:G	F201L	1.000
22:41394228:C:A	P203H	1.000
22:41394228:C:G	P203R	1.000
22:41394242:T:C	F208L	1.000
22:41394243:T:C	F208S	1.000
22:41394243:T:G	F208C	1.000
22:41394244:T:A	F208L	1.000
22:41394244:T:G	F208L	1.000
22:41394258:T:C	L213P	1.000
22:41394263:C:T	P215S	1.000
22:41394278:A:G	K220E	1.000
22:41394280:A:C	K220N	1.000
22:41394280:A:T	K220N	1.000
22:41394281:A:G	K221E	1.000
22:41394283:G:C	K221N	1.000

dbSNP variants (sampled 300 via entrez): RS1000049537 (22:41389638 T>G), RS1000124450 (22:41370210 GT>G), RS1000168429 (22:41366400 C>A,G,T), RS1000275310 (22:41370096 CTTTCT>C), RS1000343381 (22:41384157 T>A), RS1000402728 (22:41368916 C>T), RS1000452973 (22:41394023 T>C), RS1000460870 (22:41374831 G>A), RS1000524316 (22:41388331 T>C), RS1000635049 (22:41373309 A>C,G), RS1000639352 (22:41374177 G>A), RS1000748334 (22:41375137 G>A), RS1000786851 (22:41399229 G>A), RS1000820751 (22:41388402 A>C), RS1000830588 (22:41388671 A>C,G)

Disease associations

OMIM: gene MIM:188595 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

16 associations (top):

Study	Trait	p-value
GCST003043_197	Inflammatory bowel disease	3.000000e-06
GCST003044_35	Crohn’s disease	2.000000e-10
GCST004521_55	Autism spectrum disorder or schizophrenia	9.000000e-09
GCST004632_82	Lymphocyte percentage of white cells	2.000000e-09
GCST004785_25	Vitiligo	3.000000e-15
GCST005232_52	Neuroticism	3.000000e-18
GCST005531_74	Multiple sclerosis	1.000000e-06
GCST008529_37	Tea consumption	1.000000e-07
GCST010002_83	Refractive error	2.000000e-27
GCST010133_13	Lamb consumption	3.000000e-08
GCST010143_2	Meat-related diet	4.000000e-08
GCST010769_1	Asthma (time to event)	2.000000e-08
GCST011124_12	Caffeine consumption from tea	2.000000e-10
GCST90002389_490	Lymphocyte percentage of white cells	3.000000e-27
GCST90002396_93	Mean reticulocyte volume	7.000000e-11
GCST90002399_104	Neutrophil percentage of white cells	2.000000e-23

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0007993	lymphocyte percentage of leukocytes
EFO:0007660	neuroticism measurement
EFO:0010091	tea consumption measurement
EFO:0008111	diet measurement
EFO:0004918	age at diagnosis
EFO:0010701	mean reticulocyte volume
EFO:0007990	neutrophil percentage of leukocytes

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	6
Benzo(a)pyrene	decreases expression, decreases methylation	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
arsenite	increases methylation	1
sodium arsenite	increases expression	1
butyraldehyde	decreases expression	1
pentanal	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
fipronil	increases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
clothianidin	increases expression	1
nutlin 3	affects cotreatment, increases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
theaflavin-3,3’-digallate	affects expression	1
Sunitinib	increases expression	1
Vorinostat	decreases expression	1
Acetaminophen	decreases expression	1
Amiodarone	increases expression	1
Atrazine	increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Estradiol	affects cotreatment, decreases expression	1
Methotrexate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Phthalic Acids	increases methylation	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A7G1	SEES3-1V human TEF, clone1	Embryonic stem cell	Male
CVCL_A7G2	SEES3-1V human TEF, clone2	Embryonic stem cell	Male
CVCL_A7G3	SEES3-1V human TEF, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.