TEKTL1

Summary

TEKTL1 (tektin like 1, HGNC:26866) is a protein-coding gene on chromosome 19p13.12, encoding Tektin-like protein 1 (Q8IYK2). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in sperm flagellar axoneme, which is required for motile flagellum beating.

Predicted to be involved in flagellated sperm motility. Located in extracellular exosome.

Source: NCBI Gene 126402 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 72 total
• MANE Select transcript: NM_173482

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26866
Approved symbol	TEKTL1
Name	tektin like 1
Location	19p13.12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ40365
Ensembl gene	ENSG00000160994
Ensembl biotype	protein_coding
Entrez	126402

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000292574

RefSeq mRNA: 1 — MANE Select: NM_173482 NM_173482

CCDS: CCDS12322

Canonical transcript exons

ENST00000292574 — 7 exons

Exon	Start	End
ENSE00001055857	15021616	15021711
ENSE00001055858	15021353	15021519
ENSE00001055863	15010726	15011395
ENSE00001055869	15020461	15020659
ENSE00001055874	15013672	15013776
ENSE00001137559	15021806	15021919
ENSE00001237406	15022871	15023276

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 77.37.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0644 / max 63.6030, expressed in 4 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
174294	0.0644	4

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	77.37	gold quality
right testis	UBERON:0004534	77.08	gold quality
testis	UBERON:0000473	75.09	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	65.24	gold quality
vena cava	UBERON:0004087	64.05	gold quality
biceps brachii	UBERON:0001507	62.71	gold quality
heart right ventricle	UBERON:0002080	62.16	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	61.62	gold quality
adult organism	UBERON:0007023	60.47	gold quality
quadriceps femoris	UBERON:0001377	59.77	gold quality
vastus lateralis	UBERON:0001379	59.69	gold quality
nasal cavity epithelium	UBERON:0005384	59.52	gold quality
oocyte	CL:0000023	59.50	gold quality
sperm	CL:0000019	59.27	gold quality
parotid gland	UBERON:0001831	58.59	gold quality
substantia nigra pars reticulata	UBERON:0001966	55.82	gold quality
myocardium	UBERON:0002349	54.57	gold quality
tendon of biceps brachii	UBERON:0008188	54.28	gold quality
lateral globus pallidus	UBERON:0002476	54.15	gold quality
cerebellar vermis	UBERON:0004720	53.80	gold quality
Brodmann (1909) area 46	UBERON:0006483	53.77	gold quality
postcentral gyrus	UBERON:0002581	53.67	gold quality
esophagus squamous epithelium	UBERON:0006920	52.84	gold quality
deltoid	UBERON:0001476	52.78	gold quality
entorhinal cortex	UBERON:0002728	52.64	gold quality
parietal lobe	UBERON:0001872	51.32	gold quality
tibia	UBERON:0000979	49.94	gold quality
skeletal muscle tissue	UBERON:0001134	49.93	gold quality
cardia of stomach	UBERON:0001162	49.88	gold quality
mammalian vulva	UBERON:0000997	48.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.13

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting TEKTL1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-1249-5P	99.61	66.55	2049
HSA-MIR-6797-5P	99.61	66.55	2084
HSA-MIR-5571-5P	99.49	66.99	1764
HSA-MIR-4505	99.27	67.81	2678
HSA-MIR-5787	99.22	67.86	2628
HSA-MIR-1207-3P	98.99	66.22	1532
HSA-MIR-6873-5P	98.45	66.14	1417
HSA-MIR-6804-5P	98.39	65.77	1084
HSA-MIR-6515-5P	97.08	65.48	1219

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tektl1	ENSMUSG00000078442
rattus_norvegicus	Tektl1	ENSRNOG00000007375

Protein

Protein identifiers

Tektin-like protein 1 — Q8IYK2 (reviewed: Q8IYK2)

Alternative names: Coiled-coil domain-containing protein 105

All UniProt accessions (1): Q8IYK2

UniProt curated annotations — full annotation on UniProt →

Function. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in sperm flagellar axoneme, which is required for motile flagellum beating. Forms an extensive interaction network cross-linking the lumen of axonemal doublet microtubules.

Subunit / interactions. Microtubule inner protein component of sperm flagellar doublet microtubules.

Subcellular location. Cytoplasm. Cytoskeleton. Flagellum axoneme.

RefSeq proteins (1): NP_775753* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR038949	TEKTL1	Family
IPR048256	Tektin-like	Family

Pfam: PF03148

UniProt features (9 total): sequence variant 5, coiled-coil region 2, chain 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IYK2-F1	79.02	0.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 372

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 37 (showing top): GOBP_CILIUM_MOVEMENT, GOBP_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY, GOCC_CYTOPLASMIC_REGION, GOCC_MOTILE_CILIUM, GOCC_CYTOPLASMIC_MICROTUBULE, chr19p13, GOCC_CILIUM, GOCC_AXONEMAL_MICROTUBULE, GOCC_9PLUS2_MOTILE_CILIUM, GOCC_SUPRAMOLECULAR_COMPLEX, GOCC_POLYMERIC_CYTOSKELETAL_FIBER, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, GOCC_SUPRAMOLECULAR_POLYMER, MIR944, MIR5571_5P

GO Biological Process (1): flagellated sperm motility (GO:0030317)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (8): sperm flagellum (GO:0036126), extracellular exosome (GO:0070062), axonemal B tubule inner sheath (GO:0160112), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), cilium (GO:0005929), motile cilium (GO:0031514), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
cilium-dependent cell motility	1
cilium movement involved in cell motility	1
sperm motility	1
binding	1
9+2 motile cilium	1
extracellular vesicle	1
A axonemal microtubule	1
axonemal microtubule doublet inner sheath	1
intracellular anatomical structure	1
intracellular membraneless organelle	1
intraciliary transport particle	1
membrane-bounded organelle	1
plasma membrane bounded cell projection	1
cilium	1

Protein interactions and networks

STRING

3150 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TEKTL1	TEX13D	A0A0J9YY54	512
TEKTL1	SLC25A38	Q96DW6	505
TEKTL1	OR5H2	Q8NGV7	446
TEKTL1	EFCAB8	A8MWE9	439
TEKTL1	FARSB	Q9NSD9	434
TEKTL1	SYCE3	A1L190	412
TEKTL1	TEX12	Q9BXU0	411
TEKTL1	TMEM208	Q9BTX3	409
TEKTL1	OR5A2	Q8NGI9	402
TEKTL1	CENPW	Q5EE01	395
TEKTL1	CNOT10	Q9H9A5	386
TEKTL1	EFCAB5	A4FU69	384
TEKTL1	RBMXL3	Q8N7X1	383
TEKTL1	HACL2	A1L0T0	376
TEKTL1	HMGCLL1	Q8TB92	375

IntAct

8 interactions, top by confidence:

A	B	Type	Score
MAGEA11	TEKTL1	psi-mi:“MI:0915”(physical association)	0.560
MESD	TEKTL1	psi-mi:“MI:0915”(physical association)	0.560
BRAP	TEKTL1	psi-mi:“MI:0915”(physical association)	0.370
TEKTL1	MAGEA11	psi-mi:“MI:0915”(physical association)	0.000
TEKTL1	MESD	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (5): CCDC105 (Two-hybrid), CCDC105 (Affinity Capture-MS), CCDC105 (Two-hybrid), MAGEA11 (Two-hybrid), CCDC105 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0A125S9M4, A0A287B8J2, A4H3Z2, A4HS78, A8B1U4, A8B296, A8BE61, A8BGV3, A8HQ54, A8IQT2, A8IUG5, A8J0N6, A8J8F6, A8JF70, A8WUP2, B4M3W0, C9ZN16, F4HXZ1, G5EGS3, O08788, O10339, O45935, O97209, P28023, P46870, Q09350, Q0P426, Q14203, Q26648, Q2YDN4, Q382V9, Q386N1, Q4E409, Q4V7B5, Q57ZB2, Q585H6, Q5Z6N9, Q60YN5, Q68RJ5, Q6C0L6

Diamond homologs: Q2YDN4, Q4V7B5, Q8IYK2, Q9D4K7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	71
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

994 predictions. Top by Δscore:

Variant	Effect	Δscore
19:15020455:A:AG	acceptor_gain	1.0000
19:15020456:CCCA:C	acceptor_loss	1.0000
19:15020457:CCA:C	acceptor_loss	1.0000
19:15020459:A:AG	acceptor_gain	1.0000
19:15020459:A:C	acceptor_loss	1.0000
19:15020460:G:GC	acceptor_gain	1.0000
19:15020460:GA:G	acceptor_gain	1.0000
19:15020460:GAC:G	acceptor_gain	1.0000
19:15020460:GACC:G	acceptor_gain	1.0000
19:15020460:GACCC:G	acceptor_gain	1.0000
19:15021350:CAGC:C	acceptor_loss	1.0000
19:15021351:A:AG	acceptor_gain	1.0000
19:15021351:AGC:A	acceptor_gain	1.0000
19:15021351:AGCG:A	acceptor_loss	1.0000
19:15021352:G:GA	acceptor_gain	1.0000
19:15021352:GC:G	acceptor_gain	1.0000
19:15021352:GCG:G	acceptor_gain	1.0000
19:15021352:GCGT:G	acceptor_gain	1.0000
19:15021516:GAAG:G	donor_gain	1.0000
19:15021518:AGGT:A	donor_loss	1.0000
19:15021519:GGTG:G	donor_loss	1.0000
19:15021520:G:GG	donor_gain	1.0000
19:15021520:GT:G	donor_loss	1.0000
19:15021607:T:TA	acceptor_gain	1.0000
19:15021708:CAAG:C	donor_loss	1.0000
19:15021709:AAG:A	donor_loss	1.0000
19:15021712:GT:G	donor_loss	1.0000
19:15021801:ACCAG:A	acceptor_gain	1.0000
19:15021804:A:AG	acceptor_gain	1.0000
19:15021804:AG:A	acceptor_gain	1.0000

AlphaMissense

3242 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:15011357:A:C	S178R	0.990
19:15011359:C:A	S178R	0.990
19:15011359:C:G	S178R	0.990
19:15011042:T:C	F73L	0.983
19:15011044:C:A	F73L	0.983
19:15011044:C:G	F73L	0.983
19:15011350:C:A	N175K	0.972
19:15011350:C:G	N175K	0.972
19:15013718:T:C	L206P	0.971
19:15013706:A:T	E202V	0.967
19:15011036:T:A	W71R	0.960
19:15011036:T:C	W71R	0.960
19:15013707:G:C	E202D	0.960
19:15013707:G:T	E202D	0.960
19:15011331:G:C	R169P	0.959
19:15022969:G:C	K450N	0.959
19:15022969:G:T	K450N	0.959
19:15013731:G:C	K210N	0.957
19:15013731:G:T	K210N	0.957
19:15011380:G:C	R185S	0.953
19:15011380:G:T	R185S	0.953
19:15011043:T:C	F73S	0.949
19:15021806:G:C	G380R	0.949
19:15023009:C:A	R464S	0.947
19:15010888:G:C	W21C	0.945
19:15010888:G:T	W21C	0.945
19:15011298:G:C	R158P	0.940
19:15021495:G:C	K339N	0.938
19:15021495:G:T	K339N	0.938
19:15010964:T:A	W47R	0.937

dbSNP variants (sampled 300 via entrez): RS1000004150 (19:15019376 C>A,T), RS1000638832 (19:15009643 T>C), RS1000751994 (19:15009802 G>A), RS1000968923 (19:15016949 G>A,C), RS1001011014 (19:15020940 C>A), RS1001024610 (19:15017262 T>C,G), RS1001026614 (19:15015441 C>G,T), RS1001028527 (19:15021110 A>C), RS1001110376 (19:15021126 C>G), RS1001318567 (19:15022423 G>A), RS1001592295 (19:15015852 T>C), RS1001934324 (19:15009310 T>A), RS1002193448 (19:15017342 T>C), RS1002305207 (19:15011813 A>C), RS1002512535 (19:15017668 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation, increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.