TEPSIN

Summary

TEPSIN (TEPSIN adaptor related protein complex 4 accessory protein, HGNC:26458) is a protein-coding gene on chromosome 17q25.3, encoding AP-4 complex accessory subunit Tepsin (Q96N21). Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. It is a selective cancer dependency (DepMap: 10.0% of cell lines).

Located in coated vesicle membrane and trans-Golgi network membrane.

Source: NCBI Gene 146705 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 24 total
• Cancer dependency (DepMap): dependent in 10.0% of screened cell lines
• MANE Select transcript: NM_001363764

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26458
Approved symbol	TEPSIN
Name	TEPSIN adaptor related protein complex 4 accessory protein
Location	17q25.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ31528
Ensembl gene	ENSG00000167302
Ensembl biotype	protein_coding
Entrez	146705

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 8 protein_coding, 5 retained_intron, 3 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined

ENST00000300714, ENST00000570854, ENST00000571094, ENST00000571115, ENST00000571601, ENST00000572050, ENST00000573295, ENST00000574517, ENST00000574944, ENST00000575891, ENST00000575961, ENST00000576090, ENST00000637944, ENST00000883794, ENST00000883795, ENST00000883796, ENST00000918162, ENST00000918165

RefSeq mRNA: 2 — MANE Select: NM_001363764 NM_001363764, NM_144679

CCDS: CCDS11779, CCDS86648

Canonical transcript exons

ENST00000637944 — 13 exons

Exon	Start	End
ENSE00003461269	81231847	81232021
ENSE00003484143	81231578	81231691
ENSE00003485422	81236980	81237071
ENSE00003487992	81230544	81230678
ENSE00003534151	81231398	81231476
ENSE00003542883	81233638	81233716
ENSE00003546467	81233432	81233503
ENSE00003618994	81236708	81236801
ENSE00003621272	81237387	81237459
ENSE00003633404	81233981	81234048
ENSE00003794828	81232315	81232518
ENSE00003795218	81238986	81239055
ENSE00003919580	81228277	81229476

Expression profiles

Bgee: expression breadth ubiquitous, 204 present calls, max score 96.78.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.0090 / max 70.9613, expressed in 1757 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
168677	6.8168	1754
168678	0.1923	55

Top tissues by expression

234 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	96.78	gold quality
metanephros cortex	UBERON:0010533	93.90	gold quality
small intestine Peyer’s patch	UBERON:0003454	93.46	gold quality
spleen	UBERON:0002106	93.41	gold quality
right lobe of thyroid gland	UBERON:0001119	93.26	gold quality
left lobe of thyroid gland	UBERON:0001120	92.75	gold quality
body of stomach	UBERON:0001161	92.52	gold quality
transverse colon	UBERON:0001157	91.57	gold quality
minor salivary gland	UBERON:0001830	91.38	gold quality
small intestine	UBERON:0002108	91.22	gold quality
apex of heart	UBERON:0002098	91.09	gold quality
thyroid gland	UBERON:0002046	91.06	gold quality
mucosa of transverse colon	UBERON:0004991	91.05	gold quality
body of pancreas	UBERON:0001150	90.94	gold quality
skin of leg	UBERON:0001511	90.84	gold quality
right lobe of liver	UBERON:0001114	90.80	gold quality
lower esophagus muscularis layer	UBERON:0035833	90.80	gold quality
lower esophagus	UBERON:0013473	90.79	gold quality
skin of abdomen	UBERON:0001416	90.78	gold quality
muscle layer of sigmoid colon	UBERON:0035805	90.72	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	90.70	gold quality
body of uterus	UBERON:0009853	90.58	gold quality
right adrenal gland cortex	UBERON:0035827	90.17	gold quality
left uterine tube	UBERON:0001303	90.09	gold quality
right adrenal gland	UBERON:0001233	90.08	gold quality
lower esophagus mucosa	UBERON:0035834	89.92	gold quality
pancreatic ductal cell	CL:0002079	89.82	silver quality
tibial nerve	UBERON:0001323	89.81	gold quality
descending thoracic aorta	UBERON:0002345	89.67	gold quality
right coronary artery	UBERON:0001625	89.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.46

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

47 targeting TEPSIN, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4500	99.99	72.72	2367
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-3934-3P	99.76	65.51	1351
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-4255	99.72	67.70	1541
HSA-MIR-646	99.68	67.84	1645
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-4251	99.40	69.19	3363

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 10.0% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 1)

• The bivalency of the interactions contributes to a higher avidity of tepsin for AP-4. (PMID:26542808)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tepsin	ENSDARG00000071406
mus_musculus	Tepsin	ENSMUSG00000025377
rattus_norvegicus	Tepsin	ENSRNOG00000028161

Protein

Protein identifiers

AP-4 complex accessory subunit Tepsin — Q96N21 (reviewed: Q96N21)

Alternative names: ENTH domain-containing protein 2, Epsin for AP-4, Tetra-epsin

All UniProt accessions (6): A0A1B0GV70, Q96N21, I3L3N1, I3L3R3, I3L4J0, I3L4S7

UniProt curated annotations — full annotation on UniProt →

Function. Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.

Subunit / interactions. Interacts with AP4B1 and AP4E1; the interaction is direct and mediates the association of TEPSIN with the adapter-like complex 4 (AP-4), a heterotetramer composed of AP4B1, AP4E1, AP4M1 and AP4S1.

Subcellular location. Golgi apparatus. trans-Golgi network membrane. Cytoplasmic vesicle. Cytoplasm. Cytosol.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96N21-1	1	yes
Q96N21-2	2

RefSeq proteins (2): NP_001350693, NP_653280 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008942	ENTH_VHS	Homologous_superfamily
IPR013809	ENTH	Domain
IPR035802	ENTH/VHS_tepsin	Domain
IPR039273	TEPSIN	Family
IPR058028	Tepsin_VHS/ENTH-like	Domain

Pfam: PF01417, PF25827

UniProt features (53 total): mutagenesis site 28, helix 7, region of interest 5, compositionally biased region 4, modified residue 2, splice variant 2, chain 1, domain 1, strand 1, turn 1, sequence conflict 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
5WFB	X-RAY DIFFRACTION	1.38
5WF9	X-RAY DIFFRACTION	1.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96N21-F1	68.96	0.46

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 333, 356

Mutagenesis-validated functional residues (28):

Position	Phenotype
467	no effect on interaction with ap4b1 in vitro.
468	no effect on interaction with ap4b1 in vitro.
469	no effect on interaction with ap4b1 in vitro.
470	loss of interaction with ap4b1 n vitro.
470	loss of interaction with ap4b1 in vitro; when associated with s-471.
471	loss of interaction with ap4b1 in vitro.
471	loss of interaction with ap4b1 in vitro; when associated with s-470.
472	no effect on interaction with ap4b1 in vitro.
473	no effect on interaction with ap4b1 in vitro.
473	loss of interaction with ap4b1 in vitro; when associated with q-474.
474	decreased interaction with ap4b1 in vitro.
474	decreased interaction with ap4b1 in vitro; when associated with a-476.
474	loss of interaction with ap4b1 in vitro; when associated with i-473.
475	no effect on interaction with ap4b1 in vitro.
476	no effect on interaction with ap4b1 in vitro. decreased interaction with ap4b1; when associated with d-474.
476	decreased interaction with ap4b1 in vitro; when associated with s-477.
477	no effect on interaction with ap4b1 in vitro.
477	decreased interaction with ap4b1 in vitro; when associated with s-476.
516	no effect on interaction with ap4e1 in vitro.
517	no effect on interaction with ap4e1 in vitro.
518	loss of interaction with ap4e1 in vitro.
519	loss of interaction with ap4e1 in vitro.
520	loss of interaction with ap4e1 in vitro.
521	no effect on interaction with ap4e1 in vitro.
522	loss of interaction with ap4e1 in vitro.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 77 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_UP, RNGTGGGC_UNKNOWN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOCC_TRANS_GOLGI_NETWORK, GOCC_COATED_VESICLE, NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON, GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN, GOCC_TRANS_GOLGI_NETWORK_MEMBRANE, GOCC_ORGANELLE_SUBCOMPARTMENT, AAGWWRNYGGC_UNKNOWN, GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN, BRUINS_UVC_RESPONSE_MIDDLE, FEVR_CTNNB1_TARGETS_UP, GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING

GO Biological Process (0):

GO Molecular Function (2): protein-containing complex binding (GO:0044877), protein binding (GO:0005515)

GO Cellular Component (8): cytoplasm (GO:0005737), cytosol (GO:0005829), coated vesicle membrane (GO:0030662), organelle membrane (GO:0031090), trans-Golgi network membrane (GO:0032588), Golgi apparatus (GO:0005794), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
cytoplasm	3
binding	2
intracellular anatomical structure	1
coated vesicle	1
cytoplasmic vesicle membrane	1
bounding membrane of organelle	1
membrane	1
membrane-bounded organelle	1
trans-Golgi network	1
organelle membrane	1
endomembrane system	1
intracellular membrane-bounded organelle	1
intracellular vesicle	1

Protein interactions and networks

STRING

730 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TEPSIN	AP4E1	Q9UPM8	667
TEPSIN	AP4B1	Q9Y6B7	655
TEPSIN	AP4S1	Q9Y587	635
TEPSIN	LRRC73	Q5JTD7	626
TEPSIN	ANKRD13D	Q6ZTN6	626
TEPSIN	AP4M1	O00189	585
TEPSIN	VSIG10	Q8N0Z9	532
TEPSIN	TMEM87A	Q8NBN3	509
TEPSIN	RUSC2	Q8N2Y8	509
TEPSIN	POLR3H	Q9Y535	468
TEPSIN	GPAA1	O43292	462
TEPSIN	ZCCHC8	Q6NZY4	460
TEPSIN	CLINT1	Q14677	448
TEPSIN	CCDC170	Q8IYT3	445
TEPSIN	NWD2	Q9ULI1	430

IntAct

390 interactions, top by confidence:

A	B	Type	Score
DUSP29	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
DZIP1L	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
EIF1AD	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
TEPSIN	ZNF343	psi-mi:“MI:0915”(physical association)	0.560
FAM90A1	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
IL16	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
NEK6	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
NME7	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
TCEA2	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
UBASH3B	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
SORBS2	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
ZIC1	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
CLCNKA	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
CNTF	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
BCL2L15	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
ASAP3	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
CSNK2A1	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
TFAP2D	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
DUSP4	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
AATK	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
CDC23	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
LSM3	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
GRIPAP1	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
LGALS14	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
MED18	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
TRIM68	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
HSPB7	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
LENG1	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
NTAQ1	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560
KHNYN	TEPSIN	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (183): ENTHD2 (Affinity Capture-MS), HNRNPC (Affinity Capture-MS), HSPA5 (Affinity Capture-MS), IMPDH2 (Affinity Capture-MS), TNPO1 (Affinity Capture-MS), LAMA2 (Affinity Capture-MS), RPL10 (Affinity Capture-MS), TNFAIP1 (Affinity Capture-MS), RBM10 (Affinity Capture-MS), BAP1 (Affinity Capture-MS), SLC25A11 (Affinity Capture-MS), AP4M1 (Affinity Capture-MS), SCAMP3 (Affinity Capture-MS), SF3A1 (Affinity Capture-MS), YME1L1 (Affinity Capture-MS)

ESM2 similar proteins: A0JNJ4, A1L443, A2APT9, A2IDD5, A6NDY0, A6NNL0, A7E321, B0BNE4, B1AL46, B1ASB6, E9PGG2, F5GYI3, G3V8Y7, O88286, Q14684, Q28165, Q3TYG6, Q3TYX8, Q3U3N6, Q49AM3, Q4V8C9, Q5R866, Q5RCJ6, Q5T7N3, Q5VT03, Q5VTJ3, Q5VZR2, Q5XFR0, Q60465, Q6ZMY3, Q6ZNE9, Q6ZUT6, Q6ZUX3, Q80VJ8, Q80VR2, Q86U42, Q8BSI6, Q8CCS6, Q8IVF1, Q8IY92

Diamond homologs: G3V8Y7, Q3U3N6, Q4V832, Q96N21, Q9C5H4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

24 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	8
Likely benign	6
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

2215 predictions. Top by Δscore:

Variant	Effect	Δscore
17:81230674:GCCCT:G	acceptor_gain	1.0000
17:81230675:CCCT:C	acceptor_gain	1.0000
17:81230675:CCCTC:C	acceptor_gain	1.0000
17:81230676:CCTC:C	acceptor_gain	1.0000
17:81230677:CT:C	acceptor_gain	1.0000
17:81230677:CTCTG:C	acceptor_loss	1.0000
17:81230678:TCTG:T	acceptor_loss	1.0000
17:81230679:C:CC	acceptor_gain	1.0000
17:81230679:CTGCG:C	acceptor_loss	1.0000
17:81230680:T:C	acceptor_loss	1.0000
17:81231392:GCTCA:G	donor_loss	1.0000
17:81231393:CTCA:C	donor_loss	1.0000
17:81231394:TCA:T	donor_loss	1.0000
17:81231395:CA:C	donor_loss	1.0000
17:81231396:A:AC	donor_gain	1.0000
17:81231397:C:CC	donor_gain	1.0000
17:81231397:CCAG:C	donor_gain	1.0000
17:81231473:ACACC:A	acceptor_loss	1.0000
17:81231475:ACCTG:A	acceptor_loss	1.0000
17:81231477:CTGC:C	acceptor_loss	1.0000
17:81231478:T:A	acceptor_loss	1.0000
17:81231574:TCAC:T	donor_loss	1.0000
17:81231575:CA:C	donor_loss	1.0000
17:81231576:A:AC	donor_gain	1.0000
17:81231577:C:A	donor_loss	1.0000
17:81231577:C:CT	donor_gain	1.0000
17:81231577:CG:C	donor_gain	1.0000
17:81231577:CGCT:C	donor_gain	1.0000
17:81231577:CGCTT:C	donor_gain	1.0000
17:81231687:CGACC:C	acceptor_gain	1.0000

AlphaMissense

3808 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:81236797:A:G	L73P	0.995
17:81237023:A:G	L57P	0.995
17:81236980:C:A	K71N	0.994
17:81236980:C:G	K71N	0.994
17:81237035:A:G	L53P	0.994
17:81237441:C:G	G23R	0.994
17:81237441:C:T	G23R	0.994
17:81231587:A:G	F269S	0.993
17:81233997:A:T	V120D	0.993
17:81236788:A:G	L76P	0.992
17:81233986:C:G	A124P	0.991
17:81237441:C:A	G23W	0.991
17:81230553:C:A	K340N	0.990
17:81230553:C:G	K340N	0.990
17:81234018:C:A	G113V	0.990
17:81237417:A:G	C31R	0.990
17:81234018:C:T	G113E	0.989
17:81237449:A:T	L20H	0.989
17:81230677:C:A	R299M	0.988
17:81233985:G:T	A124E	0.988
17:81233989:C:G	A123P	0.988
17:81230552:C:G	A341P	0.987
17:81233994:C:G	R121P	0.987
17:81234019:C:A	G113W	0.987
17:81236743:A:G	L91P	0.987
17:81237415:A:C	C31W	0.987
17:81237440:C:T	G23E	0.987
17:81230676:C:A	R299S	0.986
17:81230676:C:G	R299S	0.986
17:81231613:G:C	F260L	0.986

dbSNP variants (sampled 300 via entrez): RS1000044596 (17:81235321 G>A,T), RS1000104182 (17:81235222 A>G), RS1000200703 (17:81239782 C>G,T), RS1000688124 (17:81238509 C>A,T), RS1001065340 (17:81230213 T>C), RS1001136864 (17:81230025 A>C,G), RS1001175024 (17:81227959 G>A,T), RS1001875768 (17:81234704 G>A), RS1001987458 (17:81239366 G>A), RS1002442907 (17:81239216 A>G,T), RS1002564426 (17:81240738 T>TA), RS1002804031 (17:81241008 G>C,T), RS1003353817 (17:81236594 C>A,T), RS1003479684 (17:81227966 A>G), RS1003616531 (17:81232625 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST002960_1	Frontotemporal dementia	1.000000e-07
GCST002960_6	Frontotemporal dementia	7.000000e-06
GCST002960_7	Frontotemporal dementia	8.000000e-07
GCST002960_8	Frontotemporal dementia	4.000000e-06
GCST009860_8	IgG N-glycosylation phenotypes (multivariate analysis)	1.000000e-15

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005193	serum IgG glycosylation measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	increases expression, affects expression, increases abundance	2
Smoke	decreases expression, increases abundance, increases expression	2
Valproic Acid	affects expression, increases methylation	2
aristolochic acid I	increases expression	1
FR900359	decreases phosphorylation	1
alpha phellandrene	decreases expression	1
triphenyl phosphate	affects expression	1
2,5,2’,5’-tetrachlorobiphenyl	decreases expression	1
sodium arsenite	increases expression	1
ferrous chloride	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
abrine	increases expression	1
Vorinostat	decreases expression	1
Caffeine	decreases phosphorylation	1
Drugs, Chinese Herbal	increases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Methyl Methanesulfonate	increases expression	1
Naphthoquinones	increases expression	1
Ozone	affects expression, increases abundance	1
Tobacco Smoke Pollution	decreases expression	1
Triclosan	increases expression	1
Antirheumatic Agents	decreases expression	1
Vitamin K 3	affects expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SM06	HAP1 ENTHD2 (-) 1	Cancer cell line	Male
CVCL_SM07	HAP1 ENTHD2 (-) 2	Cancer cell line	Male
CVCL_SM08	HAP1 ENTHD2 (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.