TERB1

Summary

TERB1 (telomere repeat binding bouquet formation protein 1, HGNC:26675) is a protein-coding gene on chromosome 16q22.1, encoding Telomere repeats-binding bouquet formation protein 1 (Q8NA31). Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis.

Predicted to be involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Predicted to act upstream of or within double-strand break repair involved in meiotic recombination. Predicted to be located in nuclear inner membrane and shelterin complex. Implicated in spermatogenic failure 60.

Source: NCBI Gene 283847 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 21 total — 5 pathogenic
• Phenotypes (HPO): 11
• Druggable target: yes
• MANE Select transcript: NM_001136505

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26675
Approved symbol	TERB1
Name	telomere repeat binding bouquet formation protein 1
Location	16q22.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ35894
Ensembl gene	ENSG00000249961
Ensembl biotype	protein_coding
OMIM	617332
Entrez	283847

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 5 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000313294, ENST00000433154, ENST00000558713, ENST00000559050, ENST00000559403, ENST00000561333, ENST00000673664

RefSeq mRNA: 1 — MANE Select: NM_001136505 NM_001136505

Canonical transcript exons

ENST00000433154 — 19 exons

Exon	Start	End
ENSE00002230803	66768104	66768168
ENSE00002556411	66801468	66801584
ENSE00002606553	66800977	66801053
ENSE00003480985	66788169	66788297
ENSE00003495236	66777203	66777334
ENSE00003496530	66759141	66759290
ENSE00003523020	66767415	66767510
ENSE00003544702	66796768	66796830
ENSE00003562552	66772589	66772749
ENSE00003573930	66785786	66785908
ENSE00003589222	66778863	66779015
ENSE00003607903	66775118	66775243
ENSE00003631178	66786014	66786129
ENSE00003635446	66790909	66791019
ENSE00003649513	66769963	66770309
ENSE00003656794	66790595	66790723
ENSE00003674370	66758773	66758838
ENSE00003690840	66786225	66786285
ENSE00003896586	66754640	66755163

Expression profiles

Bgee: expression breadth ubiquitous, 141 present calls, max score 84.52.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0199 / max 19.3967, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
157718	0.0199	3

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.52	gold quality
right testis	UBERON:0004534	81.15	gold quality
left testis	UBERON:0004533	80.36	gold quality
testis	UBERON:0000473	78.83	gold quality
secondary oocyte	CL:0000655	75.54	silver quality
sperm	CL:0000019	72.66	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	72.14	gold quality
calcaneal tendon	UBERON:0003701	57.05	gold quality
ectocervix	UBERON:0012249	52.25	gold quality
lower esophagus mucosa	UBERON:0035834	52.07	gold quality
adult organism	UBERON:0007023	51.38	gold quality
tendon	UBERON:0000043	50.63	gold quality
stromal cell of endometrium	CL:0002255	49.70	silver quality
ventricular zone	UBERON:0003053	49.08	gold quality
buccal mucosa cell	CL:0002336	48.87	silver quality
descending thoracic aorta	UBERON:0002345	47.88	gold quality
subcutaneous adipose tissue	UBERON:0002190	47.13	gold quality
tibial nerve	UBERON:0001323	46.16	gold quality
right lobe of liver	UBERON:0001114	44.89	silver quality
cerebellar cortex	UBERON:0002129	44.71	silver quality
cerebellar hemisphere	UBERON:0002245	44.69	silver quality
right adrenal gland cortex	UBERON:0035827	44.68	gold quality
uterine cervix	UBERON:0000002	44.48	gold quality
right adrenal gland	UBERON:0001233	44.47	gold quality
popliteal artery	UBERON:0002250	44.42	gold quality
tibial artery	UBERON:0007610	44.33	gold quality
cerebellum	UBERON:0002037	44.27	silver quality
skin of leg	UBERON:0001511	44.22	gold quality
skin of abdomen	UBERON:0001416	44.17	gold quality
metanephros cortex	UBERON:0010533	44.17	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.70
E-MTAB-5061	no	1.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• complementary structured illumination microscopy studies and biochemical findings reveal a telomere attachment mechanism in which MAJIN-TERB2-TERB1 recruits telomere-bound TRF1, which is then displaced during pachytene, allowing MAJIN-TERB2-TERB1 to bind telomeric DNA and form a mature attachment plate. (PMID:30559341)
• The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope (PMID:30718482)
• Disruption of human meiotic telomere complex genes TERB1, TERB2 and MAJIN in men with non-obstructive azoospermia. (PMID:33211200)
• A report of two homozygous TERB1 protein-truncating variants in two unrelated women with primary infertility. (PMID:38277113)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	terb1	ENSDARG00000058587
mus_musculus	Terb1	ENSMUSG00000052616
rattus_norvegicus	Terb1	ENSRNOG00000055097

Protein

Protein identifiers

Telomere repeats-binding bouquet formation protein 1 — Q8NA31 (reviewed: Q8NA31)

Alternative names: Coiled-coil domain-containing protein 79

All UniProt accessions (4): A0A669KAY0, Q8NA31, J3KSG9, J3KT78

UniProt curated annotations — full annotation on UniProt →

Function. Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment’. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity.

Subunit / interactions. Component of the MAJIN-TERB1-TERB2 complex, composed of MAJIN, TERB1 and TERB2. Interacts with TERF1, STAG3 and SUN1. Interacts (via Myb-like domain) with the cohesin complex; probably mediated via interaction with STAG3.

Subcellular location. Chromosome. Telomere. Nucleus inner membrane.

Post-translational modifications. Phosphorylated by CDK. Phosphorylation by CDK takes place in late prophase when the cap exchange is prominent. is important for the stabilization of telomere attachment but dispenable for the cap exchange.

Disease relevance. Spermatogenic failure 60 (SPGF60) [MIM:619646] An autosomal recessive male infertility disorder characterized by non-obstructive azoospermia, due to sperm maturation arrest before the pachytene stage. The disease is caused by variants affecting the gene represented in this entry.

Similarity. Belongs to the TERB1 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8NA31-1	1	yes
Q8NA31-2	2
Q8NA31-3	3

RefSeq proteins (1): NP_001129977* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001005	SANT/Myb	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR011989	ARM-like	Homologous_superfamily
IPR016024	ARM-type_fold	Homologous_superfamily
IPR042359	TERB1	Family

Pfam: PF00249

UniProt features (21 total): sequence variant 4, splice variant 3, repeat 2, turn 2, helix 2, region of interest 2, chain 1, strand 1, domain 1, coiled-coil region 1, compositionally biased region 1, modified residue 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
5WIR	X-RAY DIFFRACTION	2.1
5XUP	X-RAY DIFFRACTION	2.1
6J07	X-RAY DIFFRACTION	3.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NA31-F1	71.42	0.41

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 648

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 103 (showing top): GOBP_MEIOTIC_CHROMOSOME_SEGREGATION, GOBP_CHROMOSOME_ORGANIZATION, chr16q22, GOBP_CHROMOSOME_LOCALIZATION, GOBP_ORGANELLE_FISSION, GOBP_DNA_DAMAGE_RESPONSE, GOBP_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE, GOBP_HOMOLOGOUS_CHROMOSOME_SEGREGATION, GOBP_MEIOTIC_CELL_CYCLE_PROCESS, GOBP_ORGANELLE_LOCALIZATION, GOBP_HOMOLOGOUS_CHROMOSOME_PAIRING_AT_MEIOSIS, GOBP_NUCLEAR_CHROMOSOME_SEGREGATION, GOCC_NUCLEAR_ENVELOPE, GOBP_MEIOTIC_CELL_CYCLE, GOCC_CHROMOSOMAL_REGION

GO Biological Process (5): homologous chromosome pairing at meiosis (GO:0007129), meiotic telomere clustering (GO:0045141), meiotic attachment of telomere to nuclear envelope (GO:0070197), double-strand break repair involved in meiotic recombination (GO:1990918), meiotic cell cycle (GO:0051321)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (7): chromosome, telomeric region (GO:0000781), nuclear envelope (GO:0005635), nuclear inner membrane (GO:0005637), shelterin complex (GO:0070187), nucleus (GO:0005634), chromosome (GO:0005694), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
chromosome organization involved in meiotic cell cycle	2
meiotic cell cycle process	2
homologous chromosome segregation	1
telomere localization	1
chromosome localization to nuclear envelope involved in homologous chromosome segregation	1
meiotic telomere tethering at nuclear periphery	1
chromosome attachment to the nuclear envelope	1
double-strand break repair	1
reciprocal meiotic recombination	1
cell cycle	1
sexual reproduction	1
reproductive process	1
meiotic nuclear division	1
binding	1
chromosomal region	1
nucleus	1
endomembrane system	1
organelle envelope	1
organelle inner membrane	1
nuclear membrane	1
nuclear telomere cap complex	1
intracellular membrane-bounded organelle	1
intracellular membraneless organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

596 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TERB1	TERB2	Q8NHR7	995
TERB1	H0YEC1	H0YEC1	991
TERB1	SUN1	O94901	968
TERB1	KASH5	Q8N6L0	875
TERB1	TERF1	P54274	800
TERB1	SUN2	Q9UH99	740
TERB1	SPDYA	Q5MJ70	728
TERB1	HORMAD2	Q8N7B1	674
TERB1	SMC1B	Q8NDV3	652
TERB1	HORMAD1	Q86X24	649
TERB1	STAG3	Q9UJ98	621
TERB1	RAD21L1	Q9H4I0	603
TERB1	CDK2	P24941	579
TERB1	CTC1	Q2NKJ3	560
TERB1	MEIOB	Q8N635	533

IntAct

5 interactions, top by confidence:

A	B	Type	Score
TERF1	TERB1	psi-mi:“MI:0407”(direct interaction)	0.650
TERB1	TERF1	psi-mi:“MI:0407”(direct interaction)	0.650
TERF1	TERB1	psi-mi:“MI:0403”(colocalization)	0.650

BioGRID (1): CCDC79 (Affinity Capture-MS)

ESM2 similar proteins: A1L3L1, A2RT67, A3KPW7, A4IIA7, A8C750, A8C752, D2HNY3, E1BGQ2, E1C3P4, Q08CL8, Q08DZ8, Q0IHB3, Q149N8, Q1RMU2, Q1RMZ1, Q3MJ13, Q3T1H6, Q5F3F2, Q5RED8, Q5VVJ2, Q5ZJ87, Q66J91, Q69Z66, Q6AYF5, Q6DE97, Q6GR37, Q6P1E7, Q6PNC0, Q6YHU6, Q7TPQ3, Q8BKW4, Q8BXK4, Q8IWR0, Q8IYF3, Q8IZE3, Q8K2I9, Q8NA31, Q8NEN0, Q8NFZ0, Q96EW2

Diamond homologs: Q1LX29, Q8C0V1, Q8NA31

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
SUN1	“up-regulates activity”	TERB1	binding
TERB1	“form complex”	“TTM complex”	binding
TERB1	“up-regulates activity”	TERF1	relocalization

Disease & clinical

Clinical variants and AI predictions

ClinVar

21 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	5
Likely pathogenic	0
Uncertain significance	6
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (5)

Variant ID	HGVS	Classification
1244235	NM_001136505.2(TERB1):c.1703C>G (p.Ser568Ter)	Pathogenic
1326959	NM_001136505.2(TERB1):c.289_290del (p.Leu97fs)	Pathogenic
1326960	NM_001136505.2(TERB1):c.1813C>T (p.Arg605Ter)	Pathogenic
1328957	NM_001136505.2(TERB1):c.733G>A (p.Gly245Arg)	Pathogenic
395502	GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3	Pathogenic

SpliceAI

3056 predictions. Top by Δscore:

Variant	Effect	Δscore
16:66758775:A:AC	donor_gain	1.0000
16:66758775:ATT:A	donor_gain	1.0000
16:66758775:ATTC:A	donor_gain	1.0000
16:66758776:T:C	donor_gain	1.0000
16:66759139:A:AC	donor_gain	1.0000
16:66759140:C:CC	donor_gain	1.0000
16:66759162:T:A	donor_gain	1.0000
16:66759167:A:AC	donor_gain	1.0000
16:66759167:AGTT:A	donor_gain	1.0000
16:66772592:ATTT:A	donor_gain	1.0000
16:66772595:T:TA	donor_gain	1.0000
16:66772632:T:A	donor_gain	1.0000
16:66772642:T:A	donor_gain	1.0000
16:66772752:T:C	acceptor_gain	1.0000
16:66772752:T:TC	acceptor_gain	1.0000
16:66772757:G:GC	acceptor_gain	1.0000
16:66772759:A:AC	acceptor_gain	1.0000
16:66775111:CACTT:C	donor_loss	1.0000
16:66775112:ACTT:A	donor_loss	1.0000
16:66775113:CTTAC:C	donor_loss	1.0000
16:66775114:TTA:T	donor_loss	1.0000
16:66775115:TA:T	donor_loss	1.0000
16:66775116:A:AC	donor_gain	1.0000
16:66775116:AC:A	donor_loss	1.0000
16:66775117:C:A	donor_loss	1.0000
16:66775117:C:CA	donor_gain	1.0000
16:66775117:CT:C	donor_gain	1.0000
16:66775117:CTA:C	donor_gain	1.0000
16:66775117:CTAA:C	donor_gain	1.0000
16:66775117:CTAAT:C	donor_gain	1.0000

AlphaMissense

4844 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:66786065:A:G	W176R	0.994
16:66786065:A:T	W176R	0.994
16:66755083:A:G	W693R	0.993
16:66755083:A:T	W693R	0.993
16:66791004:A:G	L16P	0.993
16:66759219:A:G	C618R	0.990
16:66790669:A:G	L66P	0.990
16:66790983:A:G	L23P	0.989
16:66785819:A:G	C223R	0.988
16:66786043:A:G	L183P	0.988
16:66790631:C:G	A79P	0.988
16:66767421:A:G	C592R	0.987
16:66786275:T:A	Q137H	0.987
16:66786275:T:G	Q137H	0.987
16:66775138:A:G	L364P	0.986
16:66775225:A:G	L335P	0.986
16:66786035:A:G	C186R	0.986
16:66767420:C:G	C592S	0.985
16:66767421:A:T	C592S	0.985
16:66778878:A:G	C280R	0.985
16:66778908:C:G	A270P	0.984
16:66785901:A:C	N195K	0.984
16:66785901:A:T	N195K	0.984
16:66759218:C:G	C618S	0.983
16:66759219:A:T	C618S	0.983
16:66778958:A:G	L253P	0.983
16:66785857:A:G	L210P	0.983
16:66785898:T:A	Q196H	0.983
16:66785898:T:G	Q196H	0.983
16:66786279:C:T	G136E	0.983

dbSNP variants (sampled 300 via entrez): RS1000101033 (16:66759100 T>A), RS1000252941 (16:66797812 T>C), RS1000401105 (16:66791166 T>C), RS1000530320 (16:66756273 T>C), RS1000596763 (16:66754308 C>A,T), RS1000638373 (16:66800086 G>A), RS1000701872 (16:66757390 G>A,C), RS1000733461 (16:66792732 G>A), RS1000753359 (16:66793062 C>G), RS1000804665 (16:66800852 C>T), RS1000890474 (16:66801047 G>A,C), RS1000907407 (16:66793719 C>T), RS1001009581 (16:66777737 A>C,T), RS1001123256 (16:66785824 G>A,C), RS1001135529 (16:66757676 A>G)

Disease associations

OMIM: gene MIM:617332 | disease phenotypes: MIM:619646

GenCC curated gene-disease

Mondo (2): spermatogenic failure 60 (MONDO:0030493), azoospermia (MONDO:0100459)

Orphanet (0):

HPO phenotypes

11 total (11 of 11 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000027	Azoospermia
HP:0000118	Phenotypic abnormality
HP:0000837	Increased circulating gonadotropin level
HP:0003251	Male infertility
HP:0008669	Abnormal spermatogenesis
HP:0008734	Decreased testicular size
HP:0011462	Young adult onset
HP:0011961	Non-obstructive azoospermia
HP:0011962	Obstructive azoospermia
HP:0031038	Spermatogenesis maturation arrest

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D053713	Azoospermia	C12.100.500.430.380; C12.100.750.700.380; C12.200.294.430.380

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066367 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Arsenic	affects methylation	1
Copper	affects cotreatment, decreases expression	1
Valproic Acid	increases methylation	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651052	Binding	Binding affinity to human CCDC79 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

27 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT02307994	PHASE4	UNKNOWN	Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH
NCT02275169	PHASE3	UNKNOWN	FSH Treatment for Non-obstructive Azoospermic Patients
NCT02544191	PHASE2	UNKNOWN	GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia
NCT03762967	PHASE2	UNKNOWN	Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With Infertility
NCT02041910	PHASE1/PHASE2	UNKNOWN	Testicular Injection of Autologous Stem Cells for Treatment of Patients With Azoospermia
NCT00282477	Not specified	UNKNOWN	Trial to Evaluate Erectile Function, Fertility and Sperm Count in Male Cyclists Compared to Age Matched Controls
NCT00484081	Not specified	COMPLETED	Microdissection Testicular Sperm Extraction (MicroTESE) and IVF-ICSI Outcome in Non-Obstructive Azoospermia (NOA)
NCT00548977	Not specified	COMPLETED	Genetic Studies Spermatogenic Failure
NCT01375062	Not specified	COMPLETED	Obtaining Undifferentiated Cells From Testis Biopsy
NCT01509482	Not specified	COMPLETED	Insulin Resistance in Idiopathic Oligospermia and Azoospermia
NCT02008799	Not specified	UNKNOWN	Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia
NCT02339272	Not specified	COMPLETED	Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility
NCT02414295	Not specified	COMPLETED	Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection
NCT02418832	Not specified	RECRUITING	Testis Needle Aspiration of Sperm in Men With Azoospermia
NCT02617173	Not specified	UNKNOWN	The Effect of Low Electrical Current on Testicular Spermatocyte Count
NCT02773498	Not specified	TERMINATED	Comparison of Medical Results of Testicular Sperm Extraction by Conventional Surgery and Microsurgical Track
NCT03497728	Not specified	TERMINATED	Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male Patients
NCT04675164	Not specified	COMPLETED	Laser Assisted Sperm Selection of Viable Immotile Testicular Sperm in Azoospermic Infertile Men
NCT05479474	Not specified	RECRUITING	Platelet Rich Plasma Testis Treatment for Infertile Men
NCT05628987	Not specified	RECRUITING	The Association of Gut Microbiota and Spermatogenic Dysfunction
NCT05866484	Not specified	COMPLETED	Testicular Sperm Aspiration (TESA) vs. Microfluidic Sperm Separation (MSS)
NCT06524258	Not specified	COMPLETED	Testicular Elastography for Microscopic Testicular Sperm Extraction
NCT06841328	Not specified	RECRUITING	Fertility Enhancement Through Regenerative Treatment in Ovaries and Testes
NCT06941922	Not specified	RECRUITING	Testicular Evaluation of Azoospermia Using Micro-Ultrasound
NCT07074015	Not specified	RECRUITING	IntelliWell: An AI-Assisted Imaging Platform for Detection and Location of Ultra-Rare Testicular Sperm in Surgical Specimens
NCT07357701	Not specified	RECRUITING	Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)
NCT07542626	Not specified	RECRUITING	Fertility Restoration With Autografting of Cryopreserved Immature Testicular Tissue