TEX10

Summary

TEX10 (testis expressed 10, HGNC:25988) is a protein-coding gene on chromosome 9q31.1, encoding Testis-expressed protein 10 (Q9NXF1). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. It is a selective cancer dependency (DepMap: 83.9% of cell lines).

Located in mitochondrion and nucleoplasm. Part of MLL1 complex.

Source: NCBI Gene 54881 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 112 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 83.9% of screened cell lines
• MANE Select transcript: NM_017746

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25988
Approved symbol	TEX10
Name	testis expressed 10
Location	9q31.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20287, bA208F1.2, Ipi1
Ensembl gene	ENSG00000136891
Ensembl biotype	protein_coding
OMIM	616717
Entrez	54881

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 20 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000374902, ENST00000429235, ENST00000477648, ENST00000535814, ENST00000886294, ENST00000886295, ENST00000886296, ENST00000886297, ENST00000886298, ENST00000911375, ENST00000911376, ENST00000911377, ENST00000911378, ENST00000911379, ENST00000911380, ENST00000911381, ENST00000911382, ENST00000911383, ENST00000911384, ENST00000911385, ENST00000969642

RefSeq mRNA: 2 — MANE Select: NM_017746 NM_001161584, NM_017746

CCDS: CCDS55330, CCDS6748

Canonical transcript exons

ENST00000374902 — 15 exons

Exon	Start	End
ENSE00000805782	100303632	100303842
ENSE00000805783	100308500	100308681
ENSE00000805784	100310299	100310379
ENSE00000805785	100320265	100320398
ENSE00000805786	100321683	100321771
ENSE00000805787	100326302	100326479
ENSE00000805788	100327787	100327962
ENSE00000805789	100329140	100329275
ENSE00000805790	100329931	100330169
ENSE00001090744	100340257	100340369
ENSE00001465095	100349184	100349372
ENSE00001903289	100352772	100352942
ENSE00001954602	100302084	100302304
ENSE00003465854	100346694	100347406
ENSE00003654148	100346072	100346315

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 92.01.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.8468 / max 301.7918, expressed in 1805 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
101728	16.9111	1799
101727	5.7555	1653
101729	0.1802	49

Top tissues by expression

273 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	92.01	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.00	gold quality
ganglionic eminence	UBERON:0004023	90.81	gold quality
embryo	UBERON:0000922	90.57	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.95	gold quality
cortical plate	UBERON:0005343	89.77	gold quality
sperm	CL:0000019	88.41	silver quality
calcaneal tendon	UBERON:0003701	88.31	gold quality
cartilage tissue	UBERON:0002418	87.53	gold quality
endothelial cell	CL:0000115	87.47	gold quality
adrenal tissue	UBERON:0018303	87.02	gold quality
gastrocnemius	UBERON:0001388	86.30	gold quality
right testis	UBERON:0004534	86.15	gold quality
placenta	UBERON:0001987	86.09	gold quality
right ovary	UBERON:0002118	86.04	gold quality
male germ cell	CL:0000015	86.03	silver quality
testis	UBERON:0000473	85.95	gold quality
muscle of leg	UBERON:0001383	85.75	gold quality
left ovary	UBERON:0002119	85.66	gold quality
tibia	UBERON:0000979	85.62	gold quality
tibialis anterior	UBERON:0001385	85.45	gold quality
left testis	UBERON:0004533	85.44	gold quality
body of uterus	UBERON:0009853	85.18	gold quality
ovary	UBERON:0000992	85.07	gold quality
stromal cell of endometrium	CL:0002255	84.89	gold quality
skin of leg	UBERON:0001511	84.84	gold quality
skin of abdomen	UBERON:0001416	84.77	gold quality
ectocervix	UBERON:0012249	84.66	gold quality
secondary oocyte	CL:0000655	84.22	gold quality
left uterine tube	UBERON:0001303	84.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.10

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

7 targeting TEX10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-302B-5P	99.50	69.49	1857
HSA-MIR-302D-5P	99.50	69.34	1863
HSA-MIR-676-5P	98.49	68.87	1492
HSA-MIR-4662A-3P	97.02	67.77	941
HSA-MIR-3156-5P	96.93	67.36	800
HSA-MIR-576-3P	96.14	65.63	773

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 83.9% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 9)

• These data define the PELP1-TEX10-WDR18 complex as a regulator of ribosome biogenesis and suggests that its SUMO-controlled distribution coordinates the rate of ribosome formation. (PMID:21326211)
• Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC] (PMID:22872859)
• Data suggest that TEX101 is a cancer-related protein and may be useful as a marker for prognosis/diagnosis of and neck squamous cell carcinomas (HNSCC). (PMID:23481573)
• Tex10 is a core component of the pluripotency network. (PMID:25936917)
• Tex10 plays a potent carcinogenic role in hepatocellular carcinoma tumorigenesis by maintaining cancer stem cell properties through activation of the STAT3 signaling pathway and promoting chemo-resistance. (PMID:30045663)
• Elevated expression of TEX10 was positively associated with malignancy and with epithelialmesenchymal transition (EMT)associated mesenchymal markers in human esophageal squamous cell carcinoma (ESCC) specimens. Study revealed that TEX10 promotes stem celllike features and plays an essential role in regulating EMT via the activation of Wnt/betacatenin signaling in ESCC. (PMID:31638260)
• LncRNA GATA3AS1miR30b5pTex10 axis modulates tumorigenesis in pancreatic cancer. (PMID:33760161)
• TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6. (PMID:34966825)
• LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis modulates tumorigenesis and cancer stem cell-like properties in liver cancer. (PMID:35156514)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tex10	ENSDARG00000055885
mus_musculus	Tex10	ENSMUSG00000028345
rattus_norvegicus	Tex10	ENSRNOG00000008618
drosophila_melanogaster	CG1575	FBGN0029999
caenorhabditis_elegans		WBGENE00012977

Paralogs (3): RMDN2 (ENSG00000115841), RMDN3 (ENSG00000137824), RMDN1 (ENSG00000176623)

Protein

Protein identifiers

Testis-expressed protein 10 — Q9NXF1 (reviewed: Q9NXF1)

All UniProt accessions (2): A0A0A0MSR3, Q9NXF1

UniProt curated annotations — full annotation on UniProt →

Function. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit.

Subunit / interactions. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles.

Subcellular location. Nucleus. Nucleoplasm. Cytoplasm. Nucleolus.

Similarity. Belongs to the IPI1/TEX10 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NXF1-1	1	yes
Q9NXF1-2	2

RefSeq proteins (2): NP_001155056, NP_060216* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011989	ARM-like	Homologous_superfamily
IPR016024	ARM-type_fold	Homologous_superfamily
IPR021133	HEAT_type_2	Repeat
IPR024679	Ipi1_N	Domain
IPR057949	TPR_TEX10	Domain

Pfam: PF12333, PF25781

UniProt features (9 total): sequence conflict 4, splice variant 2, chain 1, repeat 1, modified residue 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
8FL3	ELECTRON MICROSCOPY	2.53
8FL2	ELECTRON MICROSCOPY	2.67
8FL4	ELECTRON MICROSCOPY	2.89
9DUM	ELECTRON MICROSCOPY	3.56

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NXF1-F1	80.04	0.46

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 29

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72312	rRNA processing
R-HSA-8868773	rRNA processing in the nucleus and cytosol
R-HSA-8953854	Metabolism of RNA

MSigDB gene sets: 130 (showing top): GOBP_RIBOSOME_BIOGENESIS, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, GOBP_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA, GOBP_MATURATION_OF_LSU_RRNA, GOBP_MATURATION_OF_5_8S_RRNA, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOBP_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS, REACTOME_METABOLISM_OF_RNA, MULLIGHAN_MLL_SIGNATURE_2_DN, GOCC_TRANSFERASE_COMPLEX, GOCC_HISTONE_METHYLTRANSFERASE_COMPLEX, GOCC_MLL1_2_COMPLEX, GOCC_METHYLTRANSFERASE_COMPLEX, GOCC_NUCLEOLUS

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), mitochondrion (GO:0005739), MLL1 complex (GO:0071339), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
rRNA processing in the nucleus and cytosol	1
Metabolism of RNA	1
rRNA processing	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membrane-bounded organelle	2
nuclear lumen	2
cellular anatomical structure	2
binding	1
intracellular membraneless organelle	1
cytoplasm	1
MLL1/2 complex	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1996 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TEX10	WDR18	Q9BV38	993
TEX10	PELP1	Q8IZL8	983
TEX10	LAS1L	Q9Y4W2	924
TEX10	SENP3	Q9H4L4	909
TEX10	SOX2	P48431	780
TEX10	NOL9	Q5SY16	678
TEX10	GNL2	Q13823	563
TEX10	CHTOP	Q9Y3Y2	557
TEX10	EP300	Q09472	536
TEX10	MDN1	Q9NU22	532
TEX10	PES1	O00541	524
TEX10	NVL	O15381	504
TEX10	NANOG	Q9H9S0	498
TEX10	POU5F1	P31359	495
TEX10	TET1	Q8NFU7	494

IntAct

156 interactions, top by confidence:

A	B	Type	Score
PELP1	WDR18	psi-mi:“MI:0914”(association)	0.900
PELP1	WDR18	psi-mi:“MI:0915”(physical association)	0.900
SENP3	NPM1	psi-mi:“MI:0914”(association)	0.780
PHF19	EED	psi-mi:“MI:0914”(association)	0.730
TEX10	PELP1	psi-mi:“MI:0915”(physical association)	0.720
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
WDR18	TEX10	psi-mi:“MI:0915”(physical association)	0.670
NEUROG3	GXYLT2	psi-mi:“MI:0914”(association)	0.640
H2BC1	PPM1G	psi-mi:“MI:0914”(association)	0.640
SLX4	ERCC1	psi-mi:“MI:0914”(association)	0.640
NOL9	SENP3	psi-mi:“MI:0914”(association)	0.640
TEX10	SENP3	psi-mi:“MI:0915”(physical association)	0.620
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
	TEX10	psi-mi:“MI:0915”(physical association)	0.560
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
H1-4	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
RPS2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
RSBN1	SETD1A	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
ZBTB48	ZBTB24	psi-mi:“MI:0914”(association)	0.530
PDGFB	DKC1	psi-mi:“MI:0914”(association)	0.530
WDR18	NOL9	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530

BioGRID (266): TEX10 (Affinity Capture-MS), TEX10 (Affinity Capture-MS), TEX10 (Affinity Capture-MS), TEX10 (Reconstituted Complex), TEX10 (Affinity Capture-MS), TEX10 (Affinity Capture-MS), TEX10 (Affinity Capture-MS), TEX10 (Affinity Capture-MS), TEX10 (Affinity Capture-MS), TEX10 (Affinity Capture-MS), GNL3 (Co-fractionation), NOL9 (Co-fractionation), PELP1 (Co-fractionation), SENP3 (Co-fractionation), TEX10 (Co-fractionation)

ESM2 similar proteins: A0JM49, A2AKG8, B0V0U5, B1AUR6, C5J7W8, E1BGH8, E1C231, E1C2Z0, E7FGT5, E7FH61, E9Q3L2, F6S215, O08662, O60287, O94822, P42356, P57678, P78527, P97313, Q13315, Q13535, Q14146, Q1RLU1, Q2TAW0, Q3TQQ9, Q3URQ0, Q571H0, Q5RDK1, Q5VW36, Q5WNI9, Q5XI94, Q5ZM41, Q62388, Q6A009, Q6DFV1, Q6PQD5, Q6ZRQ5, Q7SY48, Q86XI2, Q8BKX6

Diamond homologs: A1CMX6, A1DL11, A4RBW8, A7EI93, O94718, P0CT45, Q2UU13, Q3URQ0, Q4WCP8, Q59JU3, Q5ASR2, Q5RDK1, Q5ZM41, Q7SFQ6, Q803M3, Q9NXF1, A3M0B1, A5DKN0, A5E181, A6ZSZ4, P38803, Q6BLC4, Q6CJZ2, Q6FK47, Q759I2

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
TEX10	“form complex”	“Rix1 complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 178 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Eukaryotic Translation Initiation	5	11.3×	2e-03
Cap-dependent Translation Initiation	5	11.3×	2e-03
SARS-CoV-1 modulates host translation machinery	5	11.3×	2e-03
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	12	10.3×	3e-07
SRP-dependent cotranslational protein targeting to membrane	14	10.2×	3e-08
Peptide chain elongation	11	10.2×	1e-06
Viral mRNA Translation	11	10.2×	1e-06
Eukaryotic Translation Elongation	5	10.2×	3e-03

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	14	15.8×	2e-10
rRNA processing	14	12.1×	5e-09
ribosomal small subunit biogenesis	8	11.1×	2e-04
heterochromatin formation	6	9.3×	9e-03
translation	12	7.5×	2e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

112 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	87
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2349 predictions. Top by Δscore:

Variant	Effect	Δscore
9:100303629:TA:T	donor_loss	1.0000
9:100303630:A:AC	donor_gain	1.0000
9:100303630:A:AG	donor_loss	1.0000
9:100303630:AC:A	donor_gain	1.0000
9:100303631:C:CC	donor_gain	1.0000
9:100303631:CC:C	donor_gain	1.0000
9:100303631:CCGTG:C	donor_gain	1.0000
9:100303838:TGTCC:T	acceptor_gain	1.0000
9:100303839:GTCC:G	acceptor_gain	1.0000
9:100303840:TCC:T	acceptor_gain	1.0000
9:100303841:CC:C	acceptor_gain	1.0000
9:100303841:CCC:C	acceptor_gain	1.0000
9:100303842:CC:C	acceptor_gain	1.0000
9:100303843:C:CC	acceptor_gain	1.0000
9:100320259:TATTA:T	donor_loss	1.0000
9:100320260:ATTAC:A	donor_loss	1.0000
9:100320261:TTACC:T	donor_loss	1.0000
9:100320262:TAC:T	donor_loss	1.0000
9:100320263:A:AT	donor_loss	1.0000
9:100320264:CCT:C	donor_gain	1.0000
9:100320397:CC:C	acceptor_gain	1.0000
9:100320398:CC:C	acceptor_gain	1.0000
9:100320422:CAATT:C	acceptor_gain	1.0000
9:100322352:C:A	donor_gain	1.0000
9:100326375:A:C	donor_gain	1.0000
9:100327964:T:C	acceptor_gain	1.0000
9:100346088:T:TA	donor_gain	1.0000
9:100346311:GATAC:G	acceptor_gain	1.0000
9:100346312:ATAC:A	acceptor_gain	1.0000
9:100346313:TAC:T	acceptor_gain	1.0000

AlphaMissense

6080 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:100347153:A:G	L145P	1.000
9:100327937:A:G	W551R	0.999
9:100327937:A:T	W551R	0.999
9:100347021:A:G	L189P	0.999
9:100347144:G:T	A148D	0.999
9:100347145:C:G	A148P	0.999
9:100347345:A:G	L81P	0.999
9:100346226:A:G	L328P	0.998
9:100346883:A:G	L235P	0.998
9:100346895:A:G	L231P	0.998
9:100347109:A:G	S160P	0.998
9:100347141:A:C	M149R	0.998
9:100347159:G:T	A143D	0.998
9:100347243:C:G	R115P	0.998
9:100347336:A:G	L84P	0.998
9:100302274:A:G	W903R	0.997
9:100302274:A:T	W903R	0.997
9:100347141:A:T	M149K	0.997
9:100347157:G:C	H144D	0.997
9:100347357:G:T	A77D	0.997
9:100347358:C:G	A77P	0.997
9:100347365:T:A	K74N	0.997
9:100347365:T:G	K74N	0.997
9:100346215:A:G	W332R	0.996
9:100346215:A:T	W332R	0.996
9:100346907:A:T	V227D	0.996
9:100346920:A:G	W223R	0.996
9:100346920:A:T	W223R	0.996
9:100347084:A:G	L168P	0.996
9:100347087:A:G	L167P	0.996

dbSNP variants (sampled 300 via entrez): RS1000103894 (9:100322904 C>T), RS1000124424 (9:100316031 A>G), RS1000232457 (9:100322558 T>A), RS1000241184 (9:100316267 C>T), RS1000303473 (9:100328698 T>C), RS1000351220 (9:100309960 A>G), RS1000360522 (9:100353576 C>A,T), RS1000394776 (9:100353172 T>C), RS1000411008 (9:100303242 GA>G), RS1000413550 (9:100322702 A>AC), RS1000435319 (9:100335492 C>T), RS1000511575 (9:100317221 T>C), RS1000543201 (9:100342718 A>C), RS1000604146 (9:100349923 G>A), RS1000733517 (9:100310604 A>G)

Disease associations

OMIM: gene MIM:616717 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010988_401	Adult body size	3.000000e-13

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067270 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

5 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs10124893	Efficacy	3	duloxetine	Major Depressive Disorder
rs10989064	Efficacy	3	duloxetine	Major Depressive Disorder
rs6479008	Efficacy	3	duloxetine	Major Depressive Disorder
rs7035619	Efficacy	3	duloxetine	Major Depressive Disorder
rs7472	Efficacy	3	duloxetine	Major Depressive Disorder

PharmGKB variants

5 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs10124893	TEX10	3	0.00	1	duloxetine
rs10989064	TEX10	3	0.00	1	duloxetine
rs6479008	TEX10	3	0.00	1	duloxetine
rs7035619	TEX10	3	0.00	1	duloxetine
rs7472	INVS, TEX10	3	0.00	1	duloxetine

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, affects cotreatment	2
Benzo(a)pyrene	increases expression, increases methylation	2
Cyclosporine	increases expression	2
Aflatoxin B1	decreases methylation, increases expression	2
FR900359	decreases phosphorylation	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
sodium arsenite	decreases expression, increases abundance	1
cobaltous chloride	increases expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
jinfukang	decreases expression	1
LDN 193189	affects cotreatment, decreases expression	1
Vorinostat	decreases expression	1
Arsenic	decreases expression, increases abundance	1
Atrazine	increases expression	1
Caffeine	decreases phosphorylation	1
Dexamethasone	affects cotreatment, decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Estradiol	increases expression	1
Hydrogen Peroxide	affects expression	1
Indomethacin	affects cotreatment, decreases expression	1
Ivermectin	decreases expression	1
Potassium Chloride	decreases response to substance, increases expression	1
Ribonucleotides	affects binding	1
Silicon Dioxide	increases expression	1
Dronabinol	decreases response to substance, increases expression	1
Thimerosal	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652993	Binding	Binding affinity to human TEX10 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.