TEX13B

Summary

TEX13B (testis expressed 13B, HGNC:11736) is a protein-coding gene on chromosome Xq22.3, encoding Testis-expressed protein 13B (Q9BXU2).

This gene is similar to a mouse gene that is expressed in the testis.

Source: NCBI Gene 56156 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 27 total
• MANE Select transcript: NM_031273

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11736
Approved symbol	TEX13B
Name	testis expressed 13B
Location	Xq22.3
Locus type	gene with protein product
Status	Approved
Aliases	TSGA5, TGC3B
Ensembl gene	ENSG00000170925
Ensembl biotype	protein_coding
OMIM	300313
Entrez	56156

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000302917

RefSeq mRNA: 1 — MANE Select: NM_031273 NM_031273

CCDS: CCDS14534

Canonical transcript exons

ENST00000302917 — 3 exons

Exon	Start	End
ENSE00001153464	107982310	107982370
ENSE00001164893	107980864	107981559
ENSE00001164901	107981669	107982159

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 87.87.

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.87	gold quality
myocardium	UBERON:0002349	67.70	gold quality
sperm	CL:0000019	66.80	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	66.66	gold quality
nasal cavity epithelium	UBERON:0005384	63.18	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	63.12	gold quality
superficial temporal artery	UBERON:0001614	61.85	gold quality
cartilage tissue	UBERON:0002418	59.80	gold quality
subthalamic nucleus	UBERON:0001906	58.86	gold quality
inferior vagus X ganglion	UBERON:0005363	58.78	gold quality
tibia	UBERON:0000979	57.93	gold quality
secondary oocyte	CL:0000655	57.64	gold quality
seminal vesicle	UBERON:0000998	57.43	gold quality
dorsal plus ventral thalamus	UBERON:0001897	57.42	gold quality
vastus lateralis	UBERON:0001379	57.36	gold quality
quadriceps femoris	UBERON:0001377	57.31	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	57.29	gold quality
mammalian vulva	UBERON:0000997	57.06	gold quality
saphenous vein	UBERON:0007318	56.81	gold quality
medulla oblongata	UBERON:0001896	56.71	gold quality
pericardium	UBERON:0002407	56.71	gold quality
ventral tegmental area	UBERON:0002691	56.58	gold quality
nipple	UBERON:0002030	56.53	gold quality
Brodmann (1909) area 23	UBERON:0013554	56.52	gold quality
layer of synovial tissue	UBERON:0007616	56.51	gold quality
urethra	UBERON:0000057	56.49	gold quality
superior vestibular nucleus	UBERON:0007227	56.42	gold quality
thymus	UBERON:0002370	56.29	gold quality
lateral globus pallidus	UBERON:0002476	56.29	gold quality
middle temporal gyrus	UBERON:0002771	56.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

16 targeting TEX13B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-4446-5P	99.72	69.19	2544
HSA-MIR-942-5P	99.41	68.40	1977
HSA-MIR-6828-5P	99.31	69.21	1433
HSA-MIR-6846-5P	98.81	65.86	1121
HSA-MIR-6848-5P	98.81	65.49	1126
HSA-MIR-6728-3P	98.63	67.63	1534
HSA-MIR-3188	98.58	65.60	878
HSA-MIR-7156-3P	98.25	67.66	859
HSA-MIR-93-3P	98.15	66.65	1309
HSA-MIR-4421	97.99	64.89	701
HSA-MIR-6847-5P	97.93	66.74	1808
HSA-MIR-5699-3P	97.81	65.00	861

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tex13b	ENSMUSG00000042386
mus_musculus	Tex13a	ENSMUSG00000071686
rattus_norvegicus	Tex13a	ENSRNOG00000026712
rattus_norvegicus	Tex13b	ENSRNOG00000058904
drosophila_melanogaster	CG14718	FBGN0037939

Paralogs (3): TEX13A (ENSG00000268629), TEX13D (ENSG00000282419), TEX13C (ENSG00000282815)

Protein

Protein identifiers

Testis-expressed protein 13B — Q9BXU2 (reviewed: Q9BXU2)

All UniProt accessions (1): Q9BXU2

UniProt curated annotations — full annotation on UniProt →

Tissue specificity. Testis specific.

Similarity. Belongs to the TEX13 family.

RefSeq proteins (1): NP_112563* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR028193	TEX13A-D_N	Domain
IPR054602
IPR055047

Pfam: PF15186, PF22835, PF22836

UniProt features (1 total): chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BXU2-F1	69.29	0.48

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 31 (showing top): SHEN_SMARCA2_TARGETS_DN, GOMF_MRNA_BINDING, MIKKELSEN_IPS_HCP_WITH_H3_UNMETHYLATED, MIKKELSEN_ES_HCP_WITH_H3_UNMETHYLATED, MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED, chrXq22, FOSTER_KDM1A_TARGETS_UP, PTEN_DN.V2_DN, DCA_UP.V1_UP, IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_UP, MIR6828_5P, GARCIA_PINERES_PBMC_HPV_16_L1_VLP_AGE_18_25YO_2MO_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_DN, GSE27786_LIN_NEG_VS_CD8_TCELL_UP, GSE27786_LIN_NEG_VS_NEUTROPHIL_UP

GO Biological Process (0):

GO Molecular Function (2): mRNA binding (GO:0003729), protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA binding	1
binding	1

Protein interactions and networks

STRING

728 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TEX13B	ZNF711	Q9Y462	493
TEX13B	H3BQ15	H3BQ15	471
TEX13B	DIAPH2	O60879	470
TEX13B	AMDHD2	Q9Y303	470
TEX13B	ZNF142	P52746	456
TEX13B	ZMYM6	O95789	429
TEX13B	TRIM48	Q8IWZ4	419
TEX13B	FTHL17	Q9BXU8	399
TEX13B	ZYG11A	Q6WRX3	397
TEX13B	VSIG1	Q86XK7	394
TEX13B	NBEAL1	Q6ZS30	379
TEX13B	ZFX	P17010	358
TEX13B	POLR3C	Q9BUI4	352
TEX13B	LRRC3	Q9BY71	326
TEX13B	ZC3H14	Q6PJT7	322

IntAct

14 interactions, top by confidence:

A	B	Type	Score
VSNL1	TEX13B	psi-mi:“MI:0915”(physical association)	0.560
TEX13B	HPCAL4	psi-mi:“MI:0915”(physical association)	0.560
TEX13B	ARID1A	psi-mi:“MI:0914”(association)	0.350
TEX13A	CNOT1	psi-mi:“MI:0914”(association)	0.350
TEX13B	VSNL1	psi-mi:“MI:0915”(physical association)	0.000
TEX13B	HPCAL4	psi-mi:“MI:0915”(physical association)	0.000
VSNL1	TEX13B	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (19): TEX13B (Two-hybrid), TEX13B (Two-hybrid), THTPA (Affinity Capture-MS), SMARCD3 (Affinity Capture-MS), SMARCB1 (Affinity Capture-MS), SMARCC1 (Affinity Capture-MS), ARID2 (Affinity Capture-MS), ARID1B (Affinity Capture-MS), SMARCD2 (Affinity Capture-MS), ARID1A (Affinity Capture-MS), DPF3 (Affinity Capture-MS), CRLF2 (Affinity Capture-MS), SMARCC2 (Affinity Capture-MS), SMARCD1 (Affinity Capture-MS), DPF2 (Affinity Capture-MS)

ESM2 similar proteins: A6NC78, A6NCC3, A6NDK9, A6NDN3, A6NEF3, A6NEM1, A6NI86, A6NJZ7, A6NMD2, A6NN73, A6NNM3, A7E2F4, A8MQT2, D6RF30, F8WBI6, H0YKK7, H3BPF8, H3BQL2, H3BSY2, H3BV12, I6L899, M3WHG5, P0C7N4, P0CG33, P0CJ92, P0DX52, P0DX53, P54257, Q0D2H9, Q2M243, Q3T1I3, Q3TCJ8, Q3V0F0, Q497K7, Q5D525, Q7Z572, Q7Z6P3, Q86XG9, Q8C0G2, Q8C0X0

Diamond homologs: A0A0J9YWL9, A0A0J9YY54, A2AFS9, D3YU32, Q9BXU2, Q9BXU3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

27 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	26
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

466 predictions. Top by Δscore:

Variant	Effect	Δscore
X:107981667:A:AC	donor_gain	0.9900
X:107981668:C:CC	donor_gain	0.9900
X:107981668:CGG:C	donor_gain	0.9900
X:107981683:T:TA	donor_gain	0.9900
X:107981667:ACGG:A	donor_gain	0.9700
X:107981668:CGGC:C	donor_gain	0.9700
X:107982159:CCTG:C	acceptor_gain	0.9700
X:107981684:C:A	donor_gain	0.9400
X:107981937:TTG:T	donor_gain	0.9300
X:107982158:CC:C	acceptor_gain	0.9200
X:107981668:CG:C	donor_gain	0.9100
X:107982161:T:A	acceptor_loss	0.9100
X:107981661:GATCT:G	donor_loss	0.9000
X:107981662:ATCTT:A	donor_loss	0.9000
X:107981663:TCTTA:T	donor_loss	0.9000
X:107981664:CT:C	donor_loss	0.9000
X:107981665:TT:T	donor_loss	0.9000
X:107981666:TACGG:T	donor_loss	0.9000
X:107981667:A:C	donor_loss	0.9000
X:107981668:C:A	donor_loss	0.9000
X:107981668:CGGCA:C	donor_gain	0.9000
X:107982158:CCCTG:C	acceptor_gain	0.9000
X:107982160:C:CC	acceptor_gain	0.9000
X:107981559:CCTGG:C	acceptor_loss	0.8900
X:107981560:CTGGA:C	acceptor_loss	0.8900
X:107981660:GGATC:G	donor_loss	0.8900
X:107981561:T:A	acceptor_loss	0.8800
X:107981560:C:CC	acceptor_gain	0.8700
X:107982141:C:A	acceptor_gain	0.8700
X:107982304:CCTCA:C	donor_loss	0.8700

AlphaMissense

2025 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:107982026:G:C	F34L	0.977
X:107982026:G:T	F34L	0.977
X:107982028:A:G	F34L	0.977
X:107982092:G:C	F12L	0.967
X:107982092:G:T	F12L	0.967
X:107982094:A:G	F12L	0.967
X:107982068:G:C	F20L	0.948
X:107982068:G:T	F20L	0.948
X:107982070:A:G	F20L	0.948
X:107981999:C:A	W43C	0.937
X:107981999:C:G	W43C	0.937
X:107982001:A:G	W43R	0.933
X:107982001:A:T	W43R	0.933
X:107981923:A:G	W69R	0.920
X:107981923:A:T	W69R	0.920
X:107981921:C:A	W69C	0.909
X:107981921:C:G	W69C	0.909
X:107982093:A:G	F12S	0.908
X:107981915:G:C	S71R	0.902
X:107981915:G:T	S71R	0.902
X:107981917:T:G	S71R	0.902
X:107982027:A:G	F34S	0.901
X:107981987:T:A	E47D	0.900
X:107981987:T:G	E47D	0.900
X:107981894:A:C	F78L	0.878
X:107981894:A:T	F78L	0.878
X:107981896:A:G	F78L	0.878
X:107982037:C:G	G31R	0.872
X:107982093:A:C	F12C	0.860
X:107982014:A:C	N38K	0.848

dbSNP variants (sampled 300 via entrez): RS1007306452 (X:107984245 T>A), RS1007345717 (X:107980815 A>C,G), RS1008329599 (X:107982813 G>A), RS1008404561 (X:107983103 G>A), RS1008986803 (X:107981996 C>T), RS1010011952 (X:107982121 A>G), RS1010372156 (X:107983493 T>A), RS1013691830 (X:107983261 C>G,T), RS1017597061 (X:107981817 G>A), RS1017671165 (X:107980829 T>C,G), RS1017901443 (X:107983805 A>AT), RS1018677002 (X:107982815 C>T), RS1019981423 (X:107983512 G>C), RS1021023497 (X:107984321 G>A,C), RS1022277002 (X:107982132 G>A,C)

Disease associations

OMIM: gene MIM:300313 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases methylation, affects methylation	2
Aflatoxin B1	decreases methylation, increases methylation	2
Resveratrol	affects cotreatment, decreases expression	1
Arbutin	decreases expression	1
Diazinon	increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.