TEX13C

Summary

TEX13C (TEX13 family member C, HGNC:52277) is a protein-coding gene on chromosome Xq25, encoding Testis-expressed protein 13C (A0A0J9YWL9).

Predicted to enable mRNA binding activity.

Source: NCBI Gene 100129520 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 11 total
• MANE Select transcript: NM_001195272

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52277
Approved symbol	TEX13C
Name	TEX13 family member C
Location	Xq25
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000282815
Ensembl biotype	protein_coding
OMIM	301123
Entrez	100129520

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000632600, ENST00000695840, ENST00000695841

RefSeq mRNA: 1 — MANE Select: NM_001195272 NM_001195272

CCDS: CCDS83488

Canonical transcript exons

ENST00000695840 — 2 exons

Exon	Start	End
ENSE00003783059	125319871	125323120
ENSE00003965181	125323700	125325214

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 78.74.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.74	gold quality
right testis	UBERON:0004534	54.36	gold quality
testis	UBERON:0000473	52.37	gold quality
left testis	UBERON:0004533	50.93	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	49.98	silver quality
right uterine tube	UBERON:0001302	47.68	gold quality
cortical plate	UBERON:0005343	39.76	gold quality
bone marrow cell	CL:0002092	38.68	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
sural nerve	UBERON:0015488	35.91	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.28	gold quality
skeletal muscle tissue	UBERON:0001134	34.88	gold quality
granulocyte	CL:0000094	33.96	gold quality
muscle tissue	UBERON:0002385	33.24	gold quality
bone marrow	UBERON:0002371	33.03	gold quality
prefrontal cortex	UBERON:0000451	32.98	gold quality
primary visual cortex	UBERON:0002436	32.63	gold quality
blood	UBERON:0000178	32.41	gold quality
cerebellar cortex	UBERON:0002129	31.31	gold quality
cerebellum	UBERON:0002037	31.30	gold quality
cerebellar hemisphere	UBERON:0002245	31.03	gold quality
liver	UBERON:0002107	30.77	gold quality
Brodmann (1909) area 9	UBERON:0013540	30.63	gold quality
right hemisphere of cerebellum	UBERON:0014890	30.37	gold quality
frontal cortex	UBERON:0001870	29.88	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
nucleus accumbens	UBERON:0001882	29.76	gold quality
superior frontal gyrus	UBERON:0002661	29.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.45

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tex13c1	ENSMUSG00000078320
mus_musculus	Tex13d	ENSMUSG00000105993
rattus_norvegicus	Tex13c	ENSRNOG00000045953
rattus_norvegicus	LOC134484021	ENSRNOG00000057469
drosophila_melanogaster	CG14718	FBGN0037939

Paralogs (3): TEX13B (ENSG00000170925), TEX13A (ENSG00000268629), TEX13D (ENSG00000282419)

Protein

Protein identifiers

Testis-expressed protein 13C — A0A0J9YWL9 (reviewed: A0A0J9YWL9)

All UniProt accessions (1): A0A0J9YWL9

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the TEX13 family.

RefSeq proteins (1): NP_001182201* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001876	Znf_RanBP2	Domain
IPR028193	TEX13A-D_N	Domain
IPR049367	TX13C/D_rpt	Repeat
IPR049534	TEX13A/C/D_Znf	Domain

Pfam: PF15186, PF20864, PF20868

UniProt features (8 total): region of interest 3, compositionally biased region 3, chain 1, zinc finger region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A0J9YWL9-F1	51.91	0.10

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 3 (showing top): GOMF_MRNA_BINDING, chrXq25, ZHANG_FH_DEFICIENT_RCC_C2_VS_OTHERS_UP

GO Biological Process (0):

GO Molecular Function (3): mRNA binding (GO:0003729), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA binding	1
transition metal ion binding	1
cation binding	1

Protein interactions and networks

STRING

300 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TEX13C	TEX36	Q5VZQ5	495
TEX13C	TEX22	C9J3V5	480
TEX13C	TEX30	Q5JUR7	472
TEX13C	TEX29	Q8N6K0	449
TEX13C	FAM9C	Q8IZT9	447
TEX13C	TEX28	O15482	439
TEX13C	SPMIP9	Q96LM6	433
TEX13C	BTBD19	C9JJ37	370
TEX13C	SMAD3	P84022	354
TEX13C	ZFP41	Q8N8Y5	348
TEX13C	A0A0G2JH32	A0A0G2JH32	348
TEX13C	TEX10	Q9NXF1	339
TEX13C	TEX19	Q8NA77	333
TEX13C	C14orf39	Q8N1H7	330
TEX13C	DMC1	Q14565	314

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A087WUL8, A0A0J9YWL9, A0A0U1RQI7, A0A1D9BZF0, A6NJU9, A6NKU9, A6NNC1, A6QL64, A8MRT5, B2SU53, B4DH59, B5DUH6, C9JG80, E5RHQ5, F8W0I5, P01068, P02895, P06916, P07907, P0DKL2, P0DPF3, P0DRJ4, P13208, P14417, P32072, P83060, Q26755, Q3BBV0, Q3BBV2, Q4ZJY7, Q4ZJZ0, Q4ZJZ1, Q4ZJZ3, Q5TAG4, Q5TI25, Q6P3W6, Q6RY98, Q7T3L1, Q86SG3, Q86T75

Diamond homologs: A0A0J9YWL9, A0A0J9YY54, A2AFS9, D3YU32, Q9BXU2, Q9BXU3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

11 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	11
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

213 predictions. Top by Δscore:

Variant	Effect	Δscore
X:125323875:G:GT	donor_gain	1.0000
X:125323884:G:T	donor_gain	0.9900
X:125323698:A:AG	acceptor_gain	0.9800
X:125323698:AGT:A	acceptor_loss	0.9800
X:125323699:G:GC	acceptor_gain	0.9800
X:125323801:G:GT	donor_gain	0.9800
X:125323875:G:T	donor_gain	0.9700
X:125323884:G:GT	donor_gain	0.9700
X:125323699:GT:G	acceptor_gain	0.9500
X:125323116:GGAAG:G	donor_gain	0.9400
X:125323117:GAAGG:G	donor_gain	0.9400
X:125323699:GTT:G	acceptor_gain	0.9300
X:125323921:G:GT	donor_gain	0.9300
X:125323119:AGGTA:A	donor_loss	0.9200
X:125323121:G:GC	donor_loss	0.9200
X:125323122:T:A	donor_loss	0.9200
X:125323699:GTTTT:G	acceptor_gain	0.9200
X:125323123:AA:A	donor_loss	0.9000
X:125323731:A:AG	acceptor_gain	0.8600
X:125323732:G:GG	acceptor_gain	0.8600
X:125323117:GAAG:G	donor_gain	0.8500
X:125323757:A:C	acceptor_gain	0.8400
X:125323118:A:T	donor_gain	0.8200
X:125323699:GTTT:G	acceptor_gain	0.8200
X:125323887:G:GT	donor_gain	0.8000
X:125322723:G:GA	donor_gain	0.7900
X:125323124:AGT:A	donor_loss	0.7900
X:125323694:TATTA:T	acceptor_gain	0.7900
X:125323695:ATTAG:A	acceptor_gain	0.7900
X:125323696:TTAG:T	acceptor_gain	0.7900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000589049 (X:125318878 C>A,G,T), RS1001033340 (X:125318208 G>C), RS1001645670 (X:125319695 A>T), RS1001745401 (X:125320156 C>T), RS1001991483 (X:125319897 T>C), RS1002736953 (X:125320611 C>T), RS1003153133 (X:125323309 C>CG), RS1004577684 (X:125320146 C>T), RS1004593050 (X:125320337 C>T), RS1004690876 (X:125325392 C>T), RS1005045475 (X:125325664 C>G), RS1005275020 (X:125324994 AC>A), RS1005989584 (X:125319181 C>A,G,T), RS1006905046 (X:125320534 C>G,T), RS1007782328 (X:125318450 C>G,T)

Disease associations

OMIM: gene MIM:301123 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
2,4,6-tribromophenol	decreases expression	1
bisphenol A	decreases expression	1
tetrabromobisphenol A	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.