TEX26

Summary

TEX26 (testis expressed 26, HGNC:28622) is a protein-coding gene on chromosome 13q12.3, encoding Testis-expressed protein 26 (Q8N6G2).

Predicted to be active in cytoplasm.

Source: NCBI Gene 122046 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 61 total
• Dosage sensitivity (ClinGen): haploinsufficiency dosage sensitivity unlikely, triplosensitivity no evidence
• MANE Select transcript: NM_152325

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28622
Approved symbol	TEX26
Name	testis expressed 26
Location	13q12.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC40178
Ensembl gene	ENSG00000175664
Ensembl biotype	protein_coding
Entrez	122046

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 4 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000380473, ENST00000479195, ENST00000530916, ENST00000531960, ENST00000906072, ENST00000944411, ENST00000944412

RefSeq mRNA: 5 — MANE Select: NM_152325 NM_001353388, NM_001353389, NM_001353390, NM_001353391, NM_152325

CCDS: CCDS9339

Canonical transcript exons

ENST00000380473 — 7 exons

Exon	Start	End
ENSE00001221318	30952660	30952825
ENSE00001221322	30939694	30939778
ENSE00001485094	30974846	30975500
ENSE00003529363	30932656	30932776
ENSE00003551000	30968885	30969046
ENSE00003604543	30956873	30957029
ENSE00003673381	30966222	30966398

Expression profiles

Bgee: expression breadth ubiquitous, 142 present calls, max score 97.51.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5866 / max 69.9182, expressed in 165 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134645	0.3067	108
134646	0.2799	110

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	97.51	gold quality
bronchial epithelial cell	CL:0002328	91.60	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.07	gold quality
left testis	UBERON:0004533	90.56	gold quality
right testis	UBERON:0004534	90.03	gold quality
bronchus	UBERON:0002185	89.78	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.19	gold quality
testis	UBERON:0000473	87.74	gold quality
mucosa of paranasal sinus	UBERON:0005030	85.98	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.15	gold quality
adult organism	UBERON:0007023	77.69	gold quality
ventricular zone	UBERON:0003053	75.87	gold quality
hypothalamus	UBERON:0001898	75.62	gold quality
ganglionic eminence	UBERON:0004023	71.62	gold quality
adenohypophysis	UBERON:0002196	68.72	gold quality
nucleus accumbens	UBERON:0001882	68.52	gold quality
buccal mucosa cell	CL:0002336	67.67	silver quality
nasal cavity mucosa	UBERON:0001826	67.36	gold quality
anterior cingulate cortex	UBERON:0009835	66.17	gold quality
pituitary gland	UBERON:0000007	65.38	gold quality
caudate nucleus	UBERON:0001873	65.06	gold quality
amygdala	UBERON:0001876	64.39	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.32	gold quality
prefrontal cortex	UBERON:0000451	63.15	gold quality
Brodmann (1909) area 9	UBERON:0013540	62.43	gold quality
spinal cord	UBERON:0002240	62.13	gold quality
tibialis anterior	UBERON:0001385	61.88	silver quality
putamen	UBERON:0001874	61.19	gold quality
forebrain	UBERON:0001890	60.02	gold quality
epithelium of nasopharynx	UBERON:0001951	59.73	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.38

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

7 targeting TEX26, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-580-3P	99.67	69.23	1841
HSA-MIR-3942-3P	99.57	69.03	2854
HSA-MIR-502-5P	98.77	66.51	906
HSA-MIR-2115-5P	98.66	68.07	1191
HSA-MIR-10397-5P	97.31	69.06	710

Functional genomics

ClinGen dosage: haploinsufficiency 40 (dosage sensitivity unlikely), triplosensitivity 0 (no evidence). ClinGen Gene Dosage Map

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tex26	ENSMUSG00000029660
rattus_norvegicus	Tex26	ENSRNOG00000000905

Protein

Protein identifiers

Testis-expressed protein 26 — Q8N6G2 (reviewed: Q8N6G2)

All UniProt accessions (2): Q8N6G2, H0YE92

RefSeq proteins (5): NP_001340317, NP_001340318, NP_001340319, NP_001340320, NP_689538* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR043460	MEDAG/TEX26	Family

UniProt features (8 total): region of interest 6, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N6G2-F1	63.42	0.01

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 26 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_DN, DARWICHE_PAPILLOMA_PROGRESSION_RISK, CDP_01, TGGAAA_NFAT_Q4_01, DODD_NASOPHARYNGEAL_CARCINOMA_DN, HATADA_METHYLATED_IN_LUNG_CANCER_UP, MIR3942_3P, MIR2115_5P, GSE14350_TREG_VS_TEFF_IN_IL2RB_KO_DN, DESCARTES_MAIN_FETAL_CILIATED_EPITHELIAL_CELLS, DESCARTES_FETAL_LUNG_CILIATED_EPITHELIAL_CELLS, TRAVAGLINI_LUNG_PROXIMAL_CILIATED_CELL, CARRILLOREIXACH_HEPATOBLASTOMA_VS_NORMAL_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE39820_IL1B_IL6_VS_IL1B_IL6_IL23A_TREATED_CD4_TCELL_UP

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

246 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TEX26	SYNGR4	O95473	644
TEX26	TEX2	Q8IWB9	507
TEX26	TEX22	C9J3V5	507
TEX26	TEX261	Q6UWH6	506
TEX26	FAM241B	Q96D05	506
TEX26	PLEKHB1	Q9UF11	505
TEX26	MXD3	Q9BW11	496
TEX26	OR2I1	Q8NGU4	480
TEX26	TEX9	Q8N6V9	435
TEX26	CYTL1	Q9NRR1	416
TEX26	TEX19	Q8NA77	398
TEX26	SPEF1	Q9Y4P9	393
TEX26	PDIA2	Q13087	391
TEX26	KATNAL1	Q9BW62	381
TEX26	F2RL3	Q96RI0	367
TEX26	SPATA4	Q8NEY3	367

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A087WRI3, A2BFC9, A2RRW4, A4QMS7, A6NJV1, A6NL82, A6QPC0, A6QQ68, A8E4X8, A8E5W8, A8QW39, A9JS51, D6REC4, F1P3Y5, G3X6E2, P0C875, Q0VB26, Q1MSJ5, Q2IA00, Q2T9Q3, Q2TA11, Q3UY96, Q494V2, Q497Q6, Q4KKZ1, Q4QR77, Q4R5Y0, Q4R8V8, Q5NC57, Q5ZIH9, Q6J272, Q6PII3, Q6ZQR2, Q6ZVS7, Q7Z4T9, Q8CFW7, Q8N1D5, Q8N6G2, Q8WW14, Q95LR0

Diamond homologs: Q0VB26, Q8N6G2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

61 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	55
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1173 predictions. Top by Δscore:

Variant	Effect	Δscore
13:30932777:G:GG	donor_gain	1.0000
13:30932772:GCCAA:G	donor_gain	0.9900
13:30952658:A:AG	acceptor_gain	0.9900
13:30952659:G:GG	acceptor_gain	0.9900
13:30952823:G:GT	donor_gain	0.9900
13:30952823:GAA:G	donor_gain	0.9900
13:30952826:G:GG	donor_gain	0.9900
13:30960132:G:GT	donor_gain	0.9900
13:30966215:A:AG	acceptor_gain	0.9900
13:30966216:C:G	acceptor_gain	0.9900
13:30966220:A:AG	acceptor_gain	0.9800
13:30966221:G:GG	acceptor_gain	0.9800
13:30968883:A:AG	acceptor_gain	0.9800
13:30968884:G:GG	acceptor_gain	0.9800
13:30932775:AA:A	donor_gain	0.9700
13:30932776:AG:A	donor_loss	0.9700
13:30932777:GTAA:G	donor_loss	0.9700
13:30932778:T:A	donor_loss	0.9700
13:30952831:A:G	donor_gain	0.9700
13:30974845:GATA:G	acceptor_gain	0.9700
13:30952659:GCC:G	acceptor_gain	0.9600
13:30952659:GCCA:G	acceptor_gain	0.9500
13:30952823:GAAG:G	donor_loss	0.9500
13:30952824:AAGT:A	donor_loss	0.9500
13:30952825:AG:A	donor_loss	0.9500
13:30952826:GTAAG:G	donor_loss	0.9500
13:30952827:T:TC	donor_loss	0.9500
13:30966392:GGTC:G	donor_gain	0.9500
13:30932774:CAA:C	donor_gain	0.9400
13:30952821:ATGAA:A	donor_gain	0.9400

AlphaMissense

1906 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:30939741:T:C	F37L	0.973
13:30939743:C:A	F37L	0.973
13:30939743:C:G	F37L	0.973
13:30957011:T:C	F151L	0.949
13:30957013:T:A	F151L	0.949
13:30957013:T:G	F151L	0.949
13:30966296:T:C	F182L	0.944
13:30966298:C:A	F182L	0.944
13:30966298:C:G	F182L	0.944
13:30956987:T:C	F143L	0.930
13:30956989:T:A	F143L	0.930
13:30956989:T:G	F143L	0.930
13:30966300:G:C	R183P	0.896
13:30974866:T:C	F277L	0.876
13:30974868:T:A	F277L	0.876
13:30974868:T:G	F277L	0.876
13:30966392:G:C	G214R	0.875
13:30952740:A:C	Y76S	0.858
13:30974867:T:C	F277S	0.856
13:30939742:T:C	F37S	0.851
13:30939724:C:T	T31I	0.847
13:30968885:T:A	V216E	0.833
13:30956972:G:C	A138P	0.832
13:30969026:T:C	L263P	0.831
13:30952745:T:A	W78R	0.825
13:30952745:T:C	W78R	0.825
13:30952739:T:G	Y76D	0.817
13:30966308:T:G	Y186D	0.816
13:30956885:T:A	W109R	0.814
13:30956885:T:C	W109R	0.814

dbSNP variants (sampled 300 via entrez): RS1000009977 (13:30957401 G>A), RS1000076530 (13:30956351 T>C), RS1000124541 (13:30952261 T>A,C), RS1000136541 (13:30968803 G>A,C), RS1000196317 (13:30975456 C>T), RS1000211460 (13:30943404 A>C), RS1000212502 (13:30945727 T>A,C), RS1000289005 (13:30937558 T>C), RS1000461199 (13:30953456 C>T), RS1000512982 (13:30953202 C>T), RS1000553065 (13:30948975 C>A,T), RS1000598610 (13:30937714 A>G), RS1000617220 (13:30954538 A>G), RS1000707200 (13:30954346 G>A,T), RS1000794392 (13:30964844 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010396_269	Gut microbiota (bacterial taxa, hurdle binary method)	4.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007874	gut microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium Chloride	increases expression	2
sodium arsenite	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Benzo(a)pyrene	increases methylation	1
Smoke	increases abundance, increases expression	1
Tobacco Smoke Pollution	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.