TEX261

Summary

TEX261 (testis expressed 261, HGNC:30712) is a protein-coding gene on chromosome 2p13.3, encoding Protein TEX261 (Q6UWH6).

Predicted to enable COPII receptor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in cytoplasm and membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum membrane.

Source: NCBI Gene 113419 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 23 total
• MANE Select transcript: NM_144582

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30712
Approved symbol	TEX261
Name	testis expressed 261
Location	2p13.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC32043, TEG-261
Ensembl gene	ENSG00000144043
Ensembl biotype	protein_coding
OMIM	618562
Entrez	113419

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 3 retained_intron, 2 nonsense_mediated_decay, 1 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000272438, ENST00000433258, ENST00000466731, ENST00000473055, ENST00000478068, ENST00000489894, ENST00000703745

RefSeq mRNA: 1 — MANE Select: NM_144582 NM_144582

CCDS: CCDS1914

Canonical transcript exons

ENST00000272438 — 6 exons

Exon	Start	End
ENSE00001920719	70985942	70988715
ENSE00001957494	70994688	70994873
ENSE00003472930	70993696	70993775
ENSE00003541998	70988915	70989017
ENSE00003673654	70989749	70989816
ENSE00003989778	70991830	70991983

Expression profiles

Bgee: expression breadth ubiquitous, 297 present calls, max score 95.51.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.8834 / max 55.0324, expressed in 1810 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29055	16.9650	1808
29054	0.7721	473
29052	0.1222	44
29053	0.0240	5

Top tissues by expression

299 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	95.51	gold quality
body of pancreas	UBERON:0001150	95.24	gold quality
pancreas	UBERON:0001264	94.79	gold quality
parotid gland	UBERON:0001831	94.24	gold quality
right lobe of thyroid gland	UBERON:0001119	94.19	gold quality
ileal mucosa	UBERON:0000331	94.14	gold quality
left testis	UBERON:0004533	94.14	gold quality
gastrocnemius	UBERON:0001388	94.07	gold quality
stromal cell of endometrium	CL:0002255	94.04	gold quality
right testis	UBERON:0004534	94.00	gold quality
right coronary artery	UBERON:0001625	93.96	gold quality
left lobe of thyroid gland	UBERON:0001120	93.88	gold quality
muscle of leg	UBERON:0001383	93.83	gold quality
right ovary	UBERON:0002118	93.82	gold quality
left adrenal gland	UBERON:0001234	93.76	gold quality
left ovary	UBERON:0002119	93.74	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.69	gold quality
smooth muscle tissue	UBERON:0001135	93.59	gold quality
thyroid gland	UBERON:0002046	93.59	gold quality
metanephric glomerulus	UBERON:0004736	93.58	gold quality
left adrenal gland cortex	UBERON:0035825	93.52	gold quality
adenohypophysis	UBERON:0002196	93.46	gold quality
adrenal cortex	UBERON:0001235	93.41	gold quality
gluteal muscle	UBERON:0002000	93.40	gold quality
right adrenal gland	UBERON:0001233	93.39	gold quality
right adrenal gland cortex	UBERON:0035827	93.38	gold quality
cardia of stomach	UBERON:0001162	93.30	gold quality
muscle organ	UBERON:0001630	93.27	gold quality
skeletal muscle organ	UBERON:0014892	93.27	gold quality
renal glomerulus	UBERON:0000074	93.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.11

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

116 targeting TEX261, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	tex261	ENSDARG00000044584
mus_musculus	Tex261	ENSMUSG00000014748
rattus_norvegicus	Tex261	ENSRNOG00000013712
drosophila_melanogaster	CG3500	FBGN0034849

Protein

Protein identifiers

Protein TEX261 — Q6UWH6 (reviewed: Q6UWH6)

All UniProt accessions (3): Q6UWH6, A0A994J4F9, F8WAR8

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the SVP26 family.

RefSeq proteins (1): NP_653183* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007277	Svp26/Tex261	Family

Pfam: PF04148

UniProt features (6 total): transmembrane region 5, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6UWH6-F1	82.56	0.55

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 160 (showing top): BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GCM_GSPT1, MORF_UBE2I, MORF_HDAC1, MORF_CDK2, GOBP_VESICLE_MEDIATED_TRANSPORT, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, GTGCCTT_MIR506, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT, MARTINEZ_RB1_TARGETS_DN, GOCC_COATED_VESICLE, MORF_BUB3, GCM_NUMA1, GCM_DDX11, SENESE_HDAC1_TARGETS_UP

GO Biological Process (2): endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), positive regulation of apoptotic process (GO:0043065)

GO Molecular Function (1): COPII receptor activity (GO:0097020)

GO Cellular Component (5): Golgi membrane (GO:0000139), endoplasmic reticulum membrane (GO:0005789), COPII-coated ER to Golgi transport vesicle (GO:0030134), cytoplasm (GO:0005737), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cytoplasm	1
intercellular transport	1
intracellular transport	1
Golgi vesicle transport	1
apoptotic process	1
regulation of apoptotic process	1
positive regulation of programmed cell death	1
cargo receptor activity	1
Golgi apparatus	1
bounding membrane of organelle	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
coated vesicle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

340 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TEX261	TTC16	Q8NEE8	537
TEX261	TEX26	Q8N6G2	506
TEX261	BPIFB3	P59826	449
TEX261	SLC25A52	Q3SY17	447
TEX261	TM4SF20	Q53R12	446
TEX261	CXorf58	Q96LI9	445
TEX261	SPAG7	O75391	439
TEX261	SNAPC5	O75971	436
TEX261	AQP12B	A6NM10	420
TEX261	FAM124A	Q86V42	419
TEX261	SMIM26	A0A096LP01	401
TEX261	TMEM14B	Q9NUH8	392
TEX261	LRRC41	Q15345	370
TEX261	DHRSX	Q8N5I4	353
TEX261	C19orf81	C9J6K1	349

IntAct

4 interactions, top by confidence:

A	B	Type	Score
SIGLEC12	HSPA5	psi-mi:“MI:0914”(association)	0.530
CD226	TMED7-TICAM2	psi-mi:“MI:0914”(association)	0.350

BioGRID (3): TEX261 (Affinity Capture-MS), TEX261 (Affinity Capture-RNA), TEX261 (Affinity Capture-MS)

ESM2 similar proteins: A2AF53, A4FV75, A4K2N5, A4K2W1, A5A6S6, A6QL84, A6ZIQ8, A9JRA0, B1AZA5, D3ZEH5, D3ZXD8, E1BD52, O60337, P58749, Q08DE2, Q108U3, Q2TBU2, Q3SYY9, Q3TMP8, Q4R5E3, Q58DA4, Q5BJW3, Q5JZQ8, Q5R8H8, Q5R9W1, Q5RBJ7, Q5RFE0, Q5ZII3, Q62302, Q6UWH6, Q6ZQ89, Q78S06, Q7SYC7, Q7ZUA6, Q86W33, Q8CIF6, Q8K0B2, Q8N2H4, Q8NBJ9, Q8NFB2

Diamond homologs: P38869, Q1MTR8, Q54ER8, Q58DA4, Q5BJW3, Q5RFE0, Q62302, Q6UWH6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

23 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	17
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2146 predictions. Top by Δscore:

Variant	Effect	Δscore
2:70979342:AGGTA:A	donor_loss	1.0000
2:70979343:GGTA:G	donor_loss	1.0000
2:70979344:G:GA	donor_loss	1.0000
2:70979344:G:GG	donor_gain	1.0000
2:70979857:ATGC:A	donor_gain	1.0000
2:70979859:GC:G	donor_gain	1.0000
2:70979860:CGT:C	donor_loss	1.0000
2:70979861:G:GG	donor_gain	1.0000
2:70979862:T:G	donor_loss	1.0000
2:70981903:T:TA	acceptor_gain	1.0000
2:70981910:A:AG	acceptor_gain	1.0000
2:70981911:T:G	acceptor_gain	1.0000
2:70981916:A:AG	acceptor_gain	1.0000
2:70981916:ACT:A	acceptor_gain	1.0000
2:70981916:ACTG:A	acceptor_gain	1.0000
2:70981917:C:G	acceptor_gain	1.0000
2:70981918:T:A	acceptor_gain	1.0000
2:70981919:G:A	acceptor_gain	1.0000
2:70981934:A:AG	acceptor_gain	1.0000
2:70981935:G:GA	acceptor_gain	1.0000
2:70982105:GAGT:G	donor_gain	1.0000
2:70982107:GT:G	donor_gain	1.0000
2:70982685:GAT:G	donor_gain	1.0000
2:70982687:T:G	donor_gain	1.0000
2:70982687:T:TG	donor_gain	1.0000
2:70982691:G:GG	donor_gain	1.0000
2:70982698:G:GG	donor_gain	1.0000
2:70988563:T:A	donor_gain	1.0000
2:70988583:T:TA	donor_gain	1.0000
2:70988608:T:C	donor_gain	1.0000

AlphaMissense

1267 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:70988990:A:G	W134R	1.000
2:70988990:A:T	W134R	1.000
2:70988959:A:G	L144P	0.999
2:70988980:G:C	P137R	0.999
2:70988980:G:T	P137Q	0.999
2:70991833:A:G	C101R	0.999
2:70991873:G:C	F87L	0.999
2:70991873:G:T	F87L	0.999
2:70991875:A:G	F87L	0.999
2:70993748:A:G	L33P	0.999
2:70993769:C:T	G26E	0.999
2:70993770:C:G	G26R	0.999
2:70993770:C:T	G26R	0.999
2:70988938:A:T	L151Q	0.998
2:70988953:G:T	A146D	0.998
2:70991871:G:T	P88H	0.998
2:70991872:G:A	P88S	0.998
2:70991872:G:T	P88T	0.998
2:70991874:A:C	F87C	0.998
2:70991883:A:G	L84P	0.998
2:70993766:A:G	L27P	0.998
2:70993766:A:T	L27H	0.998
2:70993772:G:T	A25D	0.998
2:70994693:G:T	A22D	0.998
2:70988959:A:T	L144H	0.997
2:70988965:A:T	V142E	0.997
2:70988988:C:A	W134C	0.997
2:70988988:C:G	W134C	0.997
2:70988992:A:G	L133P	0.997
2:70989003:G:C	F129L	0.997

dbSNP variants (sampled 300 via entrez): RS1000116130 (2:70986052 C>T), RS1000188860 (2:70985812 G>A), RS1000270866 (2:70992923 T>C), RS1000680628 (2:70990995 C>T), RS1000746407 (2:70992602 G>A), RS1002456396 (2:70996327 C>T), RS1002679392 (2:70988105 T>C), RS1002761952 (2:70989410 G>A), RS1002782642 (2:70994554 G>A), RS1002812203 (2:70994245 C>G,T), RS1003015520 (2:70988477 G>A), RS1004461568 (2:70989430 T>C), RS1004495008 (2:70996687 C>A), RS1004724302 (2:70988497 G>A), RS1004892268 (2:70994599 G>A)

Disease associations

OMIM: gene MIM:618562 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST012020_584	Serum metabolite levels	5.000000e-11
GCST012021_32	Serum metabolite levels	5.000000e-11

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	5
Cadmium Chloride	decreases expression	2
aristolochic acid I	increases expression	1
titanium dioxide	decreases methylation	1
beta-lapachone	increases expression	1
sodium arsenite	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Arsenic Trioxide	increases expression	1
Acetaminophen	increases expression	1
Atrazine	decreases expression	1
Doxorubicin	decreases expression	1
Lead	affects expression	1
Smoke	decreases expression	1
Copper Sulfate	decreases expression	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.