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Atlas / Gene / TEX29

TEX29

gene
On this page

Also known as bA474D23.1MGC35169

Summary

TEX29 (testis expressed 29, HGNC:20370) is a protein-coding gene on chromosome 13q34, encoding Testis-expressed protein 29 (Q8N6K0).

Predicted to be located in membrane.

Source: NCBI Gene 121793 — RefSeq curated summary.

At a glance

  • GWAS associations: 9
  • Clinical variants (ClinVar): 37 total — 1 likely-pathogenic
  • MANE Select transcript: NM_152324

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:20370
Approved symbolTEX29
Nametestis expressed 29
Location13q34
Locus typegene with protein product
StatusApproved
AliasesbA474D23.1, MGC35169
Ensembl geneENSG00000153495
Ensembl biotypeprotein_coding
Entrez121793

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 nonsense_mediated_decay

ENST00000283547, ENST00000497241, ENST00000904792

RefSeq mRNA: 2 — MANE Select: NM_152324 NM_001303133, NM_152324

CCDS: CCDS9522

Canonical transcript exons

ENST00000283547 — 6 exons

ExonStartEnd
ENSE00001011089111328183111328293
ENSE00001235276111320642111320762
ENSE00001235286111344083111344248
ENSE00003500585111320857111320948
ENSE00003503466111342756111342931
ENSE00003655964111339863111339932

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 92.78.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0542 / max 41.9509, expressed in 5 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
1361170.03483
2071090.01162
1361160.00783

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
left testisUBERON:000453392.78gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047392.74gold quality
right testisUBERON:000453491.90gold quality
testisUBERON:000047389.52gold quality
spermCL:000001986.90gold quality
right frontal lobeUBERON:000281082.36gold quality
Brodmann (1909) area 9UBERON:001354082.12gold quality
dorsolateral prefrontal cortexUBERON:000983479.79gold quality
anterior cingulate cortexUBERON:000983578.95gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099177.70silver quality
prefrontal cortexUBERON:000045177.40gold quality
frontal cortexUBERON:000187075.63gold quality
neocortexUBERON:000195074.99gold quality
cerebral cortexUBERON:000095672.42gold quality
amygdalaUBERON:000187672.13gold quality
primary visual cortexUBERON:000243670.85gold quality
caudate nucleusUBERON:000187370.72gold quality
putamenUBERON:000187470.00gold quality
popliteal arteryUBERON:000225069.68gold quality
middle temporal gyrusUBERON:000277169.66silver quality
tibial arteryUBERON:000761069.65gold quality
left coronary arteryUBERON:000162669.17gold quality
Brodmann (1909) area 23UBERON:001355469.16silver quality
lower esophagus mucosaUBERON:003583469.13gold quality
forebrainUBERON:000189068.84gold quality
aortaUBERON:000094767.91gold quality
coronary arteryUBERON:000162167.37gold quality
brainUBERON:000095567.02gold quality
descending thoracic aortaUBERON:000234566.85gold quality
nucleus accumbensUBERON:000188266.83gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-ANND-3no0.91

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

10 targeting TEX29, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-4778-3P99.9370.401818
HSA-MIR-6809-3P99.9171.453814
HSA-MIR-4753-3P99.9071.033786
HSA-MIR-579-3P99.8671.663628
HSA-MIR-664B-3P99.8471.653590
HSA-MIR-120899.7068.281533
HSA-MIR-6804-3P98.7264.82852
HSA-MIR-126198.6268.10896
HSA-MIR-471898.5568.61814
HSA-MIR-6884-3P98.0565.32750

Cross-species orthologs

2 orthologs

OrganismSymbolGene ID
mus_musculusTex29ENSMUSG00000031512
rattus_norvegicusTex29ENSRNOG00000033585

Protein

Protein identifiers

Testis-expressed protein 29 — Q8N6K0 (reviewed: Q8N6K0)

All UniProt accessions (2): Q8N6K0, F2Z350

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

RefSeq proteins (2): NP_001290062, NP_689537* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR031685TEX29Family

Pfam: PF15839

UniProt features (6 total): topological domain 2, chain 1, transmembrane region 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q8N6K0-F159.560.14

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 22 (showing top): CHANG_IMMORTALIZED_BY_HPV31_DN, chr13q34, NFKBIA_TARGET_GENES, MIR6884_3P, BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_A594_ACE2_EXPRESSING_CELLS_UP, BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_A594_ACE2_EXPRESSING_CELLS_RUXOLITINIB_UP, NOTCH3_TARGET_GENES, GSE27786_LIN_NEG_VS_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD8_TCELL_UP, GSE27786_LIN_NEG_VS_NKTCELL_UP, GSE28237_FOLLICULAR_VS_LATE_GC_BCELL_UP, GSE6259_FLT3L_INDUCED_33D1_POS_DC_VS_BCELL_UP, GSE22229_UNTREATED_VS_IMMUNOSUPP_THERAPY_RENAL_TRANSPLANT_PATIENT_PBMC_UP, GSE21379_TFH_VS_NON_TFH_SAP_KO_CD4_TCELL_DN, GSE24210_TCONV_VS_TREG_UP

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
binding1
cellular anatomical structure1

Protein interactions and networks

STRING

306 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
TEX29CCDC112Q8NEF3669
TEX29TEX30Q5JUR7605
TEX29C21orf140B9A014570
TEX29DPH7Q9BTV6519
TEX29FAM9CQ8IZT9484
TEX29RAD51AP2Q09MP3479
TEX29TEX13CA0A0J9YWL9449
TEX29C1orf53Q5VUE5432
TEX29TEX12Q9BXU0422
TEX29IQCF3P0C7M6419
TEX29HIGD1CA8MV81414
TEX29WDR70Q9NW82404
TEX29ACRV1P26436390
TEX29TEX13AQ9BXU3368
TEX29TEX22C9J3V5367

IntAct

73 interactions, top by confidence:

ABTypeScore
APODTEX29psi-mi:“MI:0915”(physical association)0.560
ZFPL1TEX29psi-mi:“MI:0915”(physical association)0.560
DERL3TEX29psi-mi:“MI:0915”(physical association)0.560
FAM3CTEX29psi-mi:“MI:0915”(physical association)0.560
RUSF1TEX29psi-mi:“MI:0915”(physical association)0.560
TMEM140TEX29psi-mi:“MI:0915”(physical association)0.560
CMTM7TEX29psi-mi:“MI:0915”(physical association)0.560
SMCO4TEX29psi-mi:“MI:0915”(physical association)0.560
MALTEX29psi-mi:“MI:0915”(physical association)0.560
TMBIM6TEX29psi-mi:“MI:0915”(physical association)0.560
TMEM190TEX29psi-mi:“MI:0915”(physical association)0.560
NRACTEX29psi-mi:“MI:0915”(physical association)0.560
GJB2TEX29psi-mi:“MI:0915”(physical association)0.560
CLEC7ATEX29psi-mi:“MI:0915”(physical association)0.560
GPHB5TEX29psi-mi:“MI:0915”(physical association)0.560
TMEM147TEX29psi-mi:“MI:0915”(physical association)0.560
TMEM86BTEX29psi-mi:“MI:0915”(physical association)0.560

BioGRID (67): NDFIP1 (Affinity Capture-MS), FLVCR1 (Affinity Capture-MS), HIP1R (Affinity Capture-MS), TOR1A (Affinity Capture-MS), LEMD3 (Affinity Capture-MS), SLC4A7 (Affinity Capture-MS), FAM207A (Affinity Capture-MS), PLAA (Affinity Capture-MS), SLC6A15 (Affinity Capture-MS), PTS (Affinity Capture-MS), STEAP3 (Affinity Capture-MS), GOLGA5 (Affinity Capture-MS), SLC16A2 (Affinity Capture-MS), ZDHHC9 (Affinity Capture-MS), STX10 (Affinity Capture-MS)

ESM2 similar proteins: A1DWM3, A9ZLX4, F1N4M2, F1QFU0, F6QZ15, O54828, O73698, O75151, O75916, P17863, P49140, P49805, Q04679, Q08B84, Q13191, Q28C33, Q3SZT4, Q3TTA7, Q3UN70, Q4KUS2, Q5F3L9, Q5RH73, Q5U3K5, Q5ZKN3, Q62739, Q62768, Q68FR2, Q6DFR2, Q6GQL0, Q6NRE7, Q7T0Z7, Q7TPJ0, Q86XR5, Q8CB19, Q8K467, Q8K4S7, Q8N3S3, Q8N6K0, Q8NEW7, Q8TDI7

Diamond homologs: Q3SZT4, Q6AXY3, Q8N6K0, Q9DA77

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

37 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic1
Uncertain significance25
Likely benign2
Benign0

Top pathogenic / likely-pathogenic (1)

Variant IDHGVSClassification
148303GRCh38/hg38 13q34(chr13:111118651-114340331)x3Likely pathogenic

SpliceAI

1086 predictions. Top by Δscore:

VariantEffectΔscore
13:111320945:ACAGG:Adonor_loss1.0000
13:111320948:GGTA:Gdonor_loss1.0000
13:111320949:G:GAdonor_loss1.0000
13:111320949:G:GGdonor_gain1.0000
13:111320950:T:Gdonor_loss1.0000
13:111328181:A:AGacceptor_gain1.0000
13:111328182:G:GTacceptor_gain1.0000
13:111328182:GT:Gacceptor_gain1.0000
13:111328182:GTGT:Gacceptor_gain1.0000
13:111328294:G:GGdonor_gain1.0000
13:111342754:A:AGacceptor_gain1.0000
13:111342755:G:GGacceptor_gain1.0000
13:111342755:GA:Gacceptor_gain1.0000
13:111342755:GAGTC:Gacceptor_gain1.0000
13:111320762:GGT:Gdonor_loss0.9900
13:111320763:G:GCdonor_loss0.9900
13:111320764:T:Gdonor_loss0.9900
13:111320958:G:Tdonor_gain0.9900
13:111328177:TTGCA:Tacceptor_loss0.9900
13:111328178:TGCA:Tacceptor_loss0.9900
13:111328179:GCAGT:Gacceptor_loss0.9900
13:111328180:CAGTG:Cacceptor_loss0.9900
13:111328181:AGT:Aacceptor_gain0.9900
13:111328181:AGTGT:Aacceptor_gain0.9900
13:111328182:GTG:Gacceptor_gain0.9900
13:111328182:GTGTG:Gacceptor_gain0.9900
13:111339827:T:TAacceptor_gain0.9900
13:111342752:TCA:Tacceptor_loss0.9900
13:111342752:TCAG:Tacceptor_gain0.9900
13:111342753:CAG:Cacceptor_gain0.9900

AlphaMissense

990 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
13:111328236:T:AC38S0.949
13:111328237:G:CC38S0.949
13:111328257:T:CF45L0.949
13:111328259:C:AF45L0.949
13:111328259:C:GF45L0.949
13:111328272:T:AC50S0.945
13:111328273:G:CC50S0.945
13:111328272:T:CC50R0.925
13:111339902:C:AA70D0.921
13:111328236:T:CC38R0.920
13:111339877:T:CF62L0.918
13:111339879:C:AF62L0.918
13:111339879:C:GF62L0.918
13:111328274:C:GC50W0.917
13:111339904:G:AG71R0.911
13:111339904:G:CG71R0.911
13:111328273:G:AC50Y0.910
13:111320942:T:CF18L0.909
13:111320944:C:AF18L0.909
13:111320944:C:GF18L0.909
13:111339914:T:AV74D0.909
13:111328209:T:AC29S0.906
13:111328210:G:CC29S0.906
13:111328238:C:GC38W0.897
13:111328210:G:AC29Y0.895
13:111339905:G:AG71E0.885
13:111328251:T:AC43S0.883
13:111328252:G:CC43S0.883
13:111328258:T:GF45C0.883
13:111328237:G:AC38Y0.880

dbSNP variants (sampled 300 via entrez): RS1000099377 (13:111335292 A>C), RS1000159211 (13:111331746 G>A), RS1000280741 (13:111326727 C>A,T), RS1000316190 (13:111332759 G>GT), RS1000348881 (13:111332447 A>AT), RS1000441913 (13:111322197 T>C), RS1000460527 (13:111338463 C>A,G), RS1000472781 (13:111337570 C>T), RS1000649798 (13:111327907 G>A), RS1000665147 (13:111322973 C>T), RS1000687424 (13:111333860 C>T), RS1000777900 (13:111323191 G>A,T), RS1000831200 (13:111338713 T>C), RS1000877257 (13:111318512 C>A,T), RS1000950680 (13:111318319 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

StudyTraitp-value
GCST000880_2Menarche (age at onset)6.000000e-08
GCST002541_96Menarche (age at onset)2.000000e-17
GCST002935_27Lead levels9.000000e-06
GCST003993_3Menarche (age at onset)1.000000e-08
GCST004750_38Squamous cell lung carcinoma5.000000e-06
GCST005023_19Initial pursuit acceleration7.000000e-06
GCST007576_68Chronotype4.000000e-09
GCST008803_8Smoking behaviour (cigarette pack-years)8.000000e-10
GCST010988_477Adult body size2.000000e-11

EFO canonical traits (4, from GWAS)

EFO IDTrait name
EFO:0004703age at menarche
EFO:0008434initial pursuit acceleration
EFO:0008328chronotype measurement
EFO:0009115tobacco smoke exposure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

13 total (human), top 13 by PubMed support.

ChemicalActions (top 5)PubMed papers
Benzo(a)pyreneaffects methylation2
aristolochic acid Iincreases expression1
mono-(2-ethylhexyl)phthalateincreases abundance, increases methylation1
benzo(e)pyrenedecreases methylation1
aflatoxin B2decreases methylation1
theaflavin-3,3’-digallateaffects expression1
Resveratrolaffects cotreatment, decreases expression1
Acetaminophendecreases expression1
Diethylhexyl Phthalateincreases abundance, increases methylation1
Methapyrilenedecreases methylation1
Plant Extractsaffects cotreatment, decreases expression1
Valproic Acidincreases methylation1
Copper Sulfateincreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 74

This page pulls from 74 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot