TEX30

Summary

TEX30 (testis expressed 30, HGNC:25188) is a protein-coding gene on chromosome 13q33.1, encoding Testis-expressed protein 30 (Q5JUR7).

At a glance

• Clinical variants (ClinVar): 28 total
• Druggable target: yes
• MANE Select transcript: NM_138779

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25188
Approved symbol	TEX30
Name	testis expressed 30
Location	13q33.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000151287
Ensembl biotype	protein_coding
Entrez	93081

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 18 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000376019, ENST00000376021, ENST00000376022, ENST00000376027, ENST00000376029, ENST00000376032, ENST00000487260, ENST00000851861, ENST00000851862, ENST00000851863, ENST00000851864, ENST00000851865, ENST00000851866, ENST00000851867, ENST00000851868, ENST00000851869, ENST00000913262, ENST00000913263, ENST00000913264

RefSeq mRNA: 3 — MANE Select: NM_138779 NM_001286775, NM_001286776, NM_138779

CCDS: CCDS66577, CCDS66578, CCDS9503

Canonical transcript exons

ENST00000376032 — 6 exons

Exon	Start	End
ENSE00000998722	102767273	102767478
ENSE00001092522	102768260	102768311
ENSE00003598813	102769311	102769541
ENSE00003667690	102770012	102770086
ENSE00003841566	102765888	102766580
ENSE00003846141	102773682	102773786

Expression profiles

Bgee: expression breadth ubiquitous, 243 present calls, max score 98.30.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.6604 / max 238.1729, expressed in 1774 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
138109	10.5427	1765
138108	3.1177	1211

Top tissues by expression

277 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	98.30	gold quality
left testis	UBERON:0004533	98.25	gold quality
testis	UBERON:0000473	97.04	gold quality
adult organism	UBERON:0007023	95.90	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	95.50	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	95.38	gold quality
sperm	CL:0000019	94.45	gold quality
male germ cell	CL:0000015	94.12	gold quality
corpus epididymis	UBERON:0004359	90.83	gold quality
right lobe of liver	UBERON:0001114	90.13	gold quality
ventricular zone	UBERON:0003053	89.77	gold quality
endometrium epithelium	UBERON:0004811	87.82	silver quality
ganglionic eminence	UBERON:0004023	87.70	gold quality
islet of Langerhans	UBERON:0000006	86.59	gold quality
liver	UBERON:0002107	86.59	gold quality
metanephros cortex	UBERON:0010533	85.50	gold quality
cauda epididymis	UBERON:0004360	83.78	gold quality
oocyte	CL:0000023	83.71	gold quality
embryo	UBERON:0000922	83.58	gold quality
adult mammalian kidney	UBERON:0000082	83.39	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.32	gold quality
cingulate cortex	UBERON:0003027	82.52	gold quality
anterior cingulate cortex	UBERON:0009835	82.39	gold quality
gastrocnemius	UBERON:0001388	82.29	gold quality
placenta	UBERON:0001987	82.16	gold quality
stromal cell of endometrium	CL:0002255	82.00	gold quality
Brodmann (1909) area 9	UBERON:0013540	81.93	gold quality
muscle of leg	UBERON:0001383	81.89	gold quality
body of uterus	UBERON:0009853	81.76	gold quality
cerebellar hemisphere	UBERON:0002245	81.64	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-134144	yes	1291.47
E-ANND-3	yes	6.79

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

47 targeting TEX30, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-520F-3P	99.82	71.32	1216
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-3617-5P	99.75	69.41	1968
HSA-MIR-641	99.75	69.35	1975
HSA-MIR-548O-3P	99.74	69.30	2228
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-510-3P	99.54	70.06	2965
HSA-MIR-16-2-3P	99.29	70.60	1954
HSA-MIR-195-3P	99.29	70.61	1954
HSA-MIR-18A-5P	99.29	71.05	806
HSA-MIR-18B-5P	99.29	71.05	806
HSA-MIR-3160-5P	99.28	69.07	1938
HSA-MIR-4735-3P	99.14	69.85	777
HSA-MIR-8070	99.07	69.30	1303
HSA-MIR-194-5P	99.01	69.65	1465
HSA-MIR-4709-3P	98.88	68.04	1594
HSA-MIR-374A-3P	98.87	67.82	1531
HSA-MIR-3194-3P	98.83	66.22	1167

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tex30	ENSMUSG00000026049
rattus_norvegicus	Tex30	ENSRNOG00000011658

Paralogs (1): KANSL3 (ENSG00000114982)

Protein

Protein identifiers

Testis-expressed protein 30 — Q5JUR7 (reviewed: Q5JUR7)

All UniProt accessions (3): Q5JUR7, A0A0C4DFW4, Q5JUS0

UniProt curated annotations — full annotation on UniProt →

Isoforms (2)

UniProt ID	Names	Canonical?
Q5JUR7-1	1	yes
Q5JUR7-2	2

RefSeq proteins (3): NP_001273704, NP_001273705, NP_620134* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026555	NSL3/Tex30	Family
IPR029058	AB_hydrolase_fold	Homologous_superfamily
IPR046879	KANL3/Tex30_Abhydrolase	Domain

Pfam: PF20408

UniProt features (3 total): splice variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5JUR7-F1	94.24	0.89

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 152 (showing top): DACOSTA_UV_RESPONSE_VIA_ERCC3_UP, BROWNE_HCMV_INFECTION_16HR_UP, GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_DN, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP, FISCHER_DREAM_TARGETS, KOBAYASHI_EGFR_SIGNALING_24HR_DN, NUYTTEN_EZH2_TARGETS_DN, YAGI_AML_WITH_11Q23_REARRANGED, LINDGREN_BLADDER_CANCER_CLUSTER_1_DN, GEORGES_TARGETS_OF_MIR192_AND_MIR215, PUIFFE_INVASION_INHIBITED_BY_ASCITES_DN, MARTENS_TRETINOIN_RESPONSE_DN, CHICAS_RB1_TARGETS_SENESCENT, WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN, BRUINS_UVC_RESPONSE_LATE

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

512 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TEX30	TEX29	Q8N6K0	605
TEX30	FAM9C	Q8IZT9	533
TEX30	TEX13C	A0A0J9YWL9	472
TEX30	TEX12	Q9BXU0	465
TEX30	ABHD16B	Q9H3Z7	430
TEX30	TEKT5	Q96M29	427
TEX30	C14orf39	Q8N1H7	406
TEX30	CCT6B	Q92526	402
TEX30	PSMA8	Q8TAA3	392
TEX30	CENPN	Q96H22	392
TEX30	ABHD13	Q7L211	390
TEX30	TEX13A	Q9BXU3	387
TEX30	TEX36	Q5VZQ5	386
TEX30	MEIOB	Q8N635	385
TEX30	TEX13D	A0A0J9YY54	382
TEX30	TEX22	C9J3V5	382

IntAct

2 interactions, top by confidence:

A	B	Type	Score
TEX30	SHTN1	psi-mi:“MI:0914”(association)	0.350

BioGRID (7): PREPL (Affinity Capture-MS), KIAA1598 (Affinity Capture-MS), TEX30 (Protein-peptide), TEX30 (Cross-Linking-MS (XL-MS)), TEX30 (Two-hybrid), TEX30 (Affinity Capture-RNA), TEX30 (Affinity Capture-RNA)

ESM2 similar proteins: A0A7H0DN16, A5PJJ7, B5BLW5, D5H0J3, G5EDL5, O16925, O17795, O22898, O57245, O60095, O74427, O74628, O74878, P28321, P32604, P42840, P54069, P78898, P93711, P96084, Q17704, Q1ZXQ4, Q3TUU5, Q3ZC52, Q4JK73, Q54DM9, Q54K57, Q54NU9, Q556J2, Q5JUR7, Q5M875, Q5UQ83, Q5ZJL8, Q6AYS8, Q6IRP4, Q6QA32, Q7L211, Q7Z5P4, Q80UX8, Q8NBQ5

Diamond homologs: Q3TUU5, Q3ZC52, Q5JUR7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

28 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	19
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

764 predictions. Top by Δscore:

Variant	Effect	Δscore
13:102766581:C:CC	acceptor_gain	1.0000
13:102768255:CTTA:C	donor_loss	1.0000
13:102768256:TTA:T	donor_loss	1.0000
13:102768257:TACCT:T	donor_loss	1.0000
13:102768258:A:AC	donor_gain	1.0000
13:102768258:ACCT:A	donor_gain	1.0000
13:102768259:C:CC	donor_gain	1.0000
13:102768259:CCT:C	donor_gain	1.0000
13:102768259:CCTC:C	donor_gain	1.0000
13:102768307:TAATT:T	acceptor_gain	1.0000
13:102768308:AATT:A	acceptor_gain	1.0000
13:102768309:ATT:A	acceptor_gain	1.0000
13:102768310:TT:T	acceptor_gain	1.0000
13:102768311:TCT:T	acceptor_loss	1.0000
13:102768312:C:CC	acceptor_gain	1.0000
13:102768312:CTAGA:C	acceptor_loss	1.0000
13:102768313:T:G	acceptor_loss	1.0000
13:102773677:CTTA:C	donor_loss	1.0000
13:102773678:TTAC:T	donor_loss	1.0000
13:102773679:TA:T	donor_loss	1.0000
13:102773680:AC:A	donor_gain	1.0000
13:102773681:C:CT	donor_loss	1.0000
13:102773681:CC:C	donor_gain	1.0000
13:102766579:TT:T	acceptor_gain	0.9900
13:102767272:CCTTT:C	donor_gain	0.9900
13:102768258:AC:A	donor_gain	0.9900
13:102768258:ACCTC:A	donor_gain	0.9900
13:102768259:CC:C	donor_gain	0.9900
13:102768259:CCTCC:C	donor_gain	0.9900
13:102768312:CTA:C	acceptor_gain	0.9900

AlphaMissense

1498 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:102769365:A:C	F64L	0.997
13:102769365:A:T	F64L	0.997
13:102769367:A:G	F64L	0.997
13:102767473:A:G	S102P	0.996
13:102769335:T:A	R74S	0.996
13:102769335:T:G	R74S	0.996
13:102767290:C:G	D163H	0.995
13:102769366:A:G	F64S	0.994
13:102766509:A:C	H192Q	0.993
13:102766509:A:T	H192Q	0.993
13:102767289:T:A	D163V	0.992
13:102769336:C:G	R74T	0.992
13:102767454:G:T	A108D	0.991
13:102767459:T:A	R106S	0.991
13:102767459:T:G	R106S	0.991
13:102766511:G:C	H192D	0.990
13:102767472:G:A	S102L	0.990
13:102767289:T:G	D163A	0.989
13:102767345:T:A	R144S	0.989
13:102767345:T:G	R144S	0.989
13:102767392:A:G	C129R	0.989
13:102767467:C:G	G104R	0.989
13:102767279:A:C	C166W	0.988
13:102767298:C:T	G160D	0.988
13:102767310:A:G	L156P	0.988
13:102769315:A:T	V81D	0.988
13:102767397:A:G	L127P	0.987
13:102767467:C:A	G104C	0.987
13:102769325:A:C	Y78D	0.987
13:102769372:A:G	L62P	0.987

dbSNP variants (sampled 300 via entrez): RS1000266447 (13:102770253 G>A), RS1000355133 (13:102766906 T>C), RS1000379584 (13:102766647 C>A,T), RS1000576046 (13:102773873 C>A,G,T), RS1000871524 (13:102768746 T>C), RS1001824745 (13:102769030 T>A), RS1001909083 (13:102767413 C>T), RS1001970553 (13:102774372 C>T), RS1002029455 (13:102773567 T>C), RS1002323712 (13:102767165 G>A,T), RS1002856685 (13:102765405 AATT>A), RS1002920396 (13:102769094 G>A), RS1003067172 (13:102775543 C>G), RS1004370142 (13:102770342 G>A), RS1004560274 (13:102773773 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2189125 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression, increases expression	2
afuresertib	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
sodium arsenite	increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
cupric chloride	increases expression	1
epigallocatechin gallate	decreases expression, affects cotreatment	1
perfluorooctane sulfonic acid	decreases expression	1
monomethylarsonous acid	decreases expression	1
jinfukang	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Dasatinib	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Vorinostat	increases expression	1
Acetaminophen	increases expression	1
Benzene	increases expression	1
Benzo(a)pyrene	increases expression	1
Calcitriol	decreases expression, affects cotreatment	1
Cisplatin	increases expression	1
Coumestrol	affects cotreatment, increases expression	1
Cyclophosphamide	decreases expression	1
Gold	decreases expression	1
Ivermectin	decreases expression	1
Melphalan	increases expression	1
Methyl Methanesulfonate	increases expression	1
Silicon Dioxide	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL2209079	Binding	Inhibition of C13orf27 binding to FP-biotin in [12C][14N]-lysine, arginine and [13C6][15N2]-lysine, arginine labeled HEK293T cells at 20 uM after 1 hr by isotopic activity-based protein profiling-MudPIT assay	Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.