TEX36

Summary

TEX36 (testis expressed 36, HGNC:31653) is a protein-coding gene on chromosome 10q26.13, encoding Testis-expressed protein 36 (Q5VZQ5).

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 16 total
• MANE Select transcript: NM_001128202

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31653
Approved symbol	TEX36
Name	testis expressed 36
Location	10q26.13
Locus type	gene with protein product
Status	Approved
Aliases	bA383C5.1
Ensembl gene	ENSG00000175018
Ensembl biotype	protein_coding
Entrez	387718

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000368821, ENST00000526819, ENST00000532135

RefSeq mRNA: 2 — MANE Select: NM_001128202 NM_001128202, NM_001318133

CCDS: CCDS44493, CCDS81521

Canonical transcript exons

ENST00000368821 — 4 exons

Exon	Start	End
ENSE00001099740	125661021	125661101
ENSE00001099746	125661846	125661977
ENSE00001448026	125655694	125656196
ENSE00001448029	125682939	125683163

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 84.24.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0259 / max 20.2988, expressed in 3 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111890	0.0169	3
111891	0.0090	3

Top tissues by expression

210 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	84.24	gold quality
right testis	UBERON:0004534	82.95	gold quality
testis	UBERON:0000473	81.64	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.37	silver quality
sperm	CL:0000019	70.62	silver quality
ileal mucosa	UBERON:0000331	63.20	silver quality
adult organism	UBERON:0007023	56.20	gold quality
endothelial cell	CL:0000115	54.41	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
epithelial cell of pancreas	CL:0000083	53.52	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
tibialis anterior	UBERON:0001385	51.82	silver quality
deltoid	UBERON:0001476	51.32	gold quality
pancreatic ductal cell	CL:0002079	50.73	silver quality
myocardium	UBERON:0002349	50.25	gold quality
nasal cavity epithelium	UBERON:0005384	47.03	gold quality
quadriceps femoris	UBERON:0001377	46.98	gold quality
buccal mucosa cell	CL:0002336	46.47	gold quality
sural nerve	UBERON:0015488	46.43	gold quality
smooth muscle tissue	UBERON:0001135	45.83	gold quality
vastus lateralis	UBERON:0001379	45.40	gold quality
layer of synovial tissue	UBERON:0007616	43.55	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
muscle tissue	UBERON:0002385	43.22	gold quality
endocervix	UBERON:0000458	42.92	gold quality
substantia nigra pars reticulata	UBERON:0001966	42.92	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
subthalamic nucleus	UBERON:0001906	41.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.61

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting TEX36, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-4719	99.73	72.10	3329
HSA-MIR-4502	99.65	66.99	1021
HSA-MIR-651-5P	99.64	68.49	1104
HSA-MIR-548AV-5P	99.60	70.84	2107
HSA-MIR-548K	99.60	70.84	2107
HSA-MIR-8054	99.48	70.81	2084
HSA-MIR-664A-3P	99.22	71.08	2696
HSA-MIR-654-3P	98.38	67.61	905
HSA-MIR-1265	98.36	66.46	598
HSA-MIR-4457	98.09	67.12	1274
HSA-MIR-4529-5P	96.74	65.77	569
HSA-MIR-125B-2-3P	96.69	68.38	1210
HSA-MIR-7108-5P	96.42	66.17	598

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tex36	ENSMUSG00000030976
rattus_norvegicus	Tex36	ENSRNOG00000026848

Protein

Protein identifiers

Testis-expressed protein 36 — Q5VZQ5 (reviewed: Q5VZQ5)

All UniProt accessions (3): E9PJL2, E9PR91, Q5VZQ5

RefSeq proteins (2): NP_001121674, NP_001305062 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR029369	HDNR	Domain

Pfam: PF15115

UniProt features (4 total): chain 1, region of interest 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5VZQ5-F1	60.88	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 24 (showing top): RAO_BOUND_BY_SALL4_ISOFORM_B, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, MIR548N, MIR4700_5P, MIR4667_5P, MIR8089, MIR4457, MIR7108_5P, GSE13485_DAY1_VS_DAY21_YF17D_VACCINE_PBMC_UP, LAKE_ADULT_KIDNEY_C5_PROXIMAL_TUBULE_EPITHELIAL_CELLS_STRESS_INFLAM, GSE7460_CTRL_VS_FOXP3_OVEREXPR_TCONV_1_UP, GSE1740_MCSF_VS_MCSF_AND_IFNG_DAY2_DERIVED_MACROPHAGE_WITH_IFNA_STIM_DN, GSE1740_MCSF_VS_MCSF_AND_IFNG_DAY2_DERIVED_MACROPHAGE_UP, GSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_0.8H_DN, GSE4142_PLASMA_CELL_VS_GC_BCELL_UP

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

222 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TEX36	STPG3	Q8N7X2	738
TEX36	SLFNL1	Q499Z3	666
TEX36	SPMIP9	Q96LM6	624
TEX36	GLT6D1	Q7Z4J2	618
TEX36	TESK2	Q96S53	572
TEX36	SPPL2C	Q8IUH8	545
TEX36	ZNF222	Q9UK12	510
TEX36	TEX13C	A0A0J9YWL9	495
TEX36	EDRF1	Q3B7T1	476
TEX36	PRSS58	Q8IYP2	474
TEX36	DMRTB1	Q96MA1	425
TEX36	TEX13D	A0A0J9YY54	413
TEX36	ABRAXAS2	Q15018	398
TEX36	UPP1	Q16831	396
TEX36	TEX13A	Q9BXU3	392

IntAct

3 interactions, top by confidence:

A	B	Type	Score
TEX36	EFCAB2	psi-mi:“MI:0915”(physical association)	0.400
TEX36	PPP1CC	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (3): TEX36 (Affinity Capture-MS), EFCAB2 (Affinity Capture-MS), TEX36 (Two-hybrid)

ESM2 similar proteins: A0A1B0GTD5, A0A1B0GUX0, A0A3Q1MT14, A4D263, A6NL82, A6QQL5, A8QW39, B0UXH9, B5X5D0, B9EJX3, E1B9R1, F1MMV1, Q148A4, Q1JPL0, Q2T9T0, Q32KQ1, Q32L72, Q32L77, Q32P67, Q3V0J4, Q5BN46, Q5NC57, Q5NC83, Q5SPV6, Q5SS90, Q5SVJ3, Q5VTT2, Q5VZQ5, Q66HC0, Q66HR9, Q6AYM0, Q6NXP0, Q6P3G4, Q6ZVS7, Q80X60, Q8CDT5, Q8CDU5, Q8N5S3, Q8N7U6, Q8N865

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

16 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	13
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

501 predictions. Top by Δscore:

Variant	Effect	Δscore
10:125661012:AATAC:A	donor_loss	1.0000
10:125661013:ATACT:A	donor_loss	1.0000
10:125661014:TACTC:T	donor_loss	1.0000
10:125661015:AC:A	donor_loss	1.0000
10:125661016:C:CA	donor_loss	1.0000
10:125661017:T:TC	donor_loss	1.0000
10:125661018:CACGG:C	donor_loss	1.0000
10:125661019:A:AC	donor_gain	1.0000
10:125661019:A:T	donor_loss	1.0000
10:125661020:C:CA	donor_gain	1.0000
10:125661020:CG:C	donor_gain	1.0000
10:125661020:CGG:C	donor_gain	1.0000
10:125661020:CGGA:C	donor_gain	1.0000
10:125661020:CGGAG:C	donor_gain	1.0000
10:125661098:CTTG:C	acceptor_gain	1.0000
10:125661099:TTG:T	acceptor_gain	1.0000
10:125661100:TG:T	acceptor_gain	1.0000
10:125661102:C:CC	acceptor_gain	1.0000
10:125661102:CTG:C	acceptor_loss	1.0000
10:125661110:G:C	acceptor_gain	1.0000
10:125661110:G:GC	acceptor_gain	1.0000
10:125661115:A:AC	acceptor_gain	1.0000
10:125661115:A:C	acceptor_gain	1.0000
10:125661841:CTCA:C	donor_loss	1.0000
10:125661842:TCA:T	donor_loss	1.0000
10:125661843:CA:C	donor_loss	1.0000
10:125661844:A:C	donor_loss	1.0000
10:125661978:C:CC	acceptor_gain	1.0000
10:125660505:CAGT:C	donor_gain	0.9900
10:125660514:C:CT	donor_gain	0.9900

AlphaMissense

1214 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:125656032:A:C	F143L	0.972
10:125656032:A:T	F143L	0.972
10:125656034:A:G	F143L	0.972
10:125661975:G:C	F18L	0.966
10:125661975:G:T	F18L	0.966
10:125661977:A:G	F18L	0.966
10:125661081:G:C	F68L	0.961
10:125661081:G:T	F68L	0.961
10:125661083:A:G	F68L	0.961
10:125682941:A:G	W17R	0.958
10:125682941:A:T	W17R	0.958
10:125661058:C:G	R76P	0.956
10:125661064:T:A	D74V	0.939
10:125661060:A:C	N75K	0.933
10:125661060:A:T	N75K	0.933
10:125656186:C:G	R92P	0.931
10:125661075:G:C	F70L	0.931
10:125661075:G:T	F70L	0.931
10:125661077:A:G	F70L	0.931
10:125656140:A:C	F107L	0.930
10:125656140:A:T	F107L	0.930
10:125656142:A:G	F107L	0.930
10:125661064:T:G	D74A	0.930
10:125682939:C:A	W17C	0.924
10:125682939:C:G	W17C	0.924
10:125656143:A:C	N106K	0.920
10:125656143:A:T	N106K	0.920
10:125661063:G:C	D74E	0.920
10:125661063:G:T	D74E	0.920
10:125661065:C:G	D74H	0.917

dbSNP variants (sampled 300 via entrez): RS1000005590 (10:125635228 A>G), RS1000019328 (10:125577995 G>A), RS1000059648 (10:125615840 A>G), RS1000088100 (10:125674895 C>T), RS1000109511 (10:125651327 C>A), RS1000110189 (10:125615993 C>A,T), RS1000117551 (10:125597327 C>T), RS1000123724 (10:125610178 G>C), RS1000175793 (10:125611201 A>G), RS1000194387 (10:125609006 G>GA), RS1000196754 (10:125647606 C>A,T), RS1000231964 (10:125665414 A>T), RS1000236371 (10:125650560 C>T), RS1000281214 (10:125640160 T>C,G), RS1000295115 (10:125605284 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST000765_9	Non-alcoholic fatty liver disease histology (other)	7.000000e-06
GCST007012_4	Cerebrospinal fluid AB1-42 levels	9.000000e-07
GCST90000047_213	Age at first sexual intercourse	2.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004670	beta-amyloid 1-42 measurement
EFO:0009749	age at first sexual intercourse measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases methylation	1
Lead	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.