TEX41

Summary

TEX41 (testis expressed 41, HGNC:48667) is a long non-coding RNA gene on chromosome 2q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48667
Approved symbol	TEX41
Name	testis expressed 41
Location	2q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	DKFZp686O1327, LINC00953
Ensembl gene	ENSG00000226674
Ensembl biotype	lncRNA
Entrez	401014
RNAcentral	URS000075B9B4 — lncRNA, 4801 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 215 — 215 lncRNA

ENST00000414195, ENST00000414256, ENST00000420472, ENST00000423031, ENST00000431734, ENST00000432608, ENST00000445791, ENST00000451027, ENST00000451478, ENST00000451774, ENST00000594471, ENST00000594626, ENST00000594837, ENST00000595686, ENST00000596034, ENST00000596230, ENST00000596278, ENST00000596540, ENST00000596589, ENST00000596747, ENST00000596970, ENST00000597173, ENST00000597469, ENST00000597655, ENST00000597670, ENST00000597893, ENST00000598248, ENST00000598659, ENST00000599072, ENST00000599187, ENST00000599358, ENST00000600064, ENST00000600679, ENST00000601277, ENST00000601578, ENST00000602041, ENST00000602108, ENST00000604253, ENST00000605238, ENST00000608432, ENST00000608652, ENST00000609705, ENST00000614173, ENST00000625362, ENST00000625557, ENST00000625651, ENST00000625671, ENST00000625887, ENST00000626133, ENST00000626197, ENST00000626239, ENST00000626325, ENST00000626363, ENST00000626394, ENST00000626404, ENST00000626411, ENST00000626952, ENST00000627051, ENST00000627195, ENST00000627419, ENST00000627497, ENST00000627545, ENST00000627675, ENST00000627757, ENST00000627785, ENST00000627991, ENST00000628057, ENST00000628136, ENST00000628167, ENST00000628180, ENST00000628213, ENST00000628237, ENST00000628422, ENST00000628611, ENST00000628688, ENST00000628775, ENST00000628794, ENST00000628985, ENST00000629149, ENST00000629185, ENST00000629194, ENST00000629218, ENST00000629251, ENST00000629460, ENST00000629585, ENST00000629613, ENST00000629631, ENST00000629997, ENST00000630029, ENST00000630122, ENST00000630139, ENST00000630246, ENST00000630451, ENST00000630651, ENST00000630691, ENST00000630709, ENST00000630724, ENST00000630732, ENST00000630959, ENST00000631075, ENST00000631167, ENST00000631271, ENST00000650896, ENST00000652981, ENST00000653186, ENST00000653533, ENST00000653630, ENST00000653910, ENST00000653941, ENST00000653959, ENST00000654298, ENST00000654361, ENST00000654410, ENST00000654442, ENST00000655165, ENST00000655187, ENST00000655563, ENST00000656317, ENST00000656353, ENST00000656881, ENST00000656937, ENST00000657187, ENST00000657526, ENST00000657624, ENST00000657684, ENST00000657732, ENST00000658019, ENST00000658352, ENST00000658898, ENST00000659773, ENST00000659777, ENST00000659810, ENST00000660009, ENST00000660169, ENST00000660660, ENST00000660827, ENST00000660904, ENST00000661094, ENST00000661187, ENST00000661327, ENST00000661398, ENST00000661482, ENST00000661697, ENST00000661920, ENST00000662233, ENST00000662271, ENST00000662863, ENST00000663282, ENST00000663303, ENST00000663323, ENST00000664055, ENST00000664258, ENST00000664611, ENST00000664649, ENST00000664679, ENST00000664937, ENST00000665081, ENST00000665226, ENST00000665244, ENST00000665824, ENST00000666180, ENST00000666650, ENST00000666675, ENST00000666826, ENST00000666890, ENST00000666917, ENST00000666949, ENST00000666980, ENST00000667423, ENST00000667704, ENST00000667781, ENST00000667905, ENST00000667984, ENST00000668187, ENST00000668319, ENST00000668424, ENST00000668441, ENST00000669172, ENST00000669646, ENST00000669793, ENST00000670002, ENST00000670099, ENST00000670125, ENST00000670681, ENST00000670869, ENST00000671290, ENST00000671502, ENST00000671637, ENST00000671649, ENST00000747450, ENST00000758932, ENST00000758933, ENST00000758934, ENST00000758935, ENST00000758936, ENST00000758937, ENST00000758938, ENST00000758939, ENST00000758940, ENST00000758941, ENST00000758942, ENST00000762897, ENST00000762898, ENST00000762899, ENST00000762900, ENST00000762901, ENST00000762902, ENST00000762903, ENST00000762904, ENST00000762905, ENST00000762906, ENST00000762907, ENST00000762908, ENST00000762909, ENST00000762910

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414195 — 4 exons

Exon	Start	End
ENSE00001612134	145171998	145172131
ENSE00001689901	145182046	145182093
ENSE00001740187	145182204	145182649
ENSE00004118523	145023202	145023273

Expression profiles

Bgee: expression breadth ubiquitous, 181 present calls, max score 96.06.

FANTOM5 (CAGE): breadth broad, TPM avg 1.6820 / max 141.4770, expressed in 236 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
22906	1.1480	192
22905	0.2775	101
22904	0.1393	61
22907	0.0461	14
22903	0.0381	19
22880	0.0216	7
22881	0.0115	7

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	96.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.89	gold quality
sural nerve	UBERON:0015488	90.12	gold quality
colonic epithelium	UBERON:0000397	87.72	gold quality
adrenal tissue	UBERON:0018303	86.23	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.57	gold quality
tendon	UBERON:0000043	83.13	gold quality
buccal mucosa cell	CL:0002336	83.05	gold quality
right coronary artery	UBERON:0001625	82.58	gold quality
left testis	UBERON:0004533	80.39	gold quality
right testis	UBERON:0004534	79.70	gold quality
testis	UBERON:0000473	79.21	gold quality
ectocervix	UBERON:0012249	78.71	gold quality
popliteal artery	UBERON:0002250	78.08	gold quality
left coronary artery	UBERON:0001626	78.07	gold quality
tibial artery	UBERON:0007610	78.04	gold quality
skin of leg	UBERON:0001511	77.05	gold quality
skin of abdomen	UBERON:0001416	76.88	gold quality
coronary artery	UBERON:0001621	76.39	gold quality
aorta	UBERON:0000947	76.11	gold quality
subcutaneous adipose tissue	UBERON:0002190	75.73	gold quality
endocervix	UBERON:0000458	75.46	gold quality
adult mammalian kidney	UBERON:0000082	75.03	gold quality
zone of skin	UBERON:0000014	74.47	gold quality
cortex of kidney	UBERON:0001225	74.38	gold quality
metanephros cortex	UBERON:0010533	74.28	gold quality
ascending aorta	UBERON:0001496	74.20	gold quality
thoracic aorta	UBERON:0001515	73.99	gold quality
left uterine tube	UBERON:0001303	73.83	gold quality
tibial nerve	UBERON:0001323	73.19	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-GEOD-131882	yes	3484.29
E-CURD-119	yes	3348.18
E-ANND-3	yes	8.35

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Comprehensive Analysis of the Immune Implication of TEX41 in Skin Cutaneous Melanoma. (PMID:34795805)
• LncRNA TEX41 promotes the proliferation and migration of squamous cell carcinoma cells by upregulating Atg5 via sponging miR-153-3p. (PMID:38279424)
• WTAP-dependent N6-methyladenosine methylation of lncRNA TEX41 promotes renal cell carcinoma progression. (PMID:39433619)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.