TEX51

Summary

TEX51 (testis expressed 51, HGNC:52387) is a protein-coding gene on chromosome 2q14.3, encoding Testis-expressed protein 51 (A0A1B0GUA7).

Predicted to be located in membrane.

Source: NCBI Gene 101929926 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001322244

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52387
Approved symbol	TEX51
Name	testis expressed 51
Location	2q14.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000237524
Ensembl biotype	protein_coding
Entrez	101929926

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 9 protein_coding, 2 retained_intron, 1 non_stop_decay, 1 nonsense_mediated_decay

ENST00000436605, ENST00000437793, ENST00000441412, ENST00000450035, ENST00000454927, ENST00000458326, ENST00000568484, ENST00000636439, ENST00000636457, ENST00000637962, ENST00000643416, ENST00000706944, ENST00000706945

RefSeq mRNA: 10 — MANE Select: NM_001322244 NM_001322244, NM_001410921, NM_001416075, NM_001416076, NM_001416077, NM_001416078, NM_001416079, NM_001416080, NM_001416081, NM_001416082

CCDS: CCDS82507, CCDS92856

Canonical transcript exons

ENST00000568484 — 7 exons

Exon	Start	End
ENSE00001696743	126899523	126899612
ENSE00001767012	126899936	126900019
ENSE00002582154	126901872	126902097
ENSE00003794215	126901365	126901404
ENSE00003795204	126901210	126901278
ENSE00003797913	126899217	126899291
ENSE00003842780	126898890	126899063

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 94.63.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1107 / max 110.5158, expressed in 3 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
22402	0.0915	3
22403	0.0160	3
22401	0.0031	2

Top tissues by expression

219 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	94.63	gold quality
left testis	UBERON:0004533	94.45	gold quality
testis	UBERON:0000473	91.08	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.21	gold quality
sperm	CL:0000019	79.02	gold quality
adult organism	UBERON:0007023	60.40	silver quality
nasal cavity epithelium	UBERON:0005384	56.88	gold quality
oocyte	CL:0000023	54.34	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
pancreatic ductal cell	CL:0002079	54.29	silver quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
epithelial cell of pancreas	CL:0000083	53.96	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
buccal mucosa cell	CL:0002336	53.28	gold quality
myocardium	UBERON:0002349	50.25	gold quality
tibialis anterior	UBERON:0001385	50.22	silver quality
thymus	UBERON:0002370	49.60	silver quality
cerebellar vermis	UBERON:0004720	48.93	gold quality
tendon of biceps brachii	UBERON:0008188	48.69	gold quality
quadriceps femoris	UBERON:0001377	48.31	gold quality
ileal mucosa	UBERON:0000331	48.26	silver quality
amniotic fluid	UBERON:0000173	47.61	gold quality
deltoid	UBERON:0001476	47.49	gold quality
vastus lateralis	UBERON:0001379	47.00	gold quality
layer of synovial tissue	UBERON:0007616	45.94	gold quality
substantia nigra pars reticulata	UBERON:0001966	43.73	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
gingival epithelium	UBERON:0001949	42.84	gold quality
secondary oocyte	CL:0000655	42.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.29

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

12 targeting TEX51, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-7-5P	99.67	70.53	1809
HSA-MIR-7109-5P	99.18	66.13	1057
HSA-MIR-4709-3P	98.88	68.04	1594
HSA-MIR-6887-5P	98.56	68.49	1295
HSA-MIR-6795-5P	98.52	68.51	1277
HSA-MIR-758-3P	98.42	68.60	1122
HSA-MIR-193B-5P	97.91	65.88	837
HSA-MIR-5194	96.77	63.91	1021
HSA-MIR-6738-5P	96.33	63.61	815
HSA-MIR-1914-3P	95.07	63.37	762

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tex51	ENSMUSG00000109238
rattus_norvegicus	Tex51	ENSRNOG00000061675

Protein

Protein identifiers

Testis-expressed protein 51 — A0A1B0GUA7 (reviewed: A0A1B0GUA7)

All UniProt accessions (10): A0A1B0GUA7, A0A1B0GTN5, A0A1B0GUC9, A0A1B0GUP2, A0A1B0GUY8, A0A1B0GVX2, A0A1B0GWE4, A0A2R8Y5A7, A0A9L9PXS2, A0A9L9PYI6

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

RefSeq proteins (10): NP_001309173, NP_001397850, NP_001403004, NP_001403005, NP_001403006, NP_001403007, NP_001403008, NP_001403009, NP_001403010, NP_001403011 (=MANE)

Domains & families (InterPro)

UniProt features (3 total): signal peptide 1, chain 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A1B0GUA7-F1	71.09	0.25

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 4 (showing top): chr2q14, MIR5194, MIR6738_5P, MIR1914_3P

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

64 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TEX51	PRRT3	Q5FWE3	581
TEX51	PLEKHG1	Q9ULL1	571
TEX51	UQCC1	Q9NVA1	565
TEX51	SDK2	Q58EX2	542
TEX51	LHPP	Q9H008	507
TEX51	ANO2	Q9NQ90	474
TEX51	NPY5R	Q15761	448
TEX51	KRTAP10-8	P60410	377
TEX51	MAP4	P27816	371
TEX51	KRTAP4-1	Q9BYQ7	370
TEX51	EPHX2	P34913	348
TEX51	HTR2C	P28335	322
TEX51	OXTR	P30559	315
TEX51	FKBP5	Q13451	296
TEX51	RORA	P35397	285

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A1B0GUA7, A0A3Q1LRJ2, A2T6Z6, E9Q8Q8, O46673, O77049, O88823, P01588, P07865, P22301, P29676, P43480, P46651, P48411, P51496, P51497, P51746, P55029, P79338, Q0Z972, Q25BC1, Q28374, Q28C41, Q2PE73, Q3KNT9, Q4VK74, Q5Q0V6, Q5ZJY9, Q6A2H4, Q6AY06, Q6H8S9, Q6H8T0, Q6H8T1, Q6H8T2, Q6UXV1, Q865X4, Q8BGT0, Q8CGK6, Q8CJ70, Q8IU54

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1082 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:126899270:G:C	A67P	0.961
2:126899252:T:C	F61L	0.950
2:126899254:C:A	F61L	0.950
2:126899254:C:G	F61L	0.950
2:126899580:T:C	L93P	0.940
2:126901248:A:C	S145R	0.903
2:126901250:C:A	S145R	0.903
2:126901250:C:G	S145R	0.903
2:126899535:T:A	L78H	0.901
2:126899535:T:C	L78P	0.901
2:126899250:T:C	F60S	0.900
2:126899243:G:C	A58P	0.898
2:126901251:A:C	S146R	0.897
2:126901253:T:A	S146R	0.897
2:126901253:T:G	S146R	0.897
2:126898984:G:C	W22C	0.879
2:126898984:G:T	W22C	0.879
2:126899526:A:T	K75I	0.873
2:126899274:T:A	I68N	0.871
2:126899253:T:G	F61C	0.863
2:126899568:T:C	F89S	0.860
2:126899274:T:G	I68S	0.854
2:126899253:T:C	F61S	0.844
2:126899560:G:C	K86N	0.842
2:126899560:G:T	K86N	0.842
2:126899029:G:C	W37C	0.839
2:126899029:G:T	W37C	0.839
2:126899568:T:G	F89C	0.836
2:126899013:A:T	D32V	0.835
2:126899976:C:G	C117W	0.833

dbSNP variants (sampled 300 via entrez): RS1000135059 (2:126902543 T>C), RS1000466304 (2:126902379 C>G), RS1000771970 (2:126902163 G>A), RS1000795876 (2:126897637 T>C), RS1001352098 (2:126897935 C>A,T), RS1001361155 (2:126897029 G>A), RS1002367954 (2:126901618 A>T), RS1002934704 (2:126900537 C>G), RS1002967682 (2:126900253 A>G), RS1003722623 (2:126898867 C>T), RS1004097849 (2:126899147 G>A), RS1004233547 (2:126902378 C>T), RS1005054996 (2:126897096 C>T), RS1005323722 (2:126902085 T>C,G), RS1005695131 (2:126901278 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.