TEX52

Summary

TEX52 (testis expressed 52, HGNC:53643) is a protein-coding gene on chromosome 12p13.33, encoding Testis-expressed protein 52 (A6NCN8).

At a glance

• MANE Select transcript: NM_001365174

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53643
Approved symbol	TEX52
Name	testis expressed 52
Location	12p13.33
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000283297
Ensembl biotype	protein_coding
Entrez	101929469

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000637658

RefSeq mRNA: 2 — MANE Select: NM_001365174 NM_001365174, NM_001365175

CCDS: CCDS91638

Canonical transcript exons

ENST00000637658 — 3 exons

Exon	Start	End
ENSE00003791910	2856955	2857039
ENSE00003793165	2854896	2855446
ENSE00003800013	2849046	2849525

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 86.33.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0148 / max 10.9520, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
128974	0.0148	3

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.33	gold quality
left testis	UBERON:0004533	74.15	gold quality
testis	UBERON:0000473	73.45	gold quality
right testis	UBERON:0004534	73.45	gold quality
granulocyte	CL:0000094	67.85	gold quality
skin of leg	UBERON:0001511	66.93	gold quality
zone of skin	UBERON:0000014	66.01	gold quality
monocyte	CL:0000576	65.46	gold quality
leukocyte	CL:0000738	65.13	gold quality
body of pancreas	UBERON:0001150	65.04	gold quality
right uterine tube	UBERON:0001302	64.98	gold quality
left lobe of thyroid gland	UBERON:0001120	64.78	gold quality
skin of abdomen	UBERON:0001416	64.64	gold quality
minor salivary gland	UBERON:0001830	64.61	gold quality
right lobe of thyroid gland	UBERON:0001119	64.58	gold quality
saliva-secreting gland	UBERON:0001044	64.57	gold quality
thyroid gland	UBERON:0002046	64.31	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.84	gold quality
right lobe of liver	UBERON:0001114	62.68	gold quality
right adrenal gland cortex	UBERON:0035827	62.66	gold quality
cortex of kidney	UBERON:0001225	62.55	gold quality
tonsil	UBERON:0002372	62.31	gold quality
spleen	UBERON:0002106	62.25	gold quality
small intestine	UBERON:0002108	62.25	gold quality
bone marrow cell	CL:0002092	62.23	silver quality
duodenum	UBERON:0002114	62.05	gold quality
right adrenal gland	UBERON:0001233	61.95	gold quality
metanephros cortex	UBERON:0010533	61.76	gold quality
stromal cell of endometrium	CL:0002255	61.68	gold quality
fundus of stomach	UBERON:0001160	61.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.96

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tex52	ENSMUSG00000079304
rattus_norvegicus	Tex52	ENSRNOG00000062735

Protein

Protein identifiers

Testis-expressed protein 52 — A6NCN8 (reviewed: A6NCN8)

All UniProt accessions (1): A6NCN8

UniProt curated annotations — full annotation on UniProt →

Tissue specificity. Expressed in Testis.

RefSeq proteins (2): NP_001352103, NP_001352104 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR029206	DUF4532	Family

Pfam: PF15046

UniProt features (3 total): chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NCN8-F1	64.46	0.06

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 2 (showing top): MEF2D_TARGET_GENES, chr12p13

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

74 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TEX52	CCDC77	Q9BR77	542
TEX52	LRTM2	Q8N967	528
TEX52	NRIP2	Q9BQI9	505
TEX52	RHNO1	Q9BSD3	479
TEX52	IQSEC3	Q9UPP2	448
TEX52	B4GALNT3	Q6L9W6	442
TEX52	ITFG2	Q969R8	433
TEX52	DCP1B	Q8IZD4	433
TEX52	TSPAN9	O75954	398
TEX52	NINJ2	Q9NZG7	393
TEX52	FBXL14	Q8N1E6	377
TEX52	CACNA2D4	Q7Z3S7	357
TEX52	TULP3	O75386	354
TEX52	SLC6A12	P48065	321
TEX52	ERC1	Q8IUD2	278

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A2A8T7, A6NCN8, A6NFR6, A6NHR8, B2RW88, O12165, P03331, P18801, P22378, Q0P670, Q0VD86, Q0VF49, Q1LZE2, Q1RMX6, Q32KP7, Q3B8N5, Q3KPS4, Q3SZT6, Q3SZW6, Q3TTI8, Q3ULG3, Q5JTZ5, Q5PR19, Q5R498, Q67926, Q68FQ8, Q6P387, Q6PEX7, Q6ZV65, Q73370, Q75009, Q80VY2, Q86WR6, Q8BII1, Q8C5S3, Q8IYM0, Q8N4L4, Q8N6T0, Q8TAL5, Q8WUB2

Diamond homologs: A6NCN8, Q3TTI8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

711 predictions. Top by Δscore:

Variant	Effect	Δscore
12:2854894:A:AC	donor_gain	0.9900
12:2854895:C:CC	donor_gain	0.9900
12:2854895:CTT:C	donor_gain	0.9900
12:2854897:T:TA	donor_gain	0.9900
12:2855036:C:CT	acceptor_gain	0.9900
12:2855042:C:CT	acceptor_gain	0.9900
12:2855043:G:C	acceptor_gain	0.9900
12:2856951:CTACC:C	donor_loss	0.9900
12:2856952:TACCT:T	donor_loss	0.9900
12:2856953:AC:A	donor_loss	0.9900
12:2856954:CCT:C	donor_loss	0.9900
12:2856949:CCCTA:C	donor_loss	0.9800
12:2856950:CCTAC:C	donor_loss	0.9800
12:2856971:T:TA	donor_gain	0.9800
12:2854874:C:CA	donor_gain	0.9700
12:2855375:CTCG:C	acceptor_gain	0.9700
12:2851085:TGA:T	donor_gain	0.9600
12:2855443:CCAT:C	acceptor_gain	0.9600
12:2855444:CATC:C	acceptor_gain	0.9600
12:2849523:TACCT:T	acceptor_loss	0.9400
12:2849525:CCTG:C	acceptor_loss	0.9400
12:2849526:C:CG	acceptor_loss	0.9400
12:2849527:T:G	acceptor_loss	0.9400
12:2851020:AG:A	donor_gain	0.9400
12:2855379:C:CC	acceptor_gain	0.9400
12:2855444:CAT:C	acceptor_gain	0.9400
12:2855446:TC:T	acceptor_loss	0.9400
12:2855448:T:A	acceptor_loss	0.9400
12:2855036:C:T	acceptor_gain	0.9300
12:2855447:C:CC	acceptor_gain	0.9300

AlphaMissense

2029 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:2855234:A:C	F95L	0.964
12:2855234:A:T	F95L	0.964
12:2855236:A:G	F95L	0.964
12:2855354:G:C	F55L	0.949
12:2855354:G:T	F55L	0.949
12:2855356:A:G	F55L	0.949
12:2854958:A:C	S187R	0.934
12:2854958:A:T	S187R	0.934
12:2854960:T:G	S187R	0.934
12:2855165:G:C	S118R	0.934
12:2855165:G:T	S118R	0.934
12:2855167:T:G	S118R	0.934
12:2855158:A:G	W121R	0.932
12:2855158:A:T	W121R	0.932
12:2855039:A:C	F160L	0.922
12:2855039:A:T	F160L	0.922
12:2855041:A:G	F160L	0.922
12:2855060:G:C	F153L	0.918
12:2855060:G:T	F153L	0.918
12:2855062:A:G	F153L	0.918
12:2855227:A:G	W98R	0.918
12:2855227:A:T	W98R	0.918
12:2855390:G:C	F43L	0.907
12:2855390:G:T	F43L	0.907
12:2855392:A:G	F43L	0.907
12:2849339:G:C	F270L	0.902
12:2849339:G:T	F270L	0.902
12:2849341:A:G	F270L	0.902
12:2855195:G:C	F108L	0.899
12:2855195:G:T	F108L	0.899

dbSNP variants (sampled 300 via entrez): RS1000069714 (12:2851019 T>A), RS1000318680 (12:2850913 T>C), RS1000746033 (12:2854224 C>T), RS1000930747 (12:2849619 C>A), RS1001014559 (12:2852469 C>A,T), RS1001267907 (12:2854356 A>G), RS1001379359 (12:2850676 T>G), RS1001382970 (12:2849368 G>A,T), RS1001422002 (12:2851881 G>A), RS1001429816 (12:2850287 G>A), RS1001681459 (12:2855696 T>C), RS1002363703 (12:2847300 A>G), RS1002381995 (12:2849277 C>T), RS1002477096 (12:2852738 C>G,T), RS1003243990 (12:2857280 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
Smoke	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.