TEX53

Summary

TEX53 (testis expressed 53, HGNC:53655) is a protein-coding gene on chromosome 9q32, encoding Testis-expressed protein 53 (A0A1B0GU33).

At a glance

• MANE Select transcript: NM_001354645

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53655
Approved symbol	TEX53
Name	testis expressed 53
Location	9q32
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000230054
Ensembl biotype	protein_coding
Entrez	105376230

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding_CDS_not_defined, 1 protein_coding

ENST00000415101, ENST00000423632

RefSeq mRNA: 1 — MANE Select: NM_001354645 NM_001354645

CCDS: CCDS87679

Canonical transcript exons

ENST00000423632 — 2 exons

Exon	Start	End
ENSE00001596537	114656304	114656632
ENSE00001652855	114657666	114657805

Expression profiles

Bgee: expression breadth ubiquitous, 145 present calls, max score 95.16.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0703 / max 55.9345, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
102170	0.0703	3

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	95.16	gold quality
right testis	UBERON:0004534	94.65	gold quality
sperm	CL:0000019	94.58	gold quality
testis	UBERON:0000473	91.40	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.13	gold quality
tibialis anterior	UBERON:0001385	68.36	silver quality
adult organism	UBERON:0007023	65.16	gold quality
pancreatic ductal cell	CL:0002079	61.91	silver quality
spleen	UBERON:0002106	58.36	gold quality
right adrenal gland cortex	UBERON:0035827	56.74	gold quality
granulocyte	CL:0000094	56.30	gold quality
ileal mucosa	UBERON:0000331	55.40	silver quality
epithelial cell of pancreas	CL:0000083	54.88	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
monocyte	CL:0000576	52.87	gold quality
deltoid	UBERON:0001476	52.86	gold quality
right adrenal gland	UBERON:0001233	52.79	gold quality
leukocyte	CL:0000738	51.84	gold quality
right ovary	UBERON:0002118	51.27	gold quality
Brodmann (1909) area 9	UBERON:0013540	51.22	gold quality
right frontal lobe	UBERON:0002810	50.60	gold quality
myocardium	UBERON:0002349	50.25	gold quality
prostate gland	UBERON:0002367	50.21	gold quality
body of stomach	UBERON:0001161	50.17	gold quality
right lung	UBERON:0002167	49.95	gold quality
muscle layer of sigmoid colon	UBERON:0035805	49.85	gold quality
left adrenal gland	UBERON:0001234	49.69	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-134144	yes	30.81
E-MTAB-6058	no	3.40
E-ANND-3	no	1.62

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Testis-expressed protein 53 — A0A1B0GU33 (reviewed: A0A1B0GU33)

All UniProt accessions (1): A0A1B0GU33

UniProt curated annotations — full annotation on UniProt →

Tissue specificity. Expressed in Testis.

RefSeq proteins (1): NP_001341574* (*=MANE)

Domains & families (InterPro)

UniProt features (1 total): chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A1B0GU33-F1	60.13	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 3 (showing top): ZNF329_TARGET_GENES, HMGB2_TARGET_GENES, chr9q32

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

24 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TEX53	TEX48	A0A1B0GUV7	843
TEX53	RLN1	P04808	541
TEX53	ODF2	Q5BJF6	479
TEX53	DMRT3	Q9NQL9	478
TEX53	RLN2	P04090	446
TEX53	TXNDC8	Q6A555	400
TEX53	DMRT1	Q9Y5R6	349
TEX53	AQP7	O14520	324
TEX53	KDM4C	Q9H3R0	321
TEX53	TESK1	Q15569	317
TEX53	CHP1	Q99653	238
TEX53	AR	P10275	164

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A1B0GU33, A0A1B0GUV7, A6NGY3, A6ZT44, F5HHT4, G2TRR6, H3BU77, O13894, O54835, O89085, P0C2W9, P0C6G1, P0C6G2, P0C6G3, P0C6G4, P0C6G5, P0C733, P0DON5, P0DON6, P14976, P16722, P27262, P27271, P28979, P29887, P38612, P38839, Q05105, Q08588, Q1KN14, Q1KN19, Q1X6Y3, Q1X6Y4, Q1X6Z0, Q2YDL7, Q5R5R7, Q5ZK14, Q67621, Q6W0C5, Q88891

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

470 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:114657757:G:C	F6L	0.735
9:114657757:G:T	F6L	0.735
9:114657759:A:G	F6L	0.735
9:114657667:G:C	F36L	0.640
9:114657667:G:T	F36L	0.640
9:114657669:A:G	F36L	0.640

dbSNP variants (sampled 300 via entrez): RS1000904454 (9:114658671 C>T), RS1001709336 (9:114659291 T>C), RS1002449981 (9:114659495 G>A), RS1002842905 (9:114657505 G>A), RS1003126179 (9:114657204 A>T), RS1003709279 (9:114656857 C>G), RS1004907615 (9:114659390 A>C), RS1004940988 (9:114659270 A>AG), RS1005036215 (9:114659027 G>C), RS1007018921 (9:114657784 C>A,G,T), RS1007766689 (9:114658869 C>G,T), RS1007829616 (9:114657674 C>G,T), RS1007975549 (9:114656682 G>A,T), RS1008250029 (9:114656283 AAGG>A), RS1010161263 (9:114658342 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	increases abundance, decreases expression	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.