TFAP2A-AS1

Summary

TFAP2A-AS1 (TFAP2A antisense RNA 1, HGNC:40579) is a long non-coding RNA gene on chromosome 6p24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40579
Approved symbol	TFAP2A-AS1
Name	TFAP2A antisense RNA 1
Location	6p24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229950
Ensembl biotype	lncRNA
Entrez	100130275
RNAcentral	URS000075BE09 — lncRNA, 1312 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 19 lncRNA

ENST00000366312, ENST00000420777, ENST00000443546, ENST00000449333, ENST00000647739, ENST00000718199, ENST00000718200, ENST00000718201, ENST00000718202, ENST00000718203, ENST00000742300, ENST00000742301, ENST00000742302, ENST00000742303, ENST00000742304, ENST00000742305, ENST00000742306, ENST00000742307, ENST00000742308

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000366312 — 4 exons

Exon	Start	End
ENSE00001441402	10456436	10456781
ENSE00001667945	10434329	10434404
ENSE00001738796	10451903	10452056
ENSE00001744731	10452748	10452827

Expression profiles

Bgee: expression breadth ubiquitous, 151 present calls, max score 91.69.

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.69	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.53	gold quality
prostate gland	UBERON:0002367	70.88	gold quality
gingival epithelium	UBERON:0001949	69.76	gold quality
oocyte	CL:0000023	67.07	gold quality
skin of abdomen	UBERON:0001416	67.01	gold quality
metanephros cortex	UBERON:0010533	66.15	gold quality
skin of leg	UBERON:0001511	66.12	gold quality
mucosa of paranasal sinus	UBERON:0005030	65.19	gold quality
lower esophagus mucosa	UBERON:0035834	64.94	gold quality
minor salivary gland	UBERON:0001830	64.68	gold quality
saliva-secreting gland	UBERON:0001044	64.15	gold quality
gingiva	UBERON:0001828	64.04	gold quality
zone of skin	UBERON:0000014	63.84	gold quality
buccal mucosa cell	CL:0002336	63.76	gold quality
mouth mucosa	UBERON:0003729	63.74	gold quality
bronchial epithelial cell	CL:0002328	63.11	silver quality
adult mammalian kidney	UBERON:0000082	63.03	gold quality
esophagus mucosa	UBERON:0002469	62.97	gold quality
endothelial cell	CL:0000115	62.81	gold quality
secondary oocyte	CL:0000655	62.71	gold quality
bronchus	UBERON:0002185	62.62	silver quality
metanephros	UBERON:0000081	62.18	gold quality
epithelium of nasopharynx	UBERON:0001951	61.39	gold quality
tonsil	UBERON:0002372	61.22	gold quality
corpus epididymis	UBERON:0004359	61.16	silver quality
ventricular zone	UBERON:0003053	61.08	gold quality
cortex of kidney	UBERON:0001225	60.87	gold quality
seminal vesicle	UBERON:0000998	60.35	silver quality
esophagus squamous epithelium	UBERON:0006920	60.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.94

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis. (PMID:34727954)
• Long non-coding RNA TFAP2A-AS1 plays an important role in oral squamous cell carcinoma: research includes bioinformatics analysis and experiments. (PMID:35524329)
• Long noncoding RNA TFAP2A-AS1 promotes oral squamous cell carcinoma cell growth and movement via competitively binding miR-1297 and regulating TFAP2A expression. (PMID:35730908)
• Long noncoding RNA TFAP2A-AS1 exerts promotive effects in non-small cell lung cancer progression via controlling the microRNA-548a-3p/CDK4 axis as a competitive endogenous RNA. (PMID:37305398)
• Dysregulation of lncRNA TFAP2A-AS1 is involved in the pathogenesis of pulpitis by the regulation of microRNA-32-5p. (PMID:39254474)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.