TFAP2A-AS2

Summary

TFAP2A-AS2 (TFAP2A antisense RNA 2, HGNC:52289) is a long non-coding RNA gene on chromosome 6p24.3.

The product of this intronless gene is a capped lncRNA that is nuclear-enriched and associated with chromatin. The encoded transcript may be involved in the regulation of developmental gene expression in a context-dependent manner, functioning as a repressor in non-pluripotent cells and an activator in pluripotent cells. Transcription of this gene is activated in 8-cell human embryos during the major wave of zygotic genome activation, independently of and prior to the activation of TFAP2A, an overlapping gene found on the opposite strand. Expression of this gene is characterized by high cell-to-cell variability in the cells of totipotent human embryos and in stable cell lines.

Source: NCBI Gene 109729173 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52289
Approved symbol	TFAP2A-AS2
Name	TFAP2A antisense RNA 2
Location	6p24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	HIPSTR
Ensembl gene	ENSG00000285278
Ensembl biotype	lncRNA
OMIM	617136
Entrez	109729173
RNAcentral	URS0000ABD8DB — lncRNA, 3426 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000645232

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000645232 — 1 exons

Exon	Start	End
ENSE00004080694	10404456	10407928

Expression profiles

Bgee: expression breadth ubiquitous, 112 present calls, max score 83.59.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2449 / max 9.5050, expressed in 118 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
65735	0.2449	118

Top tissues by expression

112 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.51	gold quality
lower esophagus mucosa	UBERON:0035834	67.68	gold quality
skin of abdomen	UBERON:0001416	64.04	gold quality
placenta	UBERON:0001987	62.74	gold quality
zone of skin	UBERON:0000014	62.63	gold quality
esophagus mucosa	UBERON:0002469	61.73	gold quality
skin of leg	UBERON:0001511	61.55	gold quality
saliva-secreting gland	UBERON:0001044	58.74	gold quality
minor salivary gland	UBERON:0001830	58.64	gold quality
ventricular zone	UBERON:0003053	58.32	silver quality
metanephros cortex	UBERON:0010533	58.08	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	57.17	gold quality
prostate gland	UBERON:0002367	56.25	gold quality
cortex of kidney	UBERON:0001225	56.24	gold quality
tonsil	UBERON:0002372	56.23	gold quality
thoracic mammary gland	UBERON:0005200	54.92	gold quality
kidney	UBERON:0002113	54.76	gold quality
adult mammalian kidney	UBERON:0000082	54.37	gold quality
esophagus	UBERON:0001043	54.37	gold quality
vagina	UBERON:0000996	54.14	gold quality
ganglionic eminence	UBERON:0004023	54.01	silver quality
skeletal muscle tissue	UBERON:0001134	53.20	silver quality
prefrontal cortex	UBERON:0000451	50.80	gold quality
tibial nerve	UBERON:0001323	50.37	gold quality
testis	UBERON:0000473	49.91	gold quality
hindlimb stylopod muscle	UBERON:0004252	49.24	silver quality
multicellular organism	UBERON:0000468	49.23	gold quality
lymph node	UBERON:0000029	48.82	silver quality
left testis	UBERON:0004533	48.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• HIPSTR is specifically induced and heterogeneously expressed in the 8-cell-stage human embryos during the major wave of embryonic genome activation. (PMID:27605307)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.