TFAP2E-AS1

Summary

TFAP2E-AS1 (TFAP2E antisense RNA 1, HGNC:41274) is a long non-coding RNA gene on chromosome 1p34.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41274
Approved symbol	TFAP2E-AS1
Name	TFAP2E antisense RNA 1
Location	1p34.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000239636
Ensembl biotype	lncRNA
Entrez	105378645
RNAcentral	URS00026A1D37 — lncRNA, 989 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000425881, ENST00000444348

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000425881 — 2 exons

Exon	Start	End
ENSE00001600185	35573572	35573747
ENSE00001671531	35569813	35569919

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 89.45.

FANTOM5 (CAGE): breadth broad, TPM avg 1.4025 / max 195.0258, expressed in 239 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
11681	1.4025	239

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.45	gold quality
granulocyte	CL:0000094	89.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	85.77	gold quality
cerebellar hemisphere	UBERON:0002245	85.53	gold quality
cerebellar cortex	UBERON:0002129	85.17	gold quality
cerebellum	UBERON:0002037	85.03	gold quality
corpus callosum	UBERON:0002336	81.84	gold quality
leukocyte	CL:0000738	79.53	gold quality
monocyte	CL:0000576	79.47	gold quality
blood	UBERON:0000178	78.30	gold quality
bone marrow cell	CL:0002092	77.82	gold quality
bone marrow	UBERON:0002371	77.64	gold quality
lymph node	UBERON:0000029	73.71	gold quality
spleen	UBERON:0002106	73.69	gold quality
right uterine tube	UBERON:0001302	73.09	gold quality
right frontal lobe	UBERON:0002810	71.90	gold quality
nucleus accumbens	UBERON:0001882	70.78	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.48	gold quality
brain	UBERON:0000955	69.92	gold quality
tonsil	UBERON:0002372	69.74	gold quality
cortical plate	UBERON:0005343	69.49	gold quality
vermiform appendix	UBERON:0001154	68.83	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.68	gold quality
hypothalamus	UBERON:0001898	68.50	gold quality
anterior cingulate cortex	UBERON:0009835	68.11	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.96	gold quality
putamen	UBERON:0001874	67.95	gold quality
caudate nucleus	UBERON:0001873	67.90	gold quality
stromal cell of endometrium	CL:0002255	67.83	gold quality
Ammon’s horn	UBERON:0001954	67.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.04

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.