TFEC

Summary

TFEC (transcription factor EC, HGNC:11754) is a protein-coding gene on chromosome 7q31.2, encoding Transcription factor EC (O14948). Transcriptional regulator that acts as a repressor or an activator.

This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Source: NCBI Gene 22797 — RefSeq curated summary.

At a glance

• GWAS associations: 20
• Clinical variants (ClinVar): 53 total
• MANE Select transcript: NM_012252

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11754
Approved symbol	TFEC
Name	transcription factor EC
Location	7q31.2
Locus type	gene with protein product
Status	Approved
Aliases	TCFEC, TFECL, bHLHe34
Ensembl gene	ENSG00000105967
Ensembl biotype	protein_coding
OMIM	604732
Entrez	22797

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 9 protein_coding, 4 protein_coding_CDS_not_defined

ENST00000265440, ENST00000320239, ENST00000393485, ENST00000457268, ENST00000462828, ENST00000465322, ENST00000474337, ENST00000484212, ENST00000497829, ENST00000871198, ENST00000871199, ENST00000871200, ENST00000952248

RefSeq mRNA: 3 — MANE Select: NM_012252 NM_001018058, NM_001244583, NM_012252

CCDS: CCDS34738, CCDS5762, CCDS59076

Canonical transcript exons

ENST00000265440 — 8 exons

Exon	Start	End
ENSE00000881885	115974170	115974256
ENSE00001015841	116030633	116030763
ENSE00001015842	115956679	115956793
ENSE00001015845	115950874	115950949
ENSE00001015847	115954586	115954642
ENSE00003564412	115984262	115984513
ENSE00003659572	115941893	115942040
ENSE00003847030	115935152	115940931

Expression profiles

Bgee: expression breadth ubiquitous, 200 present calls, max score 95.47.

FANTOM5 (CAGE): breadth broad, TPM avg 14.5948 / max 885.0494, expressed in 473 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
85802	13.4467	446
85801	0.6061	173
85809	0.2261	101
85808	0.1140	57
85798	0.1076	15
85797	0.0943	17

Top tissues by expression

282 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	95.47	gold quality
mononuclear cell	CL:0000842	95.11	gold quality
leukocyte	CL:0000738	94.34	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.10	gold quality
granulocyte	CL:0000094	85.45	gold quality
vermiform appendix	UBERON:0001154	85.25	gold quality
nephron tubule	UBERON:0001231	83.34	gold quality
bone marrow cell	CL:0002092	82.98	gold quality
spleen	UBERON:0002106	80.76	gold quality
lymph node	UBERON:0000029	80.70	gold quality
bone marrow	UBERON:0002371	80.14	gold quality
jejunal mucosa	UBERON:0000399	79.58	gold quality
upper lobe of left lung	UBERON:0008952	79.14	gold quality
upper lobe of lung	UBERON:0008948	79.05	gold quality
right lung	UBERON:0002167	78.81	gold quality
caecum	UBERON:0001153	77.49	gold quality
calcaneal tendon	UBERON:0003701	77.18	gold quality
kidney epithelium	UBERON:0004819	76.87	gold quality
small intestine Peyer’s patch	UBERON:0003454	76.31	gold quality
gall bladder	UBERON:0002110	74.86	gold quality
adult mammalian kidney	UBERON:0000082	74.80	gold quality
rectum	UBERON:0001052	74.67	gold quality
blood	UBERON:0000178	74.64	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.13	gold quality
small intestine	UBERON:0002108	73.97	gold quality
lung	UBERON:0002048	73.85	gold quality
renal glomerulus	UBERON:0000074	73.74	gold quality
metanephric glomerulus	UBERON:0004736	73.70	gold quality
kidney	UBERON:0002113	73.63	gold quality
cortex of kidney	UBERON:0001225	73.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.92

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

4 targets.

Target	Regulation
ACP5
CD40
HMOX1	Unknown
MYH9	Activation

JASPAR motifs

Motif	Name	Family
MA0871.1	TFEC	bHLH-ZIP
MA0871.2	TFEC	bHLH-ZIP
MA0871.3	TFEC	bHLH-ZIP

JASPAR matrix evidence (PMIDs): PMID:15186484

Upstream regulators (CollecTRI, top): ETS2, ETV7, PAX6, SPI1

miRNA regulators (miRDB)

215 targeting TFEC, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-4713-3P	100.00	65.92	505
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4531	99.99	69.70	3181

Literature-anchored findings (GeneRIF, showing 1)

• Two alternatively spliced TFEC isoforms have been found to be sequence-specific transcriptional activators of the nonmuscle myosin II heavy chain-A gene in transfected cells. (PMID:11467950)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tfec	ENSDARG00000098745
mus_musculus	Tfec	ENSMUSG00000029553
rattus_norvegicus	Tfec	ENSRNOG00000061595
drosophila_melanogaster	Mitf	FBGN0263112
caenorhabditis_elegans		WBGENE00020930

Paralogs (3): TFE3 (ENSG00000068323), TFEB (ENSG00000112561), MITF (ENSG00000187098)

Protein

Protein identifiers

Transcription factor EC — O14948 (reviewed: O14948)

Alternative names: Class E basic helix-loop-helix protein 34, Transcription factor EC-like

All UniProt accessions (2): O14948, B7Z757

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Binds DNA in a homo- or heterodimeric form.

Subunit / interactions. Homodimer. Forms heterodimers with TFE3. Forms heterodimers with MITF. Interacts with MITF.

Subcellular location. Nucleus.

Tissue specificity. Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon.

Similarity. Belongs to the MiT/TFE family.

Isoforms (4)

UniProt ID	Names	Canonical?
O14948-1	1, TFEC-l, TFECL	yes
O14948-2	2, TFEC-s
O14948-3	3
O14948-4	4, TFEC-C

RefSeq proteins (3): NP_001018068, NP_001231512, NP_036384* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011598	bHLH_dom	Domain
IPR021802	MiT/TFE_C	Domain
IPR036638	HLH_DNA-bd_sf	Homologous_superfamily

Pfam: PF00010, PF11851

UniProt features (14 total): splice variant 5, sequence variant 3, region of interest 3, chain 1, domain 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O14948-F1	63.79	0.30

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-9856649	Transcriptional and post-translational regulation of MITF-M expression and activity
R-HSA-1266738	Developmental Biology
R-HSA-9730414	MITF-M-regulated melanocyte development

MSigDB gene sets: 286 (showing top): BROWNE_HCMV_INFECTION_4HR_UP, TAATAAT_MIR126, WALLACE_PROSTATE_CANCER_RACE_UP, LANG_MYB_FAMILY_TARGETS, HNF1_Q6, FOXD3_01, BLALOCK_ALZHEIMERS_DISEASE_UP, CASORELLI_APL_SECONDARY_VS_DE_NOVO_UP, ACATTCC_MIR1_MIR206, GGGNNTTTCC_NFKB_Q6_01, GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN, GOBP_CELLULAR_RESPONSE_TO_HEAT, GATA1_04, HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP, NRF2_Q4

GO Biological Process (5): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), cellular response to heat (GO:0034605), positive regulation of transcription by RNA polymerase II (GO:0045944), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (8): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), protein dimerization activity (GO:0046983), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (4): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
MITF-M-regulated melanocyte development	1
Developmental Biology	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	4
regulation of transcription by RNA polymerase II	3
transcription by RNA polymerase II	3
cellular anatomical structure	3
DNA-binding transcription factor activity, RNA polymerase II-specific	2
negative regulation of DNA-templated transcription	1
regulation of DNA-templated transcription	1
response to heat	1
cellular response to stress	1
positive regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription repressor activity	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
protein binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
chromosome	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cytoplasm	1

Protein interactions and networks

STRING

1446 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TFEC	CTSK	P43235	720
TFEC	TFE3	P19532	622
TFEC	TYR	P14679	579
TFEC	MITF	O75030	559
TFEC	DCT	P40126	555
TFEC	HMOX1	P09601	533
TFEC	ASPSCR1	Q9BZE9	525
TFEC	PRCC	Q92733	513
TFEC	GPR143	P51810	507
TFEC	TYRP1	P17643	487
TFEC	SOX10	P56693	487
TFEC	GPNMB	Q14956	454
TFEC	PAX3	P23760	433
TFEC	DIAPH1	O60610	429
TFEC	MAFB	Q9Y5Q3	406

IntAct

13 interactions, top by confidence:

A	B	Type	Score
TFEC	NAPB	psi-mi:“MI:0915”(physical association)	0.560
DEFB127	TFEC	psi-mi:“MI:0915”(physical association)	0.560
NAPB	TFEC	psi-mi:“MI:0915”(physical association)	0.560
TFEC	DEFB127	psi-mi:“MI:0915”(physical association)	0.560
	TFEC	psi-mi:“MI:0915”(physical association)	0.370
XCL1	TFEC	psi-mi:“MI:0915”(physical association)	0.370
DCK	TFEC	psi-mi:“MI:0915”(physical association)	0.370
HNRNPA1	TFEC	psi-mi:“MI:0915”(physical association)	0.370
ZMAT2	TFEC	psi-mi:“MI:0915”(physical association)	0.370
TFEB	TFEC	psi-mi:“MI:0914”(association)	0.350

BioGRID (17): NAPB (Two-hybrid), DEFB127 (Two-hybrid), TFEC (Affinity Capture-MS), TFEC (Proximity Label-MS), SMCO4 (Two-hybrid), LPAR3 (Two-hybrid), TFEC (Two-hybrid), TET2 (Affinity Capture-Western), TFEC (Positive Genetic), TFEC (Reconstituted Complex), TFE3 (Reconstituted Complex), TFEC (Affinity Capture-MS), TFEC (Affinity Capture-Western), TFEC (Affinity Capture-RNA), TFEC (Two-hybrid)

ESM2 similar proteins: A0A0A7HJC7, A0A0B2XG51, A0A0F0IP79, A1DG01, A2R6G8, A2T713, A2T7L8, B0XYJ1, B2AR36, B2W978, B8NLU5, B8NNN3, C0STD9, C7YM38, E9EMI7, E9EPV1, E9ES99, E9RD40, G4N2B2, G5ECU7, I1S0E2, I1S4T3, K9FWK0, O14948, O16850, O74252, P22022, P38165, Q00096, Q01870, Q09926, Q0U7C8, Q152V3, Q1XGE2, Q2GSA4, Q2U616, Q2UMT9, Q2UUM2, Q4W9W8, Q4WEY8

Diamond homologs: A0A286LEZ9, A2T713, A2T7L8, A4IFU7, O02818, O14948, O75030, O88368, P0DPB0, P17106, P19484, P19532, P22415, P49379, Q05B92, Q07957, Q08874, Q10186, Q5A1E3, Q5XFQ6, Q61069, Q63302, Q64092, Q6XBT4, Q9R210, Q9WTW4, H2KZZ2, P38165, A3KNA7, O43019, O97676, P36956, P56720, Q12772, Q3T1I5, Q3U1N2, Q4WIN1, Q59RL7, Q60416, Q60429

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
TFEC	“up-regulates quantity by expression”	MYH9	“transcriptional regulation”

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	1
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

1571 predictions. Top by Δscore:

Variant	Effect	Δscore
7:115941920:AG:A	donor_gain	1.0000
7:115950872:A:AC	donor_gain	1.0000
7:115950873:C:CC	donor_gain	1.0000
7:115954584:A:AC	donor_gain	1.0000
7:115954585:C:CC	donor_gain	1.0000
7:115954648:C:CT	acceptor_gain	1.0000
7:115956673:CATTA:C	donor_loss	1.0000
7:115956674:ATTAC:A	donor_loss	1.0000
7:115956675:TTACC:T	donor_loss	1.0000
7:115956676:TAC:T	donor_loss	1.0000
7:115956677:AC:A	donor_loss	1.0000
7:115956678:C:A	donor_loss	1.0000
7:115956789:GATAA:G	acceptor_gain	1.0000
7:115956790:ATAA:A	acceptor_gain	1.0000
7:115956791:TAA:T	acceptor_gain	1.0000
7:115956792:AA:A	acceptor_gain	1.0000
7:115956794:C:CC	acceptor_gain	1.0000
7:115956794:CTT:C	acceptor_loss	1.0000
7:115956795:T:C	acceptor_gain	1.0000
7:115956795:T:TC	acceptor_gain	1.0000
7:115974169:CTGTT:C	donor_gain	1.0000
7:115942041:C:CC	acceptor_gain	0.9900
7:115950873:CGGAT:C	donor_gain	0.9900
7:115950950:C:CC	acceptor_gain	0.9900
7:115954643:C:CC	acceptor_gain	0.9900
7:115954649:A:T	acceptor_gain	0.9900
7:115974168:A:AC	donor_gain	0.9900
7:115974169:C:CC	donor_gain	0.9900
7:115984261:CATG:C	donor_gain	0.9900
7:115984264:G:A	donor_gain	0.9900

AlphaMissense

2278 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:115942011:A:G	L182P	1.000
7:115942022:T:A	K178N	1.000
7:115942022:T:G	K178N	1.000
7:115942023:T:A	K178I	1.000
7:115942024:T:G	K178Q	1.000
7:115950936:T:A	R151S	1.000
7:115950936:T:G	R151S	1.000
7:115950937:C:G	R151T	1.000
7:115941981:A:G	L192P	0.999
7:115942011:A:T	L182Q	0.999
7:115942024:T:C	K178E	0.999
7:115950913:A:C	I159S	0.999
7:115950913:A:G	I159T	0.999
7:115950925:A:C	I155S	0.999
7:115950933:C:A	R152S	0.999
7:115950933:C:G	R152S	0.999
7:115950934:C:A	R152M	0.999
7:115950942:T:A	R149S	0.999
7:115950942:T:G	R149S	0.999
7:115950945:T:A	E148D	0.999
7:115950945:T:G	E148D	0.999
7:115954595:G:C	H144D	0.999
7:115940927:A:G	L223P	0.998
7:115942006:C:G	A184P	0.998
7:115942021:C:G	G179R	0.998
7:115942021:C:T	G179R	0.998
7:115950904:A:G	L162P	0.998
7:115950913:A:T	I159N	0.998
7:115950916:C:G	R158P	0.998
7:115950921:A:C	N156K	0.998

dbSNP variants (sampled 300 via entrez): RS1000019732 (7:116029819 G>C), RS1000025190 (7:116054526 G>A), RS1000043038 (7:116006142 G>A), RS1000051500 (7:116132082 C>A,T), RS1000051964 (7:116088215 A>G,T), RS1000074305 (7:116006239 T>C), RS1000097322 (7:115941531 A>G), RS1000100630 (7:116047476 C>A), RS1000102348 (7:115965023 A>G), RS1000102955 (7:115937124 T>C), RS1000120670 (7:116022772 A>G), RS1000131745 (7:115983364 A>T), RS1000147327 (7:116102606 T>A,C), RS1000176836 (7:116018695 G>A), RS1000178840 (7:116102855 C>T)

Disease associations

OMIM: gene MIM:604732 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

20 associations (top):

Study	Trait	p-value
GCST003995_22	Tonsillectomy	8.000000e-10
GCST004904_58	Body mass index	9.000000e-09
GCST005014_127	Tonsillectomy	8.000000e-10
GCST005170_3	Intraocular pressure	2.000000e-20
GCST005580_287	Intraocular pressure	1.000000e-09
GCST006412_69	Intraocular pressure	1.000000e-16
GCST007325_203	General risk tolerance (MTAG)	2.000000e-08
GCST007325_205	General risk tolerance (MTAG)	2.000000e-08
GCST007325_250	General risk tolerance (MTAG)	2.000000e-09
GCST007325_47	General risk tolerance (MTAG)	5.000000e-08
GCST007326_75	Number of sexual partners	1.000000e-08
GCST007576_200	Chronotype	8.000000e-09
GCST008163_232	Height	5.000000e-07
GCST010916_15	Proportion of activated microglia (inferior temporal cortex)	7.000000e-07
GCST012292_12	Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction	8.000000e-06
GCST012297_3	Schizophrenia, bipolar disorder or major depressive disorder	9.000000e-06
GCST012298_11	Schizophrenia, bipolar disorder or major depressive disorder x sex interaction	6.000000e-06
GCST012489_140	Heel bone mineral density x serum urate levels interaction	2.000000e-08
GCST90002400_47	Plateletcrit	4.000000e-10
GCST90002401_465	Platelet distribution width	3.000000e-09

EFO canonical traits (11, from GWAS)

EFO ID	Trait name
EFO:0007924	tonsillectomy risk measurement
EFO:0004340	body mass index
EFO:0004695	intraocular pressure measurement
EFO:0008579	risk-taking behaviour
EFO:0008328	chronotype measurement
EFO:0004952	disease recurrence
EFO:0008343	sex interaction measurement
EFO:0004531	urate measurement
EFO:0009270	heel bone mineral density
EFO:0007985	platelet crit
EFO:0007984	platelet component distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Nickel	decreases expression, increases expression	3
Ethyl Methanesulfonate	decreases expression, increases expression	2
Methyl Methanesulfonate	decreases expression, increases expression	2
propionaldehyde	decreases expression	1
bisphenol A	increases methylation	1
o,p’-DDT	increases expression	1
butyraldehyde	decreases expression	1
pentanal	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
bisphenol S	increases methylation	1
NSC 689534	affects binding, increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Air Pollutants, Occupational	decreases expression	1
Aldehydes	decreases expression	1
Amphotericin B	decreases expression	1
Cisplatin	decreases expression	1
Copper	affects binding, increases expression	1
Etoposide	decreases expression	1
Gold	decreases expression	1
Hydroxyurea	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Rifampin	increases expression	1
Silicon Dioxide	increases expression	1
Tretinoin	increases expression	1
Aflatoxin M1	decreases expression	1
Mitomycin	decreases expression	1
Antirheumatic Agents	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.