TGFB2-AS1

Summary

TGFB2-AS1 (TGFB2 antisense RNA 1, HGNC:50628) is a long non-coding RNA gene on chromosome 1q41.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50628
Approved symbol	TGFB2-AS1
Name	TGFB2 antisense RNA 1
Location	1q41
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000232480
Ensembl biotype	lncRNA
Entrez	728463
RNAcentral	URS0000126BEF — lncRNA, 557 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 28 lncRNA

ENST00000414452, ENST00000687392, ENST00000689961, ENST00000691401, ENST00000702858, ENST00000774588, ENST00000774589, ENST00000774590, ENST00000774591, ENST00000774592, ENST00000774593, ENST00000774594, ENST00000774595, ENST00000774596, ENST00000774597, ENST00000774598, ENST00000774599, ENST00000774600, ENST00000774601, ENST00000774602, ENST00000774603, ENST00000774604, ENST00000774605, ENST00000774606, ENST00000774607, ENST00000774608, ENST00000774611, ENST00000774612

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414452 — 3 exons

Exon	Start	End
ENSE00001730390	218345175	218345388
ENSE00001761418	218344190	218344462
ENSE00004140656	218345603	218346050

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 78.29.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9441 / max 80.7381, expressed in 272 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
17508	0.3445	98
17509	0.3408	96
17510	0.2588	134

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.29	gold quality
skeletal muscle tissue	UBERON:0001134	72.71	gold quality
calcaneal tendon	UBERON:0003701	72.05	gold quality
ventricular zone	UBERON:0003053	68.63	gold quality
hindlimb stylopod muscle	UBERON:0004252	67.96	gold quality
muscle of leg	UBERON:0001383	67.91	gold quality
gastrocnemius	UBERON:0001388	66.61	gold quality
ganglionic eminence	UBERON:0004023	65.57	gold quality
cortical plate	UBERON:0005343	65.15	gold quality
prefrontal cortex	UBERON:0000451	60.07	gold quality
temporal lobe	UBERON:0001871	59.55	gold quality
amygdala	UBERON:0001876	59.54	gold quality
apex of heart	UBERON:0002098	59.19	gold quality
putamen	UBERON:0001874	59.05	gold quality
caudate nucleus	UBERON:0001873	58.93	gold quality
nucleus accumbens	UBERON:0001882	58.57	gold quality
Ammon’s horn	UBERON:0001954	58.26	gold quality
substantia nigra	UBERON:0002038	57.97	gold quality
anterior cingulate cortex	UBERON:0009835	57.40	gold quality
cerebral cortex	UBERON:0000956	57.06	gold quality
frontal cortex	UBERON:0001870	57.02	gold quality
lymph node	UBERON:0000029	56.31	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	56.30	gold quality
right uterine tube	UBERON:0001302	56.09	gold quality
brain	UBERON:0000955	56.06	gold quality
hypothalamus	UBERON:0001898	56.03	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	55.93	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	55.69	gold quality
superior frontal gyrus	UBERON:0002661	55.61	gold quality
saliva-secreting gland	UBERON:0001044	55.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• The TGFB2-AS1 lncRNA Regulates TGF-beta Signaling by Modulating Corepressor Activity. (PMID:31533040)
• This gene produces a long non-coding RNA (lncRNA), that is positively regulated by the transforming growth factor beta (TGFbeta) signaling pathway. This lncRNA mediates the epigenetic silencing of specific genes that belong to TGFbeta and bone morphogenetic protein (BMP) pathways, by promoting repressive histone marks at their promoters, through interaction with components of the polycomb repressive complex 2 (PRC2). (PMID:31533040)
• lncRNA TGFbeta2-AS1 promotes ECM production via TGF-beta2 in human trabecular meshwork cells. (PMID:32423825)
• TGFB2-AS1 inhibits triple-negative breast cancer progression via interaction with SMARCA4 and regulating its targets TGFB2 and SOX2. (PMID:36126099)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.