TGFB2-OT1

Summary

TGFB2-OT1 (TGFB2 overlapping transcript 1, HGNC:50629) is a long non-coding RNA gene on chromosome 1q41.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50629
Approved symbol	TGFB2-OT1
Name	TGFB2 overlapping transcript 1
Location	1q41
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ11812
Ensembl gene	ENSG00000281453
Ensembl biotype	lncRNA
Entrez	103611157
RNAcentral	URS00007E4360 — lncRNA, 1370 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000625474

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000625474 — 1 exons

Exon	Start	End
ENSE00003772429	218442626	218443996

Expression profiles

Bgee: expression breadth ubiquitous, 127 present calls, max score 83.96.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5729 / max 129.3115, expressed in 194 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
8622	0.4010	127
8623	0.1719	64

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
amygdala	UBERON:0001876	83.96	gold quality
anterior cingulate cortex	UBERON:0009835	82.61	gold quality
Ammon’s horn	UBERON:0001954	82.56	gold quality
prostate gland	UBERON:0002367	81.89	gold quality
caudate nucleus	UBERON:0001873	81.81	gold quality
calcaneal tendon	UBERON:0003701	81.62	gold quality
ventricular zone	UBERON:0003053	81.11	gold quality
putamen	UBERON:0001874	80.99	gold quality
Brodmann (1909) area 9	UBERON:0013540	80.99	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	80.90	gold quality
nucleus accumbens	UBERON:0001882	79.82	gold quality
minor salivary gland	UBERON:0001830	79.53	gold quality
cerebral cortex	UBERON:0000956	79.45	gold quality
right frontal lobe	UBERON:0002810	79.31	gold quality
endocervix	UBERON:0000458	78.91	gold quality
saliva-secreting gland	UBERON:0001044	78.77	gold quality
hypothalamus	UBERON:0001898	78.23	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.36	gold quality
primary visual cortex	UBERON:0002436	77.24	gold quality
substantia nigra	UBERON:0002038	76.86	gold quality
brain	UBERON:0000955	76.81	gold quality
uterine cervix	UBERON:0000002	76.80	gold quality
right coronary artery	UBERON:0001625	76.74	gold quality
frontal cortex	UBERON:0001870	76.53	gold quality
myometrium	UBERON:0001296	76.45	gold quality
ectocervix	UBERON:0012249	76.19	gold quality
placenta	UBERON:0001987	75.65	gold quality
ascending aorta	UBERON:0001496	75.55	gold quality
superior frontal gyrus	UBERON:0002661	75.48	gold quality
left coronary artery	UBERON:0001626	75.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• TGFB2 overlapping transcript 1 regulated the levels of 3 microRNAs, MIR3960, MIR4488 and MIR4459 (PMID:26565952)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.