TGIF2

Summary

TGIF2 (TGFB induced factor homeobox 2, HGNC:15764) is a protein-coding gene on chromosome 20q11.23, encoding Homeobox protein TGIF2 (Q9GZN2). Transcriptional repressor, which probably repress transcription by binding directly the 5’-CTGTCAA-3’ DNA sequence or by interacting with TGF-beta activated SMAD proteins.

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene.

Source: NCBI Gene 60436 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 23 total
• MANE Select transcript: NM_021809

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15764
Approved symbol	TGIF2
Name	TGFB induced factor homeobox 2
Location	20q11.23
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000118707
Ensembl biotype	protein_coding
OMIM	607294
Entrez	60436

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 23 protein_coding

ENST00000373872, ENST00000373874, ENST00000557885, ENST00000558028, ENST00000558465, ENST00000560025, ENST00000561398, ENST00000611732, ENST00000650844, ENST00000874678, ENST00000874679, ENST00000874680, ENST00000874681, ENST00000874682, ENST00000914035, ENST00000914036, ENST00000914037, ENST00000914038, ENST00000914039, ENST00000914040, ENST00000914041, ENST00000914042, ENST00000945722

RefSeq mRNA: 4 — MANE Select: NM_021809 NM_001199513, NM_001199514, NM_001199515, NM_021809

CCDS: CCDS13278

Canonical transcript exons

ENST00000373872 — 3 exons

Exon	Start	End
ENSE00001104469	36573597	36573745
ENSE00001461802	36590910	36593950
ENSE00003658897	36578741	36578966

Expression profiles

Bgee: expression breadth ubiquitous, 231 present calls, max score 93.77.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.7666 / max 169.5902, expressed in 1750 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
184440	15.1812	1732
184442	1.7395	593
184439	0.5854	341

Top tissues by expression

278 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	93.77	gold quality
embryo	UBERON:0000922	90.91	gold quality
ganglionic eminence	UBERON:0004023	90.09	gold quality
tendon of biceps brachii	UBERON:0008188	88.83	silver quality
sural nerve	UBERON:0015488	88.49	gold quality
endometrium epithelium	UBERON:0004811	87.71	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.65	gold quality
buccal mucosa cell	CL:0002336	86.38	gold quality
granulocyte	CL:0000094	84.93	gold quality
right uterine tube	UBERON:0001302	84.85	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.84	gold quality
leukocyte	CL:0000738	84.37	gold quality
monocyte	CL:0000576	84.33	gold quality
oocyte	CL:0000023	84.22	gold quality
lymph node	UBERON:0000029	84.18	gold quality
mononuclear cell	CL:0000842	84.15	gold quality
secondary oocyte	CL:0000655	83.86	gold quality
smooth muscle tissue	UBERON:0001135	83.79	gold quality
adrenal tissue	UBERON:0018303	83.49	gold quality
body of uterus	UBERON:0009853	83.09	gold quality
ovary	UBERON:0000992	83.07	gold quality
tonsil	UBERON:0002372	82.98	gold quality
pancreatic ductal cell	CL:0002079	82.73	gold quality
body of pancreas	UBERON:0001150	82.61	gold quality
bone marrow cell	CL:0002092	82.54	gold quality
fallopian tube	UBERON:0003889	82.45	gold quality
spleen	UBERON:0002106	82.33	gold quality
left ovary	UBERON:0002119	81.97	gold quality
blood	UBERON:0000178	81.86	gold quality
cervix squamous epithelium	UBERON:0006922	81.74	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.91

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA0797.1	TGIF2	TALE-type homeo domain factors

JASPAR matrix evidence (PMIDs): PMID:8537382

Upstream regulators (CollecTRI, top): HDAC4

miRNA regulators (miRDB)

124 targeting TGIF2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-424-5P	99.89	71.90	2641

Literature-anchored findings (GeneRIF, showing 16)

• Shows that the homologous mouse Tgif2 gene is necessary for gastrulation. (PMID:20040491)
• Corneal fibroblasts demonstrate the expression of TGIF1 and TGIF2 transcription factors. These transcriptional repressors are critical, at least partially, in mediating the antifibrotic effect of vorinostat in the cornea. (PMID:26330748)
• miR-34a could inhibit tumor invasion and metastasis in gastric cancer by targeting Tgif2 (PMID:26464633)
• expression of miR-148a was regulated by DNA methylation and targeted by TGIF2. Its methylation may be a potential prognostic indicator in skin cancer (PMID:26638007)
• Data show that TGFB-induced factor 2 protein (TGIF2) is involved in microRNA miR-541-3p-regulated cell proliferation, invasion, migration, as well as cell cycle of non-small lung cancer (NSCLC) cells. (PMID:27448300)
• Authors suggest that miR-148a inhibits OC cell proliferation and invasion partly through inhibition of TGFI2. Therefore, this study highlights the importance of the miR-148a/TGFI2 axis in the malignant progression of OC. (PMID:27712592)
• Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect. (PMID:27956704)
• our study identified three mRNAs (TBX21, TGIF2, and CYCS) that were significantly altered between high- and low-risk patients with breast cancer. The three-mRNA model was independent and predicted the prognosis of patients robustly. Furthermore, this model could predict survival probability precisely in patients with or without metastasis. (PMID:30632703)
• Overexpression of TGIF1 lowers levels of cholesterol, triglycerides, and apoB. Overexpression of TGIF2 has more limited effects on lipid metabolism. (PMID:30825648)
• miRNA-34a could induce osteoarthritis synovial cell apoptosis via regulation of TGIF2 in vitro (PMID:31113203)
• TGIF2 promotes cervical cancer metastasis by negatively regulating FCMR. (PMID:32572908)
• miR-541 serves as a prognostic biomarker of osteosarcoma and its regulatory effect on tumor cell proliferation, migration and invasion by targeting TGIF2. (PMID:32709240)
• Circ-RNF13, as an oncogene, regulates malignant progression of HBV-associated hepatocellular carcinoma cells and HBV infection through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2. (PMID:33714261)
• Circular RNA circMMP1 Contributes to the Progression of Glioma Through Regulating TGIF2 Expression by Sponging miR-195-5p. (PMID:34471941)
• Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer. (PMID:34741437)
• Phosphorylation of TGIF2 represents a therapeutic target that drives EMT and metastasis of lung adenocarcinoma. (PMID:36647029)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000112895
mus_musculus	Tgif2	ENSMUSG00000062175
rattus_norvegicus	AABR07027925.2	ENSRNOG00000030925
rattus_norvegicus	Tgif2	ENSRNOG00000042374
drosophila_melanogaster	exd	FBGN0000611
drosophila_melanogaster	hth	FBGN0001235
drosophila_melanogaster	vis	FBGN0033748
drosophila_melanogaster	achi	FBGN0033749
caenorhabditis_elegans		WBGENE00000443
caenorhabditis_elegans		WBGENE00006796
caenorhabditis_elegans		WBGENE00017690

Paralogs (13): MEIS3 (ENSG00000105419), PBX4 (ENSG00000105717), MEIS2 (ENSG00000134138), MEIS1 (ENSG00000143995), TGIF2LX (ENSG00000153779), PKNOX1 (ENSG00000160199), PKNOX2 (ENSG00000165495), PBX3 (ENSG00000167081), TGIF2LY (ENSG00000176679), TGIF1 (ENSG00000177426), PBX1 (ENSG00000185630), MEIS3P2 (ENSG00000188013), PBX2 (ENSG00000204304)

Protein

Protein identifiers

Homeobox protein TGIF2 — Q9GZN2 (reviewed: Q9GZN2)

Alternative names: 5’-TG-3’-interacting factor 2, TGF-beta-induced transcription factor 2

All UniProt accessions (5): Q9GZN2, H0YKN5, U3KQ25, U3KQB5, U3KQS0

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional repressor, which probably repress transcription by binding directly the 5’-CTGTCAA-3’ DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.

Subunit / interactions. Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1.

Subcellular location. Nucleus.

Tissue specificity. Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.

Post-translational modifications. The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.

Miscellaneous. TGIF2 is amplified and overexpressed in several ovarian cancer cell lines.

Similarity. Belongs to the TALE/TGIF homeobox family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9GZN2-1	1	yes
Q9GZN2-2	2

RefSeq proteins (4): NP_001186442, NP_001186443, NP_001186444, NP_068581* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001356	HD	Domain
IPR008422	KN_HD	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR050224	TALE_homeobox	Family

Pfam: PF05920

UniProt features (12 total): region of interest 4, mutagenesis site 2, modified residue 2, splice variant 2, chain 1, DNA-binding region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9GZN2-F1	69.83	0.32

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 182, 186

Mutagenesis-validated functional residues (2):

Position	Phenotype
182	decrease of phosphorylation. strong decrease of phosphorylation; when associated with v-186.
186	decrease of phosphorylation. strong decrease of phosphorylation; when associated with v-182.

Function

Pathways and Gene Ontology

Reactome pathways

10 pathways

ID	Pathway
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-9764725	Negative Regulation of CDH1 Gene Transcription
R-HSA-162582	Signal Transduction
R-HSA-170834	Signaling by TGF-beta Receptor Complex
R-HSA-212436	Generic Transcription Pathway
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)
R-HSA-9006936	Signaling by TGFB family members

MSigDB gene sets: 310 (showing top): GGGACCA_MIR133A_MIR133B, RNGTGGGC_UNKNOWN, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GCANCTGNY_MYOD_Q6, GOBP_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION, GOZGIT_ESR1_TARGETS_DN, GOBP_NEUROGENESIS, CREBP1_Q2, CAGCTG_AP4_Q5, BONCI_TARGETS_OF_MIR15A_AND_MIR16_1, REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS, CREB_Q4, BROWNE_HCMV_INFECTION_24HR_UP

GO Biological Process (8): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355), regulation of gastrulation (GO:0010470), amacrine cell differentiation (GO:0035881), nodal signaling pathway (GO:0038092), positive regulation of amacrine cell differentiation (GO:1902871), neuron differentiation (GO:0030182), retina development in camera-type eye (GO:0060041)

GO Molecular Function (5): DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), DNA-binding transcription factor activity (GO:0003700), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677)

GO Cellular Component (4): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), centrosome (GO:0005813)

Reactome top-level categories

Rollup of top-8 pathways:

Category	Pathways
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	2
Regulation of CDH1 Gene Transcription	1
Signaling by TGFB family members	1
RNA Polymerase II Transcription	1
Signaling by TGF-beta Receptor Complex	1
Generic Transcription Pathway	1
Gene expression (Transcription)	1
Signal Transduction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
cellular anatomical structure	2
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
gastrulation	1
regulation of anatomical structure morphogenesis	1
regulation of embryonic development	1
neural retina development	1
central nervous system neuron differentiation	1
activin receptor signaling pathway	1
amacrine cell differentiation	1
positive regulation of neuron differentiation	1
regulation of amacrine cell differentiation	1
cell differentiation	1
generation of neurons	1
camera-type eye development	1
anatomical structure development	1
chromatin	1
DNA-binding transcription factor activity	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
transcription cis-regulatory region binding	1
regulation of DNA-templated transcription	1
transcription regulator activity	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
chromosome	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
centriole	1
microtubule organizing center	1

Protein interactions and networks

STRING

806 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TGIF2	TGFBI	Q15582	884
TGIF2	PABPC5	Q96DU9	784
TGIF2	PCDH11X	Q9BZA7	587
TGIF2	RBP2	P50120	585
TGIF2	PKM	P14618	579
TGIF2	CTBP1	Q13363	551
TGIF2	HDAC1	Q13547	460
TGIF2	HDAC3	O15379	454
TGIF2	SMAD3	P84022	438
TGIF2	FOXA2	Q9Y261	405
TGIF2	CYP26A1	O43174	393
TGIF2	SOX17	Q9H6I2	390
TGIF2	CDYL2	Q8N8U2	374
TGIF2	ZFYVE9	O95405	373
TGIF2	SKIL	P12756	366

IntAct

6 interactions, top by confidence:

A	B	Type	Score
H3-4	TGIF2	psi-mi:“MI:0915”(physical association)	0.400
TARBP2	TGIF2	psi-mi:“MI:0915”(physical association)	0.370
TGIF2	SAP30	psi-mi:“MI:0914”(association)	0.350
TGIF2	ZNF213	psi-mi:“MI:0914”(association)	0.350

BioGRID (36): TGIF2-C20orf24 (Affinity Capture-RNA), TGIF2 (Synthetic Lethality), TGIF2 (Affinity Capture-RNA), TGIF2-C20orf24 (Affinity Capture-RNA), TGIF2 (Negative Genetic), TGIF2 (Positive Genetic), TGIF2 (Positive Genetic), TGIF2 (Negative Genetic), TGIF2 (Biochemical Activity), TGIF2-C20orf24 (Positive Genetic), TGIF2 (Affinity Capture-Western), SMAD3 (Affinity Capture-Western), HIST3H3 (Proximity Label-MS), TGIF2 (Negative Genetic), TGIF2 (Negative Genetic)

ESM2 similar proteins: A0A1W2PPF3, A0A1W2PPM1, A1A546, A1YGI6, A2T763, A5YC49, A6NFQ7, A6NJG6, D2HQI1, G3X9P6, O42173, O57374, P09632, P0C7M4, P10242, P14837, P17278, P31272, P31538, Q1KKS8, Q28ET4, Q28G02, Q3LTE0, Q3UT54, Q4JM65, Q4KL20, Q5TM83, Q5TM84, Q5W1J6, Q68EH7, Q6NSW7, Q80Z64, Q8IUE1, Q8JH55, Q8JIT7, Q8JJ26, Q8MIB7, Q8MIB8, Q8MIE9, Q91685

Diamond homologs: A1YGI6, A6NDR6, A8K0S8, A8WL06, B7ZRT8, O00470, O04136, O14770, O22300, O42261, O46339, O65685, O70477, P41779, P41817, P46606, P48000, P48001, P48002, P48731, P53147, P54269, P55347, P56659, P56660, P56664, P56665, P56669, P70284, P78412, P78413, P78414, P78415, P79937, P81067, P81068, P97367, P97368, Q0E3C3, Q0J6N4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

23 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	23
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1231 predictions. Top by Δscore:

Variant	Effect	Δscore
20:36574631:GACAC:G	donor_gain	1.0000
20:36574636:G:GG	donor_gain	1.0000
20:36578963:GCAA:G	donor_gain	1.0000
20:36578966:AG:A	donor_loss	1.0000
20:36578967:G:GG	donor_gain	1.0000
20:36578967:GT:G	donor_loss	1.0000
20:36578968:T:G	donor_loss	1.0000
20:36573746:G:GG	donor_gain	0.9900
20:36573756:G:GT	donor_gain	0.9900
20:36574633:CACGT:C	donor_loss	0.9900
20:36574636:G:C	donor_loss	0.9900
20:36574637:T:A	donor_loss	0.9900
20:36574638:GAG:G	donor_loss	0.9900
20:36578736:CCCAG:C	acceptor_gain	0.9900
20:36578737:CCA:C	acceptor_loss	0.9900
20:36578737:CCAGG:C	acceptor_gain	0.9900
20:36578738:CAGG:C	acceptor_loss	0.9900
20:36578738:CAGGT:C	acceptor_gain	0.9900
20:36578739:A:AG	acceptor_gain	0.9900
20:36578740:G:GG	acceptor_gain	0.9900
20:36578928:C:G	donor_gain	0.9900
20:36578962:TGCAA:T	donor_gain	0.9900
20:36578963:GCAAG:G	donor_gain	0.9900
20:36578964:C:T	donor_gain	0.9900
20:36578964:CAA:C	donor_gain	0.9900
20:36578965:AA:A	donor_gain	0.9900
20:36578972:G:GT	donor_gain	0.9900
20:36590909:GATAT:G	acceptor_gain	0.9900
20:36574632:ACAC:A	donor_gain	0.9800
20:36574633:CAC:C	donor_gain	0.9800

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000256939 (20:36586386 C>G), RS1000416318 (20:36580339 G>A), RS1000556837 (20:36586513 G>A,T), RS1000809647 (20:36592564 A>C), RS1000817519 (20:36575085 G>A,C), RS1000828862 (20:36574801 G>T), RS1001237808 (20:36579463 G>A), RS1001362459 (20:36573445 G>C), RS1001370628 (20:36573272 G>A,T), RS1001632893 (20:36579374 T>C), RS1001643983 (20:36592218 C>T), RS1001719653 (20:36585860 G>A), RS1001752114 (20:36585629 C>T), RS1001845138 (20:36585524 C>G,T), RS1001888824 (20:36592643 T>C)

Disease associations

OMIM: gene MIM:607294 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, decreases expression	5
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	2
perfluorooctane sulfonic acid	decreases expression	2
(+)-JQ1 compound	decreases expression	2
Resveratrol	affects cotreatment, increases expression, decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Cadmium Chloride	decreases expression	2
dicrotophos	increases expression	1
uranyl acetate	affects expression	1
quercitrin	decreases expression	1
trichostatin A	affects expression	1
beta-lapachone	decreases expression	1
arsenite	increases methylation	1
perfluorooctanoic acid	decreases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
aflatoxin B2	decreases methylation	1
di-n-butylphosphoric acid	affects expression	1
perfluoro-n-nonanoic acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
NSC 689534	affects binding, decreases expression	1
Temozolomide	increases expression	1
Acetaminophen	decreases expression	1
Glyphosate	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation	1
Caffeine	affects phosphorylation	1
Copper	affects binding, decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A7J9	SEES3-1V human TGIF2, clone1	Embryonic stem cell	Male
CVCL_A7K0	SEES3-1V human TGIF2, clone2	Embryonic stem cell	Male
CVCL_A7K1	SEES3-1V human TGIF2, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.