TGOLN2

Summary

TGOLN2 (trans-golgi network protein 2, HGNC:15450) is a protein-coding gene on chromosome 2p11.2, encoding Trans-Golgi network integral membrane protein 2 (O43493). May be involved in regulating membrane traffic to and from trans-Golgi network.

This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Source: NCBI Gene 10618 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 66 total
• Druggable target: yes
• MANE Select transcript: NM_006464

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15450
Approved symbol	TGOLN2
Name	trans-golgi network protein 2
Location	2p11.2
Locus type	gene with protein product
Status	Approved
Aliases	TGN51, TGN46, TGN48, TGN38, TTGN2
Ensembl gene	ENSG00000152291
Ensembl biotype	protein_coding
OMIM	603062
Entrez	10618

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 protein_coding

ENST00000377386, ENST00000398263, ENST00000409015, ENST00000409232, ENST00000444342, ENST00000971851

RefSeq mRNA: 4 — MANE Select: NM_006464 NM_001206844, NM_001368095, NM_001368096, NM_006464

CCDS: CCDS46351, CCDS56126, CCDS56127, CCDS92789

Canonical transcript exons

ENST00000377386 — 4 exons

Exon	Start	End
ENSE00001004544	85326508	85327685
ENSE00001328407	85324915	85324998
ENSE00001895159	85327917	85327989
ENSE00001944098	85318027	85322741

Expression profiles

Bgee: expression breadth ubiquitous, 306 present calls, max score 99.36.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 99.2419 / max 698.9366, expressed in 1827 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29389	88.0571	1827
29388	8.8791	1666
29391	1.2971	747
29390	0.9633	543
29381	0.0452	17

Top tissues by expression

307 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
renal medulla	UBERON:0000362	99.36	gold quality
parotid gland	UBERON:0001831	99.33	gold quality
caput epididymis	UBERON:0004358	99.12	gold quality
lateral nuclear group of thalamus	UBERON:0002736	99.10	gold quality
mammary duct	UBERON:0001765	99.07	gold quality
mucosa of sigmoid colon	UBERON:0004993	99.00	gold quality
lower lobe of lung	UBERON:0008949	98.95	gold quality
corpus epididymis	UBERON:0004359	98.94	gold quality
visceral pleura	UBERON:0002401	98.84	gold quality
epididymis	UBERON:0001301	98.83	gold quality
colonic mucosa	UBERON:0000317	98.80	gold quality
choroid plexus epithelium	UBERON:0003911	98.80	gold quality
jejunal mucosa	UBERON:0000399	98.79	gold quality
subthalamic nucleus	UBERON:0001906	98.79	gold quality
epithelium of mammary gland	UBERON:0003244	98.77	gold quality
pylorus	UBERON:0001166	98.76	gold quality
germinal epithelium of ovary	UBERON:0001304	98.71	gold quality
superficial temporal artery	UBERON:0001614	98.67	gold quality
blood vessel layer	UBERON:0004797	98.67	gold quality
pleura	UBERON:0000977	98.64	gold quality
dorsal plus ventral thalamus	UBERON:0001897	98.64	gold quality
adult organism	UBERON:0007023	98.61	gold quality
inferior vagus X ganglion	UBERON:0005363	98.60	gold quality
parietal pleura	UBERON:0002400	98.58	gold quality
trigeminal ganglion	UBERON:0001675	98.55	gold quality
superior vestibular nucleus	UBERON:0007227	98.54	gold quality
medulla oblongata	UBERON:0001896	98.53	gold quality
substantia nigra pars reticulata	UBERON:0001966	98.53	gold quality
pons	UBERON:0000988	98.51	gold quality
epithelium of nasopharynx	UBERON:0001951	98.49	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-7606	no	1806.07
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

145 targeting TGOLN2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1193	100.00	65.93	529
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-130A-3P	99.90	73.31	1861
HSA-MIR-130B-3P	99.90	73.27	1850
HSA-MIR-301A-3P	99.90	73.15	1839
HSA-MIR-301B-3P	99.90	73.19	1836
HSA-MIR-3666	99.90	73.24	1833
HSA-MIR-4295	99.90	73.11	1838
HSA-MIR-7162-3P	99.89	68.16	1682
HSA-MIR-9902	99.89	69.15	2250

Literature-anchored findings (GeneRIF, showing 7)

• FXIII-A associated with podosomes & other structures adjacent to the plasma membrane, containing TGN46 & GM130 but not protein disulphide isomerase. FXIII-A was present in GM130-positive intracellular vesicles that could mediate its transport. (PMID:20086247)
• These data have identified different itineraries for the retrograde transport of Shiga toxin and TGN38 and distinct retromer components that regulate the transport of these cargos. (PMID:20138391)
• These analyses do not provide support for the hypothesis that common genetic variation in TGOLN2 contributes significantly to the risk for attempted suicide in subjects with major mood disorders. (PMID:20468057)
• These results indicate that hepatitis E virus (HEV)forms membrane-associated particles in the cytoplasm, and that the released HEV particles with a lipid membrane retain the antigenicity of TGOLN2 on their surface. (PMID:24221250)
• Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs. (PMID:34244781)
• Sorting of secretory proteins at the trans-Golgi network by human TGN46. (PMID:38466628)
• Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer. (PMID:38670394)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tgoln2	ENSDARG00000102599
mus_musculus	Tgoln1	ENSMUSG00000056429
rattus_norvegicus	Tgoln2	ENSRNOG00000014617

Protein

Protein identifiers

Trans-Golgi network integral membrane protein 2 — O43493 (reviewed: O43493)

Alternative names: Trans-Golgi network glycoprotein 46, Trans-Golgi network glycoprotein 48, Trans-Golgi network glycoprotein 51, Trans-Golgi network protein 2

All UniProt accessions (2): O43493, A0A5F9UY30

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in regulating membrane traffic to and from trans-Golgi network.

Subcellular location. Cell membrane. Golgi apparatus. trans-Golgi network membrane.

Tissue specificity. Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells.

Isoforms (6)

UniProt ID	Names	Canonical?
O43493-2	TGN46	yes
O43493-3	TGN48
O43493-4	4
O43493-5	5
O43493-6	6
O43493-7	7

RefSeq proteins (4): NP_001193773, NP_001355024, NP_001355025, NP_006455* (*=MANE)

Domains & families (InterPro)

Pfam: PF17818

UniProt features (69 total): repeat 14, compositionally biased region 9, glycosylation site 9, sequence variant 8, sequence conflict 7, splice variant 6, modified residue 5, short sequence motif 3, region of interest 2, topological domain 2, signal peptide 1, chain 1, transmembrane region 1, mutagenesis site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
6YAF	ELECTRON MICROSCOPY	9.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O43493-F1	49.67	0.02

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 71, 221, 298, 302, 351

Glycosylation sites (9): 39, 82, 96, 152, 180, 208, 222, 373, 377

Mutagenesis-validated functional residues (1):

Position	Phenotype
430	loss of relocalization to the trans-golgi.

Function

Pathways and Gene Ontology

Reactome pathways

12 pathways

ID	Pathway
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-432722	Golgi Associated Vesicle Biogenesis
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828	Clathrin-mediated endocytosis
R-HSA-8957275	Post-translational protein phosphorylation
R-HSA-199991	Membrane Trafficking
R-HSA-199992	trans-Golgi Network Vesicle Budding
R-HSA-392499	Metabolism of proteins
R-HSA-5653656	Vesicle-mediated transport
R-HSA-597592	Post-translational protein modification
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic

MSigDB gene sets: 166 (showing top): MORF_FLT1, FAELT_B_CLL_WITH_VH_REARRANGEMENTS_DN, SWEET_KRAS_ONCOGENIC_SIGNATURE, BASSO_B_LYMPHOCYTE_NETWORK, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, REACTOME_MEMBRANE_TRAFFICKING, LINDGREN_BLADDER_CANCER_CLUSTER_2A_DN, GERY_CEBP_TARGETS, GOCC_TRANS_GOLGI_NETWORK, LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP, GOCC_COATED_VESICLE, GOCC_GOLGI_ASSOCIATED_VESICLE, TIEN_INTESTINE_PROBIOTICS_24HR_UP, chr2p11

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (10): nucleoplasm (GO:0005654), endosome (GO:0005768), endoplasmic reticulum lumen (GO:0005788), Golgi apparatus (GO:0005794), trans-Golgi network (GO:0005802), plasma membrane (GO:0005886), transport vesicle (GO:0030133), trans-Golgi network transport vesicle (GO:0030140), clathrin-coated endocytic vesicle membrane (GO:0030669), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-7 pathways:

Category	Pathways
Membrane Trafficking	3
Metabolism of proteins	2
trans-Golgi Network Vesicle Budding	1
Intra-Golgi and retrograde Golgi-to-ER traffic	1
Clathrin-mediated endocytosis	1
Post-translational protein modification	1
Vesicle-mediated transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
endomembrane system	3
cellular anatomical structure	2
cytoplasmic vesicle	2
binding	1
nuclear lumen	1
endoplasmic reticulum	1
intracellular organelle lumen	1
cytoplasm	1
intracellular membrane-bounded organelle	1
Golgi apparatus subcompartment	1
membrane	1
cell periphery	1
Golgi-associated vesicle	1
transport vesicle	1
clathrin-coated vesicle	1
clathrin-coated vesicle membrane	1
endocytic vesicle membrane	1
clathrin-coated endocytic vesicle	1

Protein interactions and networks

STRING

2580 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TGOLN2	GCC1	Q96CN9	862
TGOLN2	STX6	O43752	835
TGOLN2	MARCHF2	Q9P0N8	815
TGOLN2	GOLGA2	Q08379	798
TGOLN2	EEA1	Q15075	785
TGOLN2	MARCHF3	Q86UD3	777
TGOLN2	GOLGB1	Q14789	772
TGOLN2	COPB1	P53618	764
TGOLN2	PACS1	Q6VY07	760
TGOLN2	IGF2R	P11717	756
TGOLN2	FURIN	P09958	755
TGOLN2	TFRC	P02786	732
TGOLN2	GOLPH3	Q9H4A6	731
TGOLN2	GOLGA1	Q92805	721
TGOLN2	LAMP1	P11279	705

IntAct

44 interactions, top by confidence:

A	B	Type	Score
TGOLN2	KRTAP10-9	psi-mi:“MI:0915”(physical association)	0.560
TGOLN2	ACBD3	psi-mi:“MI:0403”(colocalization)	0.550
PIK3R1	TGOLN2	psi-mi:“MI:0915”(physical association)	0.540
AP2B1	TGOLN2	psi-mi:“MI:0915”(physical association)	0.540
TGOLN2	DENND11	psi-mi:“MI:0914”(association)	0.530
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
TGOLN2	IGF2R	psi-mi:“MI:0403”(colocalization)	0.450
TGOLN2	GGA3	psi-mi:“MI:0403”(colocalization)	0.450
TGOLN2	PGRMC1	psi-mi:“MI:0914”(association)	0.420
TGOLN2	ABL1	psi-mi:“MI:0915”(physical association)	0.400
TGOLN2	CRK	psi-mi:“MI:0915”(physical association)	0.400
TGOLN2	FYN	psi-mi:“MI:0915”(physical association)	0.400
TGOLN2	GRB2	psi-mi:“MI:0915”(physical association)	0.400
TGOLN2	NCK1	psi-mi:“MI:0915”(physical association)	0.400
PLCG1	TGOLN2	psi-mi:“MI:0915”(physical association)	0.400
NS3	C15orf61	psi-mi:“MI:0914”(association)	0.350
	SHTN1	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350
	TNFRSF10A	psi-mi:“MI:0914”(association)	0.350
CD53	RAP1BL	psi-mi:“MI:0914”(association)	0.350
MAGEA8	METTL15	psi-mi:“MI:0914”(association)	0.350
DOCK5	DPYSL4	psi-mi:“MI:0914”(association)	0.350
TGOLN2	VIM	psi-mi:“MI:0914”(association)	0.350
AFG2B	MMP24OS	psi-mi:“MI:0914”(association)	0.350
SLC30A10	GOLIM4	psi-mi:“MI:0914”(association)	0.350

BioGRID (1770): KRTAP10-9 (Two-hybrid), TGOLN2 (Affinity Capture-MS), MDN1 (Affinity Capture-MS), POLE (Affinity Capture-MS), ATP1A3 (Affinity Capture-MS), NUP188 (Affinity Capture-MS), HEATR1 (Affinity Capture-MS), GPD1L (Affinity Capture-MS), INTS12 (Affinity Capture-MS), LARS2 (Affinity Capture-MS), IPO13 (Affinity Capture-MS), INTS4 (Affinity Capture-MS), PI4KA (Affinity Capture-MS), C16orf58 (Affinity Capture-MS), GOPC (Affinity Capture-MS)

ESM2 similar proteins: A0A060XQP6, A0A1S4FQ37, A2VD23, A3KQQ9, A7E371, B3A0Q3, B3EWZ0, B3EWZ1, B3EWZ4, B7W112, D1FQ14, E9Q9K5, G5EC21, O01949, O16883, O43493, O46203, O55188, O84462, P08721, P10451, P10923, P13665, P14287, P19814, P23498, P31096, P31097, P31098, P31936, P35662, P35663, P98193, Q13316, Q14093, Q28139, Q5MIT9, Q5SRN2, Q5UQ32, Q62313

Diamond homologs: O43493, P19814, Q5R5B8, Q62313, Q62314, Q8NC54, Q8K201

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 44 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Downstream signal transduction	6	65.3×	1e-07
DAP12 signaling	5	52.6×	4e-06
FCGR3A-mediated phagocytosis	5	26.7×	4e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

66 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	45
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

312 predictions. Top by Δscore:

Variant	Effect	Δscore
2:85324911:TTA:T	donor_loss	1.0000
2:85324912:TACC:T	donor_loss	1.0000
2:85324913:A:AC	donor_gain	1.0000
2:85324913:AC:A	donor_gain	1.0000
2:85324913:ACCT:A	donor_loss	1.0000
2:85324914:C:CC	donor_gain	1.0000
2:85324914:CC:C	donor_gain	1.0000
2:85324914:CCTT:C	donor_gain	1.0000
2:85324994:ATGAT:A	acceptor_gain	1.0000
2:85324995:TGAT:T	acceptor_gain	1.0000
2:85324996:GAT:G	acceptor_gain	1.0000
2:85324997:AT:A	acceptor_gain	1.0000
2:85324999:C:CC	acceptor_gain	1.0000
2:85326503:CTTA:C	donor_loss	1.0000
2:85326504:TTA:T	donor_loss	1.0000
2:85326505:TA:T	donor_loss	1.0000
2:85326506:A:AC	donor_gain	1.0000
2:85326506:AC:A	donor_gain	1.0000
2:85326506:ACCTT:A	donor_gain	1.0000
2:85326507:C:CA	donor_gain	1.0000
2:85326507:CC:C	donor_gain	1.0000
2:85326507:CCT:C	donor_gain	1.0000
2:85326507:CCTT:C	donor_gain	1.0000
2:85326507:CCTTC:C	donor_gain	1.0000
2:85327912:CTTAC:C	donor_loss	1.0000
2:85327913:TTA:T	donor_loss	1.0000
2:85327914:TACCC:T	donor_loss	1.0000
2:85327916:CCCG:C	donor_gain	1.0000
2:85324913:ACCTT:A	donor_gain	0.9900
2:85324914:CCTTC:C	donor_gain	0.9900

AlphaMissense

2862 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:85326514:C:A	K406N	0.998
2:85326514:C:G	K406N	0.998
2:85326527:G:T	A402D	0.998
2:85326542:G:T	A397D	0.998
2:85326566:A:G	L389P	0.998
2:85326518:T:A	N405I	0.997
2:85326554:G:T	A393D	0.997
2:85324985:A:T	V413D	0.996
2:85324991:G:T	A411D	0.996
2:85324925:A:G	L433S	0.995
2:85324935:A:G	Y430H	0.995
2:85324994:A:T	I410N	0.995
2:85324997:A:C	I409S	0.995
2:85324997:A:G	I409T	0.995
2:85326508:C:A	K408N	0.995
2:85326508:C:G	K408N	0.995
2:85324934:T:C	Y430C	0.994
2:85324982:A:G	L414P	0.994
2:85326515:T:A	K406M	0.994
2:85326517:G:C	N405K	0.994
2:85326517:G:T	N405K	0.994
2:85326522:G:C	H404D	0.994
2:85326528:C:G	A402P	0.994
2:85326530:A:T	I401N	0.994
2:85326534:A:C	Y400D	0.994
2:85326539:A:T	V398D	0.994
2:85326545:A:T	V396E	0.994
2:85326558:C:G	A392P	0.994
2:85324977:C:G	G416R	0.993
2:85324977:C:T	G416R	0.993

dbSNP variants (sampled 300 via entrez): RS1000521781 (2:85323603 C>A,T), RS1000611066 (2:85328306 A>C), RS1000738356 (2:85323874 G>A), RS1001134820 (2:85322221 C>A,G,T), RS1001268977 (2:85322994 T>C), RS1001414718 (2:85329124 T>C), RS1001440310 (2:85322495 G>A), RS1001486369 (2:85329425 C>T), RS1001651469 (2:85319881 A>G,T), RS1001700301 (2:85323266 A>T), RS1002202607 (2:85325123 C>A,T), RS1002420612 (2:85327983 G>A), RS1002675389 (2:85321317 T>C), RS1002799287 (2:85326619 A>G), RS1003402124 (2:85319771 G>A)

Disease associations

OMIM: gene MIM:603062 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST010241_421	Apolipoprotein A1 levels	1.000000e-12
GCST010242_351	HDL cholesterol levels	1.000000e-12

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004614	apolipoprotein A 1 measurement
EFO:0004612	high density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067035 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

59 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression	3
Cadmium Chloride	decreases expression, increases expression	3
methacrylaldehyde	increases abundance, affects cotreatment, affects expression, increases expression	2
Acrolein	increases expression, increases abundance, affects cotreatment, affects expression	2
Ozone	affects cotreatment, affects expression, increases expression, increases abundance	2
Tobacco Smoke Pollution	affects expression, decreases expression	2
Tretinoin	affects expression, increases expression	2
FR900359	increases phosphorylation	1
testosterone enanthate	affects expression	1
alpha-pinene	affects cotreatment, affects expression, increases abundance	1
uranyl acetate	affects expression	1
bisphenol A	increases expression	1
butyraldehyde	decreases expression	1
nickel sulfate	decreases expression	1
coumarin	decreases phosphorylation	1
enzacamene	increases expression	1
tamibarotene	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
octylmethoxycinnamate	decreases expression	1
torcetrapib	increases expression	1
ICG 001	increases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1
LM11 compound	affects localization	1
bisphenol AF	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Arsenic Trioxide	decreases expression	1
Air Pollutants	affects cotreatment, affects expression, increases abundance	1
Amiodarone	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652622	Binding	Binding affinity to human TGOLN2 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1I1	Abcam A-549 TGOLN2 KO	Cancer cell line	Male
CVCL_TS26	HAP1 TGOLN2 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.