TH2LCRR

Summary

TH2LCRR (T helper type 2 locus control region associated RNA, HGNC:40495) is a long non-coding RNA gene on chromosome 5q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40495
Approved symbol	TH2LCRR
Name	T helper type 2 locus control region associated RNA
Location	5q31.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	TH2-LCR
Ensembl gene	ENSG00000223442
Ensembl biotype	lncRNA
Entrez	101927761
RNAcentral	URS00008E39C6 — lncRNA, 470 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000417516, ENST00000435042, ENST00000457489, ENST00000458509, ENST00000814671, ENST00000814672, ENST00000814673, ENST00000814674, ENST00000814675, ENST00000814676, ENST00000814677, ENST00000814678, ENST00000814679, ENST00000814680, ENST00000814681, ENST00000814682, ENST00000814683, ENST00000814684

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000417516 — 2 exons

Exon	Start	End
ENSE00004215885	132655719	132656192
ENSE00004215887	132637512	132638265

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 94.26.

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	94.26	gold quality
left testis	UBERON:0004533	86.50	gold quality
right testis	UBERON:0004534	85.64	gold quality
testis	UBERON:0000473	84.50	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.87	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.51	gold quality
right uterine tube	UBERON:0001302	73.52	gold quality
calcaneal tendon	UBERON:0003701	73.27	gold quality
bone marrow cell	CL:0002092	72.99	gold quality
tendon	UBERON:0000043	72.06	gold quality
adrenal tissue	UBERON:0018303	70.39	gold quality
skin of leg	UBERON:0001511	70.13	gold quality
skin of abdomen	UBERON:0001416	70.11	gold quality
ventricular zone	UBERON:0003053	69.89	gold quality
mucosa of stomach	UBERON:0001199	69.80	gold quality
left ovary	UBERON:0002119	69.72	gold quality
sural nerve	UBERON:0015488	69.63	gold quality
tibial nerve	UBERON:0001323	69.56	gold quality
endocervix	UBERON:0000458	69.44	gold quality
right lobe of liver	UBERON:0001114	69.06	gold quality
ectocervix	UBERON:0012249	68.99	gold quality
body of uterus	UBERON:0009853	68.60	gold quality
right ovary	UBERON:0002118	68.57	gold quality
body of pancreas	UBERON:0001150	68.55	gold quality
rectum	UBERON:0001052	68.47	gold quality
ganglionic eminence	UBERON:0004023	68.38	gold quality
tibial artery	UBERON:0007610	68.23	gold quality
popliteal artery	UBERON:0002250	68.22	gold quality
aorta	UBERON:0000947	67.40	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Convergent Evidence Supports TH2LCRR as a Novel Asthma Susceptibility Gene. (PMID:34851809)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.